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| 1 | Pm21 from Haynaldia villosa Encodes a CC-NBS- LRR Protein Conferring Powdery Mildew Resistance in Wheat显示文摘 | Liping Xing Ping Hu Jiaqian Liu Kamil Witek Shuang Zhou Jiefei Xu Weihao Zhou Li Gao Zhenpu Huang Ruiqi Zhang Xiue Wang Peidu Chen Haiyan Wang Jonathan D.G. Jones Miroslava Karafiatova Jan Vrana Jan Baros Jaroslav Dolezel Yuanchun Tian Yufeng Wu Aizhong Cao | 2018 | Molecular Plant2018，11，6： | 16 |
| 2 | Three-dimensional-printed individualized porous implants:A new“implant-bone”interface fusion concept for large bone defect treatment显示文摘Bone defect repairs are based on bone graft fusion or replacement.Current large bone defect treatments are inadequate and lack of reliable technology.Therefore,we aimed to investigate a simple technique using three-dimensional(3D)-printed individualized porous implants without any bone grafts,osteoinductive agents,or surface biofunctionalization to treat large bone defects,and systematically study its long-term therapeutic effects and osseointegration characteristics.Twenty-six patients with large bone defects caused by tumor,infection,or trauma received treatment with individualized porous implants;among them,three typical cases underwent a detailed study.Additionally,a large segmental femur defect sheep model was used to study the osseointegration characteristics.Immediate and long-term biomechanical stability was achieved,and the animal study revealed that the bone grew into the pores with gradual remodeling,resulting in a long-term mechanically stable implant-bone complex.Advantages of 3D-printed microporous implants for the repair of bone defects included 1)that the stabilization devices were immediately designed and constructed to achieve early postoperative mobility,and 2)that osseointegration between the host bone and implants was achieved without bone grafting.Our osseointegration method,in which the“implant-bone”interface fusion concept was used instead of“bone-bone”fusion,subverts the traditional idea of osseointegration. | Teng Zhang Qingguang Wei Hua Zhou Zehao Jing Xiaoguang Liu Yufeng Zheng Hong Cai Feng Wei Liang Jiang Miao Yu Yan Cheng Daoyang Fan Wenhao Zhou Xinhong Lin Huijie Leng Jian Li Xinyu Li Caimei Wang Yun Tian Zhongjun Liu | 2021 | Bioactive Materials2021，6，11： | 9 |
| 3 | Large-eddy simulation of shock-wave/turbulent boundary layer interaction with and without Spark Jet control显示文摘The efficiency and mechanism of an active control device ‘‘Spark Jet' and its application in shock-induced separation control are studied using large-eddy simulation in this paper.The base flow is the interaction of an oblique shock-wave generated by 8° wedge and a spatially-developing Ma = 2.3 turbulent boundary layer.The Reynolds number based on the incoming flow property and the boundary layer displacement thickness at the impinging point without shock-wave is20000.The detailed numerical approaches were presented.The inflow turbulence was generated using the digital filter method to avoid artificial temporal or streamwise periodicity.The numerical results including velocity profile,Reynolds stress profile,skin friction,and wall pressure were systematically validated against the available wind tunnel particle image velocimetry(PIV) measurements of the same flow condition.Further study on the control of flow separation due to the strong shock-viscous interaction using an active control actuator ‘‘Spark Jet' was conducted.The single-pulsed characteristic of the device was obtained and compared with the experiment.Both instantaneous and time-averaged flow fields have shown that the jet flow issuing from the actuator cavity enhances the flow mixing inside the boundary layer,making the boundary layer more resistant to flow separation.Skin friction coefficient distribution shows that the separation bubble length is reduced by about 35% with control exerted. | Yang Guang Yao Yufeng Fang Jian Gan Tian Li Qiushi Lu Lipeng | 2016 | Chinese Journal of Aeronautics2016，29，3： | 8 |
