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| 1 | Analysis of species-dependent hydrolysis and protein binding of esmolol enantiomers显示文摘The stereoselective hydrolysis of esmolol in whole blood and in its separated components from rat,rabbit and human was investigated.Blood esterase activities were variable in different species in the order of rat>rabbit>human.Rat plasma showed the high esterase activity and had no stereoselectivity to enantiomers.Rabbit red blood cell(RBC) membrane,RBC cytosol and plasma all hydrolyzed esmolol but with different esterase activity,whereas the hydrolysis in RBC membrane and cytosol showed significant stereoselectivity towards R-(+)-esmolol.Esterase in RBC cytosol from human blood mainly contributed to the esmolol hydrolysis,which was demonstrated with no stereoselctivity.Esterase in human plasma showed a low activity,but a remarkable stereoselectivity with R-(+)-esmolol.In addition,the protein concentration affected the hydrolysis behavior of esmolol in RBC suspension.Protein binding of esmolol enantiomers in human plasma,human serum albumin(HSA) and α_1-acid glycoprotein(AGP) revealed that there was a significant difference in bound fractions between two enantiomers,especially for AGP.Our results indicated that the stereoselective protein binding might play a role in the different hydrolysis rates of esmolol enantiomers in human plasma. | Yi-Hong Tanga,b,1,Jun-Yan Wanga,1,Hai-Hong Hua,Tong-Wei Yaoa,Su Zenga,n aDepartment of Pharmaceutical Analysis and Drug Metabolism,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,Zhejiang 310058,People’s Republic of China bShanghai Institute of Technology,Shanghai 201418,People’s Republic of China | 2012 | Journal of Pharmaceutical Analysis2012，2，3： | 3 |
| 2 | Prevention and treatment for radiation-induced skin injury during radiotherapy显示文摘The skin tissue has the largest area in the human body and functions as both a barrier and a defender.As such,it tends to be the first tissue to be damaged.Advances in medical technology provide prospects as well as side effects,for example,radiation therapy for cancer.With increasing cancer morbidity and radiation widely applied for cancer therapy,radiation-induced skin injury(RSI)has become a serious concern.In recent decades,research efforts have focused on the mechanisms underlying RSI.This review summarizes the mainstream opinions on these mechanisms,including the pathological,molecular biological,and cytobiological alterations.Radiationinduced reactive oxygen species(ROS),cytokines and involved signaling pathways are evaluated.Other relevant aspects include radiation-induced skin fibrosis(RSF)and radiation-related skin cell senescence.Moreover,we review strategies for the prevention and treatment in clinical and pre-clinical studies to support the treatment of RSI during radiotherapy.The prevention strategies include dose control,pre-irradiation instructions,and RSI assessments,while the main treatments include physical therapy,external-use dressings or creams,biological therapy and surgical reconstruction. | Yimin Wang Wenling Tu Yiting Tanga Shuyu Zhang | 2020 | Radiation Medicine and Protection2020，1，2： | 2 |
| 3 | Effect of aging time on strength and microstructures of an Al-Cu-Li-Zn-Mg-Mn-Zr alloy显示文摘 | Li Hongying Yi Tanga Zeng Zaide | | 0，，498： | 2 |
| 4 | Nurse drug diversion and nursing leader's responsibilities:legal,regulatory,ethical,humanistic,and practical considerations显示文摘 | Tanga HY | 2011 | JONAS Healthc Law Ethics Regul2011，13，1： | 1 |
| 5 | Inhibition of micro- glial activation attenuates the development but not exist- ing hypersensitivity in a rat model of neuropathyl 显示文摘 | Raghavendra V Tanga F Deleo JA | 2003 | J Pharmacol Exp Ther2003，306，： | 1 |
| 6 | Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proin-flammatory cytokine expression in the CNS显示文摘 | Raghavendra V Tanga FY DeLeo JA | 2004 | Eur J Neurosci2004，20，2： | 1 |
| 7 | The contributing role of CDI4 in Toll-like receptor 4 dependent neuropathic pain 显示文摘 | Cao L Tanga FY Deleo JA | 2009 | Neuroscience2009，158，： | 1 |
