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| 1 | Pathogenesis of NSAID-induced gastric damage:Importance of cyclooxygenase inhibition and gastric hypermotility显示文摘This article reviews the pathogenic mechanism of nonsteroidal anti-inflammatory drug(NSAID)-induced gastric damage,focusing on the relation between cyclooxygenase(COX) inhibition and various functional events.NSAIDs,such as indomethacin,at a dose that inhibits prostaglandin(PG) production,enhance gastric motility,resulting in an increase in mucosal permeability,neutrophil infiltration and oxyradical production,and eventually producing gastric lesions.These lesions are prevented by pretreatment with PGE 2 and antisecretory drugs,and also via an atropine-sensitive mechanism,not related to antisecretory action.Although neither rofecoxib(a selective COX-2 inhibitor) nor SC-560(a selective COX-1 inhibitor) alone damages the stomach,the combined administration of these drugs provokes gastric lesions.SC-560,but not rofecoxib,decreases prostaglandin E 2(PGE 2) production and causes gastric hypermotility and an increase in mucosal permeability.COX-2 mRNA is expressed in the stomach after administration of indomethacin and SC-560 but not rofecoxib.The up-regulation of indomethacin-induced COX-2 expression is prevented by atropine at a dose that inhibits gastric hypermotility.In addition,selective COX-2 inhibitors have deleterious influences on the stomach when COX-2 is overexpressed under various conditions,including adrenalectomy,arthritis,and Helicobacter pylori-infection.In summary,gastric hypermotility plays a primary role in the pathogenesis of NSAID-induced gastric damage,and the response,causally related with PG deficiency due to COX-1 inhibition,occurs prior to other pathogenic events such as increased mucosal permeability;and the ulcerogenic properties of NSAIDs require the inhibition of both COX-1 and COX-2,the inhibition of COX-1 upregulates COX-2 expression in association with gastric hypermotility,and PGs produced by COX-2 counteract the deleterious effect of COX-1 inhibition. | Koji Takeuchi | 2012 | World Journal of Gastroenterology2012，18，18： | 25 |
| 2 | Feasibility of cold snare polypectomy in Japan: A pilot study显示文摘AIM: To investigate the feasibility of cold snare polypectomy(CSP) in Japan.METHODS: The outcomes of 234 non-pedunculated polyps smaller than 10 mm in 61 patients who underwent CSP in a Japanese referral center were retrospectively analyzed. The cold snare polypectomies were performed by nine endoscopists with no prior experience in CSP using an electrosurgical snare without electrocautery.RESULTS: CSPs were completed for 232 of the 234 polyps. Two(0.9%) polyps could not be removed without electrocautery. Immediate postpolypectomy bleeding requiring endoscopic hemostasis occurred in eight lesions(3.4%; 95%CI: 1.1%-5.8%), but all were easily managed. The incidence of immediate bleeding after CSP for small polyps(6-9 mm) was significantly higher than that of diminutive polyps(≤ 5 mm; 15% vs 1%, respectively). Three(5%) patients complained of minor bleeding after the procedure but required no intervention. The incidence of delayed bleeding requiringendoscopic intervention was 0.0%(95%CI: 0.0%-1.7%). In total, 12% of the resected lesions could not be retrieved for pathological examination. Tumor involvement in the lateral margin could not be histologically assessed in 70(40%) lesions.CONCLUSION: CSP is feasible in Japan. However, immediate bleeding, retrieval failure and uncertain assessment of the lateral tumor margin should not be underestimated. Careful endoscopic diagnosis before and evaluation of the tumor residue after CSP are recommended when implementing CSP in Japan. | Yoji Takeuchi Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Kengo Nagai Fumi Matsui Tomofumi Akasaka Noboru Hanaoka Koji Higashino Hiroyasu Iishi Ryu Ishihara Henrik Thorlacius Noriya Uedo | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，17： | 14 |