| 4 | Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications:Process optimization,in vitro and in vivo investigation显示文摘Laser powder bed fusion(L-PBF)of magnesium(Mg)alloy porous scaffolds is expected to solve the dual challenges from customized structures and biodegradable functions required for repairing bone defects.However,one of the key technical difficulties lies in the poor L-PBF process performance of Mg,contributed by the high susceptibility to oxidation,vaporization,thermal expansion,and powder attachment etc.This work investigated the influence of L-PBF energy input and scanning strategy on the formation quality of porous scaffolds by using WE43 powder,and characterized the microstructure,mechanical properties,biocompatibility,biodegradation and osteogenic effect of the as-built WE43 porous scaffolds.With the customized energy input and scanning strategy,the relative density of struts reached over 99.5%,and the geometrical error between the designed and the fabricated porosity declined to below 10%.Massive secondary phases including intermetallic precipitates and oxides were observed.The compressive strength(4.37-23.49 MPa)and elastic modulus(154.40-873.02 MPa)were comparable to those of cancellous bone.Good biocompatibility was observed by in vitro cell viability and in vivo implantation.The biodegradation of as-built porous scaffolds promoted the osteogenic effect,but the structural integrity devastated after 12 h by the immersion tests in Hank’s solution and after 4 weeks by the implantation in rabbits’femur,indicating an excessively rapid degradation rate. | Jinge Liu Bingchun Liu Shuyuan Min Bangzhao Yin Bo Peng Zishi Yu Caimei Wang Xiaolin Ma Peng Wen Yun Tian Yufeng Zheng | 2022 | Bioactive Materials2022，7，10： | 4 |
| 5 | Deformation analysis of transversely isotropic coal-rock mass with porous and cracks显示文摘Coal-rock as a typical sedimentary rock has obvious stratification,namely it has transversely isotropic feature.Meanwhile,deformation leads to coal-rock mass having the characteristics of different porous and crack structures as well as local anisotropy.Equivalent axial and circumferential strain' formulas of the pure coal-rock mass specimen with a single crack were derived through the establishment of equivalent mechanical model of standard cylindrical coal-rock specimen,and have been widely used to a variety of media combined different structures containing multiple cracks.The complete stress strain curve of a real coal-rock specimen was obtained by the CTC test.Additionally,according to the comparison with the theoretical value,the theoretical mechanical model could well explain the deformation characteristics of coal-rock mass and verify its validity.Further,following features were analyzed:strain normalized coefficient and elastic modulus(Poisson's ratio) in vertical and parallel direction to the stratification,stratification angle,porosity,pore radius,normal and tangential stiffness of crack,and the relationship of different crack width with different tangential stiffness of crack.Through the analysis above,it substantiate this claim that the theoretical model with better reliability reflects the transversely isotropic nature of the coal-rock and the local anisotropy caused by the porous and cracks. | Xue Dongjie Zhou Hongwei Kong Lin Tang Xianli Zhao Tian Yi Haiyang Zhao Yufeng | 2012 | International Journal of Mining Science and Technology2012，22，6： | 3 |
