|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Surgical treatment of HCC in a patient with lamivudine-resistant hepatitis B cirrhosis with adefovir dipivoxil显示文摘We describe a 77-year-old woman with chronic hepatitis B who became resistant to lamivudine.She was started on adefovir(10 mg daily)while still continuing lamivudine therapy.Four mo later her liver function improved and serum Hepatitis B virus(HBV)-DNA level became undetectable.Three years after the start of additional adefovir treatment,hepatocellular carcinoma (HCC)was detected and the patient underwent a successful hepa-tectomy.Our findings suggest tha-t the addition of adefovir to ongoing lamivudine therapy cannot completely suppress hepatocarcinogenesis,but is useful for improving liver function in patients with lamivudine-resistant HBV-related cirrhosis,allowing HCC surgery. | Takashi Akima Masaya Tamano Hidetsugu Yamagishi Keiichi Kubota Takahiro Fujimori Hideyuki Hiraishi | 2010 | World Journal of Hepatology2010，2，8： | 11 |
| 2 | Endoscopic ultrasonography can diagnose distal biliary strictures without a mass on computed tomography显示文摘AIM:To assess the diagnostic ability of endoscopic ultrasonography(EUS)for evaluating causes of dista biliary strictures shown on endoscopic retrograde chol angiopancreatography(ERCP)or magnetic resonance cholangiopancreatography(MRCP),even without iden tifiable mass on computed tomography(CT). METHODS:The diagnostic ability of EUS was retro spectively analyzed and compared with that of routine cytology(RC)and tumor markers in 34 patients with distal biliary strictures detected by ERCP or MRCP a Dokkyo Medical School Hospital from December 2005 to December 2008,without any adjacent mass or ec centric thickening of the bile duct on CT that could cause biliary strictures.Findings considered as benign strictures on EUS included preservation of the normasonographic layers of the bile duct wall,irrespective of the presence of a mass lesion.Other strictures were considered malignant.Final diagnosis of underlying diseases was made by pathological examination in 18 cases after surgical removal of the samples,and by clinical follow-up for>10 mo in 16 cases. RESULTS:Seventeen patients(50%)were finally di- agnosed with benign conditions,including 6'normal' subjects,while 17 patients(50%)were diagnosed with malignant disease.In terms of diagnostic ability,EUS showed 94.1%sensitivity,82.3%specificity,84.2% positive predictive value,93.3%negative predictive value(NPV)and 88.2%accuracy for identifying ma- lignant and benign strictures.EUS was more sensi- tive than RC(94.1%vs 62.5%,P=0.039).NPV was also better for EUS than for RC(93.3%vs 57.5%,P= 0.035).In addition,EUS provided significantly higher sensitivity than tumor markers using 100 U/mL as the cutoff level of carbohydrate antigen 19-9(94.1%vs 53%,P=0.017).On EUS,biliary stricture that was fi- nally diagnosed as malignant showed as a hypoechoic, irregular mass,with obstruction of the biliary duct and invasion to surrounding tissues. CONCLUSION:EUS can diagnose biliary strictures caused by malignant tumors that are undetectable on CT.Earlier detection by EUS would provide more therapeutic options for patients with early-stage pancreaticobiliary cancer. | Yasuyuki Saifuku Michiko Yamagata Takero Koike Genyo Hitomi Kazunari Kanke Hidetaka Watanabe Toshimitsu Murohisa Masaya Tamano Makoto Iijima Keiichi Kubota Hideyuki Hiraishi | 2010 | World Journal of Gastroenterology2010，16，2： | 5 |
| 3 | Shear wave elastography in hepatitis C patients before and after antiviral therapy显示文摘AIM To investigate shear wave(SW) propagation velocity in patients with untreated hepatitis C and patients with sustained virological response(SVR). METHODS A total of 136 hepatitis C patients [85 patients who had not received antiviral therapy(na?ve group) and 51 patients who had received antiviral therapy and subsequently achieved SVR of at least 24 wk(SVR group)] and 58 healthy volunteers and outpatients without liver disease(control group) underwent evaluation of liver stiffness by SW elastography(SWE). Various parameters were evaluated in the chronic hepatitis C patients at the time of SWE.RESULTS SW propagation velocity(Vs) was 1.23 ± 0.14 m/s in the control group, 1.56 ± 0.32 m/s in the SVR group, and 1.69 ± 0.31 m/s in the na?ve group. Significant differences were seen between the control group and the SVR group(P = 0.0000) and between the SVR group and the na?ve group(P = 0.01417). All four fibrosis markers were