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19篇 您的检索式：作者名="Talwar G P"

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		题名	作者	年代	出处	被引量
	1	Combination immunotherapy with Survivin and luteinizing hormone-releasing hormone fusion protein in murine breast cancer model显示文摘AIM To investigate the therapeutic potential of two recombinant proteins, Survivin and luteinizing hormone-releasing hormone (LHRH) fusion protein [LHRH(6 leu)-LTB] for immunotherapy of breast cancer.METHODS Murine 4 T-1 breast cancer model was used to evaluate the efficacy of recombinant proteins in vivo. Twenty four Balb/c mice were divided into 4 groups of 6 mice each. Recombinant Survivin and LHRH fusion protein, alone or in combination, were administered along with immunomodulator Mycobacterium indicus pranii (MIP) in Balb/c mice. Unimmunized or control group mice were administered with phosphate buffer saline. Each group was then challenged with syngeneic 4 T-1 cells to induce the growth of breast tumor. Tumor growth was monitored to evaluate the efficacy of immune-response in preventing the growth of cancer cells.RESULTS Preventive immunization with 20 μg recombinant Survivin and MIP was effective in suppressing growth of 4 T-1 mouse model of breast cancer (P = 0.04) but 50 μg dose was ineffective in suppressing tumor growth. However, combination of Survivin and LHRH fusion protein was more effective in suppressing tumor growth (P = 0.02) as well as metastasis in vivo in comparison to LHRH fusion protein as vaccine antigen alone.CONCLUSION Recombinant Survivin and MIP suppress tumor growth significantly. Combining LHRH fusion protein with Survivin and MIP enhances tumor suppressive effects marginally which provides evidence for recombinant Survivin and LHRH fusion protein as candidates for translating the combination cancer immunotherapy approaches.	Himani Garg Rohit Singh Hada Jagdish C Gupta G P Talwar Shweta Dubey	2018	World Journal of Clinical Oncology2018，9，8：	2
	2	Biodegradable delivery system for a birth control vaccine:immunogenicity studies in rats and monkeys显示文摘	Singh M Singh O Talwar G P	1995	Pharm Res1995，12，：	1
	3	Induced termination of pregnancy by purified extracts of Azadirachta India (Neem): Mechanisms involved 显示文摘	Talwar G P Shah S Mukherjee S	1997	Am J Reprod Immunol1997，37，：	1
	4	Plant immunomodu- lators for termination of unwanted pregnancy and for contracep- tion and reproductive health 显示文摘	Talwar G P Raghuvanshi P Misra R	1997	Immunol Cell Biol1997，75，2：	1
	5	A vaccine that prevents pregnancy in women 显示文摘	Talwar G P Singh O Pal R	1994	Proc Natl Acad Sci USA1994，91，18：	1
	6	Physiological factors of growth and susceptibility to virus regulating vero cells for optimum yield of vaccinia and cloned gene product (βhCG) 显示文摘	Mukhopadhyay A Mukhopadhyay S N Talwar G P	1998	J Biotechnol1998，36，：	1
	7	Antifertility effects of neem(Azadirachta indica) oil in male rats by single intravas administration:an alternate approach to vasectomy显示文摘	UPADHYAY S N DHAWAN S TALWAR G P	1993	Am Soc Andrology1993，14，4：	1
	8	Anti-inflammatory activity of Terminalia paniculata bark extract against acute and chronic inflam- mation in rats显示文摘	Talwar S Nandakumar K Nayak P G	2011	J Ethnopharmacol2011，134，2：	1
	9	A vaccine that prevents pregnancy in woman显示文摘	Singh O Pal R	1994	Proc Natl Acad Sci USA1994，91，：	1
	10	Comparison of Extraction Procedures on the Immunocontraceptive Activity of Neem Seed Extracts 显示文摘	GARG S TALWAR G P UPADHYAY S N	1994	Journal of Ethnopharmacology1994，22，：	1
	11	Vaccine for control of fertility显示文摘	TALWAR G P SINGH O SHAHA R	1989	Immunlolgy Suppl1989，2，：	1
	12	A vaccine that prevents pregnancy in women显示文摘	Singh O Pal R	1994	Proc Natl Acad Sci USA1994，91，：	1
	13	Fertility regulating and immunotherapeutic vaccines reaching human trials stage 显示文摘	Talwar G P	1997	Hum Reprod1997，3，：	1
	14	The HSD-hCG vaccine prevents pregnancy in women:feasibility study of a reversible safe contraceptive vaccine显示文摘	Talwar G P Singh O M Gupta S K	1997	Am J Reprod Immunol1997，37，2：	1
	15	Biodegradable delivery system for a Birth contro] vaceine:immunogenicity studies in rats and monkeys显示文摘	SINGH M SINGH O TALWAR G P	1995	Pharm Res1995，12，6：	1
	16	The HSD-hCG vaccine prevents pregnancy in women:feasibility study of a reversible safe contraceptive vaccine显示文摘	Talwar G P Singh O M Gupta S K	1997	Am J Reprod Immunol1997，37，：	1
	17	Carrier induced suppression of the antibody response to self hapten显示文摘	Sad S Talwar G P	1991	Immunol1991，74，：	1
	18	Antifertility effects of neem (Azadirachta indica) oil in male rats by single intra-vas显示文摘	UPADHYZY S N DHAWAN S TALWAR G P	1990	Pric Roy Soc1990，242，：	1
	19	Effect of vitamin A and protein-calorie undernutrition on immune responses 显示文摘	Krishnan S Bhuyan U N Talwar G P	1974	Immunology1974，27，3：	1

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