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| 1 | Calcium-dependent modulation and plasma membrane targeting of the AKT2 potassium channel by the CBL4/ ClPK6 calcium sensor/protein kinase complex显示文摘 | Katrin Held Franqois Pascaud Christian Eckert Pawel Gajdanowicz Kenji Hashimoto Claire Corratge-Faillie Jan Niklas Offenborn Benoit Lacombe Ingo Dreyer Jean-Baptiste Thibaud Jorg Kudla | 2011 | Cell Research2011，21，7： | 23 |
| 2 | Endoscopic ultrasonography-guided fine needle aspiration:Relatively low sensitivity in the endosonographer population显示文摘AIM:To assess the characteristics and quality of endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA) in a large panel of endosonographers.METHODS:A survey was conducted during the 13th annual live course of endoscopic ultrasonography(EUS) held in Amsterdam,Netherlands.A 2-page questionnaire was developed for the study.Content validity of the questionnaire was determined based on input by experts in the field and a review of the relevant literature.It contained 30 questions that pertained to demographics and the current practice for EUS-FNA of responders,including sampling technique,sample processing,cytopathological diagnosis and sensitivity of EUS-FNA for the diagnosis of solid mass lesions.One hundred and sixty-one endosonographers who attended the course were asked to answer the survey.This allowed assessing the current practice of EUS-FNA as well as the self-reported sensitivity of EUS-FNA for the diagnosis of solid mass lesions.We also examined which factors were associated with a self-reported sensitivity of EUS-FNA for the diagnosis of solid mass lesions > 80%.RESULTS:Completed surveys were collected from 92(57.1%) of 161 endosonographers who attended the conference.The endosonographers had been practicing endoscopy and EUS for 12.5 ± 7.8 years and 4.8 ± 4.1 years,respectively;one third of them worked in a hospital with an annual caseload > 100 EUS-FNA.Endoscopy practices were located in 29 countries,including 13 countries in Western Europe that totaled 75.3% of the responses.Only one third of endosonographers reported a sensitivity for the diagnosis of solid mass lesions > 80%(interquartile range of sensitivities,25.0%-75.0%).Factors independently associated with a sensitivity > 80% were(1) > 7 needle passes for pancreatic lesions or rapid on-site cytopathological evaluation(ROSE)(P < 0.0001),(2) a high annual hospital caseload(P = 0.024) and(3) routine isolation of microcores from EUS-FNA samples(P = 0.042).ROSE was routinely available to 27.9% of respondents.For lymph nodes and pancreatic masses,a maximum of three needle passes was performed by approximately two thirds of those who did not have ROSE.Microcores were routinely harvested from EUS-FNA samples by approximately one third(37.2%) of survey respondents.CONCLUSION:EUS-FNA sensitivity was considerably lower than reported in the literature.Low EUS-FNA sensitivity was associated with unavailability of ROSE,few needle passes,absence of microcore isolation and low hospital caseload. | Jean-Marc Dumonceau Thibaud Koessler Jeanin E van Hooft Paul Fockens | 2012 | World Journal of Gastroenterology2012，18，19： | 7 |
| 3 | A graph-based approach for the structural analysis of road and building layouts显示文摘A better understanding of the relationship between the structure and functions of urban and suburban spaces is one of the avenues of research still open for geographical information science.The research presented in this paper develops several graph-based metrics whose objective is to characterize some local and global structural properties that reflect the way the overall building layout can be cross-related to the one of the road layout.Such structural properties are modeled as an aggregation of parcels,buildings,and road networks.We introduce several computational measures(Ratio Minimum Distance,Minimum Ratio Minimum Distance,and Metric Compactness)that respectively evaluate the capability for a given road to be connected with the whole road network.These measures reveal emerging sub-network structures and point out differences between less-connective and moreconnective parts of the network.Based on these local and global properties derived from the topological and graph-based representation,and on building density metrics,this paper proposes an analysis of road and building layouts at different levels of granularity.The metrics developed are applied to a case study in which the derived properties reveal coherent as well as incoherent neighborhoods that illustrate the potential of the approach and the way buildings and roads can be relatively connected in a given urban environment.Overall,and by integrating the parcels and buildings layouts,this approach complements other previous and related works that mainly retain the configurational structure of the urban network as well as morphological studies whose focus is generally limited to the analysis of the building layout. | Mathieu Domingo Rémy Thibaud Christophe Claramunt | 2019 | Geo-Spatial Information Science2019，22，1： | 2 |
