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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Analysis and screening for mycotoxins and other secondary metabolites in fungal cultures by thin-layer chromatography and high-performance liquid chromatography显示文摘 | Filtenborg O Thrane U | 1989 | Arch Environ Contam Toxicol1989，18，： | 1 |
| 3 | Carbon footprint-a catalyst for life cycle assessment 显示文摘 | WEIDEMA B P THRANE M CHRISTENSEN P | 2008 | Journal of Industrial Ecology2008，12，1： | 1 |
| 4 | Persistent versus transient map kinase (ERK) activation in the proliferation of lung epithelial type 2 cells显示文摘 | Thrane EV Schwarze PE Thoresen GH | 2001 | Exp Lung Res2001，27，4： | 1 |
| 5 | Innovative path dependence: making sense of product and service inno- vation in path dependent innovation processes 显示文摘 | Thrane S Blaabjerg S Moiler R H | 2010 | Research Policy2010，39，7： | 1 |
| 6 | Fusarium taxonomy with relation to trichothecene formation 显示文摘 | Moss M O Thrane U | 2004 | Toxicology Letters2004，153，1： | 1 |
| 7 | Exploring fungal biodiversity for the production of water-soluble pigments as potential natural food colorants显示文摘 | Jens C Frisvad Anne S Meyer Ulf Thrane | 2005 | Current Opinion in Biotechnology2005，，16： | 1 |
| 8 | Secondary metabolites produced by Altemaria infectoria显示文摘 | ANDERSEN B THRANE U | 1996 | Mycotoxin1996，，12： | 1 |
| 9 | Viscosinamide-producing Pseudomonas fuorescens DR54 exerts a biocontrol effect on Pythium ultimum in sugar beet rhizosphere显示文摘 | THRANE C | 2000 | FEMS Microbiol Eco12000，33，： | 1 |
| 10 | Critical role of aquaporin-4(AQP4)in astrocytic Ca2+signaling events elicited by cerebral edema显示文摘 | Thrane AS Rappold PM Fujita T | 2011 | Proce Natio Aca Sci2011，108，2： | 1 |
| 11 | Assembly, configuration, and break-up history of Rodinia: A synthesis显示文摘 | Z.X. Li S.V. Bogdanova A.S. Collins A. Davidson B. De Waele R.E. Ernst I.C.W. Fitzsimons R.A. Fuck D.P. Gladkochub J. Jacobs K.E. Karlstrom S. Lu L.M. Natapov V. Pease S.A. Pisarevsky K. Thrane V. Vernikovsky | 2007 | Precambrian Research2007，，1： | 1 |
| 12 | Fusaria and fumonisins in maize from ghana and their co-occurrence with aflatoxins 显示文摘 | Kafui Kpodo Ulf Thrane Benedicte Hald | 2000 | InternationalJoumalof FoodMicrobiology2000，61，23： | 1 |
| 13 | Legionella and non-legionel- la bacteria in a biological treatment plant 显示文摘 | Fykse EM Aarskaug T Thrane I | 2013 | Can J Microhiol2013，59，2： | 1 |
| 14 | Diversity in metabolite production by Fusarium langsethiae,Fusarium poae and Fusarium sporotrichioides显示文摘 | Thrane U Adler A Clasen P E | 2004 | Int J Food Microbiol2004，95，： | 1 |
| 15 | The zinc potential inGreenland显示文摘 | LarsLund S0rensen Per Kalvig Kristine Thrane | 2012 | Geology and 0re2012，，21： | 1 |
| 16 | Earnings Differentiation in the Tourism Industry: Gender, Human Capital and Socio-demographic Effects 显示文摘 | Christer Thrane | 2008 | Tourism Management2008，29，3： | 1 |
| 17 | Critical role of aquaporin-4 (AQP4) in astrocytic Ca~(2-) signaling events elicited by cerebral edema显示文摘 | Thrane AS Rappold PM Fujita T | 2011 | Proc Natl Acad Sci U S A2011，108，2： | 1 |
| 18 | Fluoride-induced apoptosis in epithelial lung cells involves activation of MAP kinases p38 and possibly JNK显示文摘 | THrane EV Refsnes M Thoresen GH | 2001 | Toxicol Sci2001，61，1： | 1 |
| 19 | Emotional stress effects on immunity, gingivitis and periodontitis 显示文摘 | Breivik T Thrane PS Murison P | 1996 | Eur J Oral Sci1996，104，4： | 1 |
| 20 | Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema显示文摘 | Thrane AS Rappold PM Fujita T | 2011 | Proc Natl Acad Sci USA2011，108，： | 1 |
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