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| 1 | Prognostic significance of neutrophil to lymphocyte ratio in pancreatic cancer: A meta-analysis显示文摘AIM:To conduct a meta-analysis evaluating theassociation between the peripheral blood neutrophil to lymphocyte ratio(NLR) and the outcome of patients with pancreatic cancer.METHODS:Studies evaluating the relationship between the peripheral blood NLR and outcome of patients with pancreatic cancer published up to May 2014 were searched using electronic databases, including Pub Med, Web of Science, Embase and Ovid.A meta-analysis was performed to pool the hazard ratios(HRs) or odds ratios(ORs) and their 95% confidence intervals(CIs) using either a fixed-effects model or a random-effects model to quantitatively assess the prognostic value of NLR and its association with clinicopathological parameters.RESULTS:Eleven studies containing a total of 1804 patients were eligible according to our selection criteria, and combined hazard ratios indicated that high NLR was a poor prognostic marker for pancreatic cancer patients because it had an unfavorable impact on the overall survival(OS)(HR =2.61, 95%CI:1.68-4.06, P =0.000) and cancer specific survival(HR =1.66, 95%CI:1.08-2.57, P =0.021).Subgroup analysis revealed that high NLR was associated with poor OS in patients with mixed treatment(HR =4.36, 95%CI:2.50-7.61, P =0.000), chemotherapy(HR =2.08, 95%CI:1.49-2.9, P =0.000), or surgical resection(HR =1.2, 95%CI:1.00-1.44, P =0.048).Additionally, high NLR was significantly correlated with tumor metastasis(OR =1.69, 95%CI:1.10-2.59, P =0.016), poor tumor differentiation(OR =2.75, 95%CI:1.19-6.36, P =0.016), poor performance status(OR =2.56, 95%CI:1.63-4.03, P =0.000), high cancer antigen 199(OR =2.62, 95%CI:1.49-4.60, P =0.000), high C-reactive protein(OR =4.32, 95%CI:2.71-6.87, P =0.000), and low albumin(OR =3.56, 95%CI:1.37-9.27, P =0.009).CONCLUSION:High peripheral blood NLR suggested a poor prognosis for patients with pancreatic cancer,and it could be a novel marker of survival evaluation and could help clinicians develop therapeutic strategies for pancreatic cancer patients. | Jian-Jun Yang Zhi-Gao Hu Wu-Xiang Shi Te Deng Song-Qing He Sheng-Guang Yuan | 2015 | World Journal of Gastroenterology2015，21，9： | 15 |
| 2 | MPK14-mediated auxin signaling controls lateral root development via ERF13-regulated very-long-chain fatty acid biosynthesis显示文摘Auxin plays a critical role in lateral root(LR)formation.The signaling module composed of auxin-response factors(ARFs)and lateral organ boundaries domain transcription factors mediates auxin signaling to control almost every stage of LR development.Here,we show that auxin-induced degradation of the APETALA2/Ethylene Responsive Factor(AP2/ERF)transcription factor ERF13,dependent on MITOGENACTIVATED PROTEIN KINASE MPK14-mediated phosphorylation,plays an essential role in LR development.Overexpression of ERF13 results in restricted passage of the LR primordia through the endodermal layer,greatly reducing LR emergence,whereas the erf13 mutants showed an increase in emerged LR.ERF13 inhibits the expression of 3-ketoacyl-CoA synthase16(KCS16),which encodes a fatty acid elongase involved in very-long-chain fatty acid(VLCFA)biosynthesis.Overexpression of KCS16 or exogenous VLCFA treatment rescues the LR emergence defects in ERF13 overexpression lines,indicating a role downstream of the auxin-MPK14-ERF13 signaling module.Collectively,our study uncovers a novel molecular mechanism by which MPK14-mediated auxin signaling modulates LR development via ERF13-regulated VLCFA biosynthesis. | Bingsheng Lv Kaijing Wei Kongqin Hu Te Tian Feng Zhang Zipeng Yu Dajian Zhang Yinghua Su Yalin Sang Xiansheng Zhang Zhaojun Ding | 2021 | Molecular Plant2021，14，2： | 6 |
