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| 1 | Applying mastery learning in a clinicalskills training program for primary care nurses 显示文摘 | Tang WE Dong L | 2013 | J Contin Edue Nuts2013，44，12： | 1 |
| 2 | Proteasome inhibi- tion promotes regression of left ventricular hypertrophy 显示文摘 | Stansfield WE Tang RH Moss NC | 2008 | Am J Physiol Heart Circ Physiol2008，294，2： | 1 |
| 3 | Proteasome inhibition promotes regression of left ventricular hypertrophy显示文摘 | Stansfield WE Tang RH Moss NC | | 0，，02： | 1 |
| 4 | Periostin is a novel factor in cardiac remodeling after experimental and clinical unloading of the failing heart显示文摘 | Stansfield WE Andersen NM Tang RH | 2009 | Ann Thorac Surg2009，88，6： | 1 |
| 5 | Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance显示文摘Latent membrane protein 1(LMP1)is a major Epstein–Barr virus(EBV)-encoded oncoprotein involved in latency infection that regulates mitochondrial functions to facilitate cell survival.Recently,mitochondrial fission has been demonstrated as a crucial mechanism in oncovirus-mediated carcinogenesis.Mitochondrial dynamin-related protein 1(Drp1)-mediated mitochondrial fission has an impact on the chemoresistance of cancers.However,the mechanism by which oncogenic stress promotes mitochondrial fission,potentially contributing to tumorigenesis,is not entirely understood.The role of Drp1 in the oncogenesis and prognosis of EBV-LMP1-positive nasopharyngeal carcinoma(NPC)was determined in our study.We show that EBV-LMP1 exhibits a new function in remodeling mitochondrial morphology by activating Drp1.A high level of p-Drp1(Ser616)or a low level of p-Drp1(Ser637)correlates with poor overall survival and disease-free survival.Furthermore,the protein level of p-Drp1(Ser616)is related to the clinical stage(TNM stage)of NPC.Targeting Drp1 impairs mitochondrial function and induces cell death in LMP1-positive NPC cells.In addition,EBV-LMP1 regulates Drp1 through two oncogenic signaling axes,AMPK and cyclin B1/Cdk1,which promote cell survival and cisplatin resistance in NPC.Our findings provide novel insight into the role of EBV-LMP1-driven mitochondrial fission in regulating Drp1 phosphorylation at serine 616 and serine 637.Disruption of Drp1 could be a promising therapeutic strategy for LMP1-positive NPC. | Longlong Xie Feng Shi Yueshuo Li We Li Xinfang Yu Lin Zhao Min Zhou Jianmin Hu Xiangjian Luo Min Tang Jia Fan Jian Zhou Qiang Gao Weizhong Wu Xin Zhang Weihua Liao Ann MBode Ya Cao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 6 | Periostin is a novel factor in cardiac remodeling after experimental and clinical unloading of the failing heart显示文摘 | Stansfield WE Andersen NM Tang RH | 2009 | Ann Thorac Surg2009，88，6： | 1 |
| 7 | Applying mastery learning in a clinical skills training program for primary care nurses显示文摘 | Tang WE Dong L | 2013 | J Contin Educ Nurs2013，，12： | 1 |
| 8 | TriplefrequencyCarrier Ambiguit Resolution for Beidou Navigation Satellite System显示文摘 | We iming Tang Chenlong Deng Chuang Shi | 2014 | GPS Solut2014，，18： | 1 |
| 9 | Periostin is a novel facton in cardiac remodcling after experimental and clinical unloading of the failing heart 显示文摘 | Stansfield WE Andemen NM Tang RH | 2009 | Ann Thorac Surg2009，88，6： | 1 |
| 10 | Proteasome inhibition promotes regression of left ventricular hypeitrophy显示文摘 | Stansfield WE Tang RH Moss NC | 2008 | Am J Physiol Heart Cite Physiol2008，294，2： | 1 |
| 11 | Periostin is a novel factor in cardiac remodeling after experimental and clinical unloading of the failing heart显示文摘 | Stansfield WE Andersen NM Tang RH | 2009 | Ann Thora Surg2009，88，16： | 1 |
| 12 | Periostin is a novel factor in cardiac remodeling after experimental and clinical unloading of the failing heart显示文摘 | Stansfield WE Andersen NM Tang RH | 2009 | Ann Thorac Surg2009，88，6： | 1 |
| 13 | Periostin is a novel factor in cardiac remodeling after experimental and clinical unloading of the failing heart 显示文摘 | Stansfield WE Andersen NM Tang BH | 2009 | Ann Thorac Surg2009，88，6： | 1 |
