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| 1 | Expression of c-kit receptor in human cholangiocarcinoma and in vivo treatment with imatinib mesilate in chimeric mice显示文摘瞄准:与额外的肝的 cholangiocarcinoma (CC ) 从病人在胆道癌症房间线和组织学的节调查 c 工具包表示并且与 imatinib mesilate 评估在试管内和在试管内治疗的功效。方法:在从有额外的肝的 CC 的 19 个病人的人的胆道癌症房间线 Mz-ChA-2 和 EGI-1 和组织学的节的 c 工具包的蛋白质表示被免疫弄污,免疫细胞化学,和免疫组织化学估计。胆道癌症房间线 Mz-ChA-2 和 EGI-1 上的 imatinib mesilate 的 anti-proliferative 效果是由自动化房间数的学习在试管内。另外,免疫缺乏的 NMRI 老鼠(Taconic ) 皮下地与 5x10 (6 ) 被注射房间线 MzChA-2 和 EGI-1 的房间。在到达了 200 mm3 的瘤体积以后,每日的治疗在 50 mg/kg 或生理盐水(NS ) 的剂量以 imatinib mesilate intraperitoneally 被开始。肿瘤体积与游标 caliper 被计算。在 14 d 以后,老鼠被牺牲,肿瘤和决定的肿瘤质量切除了。结果:Immunoblotting 在 EGI-1 房间在 Mz-ChA-2 和缺席揭示了 c 工具包的存在。有 c 工具包抗体的 Immunocytochemistry 在 EGI-1 房间在 Mz-ChA-2 房间和 c 工具包的缺席显示了 cytoplasmatic 和受体蛋白质的膜的本地化。c 工具包在 19 中的 7 个被表示(37%) 额外的肝的人的 CC 织物取样, 2 出现了一中等并且染色的 5 一相当弱的免疫。在 5 micromol/L 的低集中的 Imatinib mesilate 在 c 工具包引起了重要生长抑制积极房间线 Mz-ChA-2 (31%) ,然而并非在 c 工具包 negative,房间衬里 EGI-1 (0%)(P<0.05 ) 。在 10 micromol/L 的中间的集中的 Imatinib mesilate 禁止了两根细胞线(51% 对 57%) 的细胞的生长。在 20 micromol/L 的更高的集中的 Imatinib mesilate 似乎在两根房间线上有一般有毒的效果。IC50 价值分别地是 9.7 micromol/L 和 11 micromol/L。在有 imatinib mesilate 的在试管内处理的 14 d 以后,使用妄想的老鼠模型,积极 Mz-ChA-2 肿瘤有的 c 工具包显著地减少的体积和团作为与 NS 处理(P<0.05 ) 相比。与那相对照,忍受 c 工具包 negative EGI-1 肿瘤的鼠标的处理没作为与 NS 处理相比导致肿瘤体积和质量的任何变化。结论:c 工具包表示是可检测的在一对在胆道癌症的低蛋白质水平中等。Imatinib mesilate 在肿瘤生长在试管内和 c 工具包表示诚实的在试管内依赖者上施加显著效果。 | Thomas Kamenz Karel Caca Thilo Blüthner Andrea Tannapfel Joachim Mssner Marcus Wiedmann | 2006 | World Journal of Gastroenterology2006，12，10： | 7 |
| 2 | An α‐E‐catenin ( CTNNA1 ) mutation in hereditary diffuse gastric cancer显示文摘 | Ian J Majewski Irma Kluijt Annemieke Cats Thomas S Scerri Daphne Jong Roelof JC Kluin Samantha Hansford Frans BL Hogervorst Astrid J Bosma Ingrid Hofland Marcel Winter David Huntsman Jos Jonkers Melanie Bahlo René Bernards | 2013 | J. Pathol2013，，4： | 2 |
| 3 | National Forest Inventories capture the multifunctionality of managed forests in Germany显示文摘Background:Forests perform various important ecosystem functions that contribute to ecosystem services.In many parts of the world,forest management has shifted from a focus on timber production to multi-purpose forestry,combining timber production with the supply of other forest ecosystem services.However,it is unclear which forest types provide which ecosystem services and to what extent forests primarily managed for timber already supply multiple ecosystem services.Based on a comprehensive dataset collected across 150 forest plots in three regions differing in management intensity and species composition,we develop models to predict the potential supply of 13 ecosystem services.We use those models to assess the level of multifunctionality of managed forests at the national level using national forest inventory data.Results:Looking at the potential supply of ecosystem services,we found trade-offs(e.g.between both bark beetle control or dung decomposition and both productivity or soil carbon stocks)as well as synergies(e.g.for temperature regulation,carbon storage and culturally interesting plants)across the 53 most dominant forest types in Germany.No single forest type provided all ecosystem services equally.Some ecosystem services showed comparable levels across forest types(e.g.decomposition or richness of saprotrophs),while others varied strongly,depending on forest structural attributes(e.g.phosphorous availability or cover of edible plants)or tree species composition(e.g.potential nitrification activity).Variability in potential supply of ecosystem services was only to a lesser extent driven by environmental conditions.However,the geographic variation in ecosystem function supply across Germany was closely linked with the distribution of main tree