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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Alternation of wet and dry sides during partial rootzone drying irrigation alters root-to-shoot signalling of abscisic acid显示文摘 | Dodd I C Theobald J C Bacon M A | 2006 | Functional Plant Biology2006，33，12： | 1 |
| 3 | Alternation of wet and dry sides during partial rootzone drying irri- gation alters root-to-shoot signalling of abscisic acid显示文摘 | Dodd I C Theobald J C Bacon M A | 2006 | Functional Plant Biology2006，33，12： | 1 |
| 4 | Landscape dynamics of Amazonian deforestation between 1984 and 2002 in central Rondonia, Brazil: assessment and future scenarios显示文摘 | Ferraz S F B Vettorazzi C A Theobald D M | 2005 | Forest Ecology and Management2005，204，： | 1 |
| 5 | Effects of excreta return on properties of a grazed pasture 显示文摘 | Carren R A Theobald P W | 2000 | Nutrient Cycling in Agroecosystems2000，56，： | 1 |
| 6 | A dual-channel, curved-crystal spectrograph for petawatt laser, X-ray backlighter source studies显示文摘 | Theobald W Stoeckl C Jaanimagi P A | 2009 | Review of Scientific Instruments2009，80，08： | 1 |
| 7 | Coronary artery bypass graft surgery:discharge planning for successful recovery显示文摘 | Theobald K McMurray A | 2004 | J Adv Nurs2004，47，5： | 1 |
| 8 | Semantic similarity search on semistructured data with the XXL search engine显示文摘 | Schenkel R Theobald A Weikum G | 2005 | Infor- mation Retrieval2005，8，： | 1 |
| 9 | Biomass allocation in tomato (Lycopersicon esculentum) plants grown under partial root zone drying:enhancement of root growth显示文摘 | MINGOD M Theobald J C BaconM A | 2004 | Functional Plant Biology2004，31，： | 1 |
| 10 | Biomass allocation in tomato (Lycopersicon esculentum) plants grown under partial root zone drying: Enhancement of root growth显示文摘 | Mingo D M Theobald J C Bacon M A | 2004 | Functional Plant Biology2004，31，10： | 1 |
| 11 | A numerical study of diesel ignition显示文摘 | Theobald M A Cheng W K | 1987 | ASME 87-FE-21987，，： | 1 |
| 12 | Acceptability and effectiveness of the storekeeper-based TB referral system for TB suspects in sub-districts of lilongwe in Malawi显示文摘 | Sim~aka BN Theobald S Willets A | 2012 | Plos One2012，7，39： | 1 |
| 13 | Thick GDP microshells for LIL and LMJ targets显示文摘 | Theobald M Nikroo A | 2002 | Fusion Sci and Technol2002，41，3： | 1 |
| 14 | Initial cone-in-shell fast-ignition experiments on OMEGA显示文摘 | Theobald W Solodov A A Stoeek C | 2011 | Physics of Plasmas2011，18，05： | 1 |
| 15 | High performance cache replacement using re-reference interval prediction(RRIP)显示文摘 | JALEEL A THEOBALD K B Jr STEELY S C | 2010 | ACM SIGARCH Computer Architecture News2010，38，3： | 1 |
| 16 | Pro ealci- tonin:a marker for the diagnosis and follow-up of patients with medullary thyroid carcinoma显示文摘 | Schimnich A Preissner CM Theobald JP | 2009 | J Clin Endocrinol Metab2009，94，3： | 1 |
| 17 | Occurrence of Bisphenol F Diglycidyl Ether (BFDGE) in Canned Fish in Oil显示文摘 | THEOBALD A SIMONEAU C HANNAERT P | 2000 | Food Additives and Contaminants2000，17，10： | 1 |
| 18 | Psychosocial Issues Facilitating Recovery Post-CABG Surgery显示文摘 | Theobald K Worrall C L McMurray A | | 0，，02： | 1 |
| 19 | Procalcitonin: a marker for the diagnosis and follow-up of patients with medullary thyroid carcinoma 显示文摘 | Algeciras-Schimnich A Preissner CM Theobald JP | 2009 | J Clin Endocr Metab2009，94，3： | 1 |
| 20 | Multistate Outbreak of Salmonella Infections Associated with Peanut Butter and Peanut Butter-Containing Products - United States, 2008-2009显示文摘 | Medus C Meyer S Smith K Jawahir S Miller B Viger K Forstner M Brandt E Nowicki S Salehi E Phan Q Kinney A Cartter M Flint J Bancroft J Adams J Hyytia-Trees E Theobald L Talkington D Humphrys M Bopp C Gerner-Smidt P Behravesh C Barto | 2009 | MMWR Morbidity and Mortality Weekly Report2009，，4： | 1 |
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