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| 1 | Epigenetic repression of miR-132 expression by the hepatitis B virus x protein in hepatitis B virus-related hepatocellular carcinoma显示文摘 | Xufu Wei Cui Tan Chengyong Tang Guosheng Ren Tingxiu Xiang Zhu Qiu Rui Liu Zhongjun Wu | 2013 | Cellular Signalling2013，，5： | 8 |
| 2 | The hepatitis B virus-associated estrogen receptor alpha (ERα) was regulated by microRNA-130a in HepG2.2.15 human hepatocellular carcinoma cells显示文摘雌激素受体(ERs ) 在 hepatocarcinogenesis 起重要作用,它被坚持的肝炎 B 总是促进病毒(HBV ) 感染。最近的研究连接了 microRNAs (miRNAs ) 到病毒的致病或 oncogenesis。嗯能导致房间周期前进或 apoptosis 的抑制,当时嗯有的相反的效果。这里,我们建议 HBV 在病毒的 oncogenesis 影响了 ERs 表示,它可能被 miRNAs 触发。蛋白质表示嗯在 HepG2 房间在 HepG2.2.15 房间是比那强壮得多的,它不与它在这些房间的 mRNA 表示一致。MicroRNA-130a (miR-130a ) 被预言是一个管理者嗯由指向它的 3 untranslated 区域(3-UTR ) 。提高的绿荧光蛋白质(EGFP ) 记者实验证实了 miR-130a 的直接相互作用并且嗯。而且,嗯蛋白质水平相反地与 miR-130a 水平被相关。一起拿,我们的研究支持了感染可能稀释的那 HBV miR-130a 表示并且嗯是 miR-130a 的一个直接目标。在在 HepG2 和 HepG2.2.15 房间之间的 miR-130a 层次的差别导致了差别在嗯表示,在病毒的致病暗示主人病毒串音由 miRNAs 调停了。 | Liping Tang Yong Pu Danny Ka-Ho Wong Tao Liu Hua Tang Tingxiu Xiang Man-Fung Yuen Guosheng Ren | 2011 | Acta Biochimica et Biophysica Sinica2011，43，8： | 3 |
| 3 | Abscisic Acid Suppresses the Highly Occurred Somatic Homologous Recombination in Arabidopsis rfc1 Mutant显示文摘The phytohormone abscisic acid(ABA)regulates many aspects of plant growth,including seed germination,root growth and cell division.Previous study indicates that ABA treatment increases DNA damage and somatic homologous recombination(HR)in Arabidopsis abo4/pol 3(aba overly-sensitive 4/DNA polymerase 3)mutants.DNA replication factor C(RFC)complex is required for loading PCNA(Proliferating Cell Nuclear Antigen)during DNA replication.The defect in RFC1,the largest subunit of RFC,causes the high HR and DNA damage sensitivity in Arabidopsis.Here we found that like polε/abo4,rfc1 is sensitive to ABA in both ABA-inhibiting seed germination and root growth.However,ABA treatment greatly reduces HR and also reduces the expression of the DNA-damaged marker genes in rfc1.These results suggest that RFC1 plays critical roles in ABA-mediated HR in Arabidopsis. | Tingxiu Yao Dan Jin Qian Liu Zhizhong Gong | 2013 | Journal of Genetics and Genomics2013，40，9： | 2 |
| 4 | Depression and stress levels increase risk of liver cancer through epigenetic downregulation of hypocretin显示文摘Recent studies suggest that Hypocretin (HCRT, Orexin) are involved in stress regulation of depression through the hypothalamic-pituitary-adrenal (HPA) axis. However, the molecular mechanism by which Hypocretin regulate neurobiological responses is unknown. Herein, the effects of chronic stress on the epigenetic modification of HCRT and its association with depression were explored with regard to a potential role in cancer progression. In the study, Sprague Dawley (SD) rats were used to establish an animal model of cancer with depression by administrating n-nitrosodiethylamine (DEN) and chronic unpredictable mild stress (CUMS). RNA-sequencing was used to detect differentially expressed genes in the hippocampus of rats and quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate the results of RNA-sequencing. The status of HCRT promoter methylation was assessed by methylation specific polymerase chain reaction. Behavioral tests showed that rats exposed to CUMS had significant depressive-like behaviors. The number of liver tumors and tumor load in depressed rats exposed to CUMS was higher than in SD rats without CUMS. RNA-sequencing revealed that HCRT was one of the most siginificantly downregulated gene in the hippocampus of SD rats with CUMS compared to non-stressed group, which was validated by qRT-PCR. HCRT mRNA expression was downregulated and the promoter for HCRT was hyper-methylated in those with depression. These results identified a critical role for chronic psychological stressors in tumorigenesis and cancer progression, via epigenetic HCRT downregulation. Such epigenetic downregulation may be the molecular basis for the association of cancer with depression. | Chunyun Pu Shaorong Tian Sanxiu He Weihong Chen Yuanyuan He Hongyan Ren Jing Zhu Jun Tang Xiaolan Huang Ying Xiang Yixiao Fu Tingxiu Xiang | 2022 | Genes & Diseases2022，9，4： | 2 |
