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| 1 | Pretreatment AKR1B10 expression predicts the risk of hepatocellular carcinoma development after hepatitis C virus eradication显示文摘AIM To clarify the association between aldo-keto reductase family 1 member B10(AKR1B10) expression and hepatocarcinogenesis after hepatitis C virus eradication.METHODS In this study,we enrolled 303 chronic hepatitis C patients who had achieved sustained virological response(SVR) through interferon-based antiviral therapy. Pretreatment AKR1B10 expression in the liver was immunohistochemically assessed and quantified as a percentage of positive staining area by using image-analysis software. A multivariate Cox analysis was used to estimate the hazard ratios(HRs) of AKR1B10 expression for hepatocellular carcinoma(HCC) development after achieving SVR. The cumulative incidences of HCC development were evaluated using Kaplan-Meier analysis and the log-rank test.RESULTS Of the 303 chronic hepatitis C patients,153(50.5%) showed scarce hepatic AKR1B10 expression,quantified as 0%,which was similar to the expression in control normal liver tissues. However,the remaining 150 patients(49.5%) exhibited various degrees of AKR1B10 expression in the liver,with a maximal AKR1B10 expression of 73%. During the median follow-up time of 3.6 years(range 1.0-10.0 years),8/303 patients developed HCC. Multivariate analysis revealed that only high AKR1B10 expression(≥ 8%) was an independent risk factor for HCC development(HR = 15.4,95%CI: 1. 8- 1 3 2. 5,P = 0. 0 1 2). T h e 5- y e a r c u m u l a t i v e incidences of HCC development were 13.7% and 0.5% in patients with high and low AKR1B10 expression,respectively(P < 0.001). During the follow-up period after viral eradication,patients expressing high levels of AKR1B10 expressed markedly higher levels of alanine aminotransferase and α-fetoprotein than did patients exhibiting low AKR1B10 expression.CONCLUSION Chronic hepatitis C patients expressing high levels of hepatic AKR1B10 had an increased risk of HCC development even after SVR. | Ayato Murata Takuya Genda Takafumi Ichida Nozomi Amano Sho Sato Hironori Tsuzura Shunsuke Sato Yutaka Narita Yoshio Kanemitsu Yuji Shimada Katsuharu Hirano Katsuyori Iijima Ryo Wada Akihito Nagahara Sumio Watanabe | 2016 | World Journal of Gastroenterology2016，22，33： | 2 |
| 2 | The influence of hepatitis?B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma显示文摘 | Makoto Chuma Shuhei Hige Toshiya Kamiyama Takashi Meguro Atsushi Nagasaka Kazuaki Nakanishi Yoshiya Yamamoto Mitsuru Nakanishi Toshihisa Kohara Takuya Sho Keiko Yamamoto Hiromasa Horimoto Tomoe Kobayashi Hideki Yokoo Michiaki Matsushita Satoru Todo Masahi | 2009 | Journal of Gastroenterology2009，，9： | 1 |
| 3 | The influence of hepatitis?B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma显示文摘 | Makoto Chuma Shuhei Hige Toshiya Kamiyama Takashi Meguro Atsushi Nagasaka Kazuaki Nakanishi Yoshiya Yamamoto Mitsuru Nakanishi Toshihisa Kohara Takuya Sho Keiko Yamamoto Hiromasa Horimoto Tomoe Kobayashi Hideki Yokoo Michiaki Matsushita Satoru Todo Masahi | 2009 | Journal of Gastroenterology2009，，9： | 1 |
| 4 | TRIM29 negatively regulates p53 via inhibition of Tip60显示文摘 | Takuya Sho Tadasuke Tsukiyama Tomonobu Sato Takeshi Kondo Jun Cheng Takashi Saku Masahiro Asaka Shigetsugu Hatakeyama | 2011 | BBA - Molecular Cell Research2011，，6： | 1 |
| 5 | The influence of hepatitis?B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma显示文摘 | Makoto Chuma Shuhei Hige Toshiya Kamiyama Takashi Meguro Atsushi Nagasaka Kazuaki Nakanishi Yoshiya Yamamoto Mitsuru Nakanishi Toshihisa Kohara Takuya Sho Keiko Yamamoto Hiromasa Horimoto Tomoe Kobayashi Hideki Yokoo Michiaki Matsushita Satoru Todo Masahi | 2009 | Journal of Gastroenterology2009，，9： | 1 |
