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| 1 | Engineering complex systems applied to risk management in the mining industry显示文摘Related to complexity, there is a wide diversity of concepts, ranging from ‘‘systemic' to ‘‘complex', implying a need for a unified terminology. Per different authors, the main drivers of complexity can be found in human behaviour and uncertainty. This complexity, structural or dynamic can be organizational, technological, or nested in their relationship. ISO international standard 31000:2009 definition of risk management ‘‘coordinated activities to direct and control an organization with regard to risk', when applied to economic sectors, industry, services, project, or activity, it requires the use of models or theories as guidelines. Therefore, as its basic elements comprehend human behaviour and/or uncertainty, risk management to be effective and adapted as much as possible to reality, must be operational within complex systems, as already demonstrated in different R&D environments. Risk management faces demanding challenges when approaching specific and endogenous needs, such as the mining sector. This paper presents a multivariable function analysis methodology approach based on complex system modelling and through real data corresponding to a risk management tool in the mining sector. | Domingues Maria S.Q. Baptista Adelina L.F. Diogo Miguel Tato | 2017 | International Journal of Mining Science and Technology2017，27，4： | 7 |
| 2 | Three decades of hepatitis B control with vaccination显示文摘Hepatitis B virus(HBV) continues to represent a major health problem and can lead to acute liver failure, acute hepatitis, chronic carriership, chronic hepatitis of HBV, liver cirrhosis, liver cancer, liver transplantation and death. There is a marked difference in the geographic distribution of carriers. More than 240 million people worldwide are chronic HBV carriers. Mother-to-child transmission remains the most important mechanism of infection in countries with a high prevalence of HBV. Percutaneous/parenteral transmission and unsafe sexual practices are important mode of spread transmission of HBV in other countries. Vaccination against HBV is the gold measure for primary prevention and control of the disease. Currently, 179 countries have added HBV vaccination to their routine vaccination programs with great results. Neonatal immunization with HBV vaccine has been one of the most highly effective measures in public health and the first anti-cancer program to be launched. In this paper we review the achievements for the last three decades. | Liliane C Meireles Rui Tato Marinho Pierre Van Damme | 2015 | World Journal of Hepatology2015，7，18： | 5 |
| 3 | Hepatitis C,stigma and cure显示文摘The infection with hepatitis C virus(HCV)is one of the most important global chronic viral infections worldwide.It is estimated to affect around 3%of the world population,about 170-200 million people.Great part of the infections are asymptomatic,the patient can be a chronic carrier for decades without knowing it.The most severe consequences of the chronic infection are liver cirrhosis and hepatocellular carcinoma,which appears in 20%-40%of the patients,leading to hepatic failure and death.The HCV was discovered 25 years ago in 1989,is a RNA virus and classified by the World Health Organization as an oncogenic one.Hepatocellular carcinoma is one of the most important cancers,the fifth worldwide in terms of mortality.It has been increasing in the Ocidental world,mainly due to chronic hepatitis C.Hepatitis C is not only a liver disease and a cause of cirrhosis,but also a mental,psychological,familiar,and social disease.The stigma that the infected person sometimes carries is tremendous having multiple consequences.The main cause is lack of adequate information,even in the health professionals setting.But,besides the'drama'of being infected,health professionals,family,society and the infected patients,must be aware of the chance of real cure and total and definitive elimination of the virus.The treatment for hepatitis C has begun in the last 80′s with a percentage of cure of 6%.Step by step the efficacy of the therapy for hepatitis C is rapidly increasing and nowadays with the very new medications,the so called Direct Antiviral Agents-DAAs of new generation,is around 80%-90%. | Rui Tato Marinho David Pires Barreira | 2013 | World Journal of Gastroenterology2013，19，40： | 3 |
| 4 | Interleukin - 2 sig -naling via STAT5 constrains T helper 17 cell generation显示文摘 | Laurence A Tato C M Davidson T S | 2007 | Im- munity2007，26，3： | 1 |
| 5 | The first general,efficient and highly enantioselective 5 reduction of quinoxalines and quinoxalinones显示文摘 | Rueping M Tato F Schoepke F R | 2010 | Chem Eur J2010，16，： | 1 |
| 6 | Optimal therapy of pubertal disorders in precocious/early puberty 显示文摘 | TATO L SAVAGE M O ANTONIAZZI F | 2001 | J Pediatr Endocfinol Metab2001，2，： | 1 |
| 7 | The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17 - producing effector T helper cells in vivo 显示文摘 | MCGEACHY M J CHEN Y TATO C M | 2009 | Nat Immunol2009，10，3： | 1 |
| 8 | Malignanl pheochromcytoma,still a therapeuticc challeng显示文摘 | Tato A Ortil Dizp | 1997 | American Joureal of hypertension1997，10，： | 1 |
| 9 | The interleukin23 receptor is essential for the terminal differentiation ofinterleukin 17-producing effector T helper cells in vivo显示文摘 | McGeachy MJ Chen Y Tato CM | 2009 | Nat Immunol2009，10，3： | 1 |
| 10 | Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system 显示文摘 | Stumhofer JS Laurence A Wilson EH Huang E Tato CM Johnson LM | 2006 | Nat Immunol2006，7，9： | 1 |
| 11 | The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper ceils in vivo 显示文摘 | McGeachy MJ Chen Y Tato CM | 2009 | Nat Immunol2009，10，3： | 1 |
| 12 | Interleukin - 2 signaling via STATS constrains T helper 17 cell generation显示文摘 | LAURENCE A TATO C M DAVIDSON T S | 2007 | Immunity2007，26，3： | 1 |
| 13 | Helper T cell differentiation enters a new era:le roi est mort;vive le roi !显示文摘 | TATO C M LAURENCE A O' SHEA J J | | 0，，04： | 1 |
| 14 | The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo显示文摘 | McGeachy MJ Chen Y Tato CM | 2009 | Nat Immunol2009，10，3： | 1 |
| 15 | Relation between cholesterol es- ter transfer protein activities and lipoprotein cholesterol in patients with hypereholesterolemia and combined hypedipidemia显示文摘 | Tato F Vega GL Tall AR | 1995 | Arte- rioseler Thmmb Vase Biol1995，15，1： | 1 |
| 16 | The myeloid re- ceptor PILRI3 mediates the balance of inflammatory responses through regulation of IL-27 production 显示文摘 | Tato CM Joyce-Shaikh B Banerjee A et ol | 2012 | PLoS One2012，7，31： | 1 |
| 17 | Hepatitis B virus genotyping based on cluster analysis of the region in- volved in lamivudine resistance显示文摘 | Rodyguez - Novoa S Gomez - Tato A Aguilera - Guirao A | 2004 | Virol Methods2004，115，1： | 1 |
| 18 | The cytokines interleukin 27 and interferon-',/ promote distinct Treg cell populations re- quired to limit infection-induced pathology 显示文摘 | Hall AO Belting DP Tato C et ol | 2012 | Immunity2012，37，3： | 1 |
| 19 | Tau protein concentrations in cerebrospinal fluid of patients with dementai of the Alzheimer type显示文摘 | Tato RE Frank A Hernanz A | 1995 | J Neurol Neurosurg Psychiatry1995，59，： | 1 |
| 20 | Dispersal of carbapenemace blaVIM-1 gene associated with different Tn402 variants,mercury transposons,and conjugative plasmids in Enter-obacteriaceae and Pseudomonas aeruginosa 显示文摘 | Tato M Coque TM Baquero F | 2010 | Antimicrob Agents Chemother2010，54，1： | 1 |
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