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| 1 | Hepatoprotective role of ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice显示文摘AIM: To examine the effect of ganoderma lucidumpolysaccharide (GLP) on the immune liver injuryinduced by BCG infection, and investigate therelationship between degrees of hepatic damage andNO production in mice.METHODS: Immune hepatic injury was markedlyinduced by BCG-pretreatment (125 mg.kg-1, 2-week, iv)or by BCG-pretreatment plus lipopolysaccharide (LPS,125 μg.kg-1, 12-hour, iv) in mice in vivo.Hepatocellulardamage induced by BCG-pretreated plus inflammatorycytokines mixture (CM), which was included TNF-α, IL1β, IFN-γ and LPS in culture medium in vitro.Administration of GLP was performed by oral orincubating with culture medium at immune stimulisimultaneity. Liver damage was determined by activityof alanine aminotransferase (ALT) in serum and inhepatocytes cultured supernatant, by liver weightchanges and histopathological examination. NOproduction in the cultured supematant was determinedby the Griess reaction. Moreover, inducible nitric oxidesynthase (iNOS) protein expression was alsoexaminated by immunohistochemi1cal method.RESULTS: Immune hepatic injury was markedly inducedby BCG or BCG plus inflammatory cytokines in BALB/cmice in vivoand in vitro. Under BCG-stimulated condition,augment of the liver weight and increase of the serum/supernatant ALT level were observed, as well asgranuloma forming and inflammatory cells soakage wereobserved by microscopic analysis within liver tissues.Moreover, NO production was also increased by BCG or/and CH stimuli in the culture supernatant, and a lot ofiNOS positive staining was observed in BCG-prestimulated hepatic sections. Application of GLPsignificantly mitigated hepatic tumefaction, decreasedALT enzyme release and NO production in serum/supernatant, improved the pathological changes ofchronic and acute inflammation induced by BCG-stimuliin mice. Moreover, the immunohistochemical resultshowed that GLP inhibited iNOS protein expression inBCG-immune hepatic damage model.CONCLUSION: The present study indicates that NOparticipates in immune liver injury induced byMycobacterium bovis BCG infection. The mechanismsof protective roles by GLP for BCG-induced immune liverinjury may be due to influence NO production in mice. | Guo-Liang Zhang Ye-Hong Wang Wei Ni Hui-Ling Teng Zhi-Bin Lin Department of Pharmacology,School of Basic Medical Sciences,Beijing University,Beijing 100083,China | 2002 | World Journal of Gastroenterology2002，8，4： | 47 |
| 2 | Re-evaluating Transarterial Chemoembolization Failure/Refractoriness:A Survey by Chinese College of Interventionalists显示文摘Background and Aims:The recognition of transarterial chemoembolization(TACE)failure/refractoriness among Chinese clinicians remains unclear.Using an online survey conducted by the Chinese College of Interventionalists(CCI),the aim of this study was to explore the recognition of TACE failure/refractoriness and review TACE application for hepatocellular carcinoma(HCC)treatment in clinical practice.Methods:From 27 August 2020 to 30 August 2020 during the CCI 2020 annual meeting,a survey with 34 questions was sent by email to 264 CCI clinicians in China with more than 10 years of experience using TACE for HCC treatment.Results:A total of 257 clinicians participated and responded to the survey.Most participants agreed that the concept of“TACE failure/refractoriness”has scientific and clinical significance(n=191,74.3%).Nearly half of these participants chose TACE-based combination treatment as subsequent therapy after so-called TACE failure/refractoriness(n=88,46.1%).None of the existing TACE failure/refractoriness definitions were widely accepted by the participants;thus,it is necessary to re-define this concept for the treatment of HCC in China(n=235,91.4%).Most participants agreed that continuing TACE should be performed for patients