| 3 | Effects of Maternal Screening and Universal Immunization to Prevent Mother-to-Infant Transmission of HBV显示文摘 | Huey–Ling Chen Lung–Huang Lin Fu–Chang Hu Jian–Te Lee Wen–Terng Lin Yao–Jung Yang Fu–Chen Huang Shu–Fen Wu Solomon Chih–Cheng Chen Wan–Hsin Wen Chia–Hsiang Chu Yen–Hsuan Ni Hong–Yuan Hsu Pei–Lin Tsai Cheng–Lun Chiang Ming–Kwang Shyu Ping–Ing Lee Feng–Yee | 2012 | Gastroenterology2012，，4： | 2 |
| 4 | Controlling plasmon‐exciton interactions through photothermal reshaping显示文摘We investigated the plasmon-exciton interactions in an individual gold nanorod(GNR)with monolayer MoS2 at room temperature with the single-particle spectroscopy technique.To control the plasmon-exciton interaction,we tuned the local surface plasmon resonance of an individual GNR in-situ by employing the photothermal reshaping effect.The scattering spectra of the GNR-MoS2 hybrids exhibited two dips at the frequencies of the A and B excitons of monolayer MoS2,which were caused by the plasmon-induced resonance energy transfer effect.The resonance energy transfer rate increased when the surface plasmon resonance of the nanorod matched well with the exciton transition energy.Also,we demonstrated that the plasmon-enhanced fluorescence process dominated the photoluminescence of the GNR-MoS2 hybrid.These results provide a flexible way to control the plasmon-exciton interaction in an all-solid-state operating system at room temperature. | Aiqin Hu Shuai Liu Jingyi Zhao Te Wen Weidong Zhang Qihuang Gong Yongqiang Meng Yu Ye Guowei Lu | 2020 | Opto-Electronic Advances2020，3，1： | 2 |
| 5 | Paradoxical effects of mild hypoxia and moderate altitude on human visual perception显示文摘 | Schlaepfer TE Bartsch P Fisch HU | 1992 | J Clin Sci Colch1992，83，5： | 1 |
| 6 | HER2 amplification, overexpression and score criteria in esophageal adenocarcinoma 显示文摘 | Hu Y Bandla S Godfrey TE | 2011 | Mod Pathol2011，24，7： | 1 |
| 7 | Neutrophil chemotaxis dysfunction in human pefiodontitis显示文摘 | Van Dyke TE Horoszewicz HU Cianciola LJ | 1980 | Infect Immun1980，27，1： | 1 |
| 8 | Gene Expression Profiling of Neonatal Mouse Uterine Development显示文摘 | Hu JB Gray CA Spencer TE | 2004 | Biol Reprod2004，70，6： | 1 |
| 9 | Dose inflammation or undernutrition explain the low cholesterolmortality association in high functioning older person?MacArthur studies of successful aging显示文摘 | Hu P Seeman TE Harris TB | 2003 | J Am Geriatr Soc2003，51，： | 1 |
| 10 | A novel missense (M206K) STAT3 mutation in diffuse large B cell lymphoma deregulates STAT3 signaling显示文摘 | Hu G Witzig TE Gupta M | 2013 | PLoS One2013，8，67： | 1 |
| 11 | Circadian misalignment increases cardiovascular disease risk factors in humans显示文摘 | Morris CJ Purvis TE Hu K | 2016 | Proc Natl Acad Sci USA2016，113，10： | 1 |
| 12 | Neutrophil chemotaxis dysfunction in human periodontitis 显示文摘 | Van Dyke TE Horoszew icz HU Cianciola LJ | 1980 | Infect Immun1980，27，1： | 1 |
| 13 | Biological basis of sex differences in the propensity to self-administer cocaine显示文摘 | Hu M Crombag HS Robinson TE | 2003 | Neuropsychopharmacology2003，29，1： | 1 |
| 14 | HER2 amplification,overexpression and score criteria in esophageal adenocarcinoma显示文摘 | Hu Y Bandla S Godfrey TE | 2011 | Mod Pathol2011，24，7： | 1 |
