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您的检索式：作者名="Tadahiro Iimura"
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| 1 | Two macrophages, osteoclasts and microglia: from development to pleiotropy显示文摘Tissue-resident macrophages are highly specialized to their tissue-specific microenvironments,activated by various inflammatory signals and modulated by genetic and environmental factors.Osteoclasts and microglia are distinct tissue-resident cells of the macrophage lineage in bone and brain that are responsible for pathological changes in osteoporosis and Alzheimer’s disease(AD),respectively.Osteoporosis is more frequently observed in individuals with AD compared to the prevalence in general population.Diagnosis of AD is often delayed until underlying pathophysiological changes progress and cause irreversible damages in structure and function of brain.As such earlier diagnosis and intervention of individuals at higher risk would be indispensable to modify clinical courses.Pleiotropy is the phenomenon that a genetic variant affects multiple traits and the genetic correlation between two traits could suggest a shared molecular mechanism.In this review,we discuss that the Pyk2-mediated actin polymerization pathway in osteoclasts and microglia in bone and brain,respectively,is the horizontal pleiotropic mediator of shared risk factors for osteoporosis and AD. | Ji-Won Lee In-Hee Lee Tadahiro Iimura Sek Won Kong | 2021 | Bone Research2021，9，2： | 4 |
| 2 | Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development显示文摘 | Ryo Aizawa Atsushi Yamada Dai Suzuki Tadahiro Iimura Hidetoshi Kassai Takeshi Harada Masayuki Tsukasaki Gou Yamamoto Tetsuhiko Tachikawa Kazuki Nakao Matsuo Yamamoto Akira Yamaguchi Atsu Aiba Ryutaro Kamijo | 2012 | Mechanisms of Development (-)2012，，1： | 1 |
| 3 | Chapter 7 Establishment of Hox Vertebral Identities in the Embryonic Spine Precursors显示文摘 | Tadahiro Iimura Nicolas Denans Olivier Pourquié | 2009 | Current Topics in Developmental Biology2009，，： | 1 |
| 4 | Administration frequency as well as dosage of PTH are associated with development of cortical porosity in ovariectomized rats显示文摘To investigate whether the administration frequency of parathyroid hormone(PTH) is associated with the development of cortical porosity, this study established 15 dosage regimens of teriparatide [human PTH(1–34), TPTD] with four distinct concentrations and four distinct administration frequencies of TPTD to 16-week-old ovariectomized rats. Our analyses demonstrated that the bone mineral density, mechanical properties, and bone turnover were associated with the total amount of TPTD administered. Our observations further revealed that the cortical porosity was markedly developed as a result of an increased administration frequency with a lower concentration of total TPTD administration in our setting, although the highest concentration also induced cortical porosity. Deconvolution fluorescence tiling imaging on calcein-labeled undecalcified bone sections also demonstrated the development of cortical porosity to be closely associated with the bone site where periosteal bone formation took place. This site-specific cortical porosity involved intracortical bone resorption and an increased number and proximity of osteocytic lacunae,occasionally causing fused lacunae. Taken together, these findings suggested the involvement of local distinctions in the rate of bone growth that may be related to the site-specific mechanical properties in the development of cortical porosity induced by frequent and/or high doses of TPTD. | Aya Takakura Ji-Won Lee Kyoko Hirano Yukihiro Isogai Toshinori Ishizuya Ryoko Takao-Kawabata Tadahiro Iimura | 2017 | Bone Research2017，5，2： | 0 |
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