higher in the na?ve group than in the SVR group. In the na?ve group, Vs was positively correlated with alanine aminotransferase(ALT)(r = 0.5372), α feto protein(AFP)(r = 0.4389), type Ⅳ collagen(r = 0.5883), procollagen Ⅲ peptide(P-Ⅲ-P)(r = 0.4140), hyaluronic acid(r = 0.4551), and Mac-2 binding protein glycosylation isomer(M2BPGi)(r = 0.6092) and negatively correlated with albumin(r =-0.4289), platelets(r =-0.5372), and prothrombinactivity(r =-0.5235). On multiple regression analysis, Vs was the most strongly correlated with ALT(standard partial regression std β = 0.4039, P = 0.00000). In the SVR group, Vs was positively correlated with AFP(r = 0.6977), type IV collagen(r = 0.5228), P-Ⅲ-P(r = 0.5812), hyaluronic acid(r = 0.5189), and M2BPGi(r = 0.6251) and negatively correlated with albumin(r =-0.4283), platelets(r =-0.4842), and prothrombin activity(r =-0.4771). On multiple regression analysis, Vs was strongly correlated with AFP(standard partial regression std β = 0.5953, P = 0.00000) and M2BPGi(standard partial regression std β = 0.2969, P = 0.03363).CONCLUSION In hepatitis C patients, liver stiffness is higher in treatment-na?ve patients than in those showing SVR. SWE may be a predictor of hepatocarcinogenesis in SVR patients. | Toshikuni Suda Osamu Okawa Rion Masaoka Yoshinori Gyotoku Naohiko Tokutomi Yasumi Katayama Masaya Tamano | 2017 | World Journal of Hepatology2017，9，1： | 4 |
| 4 | A new empirical formula for collapse resistance of commercial casing显示文摘 | Tamano T | 1983 | ASME Transaction of Energy Resources Technology1983，，： | 1 |
| 5 | Acquiredloss of erythrocyte complement receptor type 1 inpatients with diabetic nephropathy undergoing hemo-di-alysis 显示文摘 | Wakabayashi M Ohi H Tamano M | 2006 | Nephron Exp Nephrol2006，104，3： | 1 |
| 6 | Bile flow in a mutant Sprague-Dawley rat with defective biliary excretion of glutathione 显示文摘 | Yoshida H Okano K Tamano T | 1994 | J Gustroenterol1994，29，4： | 1 |
| 7 | Left ventricular mass relates to average systolic blood pressure,but not loss of circadian blood pressure in stable hemodialysis patients: an ambulatory 48 - hour blood pressure study 显示文摘 | Nishikimi T Minami J Tamano K | 2007 | Hypertens Res2007，24，6： | 1 |
| 8 | Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis 显示文摘 | Weinstock - Guttman B Zivadinov R Tamano - Blanco M | 2007 | J Neuroimmunol2007，188，12： | 1 |
| 9 | Drag reduction in a turbulent boundary layer on a flexible sheet undergoing a spanwise traveling wave motion显示文摘 | ITOH M TAMANO S YOKOTA K | 2006 | Journal of Turbulence2006，7，1： | 1 |
| 10 | Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis 显示文摘 | Imaida K Tamano S Kato K | 2001 | Carcinogenesis2001，22，3： | 1 |
| 11 | Acquired loss of erythrocyte compl-ement receptor type 1 in patient with diabetic nephropathy undergoing hem-odialysis显示文摘 | Wakabayashi M Ohi H Tamano M | 2006 | Nephron Exp Nephrol2006，104，3： | 1 |
| 12 | New empirical formula for collapse resistance of commercial casing 显示文摘 | Tamano T Mimake T Yanagimoto S A | 1983 | Journal of Energy Resources Technology1983，43，5： | 1 |
| 13 | Stability of slurry trench excavation in soft clay 显示文摘 | Tamano T Fukui S Suzuki H & Ueshita K | | Soils and Foundations0，36，2： | 1 |
| 14 | Facilitated Neurogenesis in the Developing Hippocampus After Intake of Theanine, an Amino Acid in Tea Leaves, and Object Recognition Memory显示文摘 | Takeda A Sakamoto K Tamano H | 2011 | Cell Mol Neurobiol2011，31，7： | 1 |
| 15 | Insight into zinc signaling from dietary zinc deficiency显示文摘 | Atsushi Takeda Haruna Tamano | 2009 | Brain Research Reviews2009，，1： | 1 |
| 16 | On compactifications显示文摘 | Tamano H | 1962 | J Math Kyoto Univ1962，1，2： | 1 |
| 17 | Is the aspect ratio a reliable index for predicting the rapture of a saccular aneurysm? 显示文摘 | Ujiie H Tamano Y Sasaki K | 2001 | Neurosurgery2001，48，3： | 1 |
| 18 | Shigella Spa32 is an essential secretory protein for functional type Ⅲ secretion machinery and uniformity of its needle length显示文摘 | Tamano K Katayama E Toyotome T | 2002 | J Bacteriol2002，184，5： | 1 |
| 19 | Synoptic surgical reporting for breast cancer surgery: an innovation in knowledge translation显示文摘 | TEMPLE W J FRANCIS W P TAMANO E | 2010 | Am J Surg2010，199，6： | 1 |
| 20 | The usefulness of measuring liver stiffness by transient elastography for assessing hepatic fibrosis in patients with various chronicliver diseases显示文摘 | Tamano M Kojima K Akima T | 2012 | Hepatogastroenterology2012，59，115： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员