| 15 | The pre-mRNA splicing factor RDM16 regulates root stem cell maintenance in Arabidopsis显示文摘Pre-mRNA(messenger RNA)splicing participates in the regulation of numerous biological processes in plants.For example,alternative splicing shapes transcriptomic responses to abiotic and biotic stress,and controls developmental programs.However,no study has revealed a role for splicing in maintaining the root stem cell niche.Here,a screen for defects in root growth in Arabidopsis thaliana identified an ethyl methane sulfonate mutant defective in pre-m RNA splicing(rdm16-4).The rdm16-4 mutant displays a short-root phenotype resulting from fewer cells in the root apical meristem.The PLETHORA1(PLT1)and PLT2 transcription factor genes are important for root development and were alternatively spliced in rdm16-4 mutants,resulting in a disordered root stem cell niche and retarded root growth.The root cap of rdm16-4 contained reduced levels of cytokinins,which promote differentiation in the developing root.This reduction was associated with the alternative splicing of genes encoding cytokinin signaling factors,such as ARABIDOPSIS HISTIDINE PHOSPHOTRANSFER PROTEIN5 and ARABIDOPSIS RESPONSE REGULATORS(ARR1,ARR2,and ARR11).Furthermore,expression of the full-length coding sequence of ARR1 or exogenous cytokinin application partially rescued the short-root phenotype of rdm16-4.This reveals that the RDM16-mediated alternative splicing of cytokinin signaling components contributes to root growth. | Bingsheng Lv Kongqin Hu Te Tian Kaijing Wei Feng Zhang Yuebin Jia Huiyu Tian Zhaojun Ding | 2021 | Journal of Integrative Plant Biology2021，63，4： | 1 |
| 16 | Paradoxical effects of mild hypoxia and moderate altitude on human visual perception显示文摘 | Schlaepfer TE Bartsch P Fisch HU | 1992 | Clin Sci (Lond)1992，83，5： | 1 |
| 17 | Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical Wnt signaling and C/EBP显示文摘 | Qiu w Hu Y Andersen TE | 2010 | J Biol Chem2010，285，14： | 1 |
| 18 | Effects of Mn Content on Mechanical Properties of FeCoCrNiMn_(x)(0≤x≤0.3)High-Entropy Alloys:A First-Principles Study显示文摘Effects of Mn content on mechanical properties of FeCoCrNiMn_(x)(0≤x≤0.3)high-entropy alloys(HEAs)are investigated via first-prmciples calculations combining EMTO-CPA method.Related physical parameters,including lattice constant.elastic constants,elastic modulus,Pugh’s ratio,anisotropy factors,Poisson’s ratio,Cauchy pressure,Vickers hardness,yield strength,and energy factor,are calculated as a function of Mn content.The results show that the resistances to bulk,elastic,and shear deformation decrease with increasing Mn content.Pugh’s ratio B/G indicates that the ductility of FeCoCrNiMn_(x) HEAs has a remarkable reduction between 22 and 24% of Mn content.Meanwhile,Cauchy pressure suggests that the atomic bonding transforms from metallic to directional characteristic from 22 to 24% of Mn content.Vickers hardness and yield strength of FeCoCrNiMn HEA are intrinsically larger than those of FeCoCrNi HEA.Dislocation nucleation easily occurs in FeCoCrNiMn HE A compared to FeCoCrNi HEA,and large dislocation width in FeCoCrNiMnO_(2) HE A results in low stacking-fault energy,which easily induces twinning deformation.This work provides a valuable msieht for further theoretical and experimental study on the mechanical properties of FeCoCrNiMn_(x)(0≤x≤0.3)HEAs. | Hui Xiao Yu Liu Kai Wang Zhipeng Wang Te Hu Touwen Fan Li Ma Pingying Tang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，4： | 1 |
| 19 | A novel missense(M206K)STAT3mutation in diffuse large B cell lymphoma deregulates STAT3 signaling显示文摘 | Hu G Witzig TE Gupta M | 2013 | PLoS One2013，8，67： | 1 |
| 20 | Functional regener-ation of respiratory pathways after spinal cord injury显示文摘 | Alilain WJ Horn KP Hu H Dick TE Silver J | | 0，，： | 1 |
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