|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Metastatic recurrence to a solitary lymph node four years after hepatic lobectomy for primary hepatocellular carcinoma显示文摘This report describes a patient that developed recurrent metastatic hepatocellular carcinoma(HCC) to a suprapancreatic lymph node four years after being treated for primary HCC via complete left hepatectomy. Metastatic HCC was proven by pathologic confirmation. The report addresses the role of surgical resection as a treatment modality for recurrent HCC to solitary lymph nodes. The role of biological chemotherapy as adjuvant treatment is also addressed. | Michael L Caparelli Nathan J Roberts Timothy S Braverman Robert M Stevens Edward R Broun Shyam Allamaneni | 2016 | World Journal of Hepatology2016，8，23： | 2 |
| 3 | Movement of the femoral head after salter osteotomy for acetabular dysplasia显示文摘 | Michael R Timothy M | 1990 | J Bone and Joint Surg1990，72，： | 1 |
| 4 | Suboptimal Minimum Cluster Volume Cover-Based Method for Measuring Fractal Dimension显示文摘 | Charles R T Timothy R M David J G | 2003 | IEEE Transactions on Geoscience and Remote Sensing2003，25，1： | 1 |
| 5 | High bandwidth fast steering mirror 显示文摘 | Francisc M Tapos Derek J Edinger Timothy R Hilby | 2005 | SPIE2005，5877，： | 1 |
| 6 | An overview of the municipal waste incineration industry in Asia and the former Soviet Union显示文摘 | TIMOTHY R CROCKETT BODE M A | 1996 | Journal of Hazardous Material1996，47，： | 1 |
| 7 | Accelerated drying of button mushrooms, brussels sprouts and cauliflower by ap- plying power ultrasound and its rehydration properties 显示文摘 | Anet R J Timothy J M Larysa P B | 2007 | Journal of Food Engineering2007，81，3： | 1 |
| 8 | Physical properties of ultrasound treated soy proteins显示文摘 | ANET R J VESNA L TIMOTHY J M | 2009 | Journal of Food Engineering2009，93，4： | 1 |
| 9 | Human Pathogens Abundant in the Bacterial Metagenome of Cigarettes显示文摘 | Sapkota Amy R Berger Sibel Vogel Timothy M | 2010 | Environmental Health Perspectives2010，，3： | 1 |
| 10 | Potential Impact of Accelerating the Primary Dose of Rotavirus Vaccine in Infants显示文摘 | Elizabeth E Halvorson Timothy R Peters Beverly M Snively | 2012 | Vaccine2012，30，17： | 1 |
| 11 | Modelling microwave heating显示文摘 | JAMES M H TIMOTHY R M | | 0，，01： | 1 |
| 12 | Functional expression of olfactory-adrenergic receptor chimeras and intracellular retention of heterologously expressed olfactory receptors显示文摘 | Timothy S McClintock Teresa M Landers Alexander A Gimelbrant Lynn Z Fuller Brian A Jackson Channa K Jayawickreme Michael R Lerner | 1997 | Molecular Brain Research1997，，2： | 1 |
| 13 | Effects of a Reduced Time - Out Interval on Compliance with the Time - Out Instruction 显示文摘 | Donaldson Jeanne M Vollmer Timothy R Yakich Theresa M | 2013 | Journal of Applied Be- havior Analysis2013，，46： | 1 |
| 14 | Stategic risk:an ordinal approach 显示文摘 | JAMES M C TIMOTHY W R | 1992 | Management Science1992，，12： | 1 |
| 15 | A Randomized Trial of Direct Mailing of Fecal Occult Blood Tests To Increase Colorectal Cancer Screening显示文摘 | Timothy R Church M Mark W | 2004 | JNCI2004，96，10： | 1 |
| 16 | Robust speaker recognition in noisy conditions 显示文摘 | Ji M Timothy J H James R G | 2007 | IEEE Transactions on Audio Speech and Language Processing2007，15，5： | 1 |
| 17 | Designing and Deploying a Building-Wide Cognitive Radio Network Testbed 显示文摘 | Timothy R N Shajedul H S M DePoy E | 2010 | IEEE Communication Magazines2010，48，9： | 1 |
| 18 | Growth and behavior of larval krill ( Euphausia superba) under the ice in late winter 2001 west of the Antarctic Peninsula 显示文摘 | ROBIN M R LANGDON B Q TIMOTHY N | 2004 | Deep-Sea Research II2004，，51： | 1 |
| 19 | Research and development of an implantable,axial-flow left ventricular assist device:the Jarvik 2000 heart显示文摘 | Frazier O H Timothy J M Jarvik R K | 2001 | Ann Thora Surg2001，71，3： | 1 |
| 20 | Multiple envi ronmental controls on phytoplankton growth strategies determine adaptive responses of the N : P ratio 显示文摘 | Stuart J D James R C Timothy M L | 2014 | E cology Letters2014，17，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员