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| 1 | Elevated blood pressure: Our family's fault?The genetics of essential hypertension显示文摘AIM: To provide an updated review on current genetic aspects possibly affecting essential hypertension(EH), and to further elucidate their role in EH. METHODS: We searched for genetic and epigenetic factors in major studies associated with EH between Jan 2008-Oct 2013 using PubMed. We limited our search to reviews that discussed mostly human studies, and were accessible through the university online re-source. We found 11 genome wide association studies(GWAS), as well as five methylation and three miRNA studies that fit our search criteria. A distinction was not made between genes with protective effects or nega-tive effects, as this article is only meant to be a sum-mary of genes associated with any aspect of EH.RESULTS: We found 130 genes from the studies that met our inclusion/exclusion criteria. Of note, genes withmultiple study references include: STK39, CYP17A1, MTHFR-NPPA, MTHFR-NPPB, ATP2B1, CSK, ZNF652, UMOD, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, CSK-ULK3, CYP1A2, NT5C2, CYP171A, PLCD3, SH2B3, ATXN2, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, and HFE. The following genes overlapped between the genetic studies and epigenetic studies: WNK4 and BDKRB2. Several of the identified genes were found to have functions associated with EH. Many epigenetic factors were also correlated with EH. Of the epigenetic factors, there were no articles discussing siRNA and its effects on EH that met the search criteria, thus the topic was not included in this review. Among the miRNA tar-gets found to be associated with EH, many of the genes involved were also identified in the GWAS studies.CONCLUSION: Genetic hypertension risk algorithms could be developed in the future but may be of limited benefit due to the multi-factorial nature of EH. With emerging technologies, like next-generation sequenc-ing, more direct causal relationships between genetic and epigenetic factors affecting EH will likely be discov-ered creating a tremendous potential for personalized medicine using pharmacogenomics. | Aniket Natekar Randi L Olds Meghann W Lau Kathleen Min Karra Imoto Thomas P Slavin | 2014 | World Journal of Cardiology2014，6，5： | 7 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 4 | Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population显示文摘AIM:To evaluate the accuracy of two non-invasivetests in a population of Alaska Native persons. Highrates of Helico bacter pylori(H. pylori) infection,H. pylori treatment failure,and gastric cancer in this population necessitate documentation of infection status atmultiple time points over a patient's life.METHODS:In 280 patients undergoing endoscopy,H. pylori was diagnosed by culture,histology,rapidurease test,13C urea breath test(UBT) ,and immuno-globulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori testby culture or,in case of a negative culture result,bypositive histology and a positive rapid urease test.RESULTS:The sensitivity and specificity of the 13C-UBT were 93% and 88%,respectively,relative to thegold standard. The antibody test had an equivalents ensitivity of 93% with a reduced specificity of 68%.The false positive results for the antibody test were as-sociated with previous treatment for an H. pylori infection [relative risk(RR) = 2.8]. High levels of antibodiesto H. pylori were associated with chronic gastritis and male gender,while high scores in the 13C-UBT testwere associated with older age and with the H. pyloribacteria load on histological examination(RR = 4.4) .CONCLUSION:The 13C-UBT out performed the anti-body test for H. pylori and could be used when a non-invasive test is clinically necessary to document treatment out come or when monitoring for reinfection. | Dana L Bruden Michael G Bruce Karen M Miernyk Julie Morris Debby Hurlburt Thomas W Hennessy Helen Peters Frank Sacco Alan J Parkinson Brian J McMahon | 2011 | World Journal of Gastroenterology2011，17，42： | 3 |
| 5 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 2 |
| 6 | The effect of decoupled low-level flow on winter orographic clouds and precipitation in the Yampa River Valley显示文摘 | Thomas C P L O Grant W R Cotton | 1991 | J Appl Meteor1991，30，3： | 1 |
| 7 | Details of crystalline growth in co-deposited electroplated nickel films with hard (nano) particles 显示文摘 | Thomas L Bernhard W Dagmar D | 2006 | Applied Surface Science2006，253，5： | 1 |
| 8 | Genetic base of 651Chinese soybean eultivars released during 1923 to 1995 显示文摘 | Cui Z L Thomas E Carter J Burton J W | 2000 | Crop Science2000，40，： | 1 |
| 9 | Structual damage detection of space truss structures using best achievable eigenvectors显示文摘 | Lim Tae W Kashangaki Thomas A L | 1994 | AIAA Journal1994，32，5： | 1 |
| 10 | Non-structural Fuzzy Decision Support System for Evaluation of Construction Safety Management System显示文摘 | Tam C M Tong Thomas K L Chiu Gerald C W Fung Ivan W H | 2002 | International Journal of Project Management2002，，20： | 1 |
| 11 | Measurement of frost characteristics on heat exchangers fins part 1: test facility and instrumentation 显示文摘 | THOMAS L CHEN H BESANT R W | 1999 | ASHRAE Trans1999，105，： | 1 |
| 12 | Encouraging 'frienAly'complaints behavior in industrial markets-reventing the loss of customers and reputation显示文摘 | Scott W Hansen John E Swan Thomas L Powers | 1996 | Industrial Marketing Management1996，，25： | 1 |
| 13 | A 270-GHz Tunner-Less Heterostructure Barrier Varactor Frequency Tripler显示文摘 | Qun Xiao Jeffrey L Hesler Thomas W Crowe | | 0，，03： | 1 |
| 14 | C-reactive pro tein causes downregulation of vascular angiotensin subtype 2 re- ceptors and systolic hypertension in mice显示文摘 | Vongpaanasn W Thomas GD Shau'l PW | 2007 | Circulation2007，115，8： | 1 |
| 15 | The Price of Ignorance-distributed Topology Control in Cognitive Networks显示文摘 | Komali R S Thomas R W Dasilva L A | 2010 | IEEE Transactions on Wireless Communications2010，9，4： | 1 |
| 16 | A resolution comparison of several time-frequency representations显示文摘 | Douglas L Jones Thomas W Parks | 1992 | IEEE Trans on Signal Processing1992，40，2： | 1 |
| 17 | Observation of a non-constant mean curvature interface in an ABC tribloek copolymer显示文摘 | Samuel P Gido Dwight W Schwark Edwin L Thomas | 1993 | Macromolecules1993，26，： | 1 |
| 18 | Influence of conservationtillage on soil properties显示文摘 | BLEVINS R L SMITH M S THOMAS G W | 1983 | Soil Water Conserve1983，38，： | 1 |
| 19 | Attitudes toward marriage and p remaritalsexual activity of college freshmen显示文摘 | Salts Connie J Seismore Melisa D L indholm Byron W Smith&Thomas | | 0，，116： | 1 |
| 20 | The efficacy of silver dressings and antibiotics on MRSA and MSSA isolated from burn patients显示文摘 | Percival S L Thomas J G Slone W | | 0，，： | 1 |
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