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| 1 | 尿激酶治疗急性心肌梗塞多中心临床试验1406例总结显示文摘为观察尿激酶天普洛欣(UKTP)经静脉溶栓治疗急性心肌梗塞(AMI)的临床有效性及安全性。收集协作组148家医院1994年11月至1996年4月经静脉UKTP溶栓治疗AMI患者1406例,观察临床疗效、副作用及病死率等。其中124例行90分钟冠状动脉造影评价梗塞血管开通情况。结果:梗塞血管临床再灌注率为73.5%,90分钟冠状动脉造影血管开通率为72.6%,5周总病死率为7.8%(109/1406),轻度出血10.2%(143/1406),中重度出血0.43%(6/1406),脑出血0.50%(7/1406)。老年(>65岁)甚至高龄(>75岁)患者溶栓及距发病超过6小时者,其用药仍然安全有效,UKTP合适的用药剂量可能为150万U左右。结果提示UKTP治疗AMI安全有效。 | The collaborative study group for national multicenter clinical trial of urokinase thrombolytic therapy (Correspondence: Hu Dayi, Xu Zhimin. Beijing Red Cross Chao Yao Hospital, Beijing 100020) | 1997 | 中华心血管病杂志1997，25，3： | 139 |
| 2 | 90分钟冠状动脉造影评价急性心肌梗塞血管开通及临床再通指标价值显示文摘通过经静脉溶栓开始后90分钟冠状动脉造影(CAG),观察国产尿激酶(天普洛欣,UKTP)静脉溶栓治疗急性心肌梗塞(AMI)血管开通疗效,并评价临床再灌注标准的判断价值如何。方法:从UKTP多中心治疗AMI1406例中,汇集其中所行冠状动脉造影(CAG)共124例资料。结果提示:(1)124例AMI患者,在溶栓开始后90分钟时的梗塞相关血管的血流达TIMIⅢ级者52例(41.9%)、Ⅱ级38例(30.7%),梗塞相关血管再开通率为72.6%;(2)溶栓距起病时间愈早,具有愈高的开通趋势,但差异无统计学意义;(3)以CAG为金标准,临床标准对血管开通判断敏感性为88%,特异性为69%,准确性为83%。结论:UKTP静脉溶栓治疗AMI血管开通疗效肯定,临床标准判断血管再通的敏感性较高,但特异性欠佳,有待提高。 | The multicentre investigating group of thrombolytic therapy on acute myocardial infarction with Urokinase Techpool Correspondence: Hu Dayi, Xu Zhimin. Chaoyang Red Cross Hospital, Capital University of Medical Sciences, Beijing 100020 | 1997 | 中华心血管病杂志1997，25，4： | 11 |
| 3 | The GUSTO investigators显示文摘 | An international randomized trial comparing four thrombolytic strate gies for acute myocardial infarction | 1993 | N Engl JM ed1993，329，10： | 1 |
| 4 | Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction显示文摘 | | 2001 | Lancet2001，358，9282： | 1 |
| 5 | Gruppo Italiano per lo Studio della Streptochinasi nelllnfarto Miocardico (GISSI)显示文摘 | Effectiveness of intravenous thrombolytic treatment in acute myocar- dial infarction | 1986 | Lancet1986，1，8478： | 1 |
| 6 | Efficacy and safety of tenecteplase in combination with enoxaparin,abciximab,or unfractioned heparin the ASSENT-3 randomized,trial in acute myocardial infarction显示文摘 | THE ASSESSMENT OF THE SAFETY AND EFFICACY OF ANEW THROMBOLYTIC REGIMEN (ASSENT-3) INVESTIGATORS | 2001 | Lancet2001，358，： | 1 |
| 7 | The GUSTO investigators 显示文摘 | An international randomized trim comparing tbur thrombolytic strategies for acute myocardial infarction | 1993 | N Engl J Med1993，329，： | 1 |
| 8 | Efficacy and safety of tenecteplase in combination with enoxaparin,abciximab,or unfractionated heparin:the ASSENT-3 randomised trial in acute myocardial infarction显示文摘 | Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT)-3 Investigators | | 0，，： | 1 |
| 9 | Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractiionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction 显示文摘 | Assessment of the Safety and Efficacy of a New Thrombolytic Regimen ( ASSENT)-3 Investigators | 2001 | Lancet2001，358，9282： | 1 |
| 10 | Single bolus tenecteplase compared with frontloaded alteplase in acute myocar- dial infarction : the ASSENT-2 double-blind randomised trial显示文摘 | Assessment of the Safety and Efficacy of a New Thrombolytic In- vestigators VAN DE WERF F ADGEY J | 1999 | Lancet1999，354，9180： | 1 |
| 11 | The Multicenter Acute Stroke Trial-Europe Study Group显示文摘 | Thrombolytic therapy with streptokinase in acute ischemie stroke | 1996 | N Engl J Med1996，335，3： | 1 |
| 12 | Gruppo Italiano per lo Studio della Streptochinasi nell′Infarto Miocardico (GISSI)显示文摘 | Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction | 1986 | Lancet1986，1，： | 1 |
| 13 | Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: the ASSENT-2 double blind randomized trial 显示文摘 | | 1999 | Lancet1999，354，9180： | 1 |
| 14 | A quantitative review 显示文摘 | Weaver WD Simes RJ Betriu A Comparison of primary coronary angioplasty and intravenous thrombolytic therapy for acute myocardial infarction | 1997 | JAMA1997，278，： | 1 |
| 15 | Antithrombotic therapy during percutaneous coronary intervention显示文摘 | The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy | 2004 | Chest2004，126，： | 1 |
| 16 | Ran domized, double - blind comparison of reteplase double - bolus ad- ministration with streptokinase in acute myocardial infarction (INJECT) :Trial to investigate equivalence 显示文摘 | International Joint Efficacy Comparison of Thrombolytics | 1995 | Lancet1995，346，8971： | 1 |
| 17 | Efficacy and safety of tenecteplase in combination with enoxaparin,abciximab, or unfractionted heparin: the ASSENT-3 randomized trial in acute myocardial infarction 显示文摘 | | 2001 | Lancet2001，358，9282： | 1 |
| 18 | Efficacy and safety of tenecteplase in combination with enoxaparin,abciximab,or unfractioned heparin the ASSENT-3 randomized,trial in acute myocardial infarction显示文摘 | The Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT-3 Investigators | 2001 | Lancet2001，358，： | 1 |
| 19 | Patho- physiological determinants of worse stroke outcome in atrial fibrilhtion显示文摘 | Tu HT Campbell BC Christensen S Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) Investigators | 2010 | Cerebrovasc DIS2010，30，4： | 1 |
| 20 | Randomised, double-blind compareison of the reteplase doublebolus administration with streptokinase in acute myocardial infarction(INJECT) : trial to investingate equivalence显示文摘 | International Joint Efficacy Comparsion of Thrombolytics | 1995 | Lancet1995，346，： | 1 |
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