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| 1 | Update on the management of gastrointestinal varices显示文摘Cirrhosis of liver is a major problem in the western world. Portal hypertension is a complication of cirrhosis and can lead to a myriad of pathology of which include the development of porto-systemic collaterals. Gastrointestinal varices are dilated submucosal veins, which often develop at sites near the formation of gastroesophageal collateral circulation. The incidence of varices is on the rise due to alcohol and obesity. The most significant complication of portal hypertension is life-threatening bleeding from gastrointestinal varices, which is associated with substantial morbidity and mortality. In addition, this can cause a significant burden on the health care facility. Gastrointestinal varices can happen in esophagus, stomach or ectopic varices. There has been considerable progress made in the understanding of the natural history, pathophysiology and etiology of portal hypertension. Despite the development of endoscopic and medical treatments, early mortality due to variceal bleeding remains high due to significant illness of the patient. Recurrent variceal bleed is common and in some cases, there is refractory variceal bleed. This article aims to provide a comprehensive review of the management of gastrointestinal varices with an emphasis on endoscopic interventions, strategies to handle refractory variceal bleed and newer endoscopic treatment modalities. Early treatment and improved endoscopic techniques can help in improving morbidity and mortality. | Umesha Boregowda Chandraprakash Umapathy Nasir Halim Madhav Desai Arpitha Nanjappa Subramanyeswara Arekapudi Thimmaiah Theethira Helen Wong Marina Roytman Shreyas Saligram | 2019 | World Journal of Gastrointestinal Pharmacology and Therapeutics2019，10，1： | 18 |
| 2 | Experimental and numerical investigation of a solar eductorassisted low-pressure water desalination system显示文摘Greenhouse solar-energy driven desalination technology is potentially well suited for supplying water and small scale irrigation in remote and/or rural areas, and for avoiding over-exploitation of available water resources.The efficiency and productivity of these systems are however low, in part because the heat of evaporation has to be transferred as waste heat to ambient air during condensation. In order to maximize energy regeneration during condensation we propose an educator based system that lowers the evaporation process temperature by reducing pressure. The feasibility of the educator assisted passive solar desalination system is investigated using a detailed computational fluid dynamics analysis complemented by experiments. The study focuses in particular on the ability of the new design to lower the required evaporation temperature and thereby reduce the energy intensity of the process. Two configurations, with open and closed educator, are investigated and a detailed analysis of the thermofluid processes is presented. The configuration with a closed educator installed outside the evaporation chamber shows very promising performance. The proposed system can maintain the maximum temperature and pressure in the evaporation chamber below the desirable temperature and pressure thresholds(30 °C and 5 k Pa). The analysis and experimental data also show it is possible to further reduce energy requirements by reducing the motive water flow rates. | Mehran Ahmadi Poovanna Thimmaiah Majid Bahrami Khaled Sedraoui Hani H.Sait Ned Djilali | 2016 | Science Bulletin2016，61，12： | 2 |
| 3 | Endoscopic ultrasound guided gallbladder drainage - is it ready for prime time?显示文摘Management of acute cholecystitis includes initial stabilization and antibiotics. However, the most definitive treatment is cholecystectomy. A small percentage of patients who are not suitable for surgery due to the severity of cholecystitis or comorbidities will require a temporary measure as a bridge to surgery or permanent nonoperative management to decrease the mortality and morbidity. Most of these patients who require conservative management were managed with percutaneous transhepatic cholecystostomy or trans-papillary drainage of gallbladder drainage with cystic duct stenting through endoscopic retrograde cholangiopancreaticography(ERCP). Although, these conservative