species.Conclusions:Our results show that forest multifunctionality is limited to subsets of ecosystem services.The importance of tree species composition highlights that a lack of multifunctionality at the stand level can be compensated by managing forests at the landscape level,when stands of complementary forest types are combined.These results imply that multi-purpose forestry should be based on a variety of forest types requiring coordinated planning across larger spatial scales. | Nadja K.Simons María R.Felipe-Lucia Peter Schall Christian Ammer Jürgen Bauhus Nico Blüthgen Steffen Boch François Buscot Markus Fischer Kezia Goldmann Martin M.Gossner Falk Hänsel Kirsten Jung Peter Manning Thomas Nauss Yvonne Oelmann Rodica Pena Andrea Polle Swen C.Renner Michael Schloter Ingo Schöning Ernst-Detlef Schulze Emily F.Solly Elisabeth Sorkau Barbara Stempfhuber Tesfaye Wubet Jörg Müller Sebastian Seibold Wolfgang W.Weisser | 2021 | Forest Ecosystems2021，8，1： | 2 |
| 4 | The psychosocial impact ofmacular degeneration 显示文摘 | Williams RA Brody BL Thomas RG | 1998 | Archives of Ophthalmology1998，116，4： | 1 |
| 5 | The psychosocial impact ofmacular degeneration显示文摘 | Williams RA Brody BL Thomas RG | 2008 | Archives of Ophthalmology2008，116，4： | 1 |
| 6 | Role of Dlx - 1 and Dlx -2 genes in patterning of the murine dentition 显示文摘 | Tucker AS Qui M | 1997 | Development1997，124，23： | 1 |
| 7 | Extracapsular dissection for clinically benign parotid lumps: reduced morbidity without oncological compromise显示文摘 | McGurk M Thomas BL Renehan AC | 2003 | Br J Cancer2003，89，9： | 1 |
| 8 | Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition显示文摘 | Thomas BL Tucker AS Qui M | | 0，，23： | 1 |
| 9 | Independent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial arch显示文摘 | Thomas BL Liu JK Rubenstein JL | 2000 | Development2000，127，2： | 1 |
| 10 | GLEPP-1, a renal glomerular epithelial (podocyte) membrane protein-tyrosine phosphatase: Identification, molecular cloning, and characterization in rabbit显示文摘 | THOMAS PE WHARRAM BL GOYAL M | 1994 | J Biol Chem1994，269，19： | 1 |
| 11 | The psychosocial impact of macular degeneration 显示文摘 | Williams RA Brody BL Thomas RG | 1998 | Archives of Ophthalmology1998，116，4： | 1 |
| 12 | Transforming growth factor β(TGF-β) induces fibrosis in a fetal wound model显示文摘 | Michna BA Thomas BL | 1988 | J Pediatr Surg1988，23，7： | 1 |
| 13 | TNF-β induces fibrosis in a fetal wound model 显示文摘 | Krummel TM Michna BA Thomas BL | 1988 | J Pediatr Surg1988，23，： | 1 |
| 14 | Convective therapies for removal of middle molecular weight uremic toxins in end-stage renal disease: a review of the evidence显示文摘 | Thomas G Jaber BL | 2009 | Semin Dial2009，22，6： | 1 |
| 15 | Generation of infectious retrovirns aerosol through medical laser irradiation 显示文摘 | Ziegler BL Thomas CA Meier T | 1998 | Laser Surg Med1998，22，1： | 1 |
| 16 | Effect of intensive insulin therapy and pentastareh resuscitation on acute kidney injury in severe sepsis 显示文摘 | Thomas G Balk EM Jaber BL | 2008 | Am J Kidney Dis2008，52，1： | 1 |
| 17 | Adsorptive membrane chromatography for purification of plasmid DNA 显示文摘 | Teeters MA Conrardy SE Thomas BL | 2003 | J Chromatogr A2003，989，1： | 1 |
| 18 | Molecular control of odontogenic patterning; positional dependent initiation and morphogenesis显示文摘 | Tucker AS Ferguson C | 1998 | Eur J Oral Sci1998，106，1： | 1 |
| 19 | Flow eytometry can diagnose classical hodgkin lymphoma in lymph nodes with high sensitivity and specificity显示文摘 | Fromm JR Thomas A Wood BL | 2009 | Am J Clin Pathol2009，131，3： | 1 |
| 20 | Extracapsular dissec- tion for clinically benign parotid lamps: Reduced morbidity without oncological compromise 显示文摘 | McGurk M Thomas BL Renehan AG | 2003 | Br J Cancer2003，89，9： | 1 |
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