with preserved liver function,presenting portal vein tumor thrombosis(n=242,94.2%)or extrahepatic spread(n=253,98.4%),after the previous TACE treatment to control intrahepatic lesion(s).Conclusions:There is an obvious difference in the recognition of TACE failure/refractoriness among Chinese clinicians based on existing definitions.Further work should be carried out to re-define TACE failure/refractoriness. | Bin-Yan Zhong Wan-Sheng Wang Shen Zhang Hai-Dong Zhu Lei Zhang Jian Shen Xiao-Li Zhu Gao-Jun Teng Cai-Fang Ni | 2021 | Journal of Clinical and Translational Hepatology2021，9，4： | 9 |
| 3 | 基于体波有限频层析成像的青藏高原南部和中部下方印度大陆岩石层俯冲和撕裂的三维图像显示文摘使用TIBET-31N无源地震台阵以及以前临时地震台阵记录到的远震体波数据进行了有限频层析成像反演,对青藏高原南部及中部的三维速度结构成像。在喜马拉雅和拉萨地块下方存在向北倾角40°的高速体。我们把这些高速异常区域解释为俯冲的印度大陆岩石层(ICL)。印度大陆岩石层似乎在青藏高原中部比东部向北延伸更多——沿85°E在31°N到达350km深处,而沿91°E则是在30°N到达350km深度。P波和S波低速异常区在当惹雍错裂谷、亚东—谷露裂谷和错那裂谷下方从下地壳延伸至≥180km深度,这表明青藏高原南部的裂谷可能包含了整个岩石层的变形。当惹雍错裂谷下方的异常区向下延伸到约180km,而亚东—谷露裂谷西部和错那裂谷东部的异常延伸到了超过300km的深度。亚东—谷露裂谷西部的低速区上地幔延伸至最北,并且似乎与青藏高原中部下方广阔的上地幔低速区相连。于是,北向俯冲的印度板块沿着南北走向的裂缝撕裂。这些裂缝允许或者导致的软流层上涌同青藏高原北部上地幔相类似。 | Xiaofeng Liang Yun Chen Xiaobo Tian Yongshun John Chen James Ni Andrea Gallegos Simon L.Klemperer Minling Wang Tao Xu Changqing Sun Shaokun Si Haiqiang Lan Jiwen Teng 左思成 | 2016 | 世界地震译丛2016，47，6： | 8 |
| 4 | Insight-HXMT:China's First X-Ray Astronomical Satellite显示文摘The Hard X-ray Modulation Telescope(HXMT) satellite is the first X-ray astronomical satellite in China. Utilizing the 'direct demodulation image reconstruction method', HXMT will perform broad band(1-250 keV) survey of large sky areas in scanning mode, which can result in source detection characterized with high sensitivity and spatial resolution. Point observation is another key working mode of HXMT, and is specified for observations of galactic bright sources like X-Ray Binary(XRB) and others. Additionally, HXMT also has a powerful capability developed for monitoring gamma-ray bursts, which is quite unique in the world due to its energy coverage of 200 keV-3 MeV and largest detection area. The HXMT satellite was launched by a Long March 4 B(LM-4 B) rocket from the Jiuquan Satellite Launch Center on June 15, 2017. The payloads onboard HXMT are a High Energy X-ray Telescope(HE), a Medium Energy X-ray Telescope(ME), a Low Energy X-ray Telescope(LE), and a Space Environment Monitor(SEM).This paper introduces the main technical aspects of the satellite, including scientific objectives, technical features, mission design, and system design. | PAN Teng NI Runli ZHANG Long HONG Bin GU Quanying LU Fangjun XU Yupeng | 2017 | Aerospace China2017，18，4： | 8 |
| 5 | Path Planning Method Based on D^(*) lite Algorithm for Unmanned Surface Vehicles in Complex Environments显示文摘In recent decades,path planning for unmanned surface vehicles(USVs)in complex environments,such as harbours and coastlines,has become an important concern.The existing algorithms for real-time path planning for USVs are either too slow at replanning or unreliable in changing environments with multiple dynamic obstacles.In this study,we developed a novel path planning method based on the D^(*) lite algorithm for real-time path planning of USVs in complex environments.The proposed method has the following advantages:(1)the computational time for replanning is reduced significantly owing to the use of an incremental algorithm and a new method for modelling dynamic obstacles;(2)a constrained artificial potential field method is employed to enhance the safety of the planned paths;and(3)the method is practical in terms of vehicle performance.The performance of the proposed method was evaluated through simulations and compared with those of existing algorithms.The simulation results confirmed the efficiency of the method for real-time path planning of USVs in complex environments. | YAO Yan-long LIANG Xiao-feng LI Ming-zhi YU Kai CHEN Zhe NI Chong-ben TENG Yue | 2021 | China Ocean Engineering2021，35，3： | 6 |