measures are effective, they can cause significant discomfort to the patients especially if used as a long-term measure. In view of this, there is a need for further minimally invasive procedures, which is safe, effective and comfortable to patients. Endoscopic ultrasound(EUS) guided gallbladder drainage is a novel method of gallbladder drainage first described in 2007^([1]). Over the last decade, EUS guided gallbladder drainage has evolved as an effective alternative to percutaneous cholecystostomy and trans-papillary gallbladder drainage. Our goal is to review available literature regarding the scope of EUS guided gallbladder drainage as a viable alternative to percutaneous cholecystostomy or cystic duct stenting through ERCP among patients who are not suitable for cholecystectomy. | UmeshaBoregowda Chandraprakash Umapathy Arpitha Nanjappa Helen Wong Madhav Desai Marina Roytman Thimmaiah Theethira Shreyas Saligram | 2018 | World Journal of Gastrointestinal Pharmacology and Therapeutics2018，9，6： | 2 |
| 4 | Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing显示文摘 | Richard I. Gregory Thimmaiah P. Chendrimada Neil Cooch Ramin Shiekhattar | 2005 | Cell2005，，4： | 2 |
| 5 | Sa1039 USA Validated Computerized Psychometric Testing System for the Diagnosis of Minimal Hepatic Encephalopathy - at Last显示文摘 | Ravi Prakash Rani Chikkanna Kiran Anna Puja Karanth Sanath K. Allampati Thimmaiah G. Theethira Grace Dosanjh Adam T. Perzynski Kevin D. Mullen | 2012 | Gastroenterology2012，，5： | 1 |
| 6 | Targeting calmodulin in reversing multi drug resistance in cancer cells 显示文摘 | Mayur YC Jagadeesh S Thimmaiah KN | 2006 | Mini Rev Med Chem2006，6，12： | 1 |
| 7 | Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erkl-Erk2 and phosphatidylinositol 3'-Kinase-Akt signaling pathways显示文摘 | Thimmaiah KN Easton J Huang S | 2003 | Cancer Res2003，63，： | 1 |
| 8 | Acridones circumvent P-glycoprotein-associated multidrug resistance (MDR) in cancer cells显示文摘 | Vadiraj S. Gopinath Padma Thimmaiah Kuntebommanahalli N. Thimmaiah | 2007 | Bioorganic & Medicinal Chemistry2007，，1： | 1 |
| 9 | Targeting calmodulin in reversing multi drug resistance in cancer cells显示文摘 | MAYUR Y C JAGADEESH S THIMMAIAH K N | 2006 | Mini Rev Med Chem2006，6，： | 1 |
| 10 | Evaluation of the relative effectiveness of different water soluble β - CD media to function as fluorescence enhancement agents显示文摘 | Raymond P F Thimmaiah K N Wille L H | 1991 | Anal Chem1991，63，24： | 1 |
| 11 | Protein identification in subproteome fractions of breastcancer cells by OFFGEL-IEF and ITRAQ labeling显示文摘 | Chandramouli K H Agrawal P Thimmaiah K N | 2009 | Current Proteomics2009，6，1： | 1 |
| 12 | Significance of serum procalcitonin in sepsis显示文摘 | Uchil Sudhir Ravi Kumar Venkatachalaiah Thimmaiah Anil Kumar | 2011 | Indian J Crit Care Med2011，15，1： | 1 |
| 13 | Human RISC couples MicroRNA biogenesis and posttranscriptional gene silencing 显示文摘 | Richard IG Thimmaiah PC Neil C | 2005 | Cell2005，123，4： | 1 |
| 14 | Determination of the betaine content of feed ingredients using high-perpormance liquid chromatography显示文摘 | THIMMAIAH P C MANOEL G N GENE M P | 2002 | Journal of the Science of Food and Agriculture2002，82，： | 1 |
| 15 | Evaluation of the relative effectiveness of different water-soluble cyclodextrin media to function as fluorescence enhancement Agents显示文摘 | Frankewich R P Thimmaiah K N Hinze W L | 1991 | Anal Chem1991，63，24： | 1 |
| 16 | Inception and entrainment in self- aerated flows 显示文摘 | Thimmaiah Gangadharaiah Nagar S Lakshmana Rao Kyathasandra Seetharamiah | 1970 | Journal of the Hydraulics Division ASCE1970，96，7： | 1 |
| 17 | Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways显示文摘 | Thimmaiah KN Easton J Huang S | 2003 | Cancer Res2003，63，2： | 1 |
| 18 | Targeting calmodu- lin in reversing muhidrug resistance in cancer cells 显示文摘 | Mayur YC Jagadeesh S Thimmaiah KN | 2006 | Mini Rev Med Chem2006，6，12： | 1 |
| 19 | Characteristics of self-aerated flows显示文摘 | Lakshmana Rao N S Kyatasandra Seetharamiah Thimmaiah Gangadharaiah | 1970 | Journal of Hydraulics Division Prae ASCH1970，2，： | 1 |
| 20 | Effect of a course of electroconvulsive therapy on interictal bispectral index values: a prospective study显示文摘 | Thimmaiah R Thirthalli J Ramesh VJ | 2012 | J ECT2012，28，1： | 1 |
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