| 3 | Pink-color sign in esophageal squamous neoplasia, and speculation regarding the underlying mechanism显示文摘AIM:To investigate the reasons for the occurrence of the pink-color sign of iodine-unstained lesions. METHODS:In chromoendoscopy, the pink-color sign of iodine-unstained lesions is recognized as useful for the diagnosis of esophageal squamous cell carcinoma. Patients with superficial esophageal neoplasms treated by endoscopic resection were included in the study. Areas of mucosa with and without the pink-color sign were evaluated histologically. The following histologic features that were possibly associated with the pinkcolor sign were evaluated. The keratinous layer and basal cell layer were classified as present or absent. Cellular atypia was classified as high grade, moderate grade or low grade, based on nuclear irregularity, mitotic figures, loss of polarity, chromatin pattern and nuclear/cytoplasmic ratio. Vascular change was assessed based on dilatation, tortuosity, caliber change and variability in shape. Vessels with these four findings were classified as positive for vascular change. Endoscopic images of the lesions were captured immediately after iodine staining, 2-3 min after iodine staining and after complete fading of iodine staining. Quantitative analysis of color changes after iodine staining was also performed. RESULTS:A total of 61 superficial esophageal neoplasms in 54 patients were included in the study. The lesions were located in the cervical esophagus in one case, the upper thoracic esophagus in 10 cases, the mid-thoracic esophagus in 33 cases, and the lower thoracic esophagus in 17 cases. The median diameter of the lesions was 20 mm (range:2-74 mm). Of the 61 lesions, 28 were classified as pink-color sign positive and 33 as pink-color sign negative. The histologic diagnosis was high-grade intraepithelial neoplasia (HGIN) or cancer invading into the lamina propria in 26 of the 28 pink-color sign positive lesions. There was a significant association between pink-color sign positive epithelium and HGIN or invasive cancer (P = 0.0001). Univariate analyses found that absence of the keratinous layer and cellular atypia were significantly associated with the pink-color sign. After Bonferroni correction, there were no significant associations between the pink-color sign and presence of the basal membrane or vascular change. Multivariate analyses found that only absence of the keratinous layer was independently associated with the pink-color sign (OR = 58.8, 95%CI:5.5-632).Quantitative analysis was performed on 10 superficial esophageal neoplasms with both pink-color sign positive and negative areas in 10 patients. Pink-color sign positive mucosa had a lower mean color value in the late phase (pinkish color) than in the early phase (yellowish color), and had similar mean color values in the late and final phases. These findings suggest that pinkcolor positive mucosa underwent color fading from the color of the iodine (yellow) to the color of the mucosa (pink) within 2-3 min after iodine staining. Pink-color sign negative mucosa had similar mean color values in the late and early phases (yellowish color), and had a lower mean color value in the final phase (pinkish color) than in the late phase. These findings suggest that pink-color sign negative mucosa did not undergo color fading during the 2-3 min after iodine staining, and underwent color fading only after spraying of sodium thiosulfate. CONCLUSION:The pink-color sign was associated with absence of the keratinous layer. This sign may be caused by early fading of iodine staining. | Ryu Ishihara Hiromitsu Kanzaki Hiroyasu Iishi Kengo Nagai Fumi Matsui Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Noriya Uedo Masaharu Tatsuta Yasuhiko Tomita Shingo Ishiguro | 2013 | World Journal of Gastroenterology2013，19，27： | 10 |
| 4 | Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins显示文摘瞄准:Lafutidine,一个组织安 H2 受体对手,展览胃保护的行动由 capsaicin 敏感的传入神经元(CSN ) 调停了。我们比较了在 lafutidine 和辣椒辣素之间的效果,关于和内长的前列腺素(PG ) 的相互作用,氮的氧化物(没有) 并且传入神经元,包括短暂受体潜力 vanilloid 子类型 1 (TRPV1 ) 。方法:男 SD 老鼠和 C57BL/6 老鼠,野类型并且 prostacyclin IP 受体大美人动物,在禁食的 18 h 以后被使用。胃的损害被 HCl/ethanol 的 po 管理导致(60% 在 150 mmol/L HCl ) 在为老鼠的 1 mL 或为老鼠的 0.3 mL 的体积。结果:lafutidine 和辣椒辣素(1-10 mg/kg, po ) 对在老鼠和老鼠的 HCl/ethanol 的负担得起的剂量依赖者保护。效果被两个稀释有 N (G)-nitro-L-arginine 甲基酉旨的 CSN 和预告的处理的脱离,然而,仅仅辣椒辣素的效果被 capsazepine, TRPV1 对手,以及消炎痛的优先的管理减轻。Lafutidine 在 IP 受体大美人老鼠保护了胃免于 HCl/ethanol,类似于野类型的动物,当辣椒辣素没能在缺乏 IP 受体的动物负担得起保护时。任何一个这些代理人都没在老鼠胃影响粘膜 PGE2 或 6-keto PGF (1alpha ) 内容。辣椒辣素唤起了增加在[Ca2+] 在老鼠 TRPV1-transfected HEK293 房间的 i 当时 lafutidine 不。结论:这些结果建议尽管 lafutidine 和辣椒辣素展出,胃保护的行动由 CSN 调停了,他们的效果的模式在内长的 PGs/IP 受体和 TRPV1 上关于相关性不同。lafutidine 在除 TRPV1 以外的还未辩别出的地点与 CSN 交往,这被假定。 | Kazuhiro Fukushima Yoko Aoi Shinichi Kato Koji Takeuchi | 2006 | World Journal of Gastroenterology2006，12，19： | 6 |