| 6 | Realization of directional single-mode lasing by a GaN-based warped microring显示文摘Multimode and random directionalities are major issues restricting the application of whispering gallery mode microcavity lasers.We demonstrated a 40μm diameter microring with an off-centered embedded hole and warped geometry from strained III-nitride quantum well multilayers.Single-mode directional whispering gallery mode lasing was achieved by the warped structure and high-order mode suppression induced by the off-centered hole.In addition,the introduction of the off-centered hole reduced the lasing threshold from 3.24 to 2.79 MW/cm^(2) compared with the warped microdisk without an embedded hole while maintaining a high-quality factor of more than 4000.Directional light emission in 3D was achieved and attributed to the warped structure,which provides a vertical component of the light emission,making it promising for building multifunctional coherent light sources in optoelectronic integration. | Shengnan Zhang Yufeng Li Peng Hu Zhenhuan Tian Qiang Li Aixing Li Ye Zhang Feng Yun | 2021 | Photonics Research2021，9，4： | 2 |
| 7 | On the Lie Algebras, Generalized Symmetries and Darboux Transformations of the Fifth-Order Evolution Equations in Shallow Water显示文摘By considering the one-dimensional model for describing long, small amplitude waves in shallow water, a generalized fifth-order evolution equation named the Olver water wave(OWW) equation is investigated by virtue of some new pseudo-potential systems. By introducing the corresponding pseudo-potential systems, the authors systematically construct some generalized symmetries that consider some new smooth functions{Xiβ}i=1,2,···,nβ =1,2,···,N depending on a finite number of partial derivatives of the nonlocal variables vβand a restriction ∑iα,β(? ξi/?vβ)2+(?ηα/?vβ)2≠0, i.e.,∑i,α,β(?Gα/?vβ)2≠0. Furthermore,the authors investigate some structures associated with the Olver water wave(AOWW)equations including Lie algebra and Darboux transformation. The results are also extended to AOWW equations such as Lax, Sawada-Kotera, Kaup-Kupershmidt, It and Caudrey-Dodd-Gibbon-Sawada-Kotera equations, et al. Finally, the symmetries are applied to investigate the initial value problems and Darboux transformations. | Shoufu TIAN Yufeng ZHANG Binlu FENG Hongqing ZHANG | 2015 | Chinese Annals of Mathematics,Series B2015，36，4： | 2 |
| 8 | Key immunity characteristics of diverse stages of brucellosis in rural population from Inner Mongolia, China显示文摘Background: Brucellosis poses a serious threat to human and animal health,particularly in developing countries such as China.The Inner Mongolia Autonomous Region is one of the most severely brucellosis-endemic provinces in China.Currently,the host immune responses functioning to control Brucella infection and development remain poorly understood.The aim of this study is to further clarify the key immunity characteristics of diverse stages of brucellosis in Inner Mongolia.Methods: We collected a total of 733 blood samples from acute(n=137),chronic(n=316),inapparent(n=35),recovery(n=99),and healthy(n=146)groups from the rural community of Inner Mongolia between 2014 and 2015.The proportions of CD4^(+),CD8^(+),Th1,Th2,and Th17 T cells in peripheral blood and the expression of TLR2 and TLR4 in lymphocytes,monocytes and granulocytes were examined using flow cytometry analysis.The differences among the five groups were compared using one-way ANOVA and the Kruskal–Wallis method,respectively.Results: Our results revealed that the proportions of CD4^(+) and CD8^(+) T cells were significantly different among the acute,chronic,recovery,and healthy control groups(P<0.05),with lower proportions of CD4^(+) T cells and a higher proportion of CD8^(+) T cells in the acute,chronic,and recovery groups.The proportion of Th1 cells in the acute,chronic,and inapparent groups was higher than that in the healthy and recovery groups;however,there was no significant difference between patients and healthy individuals(P>0.05).The proportion of Th2 lymphocytes was significantly higher in the acute and healthy groups than in the inapparent group(P<0.05).The proportion of Th17 cells in the acute group was significantly higher than that in the healthy control,chronic,and inapparent groups(P<0.05).Finally,the highest expression of TLR4 in lymphocytes,monocytes