| 5 | Effects of Polystyrene encapsulated Magnesium Hydroxide on Rheological and Flame-retarding Properties of HIPS Composites 显示文摘 | Chang Suqi Xie TingXiu Yarn Guisheng | 2006 | Polym Degrad Stab2006，91，12： | 1 |
| 6 | Effect of montmorillonite on the morphologies and properties of monomer casting polyamide 6/polystyrene blends via successive in situ polymerization显示文摘 | Liu Yan Chen Zhenming Xie Tingxiu | 2011 | Journal of Mate- rials Science2011，46，8： | 1 |
| 7 | Effects of polystyreneencapsulated magnesium hydroxide on rheological and flameretarding properties of HIPS composites显示文摘 | Chang Suqi Xie TingXiu Yang Guisheng | 2006 | Polym Degrad Stab2006，91，12： | 1 |
| 8 | Dihydroartemisinin induces endoplasmic reticulum stress-mediated apoptosis in HepG2 human hepatoma cells显示文摘 | Xiaoling Gao Ziguo Luo Tingxiu Xiang | | 0，，06： | 1 |
| 9 | Effects of shell thickness of polystyrene-encapsulated Mg(OH)2 on flammability and rheological properties of high impact polystyrene composites显示文摘 | Chang Suqin Xie Tingxiu Yang Guisheng | 2007 | Polym Int2007，56，9： | 1 |
| 10 | Toughe ning and Compatibilization of Polypropylene/Polyamide-6 Blends with a Maleated Grafted Ethylene-co-vinyl Acetate 显示文摘 | Hongzhi Liu Tingxiu Xie Lianlong Hou | 2006 | Journal of Applied Polymer Science2006，99，： | 1 |
| 11 | Effects of polystyrene-encapsulated magnesium hydroxide on rheological and flame-retarding properties of HIPS composites显示文摘 | Chang Suqin Xie Tingxiu Yang Guisheng | 2006 | Polym Degrad Stab2006，91，12： | 1 |
| 12 | Effects of interfacial modification on the thermal,mechanical,and fire properties of high-impact polystyrene/microencapsulated red phosphorous显示文摘 | Suqin Chang Tingxiu Xie Guisheng Yang | 2008 | Journal of Applied Polymer Science2008，110，： | 1 |
| 13 | Effects of interfacial modification on the thermal, mechanical, and fire properties of high-ira-pact polystyrene/microencapsulated red phosphorous 显示文摘 | Chang Suqin Xie Tingxiu Yang Guisheng | 2008 | Journal of Applied Polymer Science2008，110，： | 1 |
| 14 | Effects of shell thickness of polystyrene-encapsulated Mg(OH)2 on flammability and rheological properties of high-impact polystyrene composites 显示文摘 | Suqin Chang Tingxiu Xie Guisheng Yang | 2007 | polymer International2007，56，： | 1 |
| 15 | Effects of interfacial modification on the thermal, mechanical, and fire properties of high-impact polystyrene/microencapsulated red phosphorous 显示文摘 | Suqin Chang Tingxiu Xie Guisheng Yang | 2008 | Journal of Applied Polymer Science2008，110，： | 1 |
| 16 | Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer显示文摘 | Xiaokui T Xuedong Y Tingxiu X | 2012 | Cancer Biomarkers2012，，： | 1 |
| 17 | Effects of polystyrene-encapsulated magnesium hydroxide on rheological and flame-retarding properties of hips composites显示文摘 | Chang Suqi Xie Tingxiu Yang Guisheng | 2006 | Polym Degrad Stab2006，91，12： | 1 |
| 18 | Antioxidative and immunoprotective effects of Pyracantha fortuneana (Maxim.) Li polysaccharides in mice显示文摘 | Chengfu Yuan Changdong Wang Youquan Bu Tingxiu Xiang Xiuning Huang Zhiwei Wang Faping Yi Guosheng Ren Geli Liu Fangzhou Song | 2010 | Immunology Letters2010，，1： | 1 |
| 19 | Effects of Polystyrene Encapsulated Magnesium Hydroxide on Rheological and Flame-retarding Properties of HIPS Composites 显示文摘 | Chang Suqi Xie TingXiu Yang Guisheng | 2006 | Polym Degrad Stab2006，91，12： | 1 |
| 20 | Effects of gnesium hydroxide on rheological and flame-retarding properties of HIPS composites显示文摘 | Suqin Chang Tingxiu Xie polystyrene-encapsulated Gu ma sheng Yang | 2006 | Polymer Degradation and Stability2006，91，： | 1 |
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