| 6 | High-quality genome assembly of 'Cuiguan' pear (Pyrus pyrifolia) as a reference genome for identifying regulatory genes and epigenetic modifications responsible for bud dormancy显示文摘Dormancy-associated MADS-box(DAM)genes serve as crucial regulators of the endodormancy cycle in rosaceous plants.Although pear DAM genes have been identified previously,the lack of a high-quality reference genome and techniques to study gene function have prevented accurate genome-wide analysis and functional verification of such genes.Additionally,the contribution of other genes to the regulation of endodormancy release remains poorly understood.In this study,a high-quality genome assembly for'Cuiguan'pear(Pyrus pyrifolia),which is a leading cultivar with a low chilling requirement cultivated in China,was constructed using PacBio and Hi-C technologies.Using this genome sequence,we revealed that pear DAM genes were tandemly clustered on Chr8 and Chr15 and were differentially expressed in the buds between'Cuiguan'and the high-chilling-requirement cultivar'Suli'during the dormancy cycle.Using a virus-induced gene silencing system,we determined the repressive effects of DAM genes on bud break.Several novel genes potentially involved in the regulation of endodormancy release were identified by RNA sequencing and H3K4me3 chromatin immunoprecipitation sequencing analyses of‘Suli'buds during artificial chilling using the new reference genome.Our findings enrich the knowledge of the regulatory mechanism underlying endodormancy release and chilling requirements and provide a foundation for the practical regulation of dormancy release in fruit trees as an adaptation to climate change. | Yuhao Gao Qinsong Yang Xinhui Yan Xinyue Wu Feng Yang Jianzhao Li Jia Wei Junbei Ni Mudassar Ahmad Songling Bai Yuanwen Teng | 2021 | Horticulture Research2021，8，1： | 5 |
| 7 | Influence of earthquake input angle on seismic response of curved girder bridge显示文摘The maximum seismic response of curved bridge is significantly related to the input angle of designated earthquake. Owing to structure irregularities, bridge reactions result from the interaction between the moment and torsion forces. Based on the solving of the seismic response of structure excited by a one-way earthquake input, a uniform expression of the unfavorable angle of the earthquake input was derived, and the corresponding maximum response of structure was determined. Considering the orthotropic and skewed dualdirectional earthquake input manners, the most unfavorable angles for the two cases were also derived, respectively. Furthermore, a series finite element models were built to analyze the multi-component seismic responses by examining an example of curved girder bridge considering the variation of curvature radius and the bearings arrangement. The seismic responses of the case bridges, were excited by earthquakes at different input angles, and were calculated and analyzed using a response spectrum method. The input angles of earthquake excitation were progressively increased. From the analysis and comparison based on the calculation results mentioned above, the most unfavorable angle of earthquake excitation corresponding to the maximum seismic response of the curved bridge could be determined. It was shown that the most unfavorable angles of earthquake input resulted from the different response combination methods were essentially coherent. | Yongjun Ni Jiayu Chen Hualiang Teng Hui Jiang | 2015 | Journal of Traffic and Transportation Engineering(English Edition)2015，2，4： | 3 |
