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| 1 | Non-alcoholic fatty liver disease and the metabolic syndrome:An update显示文摘Sedentary lifestyle and poor dietary choices are leading to a weight gain epidemic in westernized countries, subsequently increasing the risk for developing the metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). NAFLD is estimated to affect approximate 30% of the general US population and is considered the hepatic manifestation of the metabolic syndrome. Recent findings linking the components of the metabolic syndrome with NAFLD and the progression to nonalcoholic steatohepatitis (NASH) will be reviewed; in particular, the role of visceral adipose tissue, insulin resistance, and adipocytokines in the exacerbation of these conditions. While no therapy has been proven effective for treating NAFLD/NASH, common recommendations will be discussed. | R Scott Rector John P Thyfault Yongzhong Wei Jamal A Ibdah | 2008 | World Journal of Gastroenterology2008，14，2： | 60 |
| 2 | Nonalcoholic fatty liver disease and mitochondrial dysfunction显示文摘Nonalcoholic fatty liver disease (NAFLD) includes hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. NAFLD is the most common liver disorder in the United States and worldwide. Due to the rapid rise of the metabolic syndrome, the prevalence of NAFLD has recently dramatically increased and will continue to increase. NAFLD has also the potential to progress to hepatocellular carcinoma (HCC) or liver failure. NAFLD is strongly linked to caloric overconsumption, physical inactivity, insulin resistance and genetic factors. Although significant progress in understanding the pathogenesis of NAFLD has been achieved in years, the primary metabolic abnormalities leading to lipid accumulation within hepatocytes has remained poorly understood. Mitochondria are critical metabolic organelles serving as 'cellular power plants'. Accumulating evidence indicate that hepatic mitochondrial dysfunction is crucial to the pathogenesis of NAFLD. This review is focused on the significant role of mitochondria in the development of NAFLD. | Yongzhong Wei R Scott Rector John P Thyfault Jamal A Ibdah | 2008 | World Journal of Gastroenterology2008，14，2： | 32 |
| 3 | The role of angiotensin II in nonalcoholic steatohepatitis显示文摘 | E. Matthew Morris Justin A. Fletcher John P. Thyfault R. Scott Rector | 2012 | Molecular and Cellular Endocrinology2012，，： | 2 |
| 4 | Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model显示文摘 | Rector RS Thyfault JP Uptergrove GM | | Journal of Hepatology0，，： | 1 |
| 5 | Gestational diabetes is associated with depressed adiponectin levels 显示文摘 | Thyfault JP Hedberg EM Anchan RM | 2005 | J Soc Gynecol Investig2005，12，1： | 1 |
| 6 | Non-alcoholic fatty liver disease and the metabolic syndrome: An update显示文摘 | Rector RS Thyfault JP Wei Y | 2011 | World J Gastroenterol2011，14，2： | 1 |
| 7 | Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model显示文摘 | R. Scott Rector John P. Thyfault Grace M. Uptergrove E. Matthew Morris Scott P. Naples Sarah J. Borengasser Catherine R. Mikus Matthew J. Laye M. Harold Laughlin Frank W. Booth Jamal A. Ibdah | 2010 | Journal of Hepatology2010，，5： | 1 |
| 8 | Lack of regular physical exercise or too much inactivity显示文摘 | Thyfault J P Booth F W | 2011 | Curr Opin Clin Nutr Metab Care2011，14，： | 1 |
| 9 | Gestational diabetes is as- sociated with depressed adiponectin levels 显示文摘 | Thyfault JP Hedberg EM Anchan RM | 2005 | J Soe Gynecol Investig2005，12，： | 1 |
| 10 | Gestational diabetes is associated with depressed adiponectin levels显示文摘 | Thyfault JP Hedberg EM Anchan RM | 2005 | J Soc Gynecol Investig,2005，12，1： | 1 |
| 11 | Simvastatin impairs exercise training adaptations显示文摘 | Catherine R. Mikus Leryn J. Boyle Sarah J. Borengasser Douglas J. Oberlin Scott P. Naples Justin Fletcher Grace M. Meers Meghan Ruebel M. Harold Laughlin Kevin C. Dellsperger Paul J. Fadel John P. Thyfault | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 12 | Daily Exercise Increase Hepatic Fatty Acid Oxidation and Prevents Steatosis in Otsuka Long-Evans Tokushima Fatty Rats 显示文摘 | Rector R S Thyfault J P Morris R T | 2008 | Am J Physio12008，294，3： | 1 |
| 13 | Modification of insulin sensi- tivity and glycemic control by activity and exercise 显示文摘 | Roberts C K Little J P Thyfault J P | 2013 | Med Sci Sports Exerc2013，45，10： | 1 |
| 14 | Gestation diabetes is associated with depressed adiponectin levels显示文摘 | John P Thyfault PhD Elizabeth M | 2005 | J Soci Gynecol Invest2005，12，1： | 1 |
| 15 | Daily exer- cise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats 显示文摘 | Rector R S Thyfault J P Morris R T | 2008 | Am J Physiol Gastrointest Liver Physiol2008，294，3： | 1 |
| 16 | Mitochondrialdysfunction precedes insulin resistance and hepatic steatosis andcontributes to the natural history of non-alcoholic fatty liver disease inan obese rodent model显示文摘 | Rector RS Thyfault JP Uptergrove GM | 2010 | J Hepatol2010，52，5： | 1 |
| 17 | Oxidative stress-mediated mitochondrial dysfunction contributes to angiotensin Ⅱ-induced nonalcoholic fatty liver disease in transgenic Ren2 rats显示文摘 | Wei Y Clark S E Thyfault J P | 2009 | Am J Pathol2009，174，4： | 1 |
| 18 | Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural hlstory of non-alcoholic fatty liver disease in an obese rodent model显示文摘 | Hector RS Thyfault JP Uptergrave GM | 2010 | J Hepatol2010，52，5： | 1 |
| 19 | Mitochondrial dysfunction precedes insulin resistanceand hepatic steatosis and contributes to the naturalhistory of non-alcoholic fatty liver disease in an obeserodent model显示文摘 | Rector RS Thyfault JP Uptergrove GM | 2010 | J Hepatol2010，52，： | 1 |
| 20 | Nonalcoholic fat- ty liver disease and mitochondrial dysfunction 显示文摘 | WEI Y RECTOR R S THYFAULT J P | 2008 | World J Gas- troenterol2008，14，2： | 1 |
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