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| 1 | Concepts of hypoxic NO signaling in remote ischemic preconditioning显示文摘Acute coronary syndromes remain a leading single cause of death worldwide. Therapeutic strategies to treat cardiomyocyte threatening ischemia/reperfusion injury are urgently needed. Remote ischemic preconditioning(r IPC) applied by brief ischemic episodes to heartdistant organs has been tested in several clinical studies, and the major body of evidence points to beneficial effects of r IPC for patients. The underlying signaling, however, remains incompletely understood. This relates particularly to the mechanism by which the protective signal is transferred from the remote site to the target organ. Many pathways have been forwarded but none can explain the protective effects completely. In light of recent experimental studies, we here outline the current knowledge relating to the generation of the protective signal in the remote organ, the signal transfer to the target organ and the transduction of the transferred signal into cardioprotection. The majority of studies favors a humoral factor that activates cardiomyocyte downstream signaling- receptor-dependent and independently. Cellular targets include deleterious calcium(Ca2+) signaling, reactive oxygen species, mitochondrial function and structure, and cellular apoptosis and necrosis. Following an outline of the existing evidence, we will furthermore characterize the existing knowledge and discuss future perspectives with particular emphasis on the interaction between the recently discovered hypoxic nitrite-nitric oxide signaling in r IPC. This refers to the protective role of nitrite, which can be activated endogenously using r IPC and which then contributes to cardioprotection by rIPC. | Matthias Totzeck Ulrike Hendgen-Cotta Tienush Rassaf | 2015 | World Journal of Cardiology2015，7，10： | 4 |
| 2 | Potential of dietary nitrate in angiogenesis显示文摘Endothelial dysfunction with impaired bioavailability of nitric oxide(NO) is the hallmark in the development of cardiovascular disease. Endothelial dysfunction leads to atherosclerosis, characterized by chronic inflammation of the arterial wall and stepwise narrowing of the vessel lumen. Atherosclerosis causes deprivation of adequate tissue blood flow with compromised oxygen supply. To overcome this undersupply, remodeling of the vascular network is necessary to reconstitute and sustain tissue viability. This physiological response is often not sufficient and therapeutic angiogenesis remains an unmet medical need in critical limb ischemia or coronary artery disease. Feasible approaches to promote blood vessel formation are sparse. Administration of pro-angiogenic factors, gene therapy, or targeting of micro RNAs has not yet entered the daily practice. Nitric oxide is an important mediator of angiogenesis that becomes limited under ischemic conditions and the maintenance of NO availability might constitute an attractive therapeutic target. Until recently it was unknown how the organism provides NO under ischemia. In recent years it could be demonstrated that NO can be formed independently of its enzymatic synthesis in the endothelium by reduction of inorganic nitrite under hypoxic conditions. Circulating nitrite derives from oxidation of NO or reduction of inorganic nitrate by commensal bacteria in the oral cavity. Intriguingly, nitrate is a common constituent of our everyday diet and particularly high concentrations are found in leafy green vegetables such as spinach, lettuce, or beetroot. Evidence suggests that dietary nitrate supplementation increases the regenerative capacity of ischemic tissue and that this effect may offer an attractive nutrition-based strategy to improve ischemia-induced revascularization. We here summarize and discuss the regenerative capacity of dietary nitrate on the vascular system. | Christos Rammos Peter Luedike Ulrike Hendgen-Cotta Tienush Rassaf | 2015 | World Journal of Cardiology2015，7，10： | 4 |
| 3 | Nitrite Regulates Hypoxic Vasodilation via Myoglobin-Dependent Nitric Oxide Generation显示文摘 | Matthias Totzeck Ulrike B. Hendgen-Cotta Peter Luedike Michael Berenbrink Johann P. Klare Heinz-Juergen Steinhoff Dominik Semmler Sruti Shiva Daryl Williams Anja Kipar Mark T. Gladwin Juergen Schrader Malte Kelm Andrew R. Cossins Tienush Rassaf | 2012 | Circulation2012，，3： | 2 |
| 4 | Dietary inorganic nitrate mobilizes circulating angiogenic cells显示文摘 | Christian Heiss Christian Meyer Matthias Totzeck Ulrike B. Hendgen-Cotta Yvonne Heinen Peter Luedike Stefanie Keymel Nassim Ayoub Jon O. Lundberg Eddie Weitzberg Malte Kelm Tienush Rassaf | 2012 | Free Radical Biology and Medicine2012，，9： | 2 |