| 5 | Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH显示文摘 | Yuki Kimura Hideyuki Hyogo Sho-ichi Yamagishi Masayoshi Takeuchi Tomokazu Ishitobi Yoshitaka Nabeshima Koji Arihiro Kazuaki Chayama | 2010 | Journal of Gastroenterology2010，，7： | 3 |
| 6 | Delayed perforation: A hazardous complication of endoscopic resection for non‐ampullary duodenal neoplasm显示文摘 | Takuya Inoue Noriya Uedo Takeshi Yamashina Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Ryu Ishihara Hiroyasu Iishi Masaharu Tatsuta Hidenori Takahashi Hidetoshi Eguchi Hiroaki Ohigashi | 2014 | Digestive Endoscopy2014，，2： | 3 |
| 7 | Longterm outcomes after endoscopic mucosal resection for early gastric cancer显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Ryu Ishihara Koji Higashino Yoji Takeuchi Kazuho Imanaka Takuya Yamada Sachiko Yamamoto Shunsuke Yamamoto Hideaki Tsukuma Shingo Ishiguro | 2006 | Gastric Cancer2006，，2： | 2 |
| 8 | Longterm outcomes after endoscopic mucosal resection for early gastric cancer显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Ryu Ishihara Koji Higashino Yoji Takeuchi Kazuho Imanaka Takuya Yamada Sachiko Yamamoto Shunsuke Yamamoto Hideaki Tsukuma Shingo Ishiguro | 2006 | Gastric Cancer2006，，2： | 2 |
| 9 | Comparison of EMR and endoscopic submucosal dissection for en bloc resection of early esophageal cancers in Japan显示文摘 | Ryu Ishihara Hiroyasu Iishi Noriya Uedo Yoji Takeuchi Sachiko Yamamoto Takuya Yamada Eriko Masuda Koji Higashino Motohiko Kato Hiroyuki Narahara Masaharu Tatsuta | 2008 | Gastrointestinal Endoscopy2008，，6： | 2 |
| 10 | Optimum culture conditions for the production of cobalt-containing nitrile hydratasa by Rhodococcus rhodochrous J1显示文摘 | Toru Nagasawa Koji Takeuchi Vincenzo Nardi-Dei | 1991 | Appl Microbiol Biotechnol1991，34，： | 1 |
| 11 | Sildenafil, an Inhibitor of Phosphodiesterase Subtype 5, Prevents Indomethacin-Induced Small-Intestinal Ulceration in Rats via a NO/cGMP-Dependent Mechanism显示文摘 | Naho Kato Yuji Mashita Shinichi Kato Shoji Mitsufuji Toshikazu Yoshikawa Koji Takeuchi | 2009 | Digestive Diseases and Sciences2009，，11： | 1 |
| 12 | Value of general surgical risk models for predicting postoperative liver failure and mortality following liver surgery显示文摘 | Yoshio Haga Koji Ikejiri Hitoshi Takeuchi Masakazu Ikenaga Yasuo Wada | 2012 | J Surg Oncol2012，，7： | 1 |
| 13 | Aggravation by Selective COX-1 and COX-2 Inhibitors of Dextran Sulfate Sodium (DSS)-Induced Colon Lesions in Rats显示文摘 | Mitsuaki Okayama Shusaku Hayashi Yoko Aoi Hikaru Nishio Shinichi Kato Koji Takeuchi | 2007 | Digestive Diseases and Sciences2007，，9： | 1 |
| 14 | Mechanism of gastric alkaline response in the stomach after damage,roles of nitric oxide and prostaglandins显示文摘 | Takeuchi koji Okabe Susumu | 1995 | Digest DisSci1995，40，： | 1 |
| 15 | Removal of low concentration nitrogen oxides through photoassisted heterogeneous catalysis显示文摘 | Koji Takeuchi | 1994 | Journal of Molecular Catalysis1994，，8： | 1 |
| 16 | Increased Expression of Long Pentraxin PTX3 in Inflammatory Bowel Diseases显示文摘 | Shingo Kato Mitsuko Ochiai Tomoya Sakurada Shino Ohno Kyoko Miyamoto Mina Sagara Masataka Ito Kyoko Takeuchi Junko Imaki Kazuro Itoh Koji Yakabi | 2008 | Digestive Diseases and Sciences2008，，7： | 1 |
| 17 | Chronic admin- istration of alogliptin,a novel,potent, and highly selective dipeptidyl pe- ptidase-4 inhibitor,improves glycemic control and beta-cell function in obese diabetic ob/ob mice显示文摘 | Yusuke Moritoh Koji Takeuchi Tomoko Asakawa | 2008 | Euro J Pharmacol2008，588，23： | 1 |
| 18 | Pressureless sintering and mechanical properties of titanium aluminum carbide显示文摘 | Shinobu Hashimoto Masaru Takeuchi Koji Inoue Sawao Honda Hideo Awaji Koichiro Fukuda Shaowei Zhang | 2007 | Materials Letters2007，，10： | 1 |
| 19 | Autofluorescence imaging with a transparent hood for detection of colorectal neoplasms: a prospective, randomized trial显示文摘 | Yoji Takeuchi Takuya Inoue Noboru Hanaoka Koji Higashino Hiroyasu Iishi Rika Chatani Masao Hanafusa Takashi Kizu Ryu Ishihara Masaharu Tatsuta Toshio Shimokawa Noriya Uedo | 2010 | Gastrointestinal Endoscopy2010，，5： | 1 |
| 20 | Gastric Mucosal Defense and Cytoprotection: Bench to Bedside显示文摘 | Loren Laine Koji Takeuchi Andrzej Tarnawski | 2008 | Gastroenterology2008，，1： | 1 |
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