维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

5篇 您的检索式：作者名="Takuya Fukazawa"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	Progress in researches about focal adhesion kinase in gastrointestinal tract显示文摘Focal adhesion kinase(FAK)is a 125-kDa non-receptor protein tyrosine.Growth factors or the clustering of integrins facilitate the rapid phosphorylation of FAK at Tyr-397 and this in turn recruits Src-family protein tyrosine kinases,resulting in the phosphorylation of Tyr-576 and Tyr-577 in the FAK activation loop and full catalytic FAK activation.FAK plays a critical role in the biological processes of normal and cancer cells including the gastrointestinal tract.FAK also plays an important role in the restitution,cell survival and apoptosis and carcinogenesis of the gastrointestinal tract.FAK is over-expressed in cancer cells and its over-expression and elevated activities are associated with motility and invasion of cancer cells.FAK has been proposed as a potential target in cancer therapy.Small molecule inhibitors effectively inhibit the kinase activity of FAK and show a potent inhibitory effect for the proliferation and migration of tumor cells,indicating a high potential for application in cancer therapy.	Hui Fang Hao Yoshio Naomoto Xiao-Hong Bao Nobuyuki Watanabe Kazufumi Sakurama Kazuhiro Noma Yasuko Tomono Takuya Fukazawa Yasuhiro Shirakawa Tomoki Yamatsuji Junji Matsuoka Munenori Takaoka	2009	World Journal of Gastroenterology2009，15，47：	8
	2	Oral administration of FAK inhibitor TAE226 inhibits the progression of peritoneal dissemination of colorectal cancer显示文摘	Hui-fang Hao Munenori Takaoka Xiao-hong Bao Zhi-gang Wang Yasuko Tomono Kazufumi Sakurama Toshiaki Ohara Takuya Fukazawa Tomoki Yamatsuji Toshiyoshi Fujiwara Yoshio Naomoto	2012	Biochemical and Biophysical Research Communications2012，，：	1
	3	Antitumor eff- ect of temsirolimus against oral squamous cell carcinoma associated with bone destruction 显示文摘	Tatsuo Okui Tsuyoshi Shimo Takuya Fukazawa	2010	Mol Cancer2010，9，11：	1
	4	Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo显示文摘	Naito Kurio Tsuyoshi Shimo Takuya Fukazawa Munenori Takaoka Tatsuo Okui Nur Mohammad Monsur Hassan Tatsuki Honami Shinji Hatakeyama Masahiko Ikeda Yoshio Naomoto Akira Sasaki	2011	Experimental Cell Research2011，，：	1
	5	Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma显示文摘	Naito Kurio Tsuyoshi Shimo Takuya Fukazawa Tatsuo Okui Nur Mohammad Monsur Hassan Tatsuki Honami Yuu Horikiri Shinji Hatakeyama Munenori Takaoka Yoshio Naomoto Akira Sasaki	2012	Oral Oncology2012，，：	1

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费