| 8 | Role of astrocytec S100βin behavioral hypersensitivity in rodent models of neuropathic pain显示文摘 | Tanga F Y Raghavendra V Nutile-McMenemy N | 2006 | Neuroscience2006，140，3： | 1 |
| 9 | Tissue kallikrein protectsneurons from hypoxia/reoxygenation-induced cell injurythrough Homerlb/c显示文摘 | Sua J Tanga Y Zhou H | 2012 | Cell Signal2012，24，11： | 1 |
| 10 | Cooling performance of roof ponds with gunny bags floating on water surface as compared with a movable insulation显示文摘 | Runsheng Tanga Etzion Y | 2005 | Renewable Energy2005，30，： | 1 |
| 11 | Electrochemical preparation of NiA1 intermetallic compound from solid oxides in molten CaCl2 and its corrosion behaviors in NaC1 aqueous solution 显示文摘 | Huayi Yina Tang Yua Diyong Tanga | 2012 | Materials Chemistry and Physics2012，133，： | 1 |
| 12 | The CNS role of Toll- like receptor 4 in innate neuroimmunity and painful neuropathy 显示文摘 | Tanga FY Nutile-McMenemy N DeLeo JA | 2005 | Proc Natl Acad Sci USA2005，102，： | 1 |
| 13 | Improved appro ach to identify cancer-associated autoantigens显示文摘 | Fe'lix-Ferna M Tanga N Alansaria H | 2005 | Autoimmunity Rev2005，4，： | 1 |
| 14 | Lanthanum-dopedα-Ni(OH)_(2)1D-2D-3D hierarchical nanostructures for robust bifunctional electro-oxidation显示文摘The development of advanced electrocatalysts for electro-oxidation reactions has attracted much attention because of the critical role of such electrocatalysts in improving the overall efficiency of coupled hydrogen production.We have developed an efficient lanthanum-dopedα-Ni(OH)_(2) bifunctional catalyst with a 1D-2D-3D hierarchical nanostructure.It shows superior activity and stability in the anodic oxygen evolution reaction(OER)and urea oxidation reaction(UOR).Enrichment of the edge sites and conducting La doping inα-Ni(OH)_(2) phase enable formation and stabilization of abundant local Ni^(3+)ions.This guarantees ultralow onset potentials in electro-oxidation reactions.The 1D-2D-3D hierarchical nanostructure significantly boosts the in situ generation of high-valence active species,which results in efficient and stable OER and UOR performances,and the synergistic merit of doping-induced facile reaction kinetics.Because of the structural benefits of a large surface area,charge-transfer promotion,good structural stability,and bifunctionality,a 1%La-dopedα-Ni(OH)_(2) hierarchical nanostructure gives superior OER and UOR performances with low overpotentials,large catalytic current densities,and excellent operational stability.It is therefore a promising catalyst for use in simultaneous alkaline wastewater treatment and hydrogen production. | Zimeng Wei Wenbin Sun Shanshan Liu Jindi Qi Luyao Kang jiechen Li Shanshan Lou Junfeng Xie Bo Tanga Yi Xie | 2021 | Particuology2021，19，4： | 1 |
| 15 | Simultaneous quantitation of aconitine, mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine and benzoylhypaeonine in human plasma by liquid chromatography tandem mass spectrometry and phannaco- kinetics evaluation of ' SHEN-FU' injectable powder 显示文摘 | Zhang F Tanga MH Chen LJ | 2008 | J Chromatogr B2008，873，2： | 1 |
| 16 | Anti-hyperalgesic and morphineparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines显示文摘 | Raghavendra V Tanga F Rutkowski MD | 2003 | Pain2003，104，3： | 1 |
| 17 | Quantitative real - time RT - PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain 显示文摘 | Tanga FY Raghavendra V Deleo JA | 2004 | Neurochemistry International2004，45，： | 1 |
| 18 | Cooling performance of roof ponds with gunny bags floating on water surface as compared with a movable insulation显示文摘 | Runsheng Tanga Etzion Y | 2005 | Renewable Energy2005，30，： | 1 |
| 19 | Attenuation of morphine tolerance, withdrawal -induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats 显示文摘 | Raghavendra V Tanga FY DeLeo JA | 2004 | Neuropsyehopharmacology2004，29，2： | 1 |
| 20 | An analysis of thermal and solar zone radiation models using an Angstrom- Prescott equation and artificial neural networks显示文摘 | WANA K K W TANGA H L YANG L | 2008 | Energy2008，33，7： | 1 |
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