| 14 | Effects of genotypes and plant density on yield, yield components and photosynthe- sis in Bt transgenic cotton显示文摘 | Dong Hezhong Li Weijiang Tang We | 2006 | Joumal of Agronomy and Crop Science2006，192，： | 1 |
| 15 | Spatiotemporal Differences and Classification Regulation of Urbanization Impact on Agricultural Development in Shrinking Areas:A Case Study of 15 Shrinking Cities in Three Provinces of Northeast China显示文摘Studying the impact of urbanization on agricultural development in shrinking areas is important for maintaining food security and promoted agricultural development in China.Based on the measurement results of the shrinking cities in the three provinces of Northeast China,this paper selects 15 shrinking cities as the research object,and constructs a multi-dimensional index system to explore the impact of the urbanization level of the shrinking areas on the agricultural development in the region since 2007–2019,analyzes the influencing factors and their differences by using the geographically-weighted regression model and Geodetector,and proposes a targeted regulation strategy.The results show that:1)overall,there is a negative correlation between the urbanization level and the agricultural development level in the contracted areas of the three northeastern provinces.The urbanization level in these areas has a certain negative impact on the overall level of agricultural development;2)regarding the time dimension,the impact of urbanization level on the agricultural development level in the contracted areas of the three northeastern provinces gradually increases over time;3)regarding the spatial pattern,the overall impact of shrinking urbanization levels in the three provinces of Northeast China on the agricultural development shows a significant distribution pattern of high in the east and low in the west;4)the total population and natural population growth rate at the end of the year were the main factors influencing a certain level of urbanization on agricultural development in the shrinking cities while population density and the urban fixed asset investment rate were the secondary factors;and 5)the main reasons why the level of agricultural development in different cities was affected by the level of urbanization were different.However,they can be categorized into areas of population loss and spatial construction,which can be further divided into area of population loss in the northeast,areas of negative population growth in the west,and areas of urban spatial change in the south.According to the causes of the impact,this paper adopted targeted regulation strategies and formulated relevant policies and solutions that cater to local conditions. | CHEN Xiaohong LIU Haihan AN Yongle DAI Yue PAN Wei WANG Ying TANG We | 2023 | Chinese Geographical Science2023，33，6： | 0 |
| 16 | Correction:Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance显示文摘Correction to:Signal Transduction and Targeted Therapy(2020)5:56,http://gffzzd3cc09b8251d45dfs596ww0kx6obv69cb.ffgz.tsg.suse.edu.cn/10.1038/s41392-020-0151-9,published online 20 May 2020 In this article1 an error was noticed in Fig.3d left(p-Drp1 Ser637).The images were misassigned.And one writing error was found in Fig.S1c.The correct figures are given.The authors confirm that these corrections do not change the result interpretation or conclusions of the article. | Longlong Xie Feng Shi Yueshuo Li We Li Xinfang Yu Lin Zhao Min Zhou Jianmin Hu Xiangjian Luo Min Tang Jia Fan Jian Zhou Qiang Gao Weizhong Wu Xin Zhang Weihua Liao Ann M.Bode Ya Cao | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 0 |
| 17 | Reconstruction of lower lip carcinoma intra- operative defects with instant dorsal tongue flap显示文摘 | Le Nan Shao Yuan Liu Guo Xiong Tang We Min Chen | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
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