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| 1 | 导致成人与儿童患者30天脑室腹腔分流失败的原因分析(英文)显示文摘OBJECTIVE The aim of this study was to provide a comprehensive benchmark of 30-day ventriculoperitoneal(VP)shunt failure rates for a single institution over a 5-year study period for both adult and pediatric patients,to compare this with the results in previously published literature,and to establish factors associated with shunt failure.METHODS A retrospective database search was undertaken to identify all VP shunt operations performed in a single,regional neurosurgical unit during a 5-year period.Data were collected regarding patient age,sex,origin of hydrocephalus,and whether the shunt was a primary or secondary shunt.Operative notes were used to ascertain the type of valve inserted,which components of the shunt were adjusted/replaced(in revision cases),level of seniority of the most senior surgeon who participated in the operation,and number of surgeons involved in the operation.Where appropriate and where available,postoperative imaging was assessed for grade of shunt placement,using a recognized grading system.Univariate and multivariate models were used to establish factors associated with early(30-day)shunt failure.RESULTS Six hundred eighty-three VP shunt operations were performed,of which 321 were pediatric and 362 were adult.The median duration of postoperative follow-up for nonfailed shunts(excluding deaths)was 1263 days(range 525-2226 days).The pediatric 30-day shunt failure rates in the authors'institution were 8.8%for primary shunts and 23.4%for revisions.In adults,the 30-day shunt failure rates are 17.7%for primary shunts and 25.6%for revisions.In pediatric procedures,the number of surgeons involved in the operating theater was significantly associated with shunt failure rate.In adults,the origin of hydrocephalus was a statistically significant variable.Primary shunts lasted longer than revision shunts,irrespective of patient age.CONCLUSIONS A benchmark of 30-day failures is presented and is consistent with current national databases and previously published data by other groups.The number of surgeons involved in shunt operations and the origin of the patient's hydrocephalus should be described in future studies and should be controlled for in any prospective work.The choice of shunt valve was not a significant predictor of shunt failure.Most previous studies on shunts have concentrated on primary shunts,but the high rate of early shunt failure in revision cases(in both adults and children)is perhaps where future research efforts should be concentrated. | Anderson IA Saukila LF Robins JMW Akhunbay-Fudge CY Goodden JR Tyagi AK Phillips N Chumas PD | 2018 | 中华神经外科疾病研究杂志2018，17，3： | 3 |
| 2 | Fibrinogen induces endothelial cell permeability显示文摘 | Tyagi N Roberts AM Dean WL | 2008 | Mol Cell Biochem2008，307，12： | 1 |
| 3 | Homocysteine enriched diet leads to prolonged QT interval and reduced left ventricular performance in telemetric monitored mice 显示文摘 | Rosenberger D Gargoum R Tyagi N | 2011 | Nutr Metab Cardiovasc Dis2011，21，7： | 1 |
| 4 | Homoeysteine enriched diet leads to prolonged QT interval and reduced left ventricular performance in telemetric monitored mice显示文摘 | Rosenberger D Gargoum R Tyagi N | 2011 | Nutr Metab Cardiovasc Dis2011，21，7： | 1 |
| 5 | Homocysteine to hydrogen sulfide or hypertension显示文摘 | Sen U Mishra PK Tyagi N | 2010 | Cell Biochem Biophys2010，57，23： | 1 |
| 6 | Homocysteine to hydrogensulfide or hypertension显示文摘 | Sen U Mishra PK Tyagi N | 2010 | Cell Biochem Biophys2010，57，23： | 1 |
| 7 | Antiproliferative and apoptotic effects of silibinin in rat prostate cancer cells 显示文摘 | Tyagi A Bhatia N Condon MS | 2002 | Prostate2002，53，3： | 1 |
| 8 | Skewing of the Thl/Th2 responses in mice due to variation in the level of expres- sion of an antigen in a recombinant BCG system显示文摘 | Dhar N Rao V Tyagi AK | 2003 | Immu- nol Lett2003，88，3： | 1 |
| 9 | Pilot plant study of simultaneous sewage sludge diges-tion and metal leaching显示文摘 | Blais J.F Meunier N Mercier G Drogui P. Tyagi J.F | | 0，，05： | 1 |
| 10 | A dual-tracer method for differentiating transendothelial transport from paracellular leakage invivo and in vitro显示文摘 | Muradashvili N Tyagi R Lominadze D | | 0，，： | 1 |
| 11 | Gender-based reciprocal expression of transforming growth factor-β1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis显示文摘 | Tyagi P Tyagi V Yoshimura N | 2009 | J Inflamm(Lond)2009，6，： | 1 |
| 12 | Management strategies for bilateral vestibular schwannomas 显示文摘 | Sahu RN Mehrotra N Tyagi I | 2007 | Clin Neurosci2007，14，8： | 1 |
| 13 | Autophagy and heart failure~a possible role for homocysteine显示文摘 | Vacek TP Vacek JC Tyagi N | 2012 | Cell Biochem Biophys2012，62，1： | 1 |
| 14 | Folio acid improves inner ear vascularization in hyperhomocysteinemic mice显示文摘 | Kundu S Munjal C Tyagi N | 2012 | Hear Res2012，284，12： | 1 |
| 15 | An efficient technique for retrieval of color images in large databases 显示文摘 | SHRIVASTAVA N TYAGI V | 2014 | Comput- ers and Electrical Engineering2014，11，9： | 1 |
| 16 | Phase transition and negative thermal expansion in A2(MOO4)3 system (A= Fe^3+, Cr^3+, Al^3+) 显示文摘 | Tyagi A K Achary S N Mathews M D | 2002 | J Alloys Compd2002，339，： | 1 |
| 17 | Double heterozygous hemoglobin Q India/hemoglobin D Punjab hemoglobinopathy: report of two rare cases显示文摘 | Mutreja D Tyagi S Tejwani N | 2013 | Indian J Hum Genet2013，19，4： | 1 |
| 18 | Production of cellulose from sugarcane molasses usin Ghtcoroacetobacter inlermedius SNT- Jptimizatiou & amp; characterization显示文摘 | Tyagi N Suresh S | 2016 | Journal of Gleaner Production2016，112，： | 1 |
| 19 | Skewing of the Th1/Th2 responses in miee due to variation in the level of expression of an antigen in a reeombinant BCG system 显示文摘 | Dhar N Rao V Tyagi A K | 2003 | Immunol Lett2003，88，3： | 1 |
| 20 | Water management--A tool for methane mitagation from irrigated paddy fields显示文摘 | Tyagi L Kumari B Singh S N | 2010 | Science of the Total Environment2010，408，： | 1 |
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