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| 1 | Transdermal delivery of 4-aminopyridine accelerates motor functional recovery and improves nerve morphology following sciatic nerve crush injury in mice显示文摘Oral 4-aminopyridine(4-AP)is clinically used for symptomatic relief in multiple sclerosis and we recently demonstrated that systemic 4-AP had previously unknown clinically-relevant effects after traumatic peripheral nerve injury including the promotion of re-myelination,improvement of nerve conductivity,and acceleration of functional recovery.We hypothesized that,instead of oral or injection administration,transdermal 4-AP(TD-4-AP)could also improve functional recovery after traumatic peripheral nerve injury.Mice with surgical traumatic peripheral nerve injury received TD-4AP or vehicle alone and were examined for skin permeability,pharmacokinetics,functional,electrophysiological,and nerve morphological properties.4-AP showed linear pharmacokinetics and the maximum plasma 4-AP concentrations were proportional to TD-4-AP dose.While a single dose of TD-4-AP administration demonstrated rapid transient improvement in motor function,chronic TD-4-AP treatment significantly improved motor function and nerve conduction and these effects were associated with fewer degenerating axons and thicker myelin sheaths than those from vehicle controls.These findings provide direct evidence for the potential transdermal applicability of 4-AP and demonstrate that 4-AP delivered through the skin can enhance in-vivo functional recovery and nerve conduction while decreasing axonal degeneration.The animal experiments were approved by the University Committee on Animal Research(UCAR)at the University of Rochester(UCAR-2009-019)on March 31,2017. | Andrew RClark Chia George Hsu M A Hassan Talukder Mark Noble John CElfar | 2020 | Neural Regeneration Research2020，15，1： | 3 |
| 2 | Atmospheric pressure gliding arc discharge plasma treatments for improving germination, growth and yield of wheat显示文摘Wheat(Triticum aestivum) seeds were treated with atmospheric pressure gliding arc discharge plasmas to investigate the effects on water absorption, seed germination rate, seedling growth and yield in wheat. The surface architectures and functionalities of the seeds were found to modify due to plasma treatments. 6 min treatment was provided 95%–100% germination rate.For the treatment duration of 3 and 9 min the growth activity, dry matter accumulation, leaves chlorophyll contents, longest spikes, number of spikes/spikelet and total soluble protein content in shoots were improved. The grain yield of wheat was increased ~20% by 6 min treatment with H_2O/O_2 plasma with respect to control. | N C ROY M M HASAN A H KABIR M A REZA M R TALUKDER A N CHOWDHURY | 2018 | Plasma Science and Technology2018，20，11： | 2 |
| 3 | Obstacle detection and terrain classification for autonomous off-road navigation显示文摘 | Manduchi R Castano A Talukder A | 2005 | Autonomous Robots2005，18，1： | 1 |
| 4 | Chromosome damage in- duced by selenium salts in human peripheral显示文摘 | BISWAS S TALUKDER G SHARMA A | 2000 | Toxicology in Vitro2000，14，： | 1 |
| 5 | Targeting calcium transport in isehaemic heart disease显示文摘 | Hassan Talukder M A Zweier J L Periasamy M | 2009 | Car Res2009，84，3： | 1 |
| 6 | Synthesis and the preliminary analysis of block copolymers of 3,3′-bis(azidomethyl)-oxetane and 3-nitratomethyl-3- methyloxetane 显示文摘 | Talukder M A H Lindsay G A | 1990 | Journal of Polymer Science Part A: Polymer Chemistry1990，28，9： | 1 |
| 7 | Effect of short-term heat stress prior to flowering and at early grain set on the utilization of water-soluble carbohydrate by wheat genotypes显示文摘 | Talukder A S M H M Mcdonald G K Gill G S | 2013 | Field Crops Research2013，14，7： | 1 |
| 8 | Seine phosphorylation ofpaxillin by heregulin-β role of p38 mitogen activated protein kinase显示文摘 | Vadlamudi R Adam L Talukder A | 1999 | Oncogene1999，18，： | 1 |
| 9 | Immunoconcentration of Shiga toxin producing Escherichia coli O157 from animal faeces and raw meats by using Dynabeads antiE, coli O157 and the VIDAS system 显示文摘 | ISLAMM A HEUVELINKA E TALUKDER K A | 2006 | International Journal of Food Microbiology2006，109，12： | 1 |
| 10 | Multiscale Gabor wavelet fusion for edge detection in microscopy images显示文摘 | Talukder A Casasent D P | 1998 | SPIE1998，3391，： | 1 |
| 11 | Effects of antimony on cellular systems in animals-a review显示文摘 | Gumai N Shanna A Talukder G | 1994 | Nucleus1994，37，： | 1 |
| 12 | An abnormal trace element in biology显示文摘 | GHOSH S SHARMA A TALUKDER Z | 1992 | Biological Trace Element Research1992，35，3： | 1 |
| 13 | Phenotypic and genotypic characterization of serologically atypical strains of shigeUaflexneri type 4 isolated in dhaka, Bangladesh显示文摘 | TALUKDER K A ISLAM M A DUTTA D K | 2002 | J Clin Microbiol2002，40，24： | 1 |
| 14 | Metastasis- associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator 显示文摘 | Talukder AH Gururaj A Mishra SK | 2004 | Mol Cell Bioi2004，24，15： | 1 |
| 15 | Synthesis and preliminary analysis of block copolymers of 3,3'-bis(azidomethyl)-oxetane and 3-nitratomethyl-3'-methyloxetane显示文摘 | Talukder A H Lindsay G A | 1990 | J Polym Sci:Part A Polym Chem1990，28，： | 1 |
| 16 | Effect of cobalt on plants显示文摘 | Palit S Sharma A Talukder G 1994 | 1994 | Bot Rev1994，60，： | 1 |
| 17 | Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction显示文摘 | Talukder MA Kalyanasundaram A Zhao X | 2007 | Am J Physiol Heart Circ Physiol2007，293，4： | 1 |
| 18 | Chromosome damage induced by selenium salts in human peripheral显示文摘 | Biswas S Talukder G Sharma A | | 0，，： | 1 |
| 19 | Structural characteristics of heparin-line domain required for interaction of midkine with embryonic neurons显示文摘 | Kaneda N Talukder A H Ishihara M | 1996 | Biochem Biophys Res Commun1996，220，1： | 1 |
| 20 | Expression of SERCA isoform with faster Ca2+ trans- port properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction 显示文摘 | Talukder MA Kalyanasundaram A Zhao X | 2007 | Am J Physiol Heart Circ Physiol2007，293，4： | 1 |
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