|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Oxidative stress and male reproductive health显示文摘有缺点的精子功能的主要原因之一是氧化应力,它不仅破坏精子 DNA 的正直而且在精子血浆膜由于蛋白质和类脂化合物的并行的损坏限制这些房间的使肥沃的潜力。如此的氧化压力的起源看起来包含精子线粒体,它有一个趋势作为一篇序言产生 superoxide 阴离子的高水平到进入内在的 apoptotic 串联。不幸地,这些房间有很小的能力因为他们仅仅在基础切除修理(BER ) 拥有第一酶,对如此的攻击作出回应小径, 8-oxoguanine glycosylase 1 (OGG1 ) 。后者成功地创造一个 abasic 地点,而是精子因为他们缺乏下游的蛋白质,不能进一步处理氧化损害(APE1, XRCC1 ) 需要完成修理过程。在第一个有丝分裂的部门的 S 阶段的开始以前继续 BER 小径是卵母细胞的责任。如果一个错误被卵母细胞在开发的这个阶段犯,一个变化将被创造那将在身体在每个房间被代表。如此的机制可以在在作为年龄的后果在他们的细菌线承受了氧化应力的男性的后代观察的童年癌症和另外的疾病解释增加,环境或生活方式因素。在男不孕病人的精子的氧化 DNA 损坏的高流行可以为在 vitro 构思的孩子的健康有含意并且在细菌线为对免费激进的产生的起源的当前的研究担任一位司机。 | Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis | 2014 | Asian Journal of Andrology2014，16，1： | 48 |
| 2 | Exploring the role of mononuclear phagocytes in the epididymis显示文摘精子在中央有免疫力的忍耐的建立以后带进 epididymis,没表明有免疫力的特权的一个机关,一十年或更多的外国抗原的猛攻提出唯一的生物挑战。历史上,到上皮的房间的一面紧交织的墙强制的 epididymal 小管的精子的物理监禁被认为足够足够阻止在配偶子和免疫系统之间并且,最终的生气谈话自体免疫的破坏。在鼠科的 epididymis 包括树枝状的房间和巨噬细胞的 mononuclear 吞噬细胞(MP ) 的复杂安排的发现建议我们可能在 posttesticular 环境低估了一个复杂 mucosal 免疫系统的存在。这评论在稳定的州的 epididymis 巩固我们 MP 的生理学的当前的知识并且由在在肠的 mucosa 对免疫系统被知道的上绘画在在 auto-antigenic 精子,病原体和免疫系统之间的可能的相互作用上推测。最终,进一步的调查将关于在 epididymis 由于自体免疫或煽动性的回答产生的病理的起源提供珍贵信息,包括附睾炎和不孕。 | Nicolas Da Silva Tegan B Smith | 2015 | Asian Journal of Andrology2015，17，4： | 3 |
| 3 | Phosphorus use efficiency and fertilizers:future opportunities for improvements显示文摘The continued supply of phosphate fertilizers that underpin global food production is an imminent crisis.The rock phosphate deposits on which the world depends are not only finite,but some are contaminated,and many are located in geopolitically unstable areas,meaning that fundamental changes will have to take place in order to maintain food production for a growing global population.No single solution exists,but a combination of approaches to phosphorus management is required not only to extend the lifespan of the remaining non-renewable rock phosphate reserves,but to result in a more efficient,sustainable phosphorus cycle.Solutions include improving the efficiency of fertilizer applications to agricultural land,alongside a better understanding of phosphorus cycling in soil-plant systems,and the interactions between soil physics,chemistry and biology,coupled with plant traits.Opportunities exist for the development of plants that can access different forms of soil phosphorus(e.g.,organic phosphorus)and that use internal phosphorus more efficiently.The development of different sources of phosphorus fertilizers are inevitably required given the finite nature of the rock phosphate supplies.Clear opportunities exist,and it is now important that a concerted effort to make advances in phosphorus use efficiency is prioritized. | Martin BLACKWELL Tegan DARCH Richard HASLAM | 2019 | Frontiers of Agricultural Science and Engineering2019，6，4： | 2 |
| 4 | A Low-cost, high-efficiency solar cell based on dye-sensitized 显示文摘 | O tegan B Gratzel M | 1991 | Nature1991，353，6364： | 1 |
| 5 | The effect of ionizing gamma radiation on natural and synthetic fibers and its implications for the forensic examination of fiber evidence显示文摘 | Michael C Andrew P Tegan E | 2011 | Journal of Forensic Sciences2011，56，3： | 1 |
| 6 | Monometallic and dimetallic tuthenium(Ⅱ)-terpyridine complexes employing the tetradentate ligands dipyridylpyrazolyl,dipyridyloxadiazole,and their dimethyl derivatives显示文摘 | Vincent J Catalano Tegan J Craig | 2003 | Inorg Chem2003，42，： | 1 |
| 7 | The vacuolar calcium sensors CBL 2 and CBL 3 affect seed size and embryonic development in Arabidopsis thaliana显示文摘 | Christian Eckert Jan Niklas Offenborn Tobias Heinz Tegan Armarego‐Marriott Stefanie Schültke Chunxia Zhang Stefan Hillmer Mareike Heilmann Karin Schumacher Ralph Bock Ingo Heilmann J?rg Kudla | 2014 | Plant J2014，，1： | 1 |
| 8 | The CER22 gene required for the synthesis of cuticular wax alkanes in Arabidopsis thali- ana is allelic to CERI显示文摘 | Eiji S Lifang Z Tegan M | 2013 | Planta2013，237，3： | 1 |
| 9 | A mu-rine model of Neurofibromatosis type 1 tibial pseudarthrosisfeaturing proliferative fibrous tissue and osteoclast ~ likecells显示文摘 | Jad El-Hoss MSc Kate Sullivan PhDI Tegan Chengl | 2012 | Journal of Bone and Mineral Research2012，27，1： | 1 |
| 10 | The influence on climate forcing of minend aerosols from disturbed soils显示文摘 | Tegan I Lacis A Fung I | 1996 | Nature1996，380，： | 1 |
| 11 | Nature:利用CRISPR/Cas9鉴定出线粒体疾病背后的遗传秘密显示文摘在一项新的研究中,来自澳大利亚莫纳什大学莫纳什生物医学发现研究所等机构的研究人员鉴定出两个新的基因与线粒体疾病的一种主要病因相关联。他们的研究为更好地对线粒体疾病进行遗传诊断铺平道路,而且也可能有助于鉴定出用于治疗的潜在治疗靶标。相关研究结果在线发表在Nature期刊上。 | David A. Stroud, Elliot E. Surgenor, Luke E. Formosa, Marris G. Dibley, Laura D. Osellame, Traude H. Beilharz, Michael T. Ryan Luke E. Formosa, Boris Reljic Ann E. Frazier, Tegan Stait, David R. Thorburn Ann E. Frazier, David R. Thorburn David R. Thorburn Agus Salim | 2017 | 现代生物医学进展2017，17，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员