| 8 | Practical strategy to construct anti-osteosarcoma bone substitutes by loading cisplatin into 3D-printed titanium alloy implants using a thermosensitive hydrogel显示文摘Surgical resection and perioperative adjuvant chemotherapy-based therapies have improved the prognosis of patients with osteosarcoma;however,intraoperative bone defects,local tumour recurrence,and chemotherapy-induced adverse effects still affect the quality of life of patients.Emerging 3D-printed titanium alloy(Ti6Al4V)implants have advantages over traditional implants in bone repair,including lower elastic modulus,lower stiffness,better bone conduction,more bone in-growth,stronger mechanical interlocking,and lager drug-loading capacity by their inherent porous structure.Here,cisplatin,a clinical first-line anti-osteosarcoma drug,was loaded into Ti6Al4V implants,within a PLGA-PEG-PLGA thermo-sensitive hydrogel,to construct bone substitutes with both anti-osteosarcoma and bone-repair functions.The optimal concentrations of cisplatin(0.8 and 1.6 mg/mL)were first determined in vitro.Thereafter,the anti-tumour effect and biosafety of the cisplatin/hydrogel-loaded implants,as well as their bone-repair potential were evaluated in vivo in tumour-bearing mouse,and bone defect rabbit models,respectively.The loading of cisplatin reduced tumour volume by more than two-thirds(from 641.1 to 201.4 mm3)with negligible organ damage,achieving better anti-tumour effects while avoiding the adverse effects of systemic cisplatin delivery.Although bone repair was hindered by cisplatin loading at 4 weeks,no difference was observed at 8 weeks in the context of implants with versus without cisplatin,indicating acceptable long-term stability of all implants(with 8.48%-10.04%bone in-growth and 16.94%-20.53%osseointegration).Overall,cisplatin/hydrogel-loaded 3D-printed Ti6Al4V implants are safe and effective for treating osteosarcoma-caused bone defects,and should be considered for clinical use. | Zehao Jing Renhua Ni Jiedong Wang Xinhong Lin Daoyang Fan Qingguang Wei Teng Zhang Yufeng Zheng Hong Cai Zhongjun Liu | 2021 | Bioactive Materials2021，6，12： | 3 |
| 9 | circBIRC6 contributes to the development of non-small cell lung cancer via regulating microRNA-217/amyloid beta precursor protein binding protein 2 axis显示文摘Background:Circular RNAs(circRNAs)are considered to be important regulators in cancer biology.In this study,we focused on the effect of circRNA baculoviral inhibitor of apoptosis protein(IAP)repeat containing 6(circBIRC6)on non-small cell lung cancer(NSCLC)progression.Methods:The NSCLC and adjacent non-tumor tissues were collected at Shanghai Ninth People's Hospital.Quantitative real-time polymerase chain reaction was conducted for assessing the levels of circBIRC6,amyloid beta precursor protein binding protein 2(APPBP2)messenger RNA(mRNA),baculoviral IAP repeat containing 6 mRNA(BIRC6),and microRNA-217(miR-217).Western blot assay was adopted for measuring the protein levels of APPBP2,E-cadherin,N-cadherin,and vimentin.Colony formation assay,transwell assay,and flow cytometry analysis were utilized for evaluating cell colony formation,metastasis,and apoptosis.Dualluciferase reporter assay and RNA immunoprecipitation assay were carried out to determine the interaction between miR-217 and circBIRC6 and APPBP2 in NSCLC tissues.The murine xenograft model assay was used to investigate the function of circBIRC6 in tumor formation in vivo.Differences were analyzed via Student's t test or one-way analysis of variance.Pearson's correlation coefficient analysis was used to analyze linear correlation.Results:CircBIRC6 was overexpressed in NSCLC tissues and cells.Knockdown of circBIRC6 repressed the colony formation and metastasis and facilitated apoptosis of NSCLC cells in vitro and restrained tumorigenesis in vivo.Mechanically,circBIRC6 functioned as miR-217 sponge to promote APPBP2 expression in NSCLC cells.MiR-217 inhibition rescued circBIRC6 knockdown-mediated effects on NSCLC cell colony formation,metastasis,and apoptosis.Overexpression of miR-217 inhibited the malignant phenotypes of NSCLC cells,while the effects were abrogated by elevating APPBP2.Conclusion:CircBIRC6 aggravated NSCLC cell progression by elevating APPBP2 via sponging miR-217,which might provide a fresh perspective on NSCLC therapy. | Da Ni Jiping Teng Youshuang Cheng Zhijun Zhu Bufeng Zhuang Zhiyin Yang | 2022 | Chinese Medical Journal2022，，6： | 2 |