| 4 | Microdialysis in awake macaque monkeys for central nervous system pharmacokinetics显示文摘Background: The brain bioavailability of novel small molecules developed to address central nervous system disease is classically documented through ex vivo or in vivo analyses conducted in rodent models. Data acquired in rodent models are, however,not easily transferrable to human as the pharmacokinetic and pharmacodynamics profiles of the species are quite different.Methods: Using drugs selected for their differential transport across the blood-brain barrier, we here demonstrate the feasibility of brain microdialysis in normal vigil macaque monkey by measuring brain extracellular fluid bioavailability of carbamazepine, digoxin, oxycodone, and quinidine.Results: All drugs, but digoxin, were found in dialysate samples. Drugs that are substrate of P-glycoprotein show a difference of bioavailability or brain pharmacokinetic parameters between rodents and primates.Conclusion: Data suggest that brain microdialysis in vigil macaque monkey, the species of choice for classic pharmacokinetic/pharmacodynamics studies could help predicting human brain bioavailability of a small molecule depending on the protein involved in the efflux transport from the brain. | Thibaud Thiollier Caisheng Wu Gregory Porras Erwan Bezard Qin Li Jinlan Zhang Hugues Contamin | 2018 | Animal Models and Experimental Medicine2018，1，4： | 2 |
| 5 | Automatic Guided Vehicles: Robust Controller Design in Image Space显示文摘 | P Martinet C Thibaud | 2000 | Autonomous Robots2000，，8： | 2 |
| 6 | Formation de chloropicrine en milieu aqueux: influence des nitrites sur la formation de prrcurseurs par oxydation de compos's or- ganiques显示文摘 | Thibaud H De Laat J Merlet N | 1987 | Water Research1987，21，7： | 1 |
| 7 | Suc- cessional changes, diversity of soil macro faunal com- munities on chalk grasslands in Upper-Normandy (France) 显示文摘 | Thierry Dutoit Thibaud Decaens Didier Alard | 1997 | Acta Oecologica1997，2，18： | 1 |
| 8 | 3D FEM simulations of shoulder milling operations on a304Lstainless steel显示文摘 | Maurel-Pantel A Fontaine M Thibaud S | 2012 | Simulation Modelling Practice and Theory2012，22，： | 1 |
| 9 | Role of apoplast acidification by the H+ pump显示文摘 | Valérie Toulon Hervé Sentenac Jean-Baptiste Thibaud Jean-Claude Davidian Claire Moulineau Claude Grignon | 1992 | Planta1992，，2： | 1 |
| 10 | Modulation of carbon and nitrogen metabolism, and of nitrate reductase, in untransformed Nicotiana plumbaginifolia during CO2 enrichment of plants grown in pots and hydroponic culture显示文摘 | Thibaud MC Betsche T | 1997 | Planta1997，202，： | 1 |
| 11 | Transcriptional regulation and functional properties of Arabidopsis Pht1 ;4,a high affinity transporter contributing greatly to phosphate uptake in phosphate deprived plants显示文摘 | Misson J Thibaud M C Bechtold N | 2004 | Plant Molecular Biology2004，55，： | 1 |
| 12 | Long-term surgical results and patient satisfaction with male pseudohermaphroditism or true hermaphroditism:a cohort of 63 patients显示文摘 | Nihoul-Fe ke te C Thibaud E Lortat-Jacob S | 2006 | J Urol2006，175，5： | 1 |
| 13 | High performance method for o-methylation of phenol with dimethyl carbonate显示文摘 | OUK S THIBAUD S BORREDON E GARS P L | 2003 | Appl Catal A2003，241，12： | 1 |
| 14 | Comment observer une ambiance?显示文摘 | Jean-Paul Thibaud | | France:'AMBIANCES ARCHITECTURALES ET URBAINES'0，77，： | 1 |
| 15 | O-methylation of phenolic compounds with dimethyl carbonate under solid/liquid phase transfer system显示文摘 | OUK S THIBAUD S BORREDON E GARS P L LECOMTE L | 2002 | Tetrahedron Lett2002，43，14： | 1 |
| 16 | Dynamics of Telomeros and Promyelocytic Leukemia Nuclear Bodies in a Telomerase-negative Human Cell Line显示文摘 | THIBAUD J CHUNG I HEUVELMAN G | 2009 | Molecular Biology of the Cell2009，20，： | 1 |
| 17 | Transcriptional regulation and functional properties of Arabidopsis Phtl; 4, a high afinity transporter contributing greatly to phosphate uptake in phos- phate deprived plants 显示文摘 | Misson Julie Thibaud Marie - Christine Bechtohl Nieole | 2004 | Plant Molecular Biology2004，，55： | 1 |
| 18 | Transcriptional regulation and functional properties of Arabidopsis Pht1;4, a high affinity transporter contributing greatly to phosphate uptake in phosphate deprived plants显示文摘 | Julie Misson Marie-Christine Thibaud Nicole Bechtold Kashchandra Raghothama Laurent Nussaume | 2004 | Plant Molecular Biology2004，，5： | 1 |
| 19 | Malignant obstructive jaundice:the role of percutaneous metallic stents显示文摘 | Dalincourt A Hamy A Thibaud C | 2000 | Gastroenterol Clin Bioi2000，24，89： | 1 |
| 20 | Deliveries optimization byexploiting production traceability information显示文摘 | SIMON T THIBAUD M NATHALIE S | 2009 | Engineering Ap-plications of Artificial Intelligence2009，，2： | 1 |
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