| 5 | Dietary Nitrate Reverses Vascular Dysfunction in Older Adults With Moderately Increased Cardiovascular Risk显示文摘 | Christos Rammos Ulrike B. Hendgen-Cotta Julia Sobierajski Andrea Bernard Malte Kelm Tienush Rassaf | 2014 | Journal of the American College of Cardiology2014，，15： | 2 |
| 6 | Circulating Nitrite Contributes to Cardioprotection by Remote Ischemic Preconditioning显示文摘 | Tienush Rassaf Matthias Totzeck Ulrike B. Hendgen-Cotta Sruti Shiva Gerd Heusch Malte Kelm | 2014 | Circulation Research2014，，10： | 2 |
| 7 | S-nitrosation of mitochondrial connexin 43 regulates mitochondrial function显示文摘 | Daniel Soetkamp Tiffany T. Nguyen Sara Menazza Christine Hirschh?user Ulrike B. Hendgen-Cotta Tienush Rassaf Klaus D. Schlüter Kerstin Boengler Elizabeth Murphy Rainer Schulz | 2014 | Basic Research in Cardiology2014，，5： | 1 |
| 8 | Initial results of using a novel irrigated multielectrode mapping and ablation catheter for pulmonary vein isolation显示文摘 | Dong-In Shin Kiriakos Kirmanoglou Christian Eickholt Jan Schmidt Lukas Clasen Britta Butzbach Tienush Rassaf Marc Merx Malte Kelm Christian Meyer | 2013 | Heart Rhythm2013，，： | 1 |
| 9 | Depletion of circulating blood NOS3 increases severity of myocardial infarction and left ventricular dysfunction显示文摘 | Marc W. Merx Simone Gorressen Annette M. Sandt Miriam M. Cortese-Krott Jan Ohlig Manuel Stern Tienush Rassaf Axel G?decke Mark T. Gladwin Malte Kelm | 2014 | Basic Research in Cardiology2014，，： | 1 |
| 10 | Impaired endothelial progenitor cell function predicts age-dependent carotid intimal thickening显示文摘 | Stefanie Keymel MD Christoph Kalka MD Tienush Rassaf MD Yerem Yeghiazarians MD FACC Malte Kelm MD FESC Christian Heiss MD | 2008 | Basic Research in Cardiology2008，，6： | 1 |
| 11 | Reabtime transesophageal three dimensional echoeardiography for guidance of percutaneous cardiac interventions first experience显示文摘 | Balzer J Harald K Tienush R | 2008 | Clin Res Cardiol2008，97，9： | 1 |
| 12 | Intraprocedural online fusion of echocardiography and fluoroscopy during transapical mitral valve-in-valve implantation显示文摘 | Jan Balzer Tobias Zeus Alexander Blehm Ralf Westenfeld Artur Lichtenberg Malte Kelm Tienush Rassaf | 2014 | Canadian Journal of Cardiology2014，，： | 1 |
| 13 | Real-time transesophageal three-dimensional echocardiography for guidance of percutaneous cardiac interventions: first experience显示文摘 | Jan Balzer MD Harald Kühl MD Tienush Rassaf MD Rainer Hoffmann MD Patrick Schauerte MD Malte Kelm MD Andreas Franke MD | 2008 | Clinical Research in Cardiology2008，，9： | 1 |
| 14 | Higher endogenous nitrite levels are associated with superior exercise capacity in highly trained athletes显示文摘 | Matthias Totzeck Ulrike B. Hendgen-Cotta Christos Rammos Lisa-Marie Frommke Christian Knackstedt Hans-Georg Predel Malte Kelm Tienush Rassaf | 2012 | Nitric Oxide2012，，2： | 1 |
| 15 | Assessment of the functional diversity of human myoglobin显示文摘 | Matthias Totzeck Ulrike B. Hendgen-Cotta Christos Rammos Aniela M. Petrescu Christian Meyer Jan Balzer Malte Kelm Tienush Rassaf | 2012 | Nitric Oxide2012，，4： | 1 |
| 16 | Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly显示文摘 | Christos Rammos Ulrike B. Hendgen-Cotta Julia Pohl Matthias Totzeck Peter Luedike Volker T. Schulze Malte Kelm Tienush Rassaf Elísio Costa | 2014 | BioMed Research International2014，，： | 1 |
| 17 | Age-related vascular gene expression profiling in mice显示文摘 | Christos Rammos Ulrike B. Hendgen-Cotta Rene Deenen Julia Pohl Pia Stock Christian Hinzmann Malte Kelm Tienush Rassaf | 2014 | Mechanisms of Ageing and Development2014，，： | 1 |
| 18 | Dietary Nitrate Supplementation Improves Revascularization in Chronic Ischemia显示文摘 | Ulrike B. Hendgen-Cotta Peter Luedike Matthias Totzeck Martina Kropp Andreas Schicho Pia Stock Christos Rammos Michael Niessen Christian Heiss Jon O. Lundberg Eddie Weitzberg Malte Kelm Tienush Rassaf | 2012 | Circulation2012，，16： | 1 |
| 19 | Cardioprotection Through S-Nitros(yl)ation of Macrophage Migration Inhibitory Factor显示文摘 | Peter Luedike Ulrike B. Hendgen-Cotta Julia Sobierajski Matthias Totzeck Marcel Reeh Manfred Dewor Hongqi Lue Christoph Krisp Dirk Wolters Malte Kelm Jürgen Bernhagen Tienush Rassaf | 2012 | Circulation2012，，15： | 1 |
| 20 | Reductase activity of polyphenols?: A commentary on “Red wine-dependent reduction of nitrite to nitric oxide in the stomach”显示文摘 | Jan Balzer Tienush Rassaf Malte Kelm | 2007 | Free Radical Biology and Medicine2007，，9： | 1 |
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