| 6 | Prospect of lenvatinib for unresectable hepatocellular carcinoma in the new era of systemic chemotherapy显示文摘The phase III clinical trial of the novel molecular targeted agent(MTA)lenvatinib for patients with advanced hepatocellular carcinoma(HCC)(REFLECT trial)found that lenvatinib was non-inferior to sorafenib in overall survival.Recently,the efficacy of multiple MTAs,including lenvatinib,in practice has been reported,and therapeutic strategies for Barcelona Clinic Liver Cancer(BCLC)intermediate stage HCC are undergoing major changes.Based on these results,lenvatinib could be recommended for patients with transcatheter arterial chemoembolization(TACE)-refractory,ALBI grade 1,within the up-to-seven criteria in the BCLC intermediate stage.Lenvatinib provides a more favorable outcome than TACE,even in cases with large or multinodular HCC beyond the up-to-seven criteria with Child-Pugh grade A.When patients meet the definitions of TACE-refractory or TACE-unsuitable,switching to systemic chemotherapy,including lenvatinib,is for favorable for preserving liver function.If initial treatment,including MTA,has a significant therapeutic effect and downstaging of HCC is obtained,additional TACE or surgical resection should be considered.Lenvatinib also has a therapeutic effect for poorly differentiated type and non-simple nodular type HCC thanks to the survival-prolonging effect of this drug.Furthermore,a significant therapeutic effect is expected in tumors with more than 50%liver involvement or main portal vein invasion,which have traditionally been considered to have a poor prognosis in patients.This suggests that at the start of lenvatinib treatment,HCC patients with ALBI grade 1 may be able to maintain liver functional reserve. | Takuya Sho Kenichi Morikawa Akinori Kubo Yoshimasa Tokuchi Takashi Kitagataya Ren Yamada Taku Shigesawa Mugumi Kimura Masato Nakai Goki Suda Mitsuteru Natsuizaka Koji Ogawa Naoya Sakamoto | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 1 |
| 7 | Pre-sarcopenia and Mac-2 binding protein glycosylation isomer as predictors of recurrence and prognosis of early-stage hepatocellular carcinoma显示文摘BACKGROUND The Mac-2 binding protein glycosylation isomer(M2BPGi),a fibrosis marker in various liver diseases,is reportedly a prognostic marker in patients with hepatocellular carcinoma(HCC)who underwent hepatectomy.AIM To evaluate whether the M2BPGi value,M2BP,and pre-sarcopenia before radiofrequency ablation(RFA)could be useful recurrence and prognostic markers in patients with early-stage HCC.METHODS In total,160 patients with early-stage primary HCC treated with RFA were separately analyzed as hepatitis C virus(HCV)-positive and HCV-negative.Factors contributing to recurrence and liver-related death,including M2BP,M2BPGi,and skeletal muscle mass index,were statistically analyzed.Eighty-three patients were HCV-positive and 77 were HCV-negative.RESULTS In HCV-positive patients,only des-γ-carboxy-prothrombin≥23 mAU/mL was a significant poor prognostic factor affecting survival after RFA.In HCV-negative patients,M2BPGi≥1.86 cutoff index was significantly associated with tumor recurrence,while M2BP was not.M2BPGi≥1.86 cutoff index(hazard ratio,4.89;95%confidence interval:1.97-12.18;P<0.001)and pre-sarcopenia(hazard ratio,3.34,95%confidence interval:1.19-9.37;P=0.022)were independent significant poor prognostic factors in HCV-negative patients.CONCLUSION In HCV-negative patients with primary HCC treated with RFA,lower M2BPGi contributed to a lower tumor recurrence rate and longer survival period.Pre-sarcopenia contributed to the poor prognosis independently in HCV-negative patients.These factors might be useful recurrence and prognostic markers for early-stage primary HCC. | Masato Nakai Kenichi Morikawa Shunichi Hosoda Sonoe Yoshida Akinori Kubo Yoshimasa Tokuchi Takashi Kitagataya Ren Yamada Masatsugu Ohara Takuya Sho Goki Suda Koji Ogawa Naoya Sakamoto | 2022 | World Journal of Hepatology2022，14，7： | 0 |
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