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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | Discovering and doing family medicine and community health research显示文摘We dedicate this issue to aspiring family medicine and community health researchers.We include as our audience students,residents and fellows who are still learning the craft of clinical care,clinician educators making innovative strides in teaching,and experienced clinical practitioners who are inquisitive and want to contribute to the science of family medicine and community health.In addition,we believe this issue will appeal to senior researchers and mentors as a resource to share with mentees.We now focus on why this special issue provides a unique niche for encouraging and making primary care research more accessible in primary care around the globe. | Michael D Fetters Timothy C Guetterman | 2019 | Family Medicine and Community Health2019，7，2： | 5 |
| 3 | Neuromuscular electrical stimulation and testosterone did not influence heterotopic ossification size after spinal cor injury: A case series显示文摘Neuromuscular electrical stimulation(NMES) and testosterone replacement therapy(TRT) are effective rehabilitation strategies to attenuate muscle atrophy and evoke hypertrophy in persons with spinal cord injury(SCI). However both interventions might increase heterotopic ossification(HO) size in SCI patients. We present the results of two men with chronic traumatic motor complete SCI who also had pre-existing HO and participated in a study investigating the effects of TRT or TRT plus NMES resistance training(RT) on body composition. The 49-year-old male, Subject A, has unilateral HO in his right thigh. The 31-year-old male, Subject B, has bilateral HO in both thighs. Both participants wore transdermal testosterone patches(4-6 mg/d) daily for 16 wk. Subject A also underwent progressive NMES-RT twice weekly for 16 wk. Magnetic resonance imaging scans were acquired prior to and post intervention. Cross-sectional areas(CSA) of thewhole thigh and knee extensor skeletal muscles, femoral bone, and HO were measured. In Subject A(NMES-RT + TRT), the whole thigh skeletal muscle CSA increased by 10%, the knee extensor CSA increased by 17%, and the HO + femoral bone CSA did not change. In Subject B(TRT), the whole thigh skeletal muscle CSA increased by 13% in the right thigh and 6% in the left thigh. The knee extensor CSA increased by 7% in the right thigh and did not change in the left thigh. The femoral bone and HO CSAs in both thighs did not change. Both the TRT and NMES-RT + TRT protocols evoked muscle hypertrophy without stimulating the growth of preexisting HO. | Pamela D Moore Ashraf S Gorgey Rodney C Wade Refka E Khalil Timothy D Lavis Rehan Khan Robert A Adler | 2016 | World Journal of Clinical Cases2016，4，7： | 3 |
| 4 | Tourism growth, national development and regional inequality in Turkey 显示文摘 | Tosun C Timothy D J Ozturk Y | 2003 | Journal of Sustainable Tourism2003，11，23： | 1 |
| 5 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 6 | Development and potential role of type-2 sodium-glucose transporter inhibitors for management of type 2 diabetes 显示文摘 | Timothy C H Simon W D | 2011 | Diabetes Ther2011，2，3： | 1 |
| 7 | Evolving space-filling curves to distribute radial basis functions over an inputspace显示文摘 | Timothy D C | 1994 | IEEE Transactions on Neural Networks1994，5，： | 1 |
| 8 | Evolving space filling curves to distribute radial basis functions over an in- put space 显示文摘 | Bruce A W Timothy D C | 1994 | IEEE Transactions on Neural Net- works1994，，5： | 1 |
| 9 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 10 | Tourism Growth National Develop- ment and Regional Inequality in Turkey显示文摘 | Tosun C Timothy D J Qzturk Y | 2013 | Journal of Sustainable Tourism2013，11，2： | 1 |
| 11 | The surgical treat ment of metastatic disease of the spine显示文摘 | Hatrick N C Lucas J D Timothy A R | 2000 | Radiother Oncol2000，56，3： | 1 |
| 12 | PI3K/Akt regulates early differentiation in human laryngeal keratinocytes 显示文摘 | Raduwan D Timothy C Bettie M | 2005 | In Vitro Cellular & Development Bio Ani2005，41，3： | 1 |
| 13 | Holmium laser percutaneous nephrolithotomy using a unique suction device显示文摘 | David C C Timothy D A | 2004 | J Endourol2004，18，： | 1 |
| 14 | Foodborne Campylobacter: Infections, Metabolism, Pathogenesis and Reservoirs显示文摘 | Epps Sharon V R Harvey Roger B Hume Michael E Phillips Timothy D Anderson Robin C Nisbet David J | 2013 | International Journal of Environmental Research and Public Health2013，，12： | 1 |
| 15 | Nano Li4Ti5O12-LiMn2O4 batteries with high power capability and improved cycle-life显示文摘 | Pasquier A D Huang C C Timothy S | 2009 | Journal of Power Sources2009，186，2： | 1 |
| 16 | NEAR Laser rangefinder: a tool for the mapping and topologic study of asteroid 433 Eroz 显示文摘 | TIMOTHY C D | 1998 | Johns Hopkins APL Technical Digest1998，19，2： | 1 |
| 17 | A papillomavirus-like particle (VLP) vaccine displaying HPV16 L2 epitopes induces cross-neutralizing antibodies to HPV11显示文摘 | Slupetzky K Ratish G Timothy D C | 2006 | Vaccine2006，25，2007： | 1 |
| 18 | Hippocampal mineralocorticoid, but not glucocorticoid, receptors modulate anxietylike behavior in rats 显示文摘 | Smythe J W Murphy D Timothy C | 1997 | Pharmacol Biochem Behav1997，56，3： | 1 |
| 19 | Tourism growth, national development and regional inequa -lityin Turkey显示文摘 | Tosun C Timothy D J Ozturk Y | 2003 | Journal of Sustainable Tourism2003，11，2： | 1 |
| 20 | Tourism growth, national development and regional inequality in Turkey显示文摘 | Tosun C Timothy D J Ozturk Y | 2003 | Journal of Sustainable Tourism2003，5，2： | 1 |
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