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| 1 | Urine-derived stem/progenitor cells:A focus on their characterization and potential显示文摘Cell therapy,i.e.,the use of cells to repair an affected tissue or organ,is at the forefront of regenerative and personalized medicine.Among the multiple cell types that have been used for this purpose[including adult stem cells such as mesenchymal stem cells or pluripotent stem cells],urine-derived stem cells(USCs)have aroused interest in the past years.USCs display classical features of mesenchymal stem cells such as differentiation capacity and immunomodulation.Importantly,they have the main advantage of being isolable from one sample of voided urine with a cheap and unpainful procedure,which is broadly applicable,whereas most adult stem cell types require invasive procedure.Moreover,USCs can be differentiated into renal cell types.This is of high interest for renal cell therapy-based regenerative approaches.This review will firstly describe the isolation and characterization of USCs.We will specifically present USC phenotype,which is not an object of consensus in the literature,as well as detail their differentiation capacity.In the second part of this review,we will present and discuss the main applications of USCs.These include use as a substrate to generate human induced pluripotent stem cells,but we will deeply focus on the use of USCs for cell therapy approaches with a detailed analysis depending on the targeted organ or system.Importantly,we will also focus on the applications that rely on the use of USC-derived products such as microvesicles including exosomes,which is a strategy being increasingly employed.In the last section,we will discuss the remaining barriers and challenges in the field of USC-based regenerative medicine. | Perrine Burdeyron Sébastien Giraud Thierry Hauet Clara Steichen | 2020 | World Journal of Stem Cells2020，12，10： | 6 |
| 2 | Sampling Variability of Liver Biopsy in Nonalcoholic Fatty Liver Disease显示文摘 | Vlad Ratziu Frédéric Charlotte Agnès Heurtier Sophie Gombert Philippe Giral Eric Bruckert André Grimaldi Frédérique Capron Thierry Poynard | 2005 | Gastroenterology2005，，7： | 4 |
| 3 | High water solubility and fold in amphipols of proteins with large hydrophobic regions: Oleosins and caleosin from seed lipid bodies显示文摘 | Yann Gohon Jean-David Vindigni Agnès Pallier Frank Wien Hervé Celia Alexandre Giuliani Christophe Tribet Thierry Chardot Pierre Briozzo | 2010 | BBA - Biomembranes2010，，3： | 2 |
| 4 | 经导管动脉栓塞术治疗肝癌:最新临床证据显示文摘对不能接受根治性治疗如肝移植、肿瘤切除术或经皮射频消融术(radiofrequency ablation,RFA)的肝细胞肝癌(hepatocellular carcinoma,HCC)患者,经导管动脉化疗栓塞术(transarterial chemoembolization,TACE)或放疗栓塞术(transarterial radioembolization,TARE)是治疗的核心手段。近期研究证据显示:对于无血管侵犯、3 cm及以下单结节型HCC患者,TACE与肿瘤切除术及RFA后的5年总生存率相似。尽管已应用数十年,碘油(超液化碘油®,Lipiodol®Ultra Fluid,Guerbet,France)作为一种亲肿瘤性且不透射线的药物运输载体在肿瘤介入治疗中的地位依然重要。药物缓释微球(drug-eluting bead,DEB)是栓塞术中一种较新型的药物输送方式,既可维持药物浓度,也可持续释放抗癌药。现有三种DEB可供临床选择使用,即Tandem®(Celo Nova Biosciences Inc.),DC-Beads®(BTG,UK)和Hepa Sphere®(Bio Sphere Medical,Inc.,USA)。经动脉TARE已被证实可安全有效地运用于晚期肝癌及有肝血管侵犯的患者。两种放射性栓塞微粒可供临床选择使用,即SIR-Spheres®(Sirtex Medical Limited,Australia)和Thera Sphere®(BTG,UK)。本文总结肝癌经导管动脉治疗的关键临床试验。 | Yì-Xiáng J.Wáng Thierry De Baere Jean-Marc Idée Sébastien Ballet 邓敏 王毅翔 | 2015 | 临床与病理杂志2015，35，7： | 2 |
| 5 | Effect of low temperature in the development cycle of Lucilia sericata (Meigen) (Diptera, Calliphoridae): implications for the minimum postmortem interval estimation显示文摘Knowledge of necrophagous insects' developmental data is necessary for the forensic entomologist to estimate a reliable minimum postmortem interval (PMImin).Among the most represented necrophagous species,Lucilia sericata (Diptera,Calliphoridae) is particularly interesting.It is regularly identified in samples,with a predominance in summer,and is commonly used by analysts of our entomology department (Institut de Recherche Criminelle de la Gendarmerie Nationale) to estimate the PMImin with the accumulated degree days (ADD) method.This method requires the mathematical lower thermal threshold to be known.This value dictates the quality of the applied ADD method but cannot be considered as fixed,especially when insect development occurs at temperatures close to the biological threshold.In such conditions,it is necessary to study the influence of such temperatures on development rate,as well as the consequences of estimating the period of first oviposition on cadavers,when using the ADD method.Seven replicate rearings were conducted at six different