and granulocytes was observed in the recovery group,and this was followed by the acute,chronic,healthy control,and inapparent groups.There was a significant difference between the recovery group and the other groups,except for the acute group(P<0.05).Moreover,a correlation in TLR4 expression was observed in lymphocytes,monocytes and granulocytes among the five groups(r>0.5),except for the inapparent group between lymphocytes and granulocytes(r=0.34).Conclusions: Two key factors(CD8^(+)T cells and TLR4)in human immune profiles may closely correlate with the progression of brucellosis.The detailed function of TLR4 in the context of a greater number of cell types or tissues in human or animal brucellosis and in larger samples should be further explored in the future. | Yongzhang Zhu Li Shi Yige Zeng Dongri Piao Yingbo Xie Juan Du Meng Gao Wei Gao Junli Tian Jun Yue Min Li XiaoKui Guo Yufeng Yao YaoXia Kang | 2022 | Infectious Diseases of Poverty2022，11，3： | 1 |
| 9 | Regional homogeneity approach to fMRI data analysis显示文摘 | Yufeng Zang Tianzi Jiang Yingli Lu Yong He Lixia Tian | 2004 | Neuroimage2004，，1： | 1 |
| 10 | The Features and Regulation of Co-transcriptional Splicing in Arabidopsis显示文摘Precursor mRNA(pre-mRNA)splicing is essential for gene expression in most eukaryotic organisms.Previous studies from mammals,Drosophila,and yeast show that the majority of splicing events occurs co-transcriptionally.In plants,however,the features of co-transcriptional splicing(CTS)and its regulation still remain largely unknown.Here,we used chromatin-bound RNA sequencing to study CTS in Arabidopsis thaliana.We found that CTS is widespread in Arabidopsis seedlings,with a large proportion of alternative splicing events determined co-transcriptionally.CTS efficiency correlated with gene expression level,the chromatin landscape and,most surprisingly,the number of introns and exons of individual genes,but is independent of gene length.In combination with enhanced crosslinking and immunoprecipitation sequencing analysis,we further showed that the hnRNP-like proteins RZ-1B and RZ-1C promote efficient CTS globally through direct binding,frequently to exonic sequences.Notably,this general effect of RZ-1B/1C on splicing promotion is mainly observed at the chromatin level,not at the mRNA level.RZ-1C promotes CTS of multiple-exon genes in association with its binding to regions both proximal and distal to the regulated introns.We propose that RZ-1C promotes efficient CTS of genes with multiple exons through cooperative interactions with many exons,introns,and splicing factors.Our work thus reveals important features of CTS in plants and provides methodologies for the investigation of CTS and RNA-binding proteins in plants. | Danling Zhu Fei Mao Yuanchun Tian Xiaoya Lin Lianfeng Gu Hongya Gu Li-jia Qu Yufeng Wu Zhe Wu | 2020 | Molecular Plant2020，13，2： | 1 |
| 11 | STUDY ON THE DESALINATION BEHAVIORS OF PA/PSF THIN FILM COMPOSITE显示文摘A polypiperazine amide (PA)/polysulfone (PSF) thin film composite (TFC) was prepared by interfacial polymerization (IP) using a trimesoyl chloride hexane solution as the oil phase and a piperazine aqueous solution as the water phase on a porous polysulfone hollow fiber substrate. Its separating behaviors were investigated systematically to various salts such as NaCl, KCl, Na2SO4, MgCl2, CaCl2 and MgSO4, showing the highest rejection rate to Na2SO4, the second to MgSO4, the third to MgCl2 and CaCl2, and the lowest to KCl, NaCl, being 99%, 98%, 70%, 60%, 15% and 10% respectively. Under an increasing pressure or with time, the rejection rate of the TFC rises to a plateau. To various concentration of the feed, the rejection rate reduced gradually with the higher concentration. | TIAN Guojun ZHANG Yufeng ZHANG Yan DU Qiyun XIAO Changfa GUO Hao | 2006 | Chinese Journal of Reactive Polymers2006，15，2： | 1 |