| 10 | Superior mechanical properties of epoxy composites reinforced by 3Dinterconnected graphene skeleton显示文摘 | NI Y CHEN L TENG K Y | 2015 | ACS Appl Mater Inter2015，7，11： | 1 |
| 11 | Bioremediation of polycyclic aromatic hydrocarbons contaminated soil with Monilinia sp.: degradation and microbial community analysis显示文摘 | Yucheng Wu Yongming Luo Dexun Zou Jinzhi Ni Wuxin Liu Ying Teng Zhengao Li | 2008 | Biodegradation2008，，2： | 1 |
| 12 | Large scale purification of metallurgical silicon for solar cell by using electron beam melting显示文摘 | Tong Liu Zhiyuan Dong Youwen Zhao Jun Wang Teng Chen Hui Xie Jian Li Haijiang Ni Dianxin Huo | 2012 | Journal of Crystal Growth2012，，： | 1 |
| 13 | Susceptibility-weighted imaging is suitable for evaluating signal strength in different brain regions of a rabbit model of acute hemorrhagic anemia显示文摘Acute hemorrhagic anemia can decrease blood flow and oxygen supply to brain,and affect its physiological function.While detecting changes in brain function in patients with acute hemorrhagic anemia is helpful for preventing neurological complications and evaluating therapeutic effects,clinical changes | Jun Xia Ni Xie Anyu Yin Guozhao Teng Fan Lin Yi Lei | 2014 | Neural Regeneration Research2014，9，9： | 1 |
| 14 | Interventional radiology in China显示文摘 | Teng GJ Xu K Ni CF | 2008 | Cardiovasc Intervent Radiol2008，31，2： | 1 |
| 15 | Interventional radiology in China显示文摘 | Teng GJ Xu K Ni CF | 2008 | Cardiovasc Intervent Radiol2008，31，： | 1 |
| 16 | An interval finite element method for electromagnetic problems with spatially uncertain parameters显示文摘During the manufacturing process of dielectric materials used in electromagnetic engineering, the electromagnetic parameters are often spatially uncertain due to the processing technology, environmental temperature, personal operations, etc. Traditionally,the random field model can be used to measure the spatial uncertainties, but its construction requires a large number of samples.On the contrary, the interval field model only needs the upper and lower bounds of the spatially uncertain parameters, which requires much less samples and furthermore is easy to understand and use for engineers. Therefore, in this paper, the interval field model is introduced to describe the spatial uncertainties of dielectric materials, and then an interval finite element method(IFEM) is proposed to calculate the upper and lower bounds of electromagnetic responses. Firstly, the interval field of the dielectric material is represented by the interval K-L expansion and inserted into the scalar Helmholtz wave equations, and thus the interval equilibrium equations are constructed according to the node-based finite element method. Secondly, a perturbation interval finite element method is developed for calculating the upper and lower bounds of electromagnetic responses such as the electric strength and magnetic strength. Finally, the effectiveness of the proposed method is verified by three numerical examples. | WANG ZhongHua JIANG Chao NI BingYu WANG CongSi ZHONG JianFeng FANG Teng | 2020 | Science China(Technological Sciences)2020，63，1： | 1 |
| 17 | Interventional radiology in China显示文摘 | Teng GJ Xu K Ni CF | 2008 | Cardiovasc Intervent Radiol2008，31，2： | 1 |
| 18 | Geochemical baseline and trace metal pollution of soil in Panzhihua mining area显示文摘 | Teng Yanguo Ni Shijun Tuo Xianguo | 2002 | Chinese Joarnal of Geochemistry2002，21，3： | 1 |
| 19 | Interleukin 10 polymorphisms and cervical cancer risk a Meta-analysis 显示文摘 | Ni J Ye Y Teng F | 2013 | Int J Gynecol Cancer2013，23，1： | 1 |
| 20 | Interleukin 10 polymor- phisms and cervical cancer risk: a meta-analysis 显示文摘 | Ni J Ye Y Teng F | 2013 | Int J Gynecol Cancer2013，23，1： | 1 |
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