temperatures: 30 ℃,24 ℃,18 ℃,15 ℃,12 ℃ and 10 ℃.Time of development and time of emergence were recorded.The effect of low temperature on the development cycle and the reliability of the ADD method under this entire temperature spectrum were studied using different linear regression models.Calculated durations of total insect time development and experimental rearing duration were then compared.A global linear model cannot be used on the whole temperature spectrum experienced by L.sericata without resulting in an overestimation at some temperatures.We found a combination of two linear regression models to be suitable for the estimation of the total development time,depending on the temperature experienced by L.sericata.This approach allowed us to obtain a variation lower than 2% at 12 ℃ and 10 ℃ between the calculated duration and experimental duration of development.In comparison,the results obtained with a global model show a variation higher than 3% at 12 ℃ and 10%at 10℃. | Laetitia Cervantès Laurent Dourel Emmanuel Gaudry Thierry Pasquerault Benoit Vincent | 2018 | Forensic Sciences Research2018，3，1： | 2 |
| 6 | Early switch to pentoxifylline in patients with severe alcoholic hepatitis is inefficient in non-responders to corticosteroids显示文摘 | Alexandre Louvet Emmanuel Diaz Sébastien Dharancy Hugues Coevoet Frédéric Texier Thierry Thévenot Pierre Deltenre Valérie Canva Christophe Plane Philippe Mathurin | 2007 | Journal of Hepatology2007，，3： | 2 |
| 7 | Studies on the diagnosis of hop stunt viroid in fruit trees: Identification of new hosts and application of a nucleic acid extraction procedure based on non-organic solvents显示文摘 | Nathalie Astruc Jose F. Marcos Guy Macquaire Thierry Candresse Dr. Vicente Pallás | 1996 | European Journal of Plant Pathology1996，，9： | 2 |
| 8 | Risk Assessment Based on Weak Information Using Belief Functions:A Case Study in Water Treatment显示文摘 | SABRINA D M WALTER S THIERRY D | | 0，，： | 1 |
| 9 | Clini-cal validation of the detection of KRAS and BRAF mutations fromcirculating tumor DNA显示文摘 | THIERRY AR MOULIERE F EL MESSAOUDI S | 2014 | Nat Med2014，20，4： | 1 |
| 10 | Nucleotide sequence of a cDNA encoding the chicken p53 nuclear oncoprotein显示文摘 | Thierry S Agnes B Michel K | 1988 | Nucleic Acids Res1988，16，11： | 1 |
| 11 | β-type natriuretic peptide (BNP) and N-terminal-proBNP for heart failure diagnosis in shock or acute respiratory distress 显示文摘 | BAL THIERRY S BROCAS E | 2006 | Acta Anaesthesiol Scand2006，50，3： | 1 |
| 12 | Nitrous Oxide for Early Analgesia in the Emergency Setting: A Randomized, Double‐blind Multicenter Prehospital Trial显示文摘 | Jean‐Louis Ducassé Georges Siksik Manon Durand‐Béchu Sébastien Couarraze Baptiste Vallé Nathalie Lecoules Patrice Marco Thierry Lacombe Vincent Bounes | 2013 | Acad Emerg Med2013，，： | 1 |
| 13 | Attacks on digital watermarks: Classification, estimation based attacks, and benchmarks显示文摘 | Voloshynovskiy S Pereira S Thierry P | 2001 | IEEE Communications Magazine2001，39，8： | 1 |
| 14 | Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA显示文摘 | Thierry AR Mouliere F E1 Messaondi S | 2014 | Nat Med2014，20，： | 1 |
| 15 | Achievable throughout optimization in OFDM systems in the presence of interference and its application to power line networks 显示文摘 | Thanh N V Karlne A Thierry C Pierre S | 2014 | IEEE Transactions on Communications2014，62，5： | 1 |
| 16 | Early assessment of apoptosis in isolated islets of langerhans 显示文摘 | PIERRE C THIERRY B STEFANO S | 2001 | Transplantation2001，71，7： | 1 |
| 17 | Rosiglitazone for Nonalcoholic Steatohepatitis: One-Year Results of the Randomized Placebo-Controlled Fatty Liver Improvement With Rosiglitazone Therapy (FLIRT) Trial显示文摘 | Vlad Ratziu Philippe Giral Sophie Jacqueminet Fréderic Charlotte Agnès Hartemann–Heurtier Lawrence Serfaty Philippe Podevin Jean–Marc Lacorte Carole Bernhardt Eric Bruckert André Grimaldi Thierry Poynard | 2008 | Gastroenterology2008，，1： | 1 |
| 18 | B - tyoe natriuretic peptide (BNP) and N - terminal - proBNP for heart failure diagnosis in shock or acute respiratory distress显示文摘 | Bal L Thierry S Brocas E | 2006 | Acta Anaesthesiol Scand2006，50，： | 1 |
| 19 | Sampling-based path planning on configuration-space costmaps显示文摘 | Leonard J Juan C Thierry S | 2010 | IEEE Transaction on Robotics2010，26，4： | 1 |
| 20 | Analysis of interactions between damage and basic creep of HPC and I-IPFRC heated between 20 and 80 ~C显示文摘 | Wahid L Thierry V Alain S | 2013 | Materials and Structures2013，46，1： | 1 |
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