| 12 | Regional homogeneity approach to fMRI data analysis显示文摘 | Yufeng Zang Tianzi Jiang Yingli Lu Yong He Lixia Tian | 2004 | Neuroimage2004，，1： | 1 |
| 13 | Hierarchical macro-microporous WPU-ECM scaffolds combined with Microfracture Promote in Situ Articular Cartilage Regeneration in Rabbits显示文摘Tissue engineering provides a promising avenue for treating cartilage defects.However,great challenges remain in the development of structurally and functionally optimized scaffolds for cartilage repair and regeneration.In this study,decellularized cartilage extracellular matrix(ECM)and waterborne polyurethane(WPU)were employed to construct WPU and WPU-ECM scaffolds by water-based 3D printing using low-temperature deposition manufacturing(LDM)system,which combines rapid deposition manufacturing with phase separation techniques.The scaffolds successfully achieved hierarchical macro-microporous structures.After adding ECM,WPU scaffolds were markedly optimized in terms of porosity,hydrophilia and bioactive components.Moreover,the optimized WPU-ECM scaffolds were found to be more suitable for cell distribution,adhesion,and proliferation than the WPU scaffolds.Most importantly,the WPU-ECM scaffold could facilitate the production of glycosaminoglycan(GAG)and collagen and the upregulation of cartilage-specific genes.These results indicated that the WPU-ECM scaffold with hierarchical macro-microporous structures could recreate a favorable microenvironment for cell adhesion,proliferation,differentiation,and ECM production.In vivo studies further revealed that the hierarchical macro-microporous WPU-ECM scaffold combined with the microfracture procedure successfully regenerated hyaline cartilage in a rabbit model.Six months after implantation,the repaired cartilage showed a similar histological structure and mechanical performance to that of normal cartilage.In conclusion,the hierarchical macro-microporous WPU-ECM scaffold may be a promising candidate for cartilage tissue engineering applications in the future. | Mingxue Chen YangYang Li Shuyun Liu Zhaoxuan Feng Hao Wang Dejin Yang Weimin Guo Zhiguo Yuan Shuang Gao Yu Zhang Kangkang Zha Bo Huang Fu Wei Xinyu Sang Qinyu Tian Xuan Yang Xiang sui Yixin Zhou Yufeng Zheng Quanyi Guo | 2021 | Bioactive Materials2021，6，7： | 1 |
| 14 | Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation显示文摘co 翻译的指向或插入能分泌并且膜蛋白质进 endoplasmic 蜂窝胃(嗯) 一个关键生物过程被信号识别粒子(SRP ) 调停。在优核质, SRP68-SRP72 (SRP68/72 ) heterodimer 在蛋白质 translocation 起一个必要作用。然而,二最大的 SRP 蛋白质, SRP68 和 SRP72 的结构的信息,被限制,特别关于他们的相互作用。此处,我们在 2.91 点报导人的 apo-SRP72 和 SRP68/72 建筑群的第一水晶结构吗?并且 1.7?分辨率分别地。SRP72 的 SRP68 有约束力的领域包含四次不正常的 tetratricopeptide 重复(TPR ) 和一顶灵活 C 终端帽子。Apo-SRP72 在答案主要作为 dimers 存在。为了绑在 SRP68, SRP72 homodimer disassociates,和不可缺少的 C 终端帽子,经历一个显著 conformational 变化帮助 SRP68/72 heterodimer 的形成。SRP68 的 A 23 残余多肽为到通过它的不平常地恐水病、扩大的表面的 SRP72 的紧密的绑定是足够的。结构,生物物理,并且 mutagenesis 分析表明联系癌症的变化破坏 SRP68-SRP72 相互作用和他们的合作本地化与嗯在哺乳动物的房间。结果在调停 SRP 的蛋白质 translocation 加亮 SRP68-SRP72 相互作用的必要角色并且为疾病诊断, pathophysiology,和药设计提供一个结构的基础。 | Yina Gao Qi Zhang Yue Lang Yang Liu Xiaofei Dong Zhenhang Chen Wenli Tian Jun Tang Wei Wu Yufeng Tong Zhongzhou Chen | 2017 | Journal of Molecular Cell Biology2017，9，3： | 1 |
| 15 | Blocking the Natural Killer (NK) Cell Inhibitory Receptor NKG2A Increases Activity of Human NK Cells and Clears HBV Infection in Mice显示文摘 | Fenglei Li Hairong Wei Haiming Wei Yufeng Gao Long Xu Wenwei Yin Rui Sun Zhigang Tian | 2012 | Gastroenterology2012，，： | 1 |
| 16 | Regional coherence changes in the early stages of Alzheimer’s disease: A combined structural and resting-state functional MRI study显示文摘 | Yong He Liang Wang Yufeng Zang Lixia Tian Xinqing Zhang Kuncheng Li Tianzi Jiang | 2006 | Neuroimage2006，，2： | 1 |
| 17 | Down-Regulation of Stromal Caveolin-1 Expression in Esophageal Squamous Cell Carcinoma: A Potent Predictor of Lymph Node Metastases, Early Tumor Recurrence, and Poor Prognosis显示文摘 | Yibin Jia Nana Wang Jianbo Wang Hui Tian Wei Ma Kai Wang Bingxu Tan Guangyu Zhang Shengsi Yang Bing Bai Yufeng Cheng | 2014 | Annals of Surgical Oncology2014，，1： | 1 |
| 18 | 3D-printed cell-free PCL-MECM scaffold with biomimetic micro-structure and micro-environment to enhance in situ meniscus regeneration显示文摘Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells,meniscus regeneration remains a great challenge in clinic.In this study,we found decellularized meniscal extracellular matrix(MECM)preserved native meniscal collagen and glycosaminoglycans which could be a good endogenous regeneration guider for stem cells.Moreover,MECM significantly promoted meniscal fibrochondrocytes viability and proliferation,increased the expression of type II collagen and proteoglycans in vitro.Meanwhile,we designed 3D-printed polycaprolactone(PCL)scaffolds which mimic the circumferential and radial collagen orientation in native meniscus.Taken these two advantages together,a micro-structure and micro-environment dually biomimetic cell-free scaffold was manipulated.This cell-free PCL-MECM scaffold displayed superior biocompatibility and yielded favorable biomechanical capacities closely to native meniscus.Strikingly,neo-menisci were regenerated within PCL-MECM scaffolds which were transplanted into knee joints underwent medial meniscectomy in rabbits and sheep models.Histological staining confirmed neo-menisci showed meniscus-like heterogeneous staining.Mankin scores showed PCL-MECM scaffold could protect articular cartilage well,and knee X-ray examination revealed same results.Knee magnetic resonance imaging(MRI)scanning also showed some neo-menisci in PCL-MECM scaffold group.In conclusion,PCL-MECM scaffold appears to optimize meniscus regeneration.This could represent a promising approach worthy of further investigation in preclinical applications. | Weimin Guo Mingxue Chen Zhenyong Wang Yue Tian Jinxuan Zheng Shuang Gao Yangyang Li Yufeng Zheng Xu Li Jingxiang Huang Wei Niu Shuangpeng Jiang Chunxiang Hao Zhiguo Yuan Yu Zhang Mingjie Wang Zehao Wang Jiang Peng Aiyuan Wang Yu Wang Xiang Sui Wenjing Xu Libo Hao Xifu Zheng Shuyun Liu Quanyi Guo | 2021 | Bioactive Materials2021，6，10： | 1 |
| 19 | Regional homogeneity approach to fMRI data analysis显示文摘 | Yufeng Zang Tianzi Jiang Yingli Lu Yong He Lixia Tian | 2004 | Neuroimage2004，，1： | 1 |
| 20 | A single-cell transcriptome atlas of the aging human and macaque retina显示文摘The human retina is a complex neural tissue that detects light and sends visual information to the brain.However,the molecular and cellular processes that underlie aging primate retina remain unclear.Here,we provide a comprehensive transcriptomic atlas based on 119520 single cells of the foveal and peripheral retina of humans and macaques covering different ages.The molecular features of retinal cells differed between the two species,suggesting distinct regional and species specializations of the human and macaque retinae.In addition,human retinal aging occurred in a region-and cell-type-specific manner.Aging of human retina exhibited a foveal to peripheral gradient.MYO9A-rods and a horizontal cell subtype were greatly reduced in aging retina,indicating their vulnerability to aging.Moreover,we generated a dataset showing the cell-type-and region-specific gene expression associated with 55 types of human retinal disease,which provides a foundation to understanding of the molecular and cellular mechanisms underlying human retinal diseases.Such datasets are valuable to understanding of the molecular characteristics of primate retina,as well as molecular regulation of aging progression and related diseases. | Wenyang Yi Yufeng Lu Suijuan Zhong Mei Zhang Le Sun Hao Dong Mengdi Wang Min Wei Haohuan Xie Hongqiang Qu Rongmei Peng Jing Hong Ziqin Yao Yunyun Tong Wei Wang Qiang Ma Zeyuan Liu Yuqian Ma Shouzhen Li Chonghai Yin Jianwei Liu Chao Ma Xiaoqun Wang Qian Wu Tian Xue | 2021 | National Science Review2021，8，4： | 1 |
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