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| 1 | Clinical analysis of propofol deep sedation for 1,104 patients undergoing gastrointestinal endoscopic procedures:A three year prospective study显示文摘瞄准:在经历 gastros 拷贝和结肠镜检查的病人上分析 propofol 的血液动力学、呼吸的效果。方法:在这未来的研究,在三年的一个时期上进行了, 1,104 个病人参考了一一样的天官方补给的内视镜检查法过程被分析。所有病人被给一丸 propofol 大丸药(0.5-1.5 mg/kg ) 。动脉的血压(BP ) 在 3 min 间隔和心搏率被监视,氧饱和(SpO2 ) 被脉搏血氧定量法连续地记录。分析数据获得以前被执行,在期间,并且在过程以后。结果:在吝啬的动脉压的统计上重要的减小被表明(P <
0.001 ) 什么时候与干预前价值,而是严重低血压相比,在 60 毫米汞柱下面定义为收缩血压,在仅仅 5 个病人(0.5%) 被注意。氧饱和从 96.5% ~ 94.4 % 减少了(P <
0.001 ) 。在氧饱和的批评减少(<
90%) 在 27 个病人(2.4%) 被记录。结论:如果小心地滴定,我们的结果证明 propofol 向好镇静提供了优秀疼痛控制,短复原时间和没有重要血液动力学的副作用。所有病人(并且特别 ASA III 组) 要求监视并且一个麻醉学者关心。 | Stojanka Gaparovi Nadan Rustemovi Milorad Opai Marina Premuzi Andelko Korui Jadranka Bozikov Tamara Bates | 2006 | World Journal of Gastroenterology2006，12，2： | 41 |
| 2 | GPC3在鉴别小肝癌与肝硬化、异型增生结节和局灶性结节性增生中的作用显示文摘 | Louis L Tamara S David C 潘敏鸿(摘译) 饶秋(摘译) 周晓军(审校) | 2006 | 临床与实验病理学杂志2006，22，6： | 44 |
| 3 | Nonalcoholic fatty liver disease-A multisystem disease?显示文摘Non-alcoholic fatty liver disease(NAFLD) is one of the most common comorbidities associated with overweight and metabolic syndrome(Met S). Importantly, NAFLD is one of its most dangerous complications because it can lead to severe liver pathologies, including fibrosis, cirrhosis and hepatic cellular carcinoma. Given the increasing worldwide prevalence of obesity, NAFLD has become the most common cause of chronic liver disease and therefore is a major global health problem. Currently, NAFLD is predominantly regarded as a hepatic manifestation of Met S. However, accumulating evidence indicates that the effects of NAFLD extend beyond the liver and are negatively associated with a range of chronic diseases, most notably cardiovascular disease(CVD), diabetes mellitus type 2(T2DM) and chronic kidney disease(CKD). It is becoming increasingly clear that these diseases are the result of the same underlying pathophysiological processes associated with Met S, such as insulin resistance, chronic systemic inflammation and dyslipidemia. As a result, they have been shown to be independent reciprocal risk factors. In addition, recent data have shown that NAFLD actively contributes to aggravation of the pathophysiology of CVD, T2 DM, and CKD, as well as several other pathologies. Thus, NAFLD is a direct cause of many chronic diseases associated with MetS, and better detection and treatment of fatty liver disease is therefore urgently needed. As non-invasive screening methods for liver disease become increasingly available, detection and treatment of NAFLD in patients with MetS should therefore be considered by both(sub-) specialists and primary care physicians. | Ivana Mikolasevic Sandra Milic Tamara Turk Wensveen Ivana Grgic Ivan Jakopcic Davor Stimac Felix Wensveen Lidija Orlic | 2016 | World Journal of Gastroenterology2016，22，43： | 32 |
| 4 | MYB34, MYB51, and MYB 122 Distinctly Regulate Indolic Glucosinolate Biosynthesis in Arabidopsis thaliana显示文摘MYB34, MYB51,和 MYB122 抄写因素被知道调整 indolic glucosinolate (IG ) 在 Arabidopsis thaliana 的生合成。决定 MYB34, MYB51,和 MYB122 的不同规章的潜力,在不同部分 ofplants 并且在有植物荷尔蒙的处理之上的 IG 的累积在 A 被分析。thaliana 幼苗。MYB34, MYB51,和 MYB122 一起行动在射击和根控制 I3M 的生合成,这被显示出,与控制主要在在 IG 的生合成的根,在射击调整生合成的 MYB51,和 MYB122 havingan 附件角色的 IG 的生合成的 MYB34。glucosinolate 的分析在 myb34 的幼苗铺平, myb51, myb122, myb34 myb51 两倍,并且面对 abscisic 酸(骆驼毛的织物) 种的 myb34 myb51 myb122 三元组大美人异种,水杨酸酸(SA ) , jasmonate (JA ) ,或乙烯(et ) 揭示了那:(1 ) MYB51 是在 SA 并且 et 发信号之上的 IG 合成的中央管理者,(2 ) MYB34 是关键 regulatorupon 骆驼毛的织物并且 JA 发信号,并且(3 ) MYB122 在 JA/ET-induced glucosinolate 生合成起仅仅一个次要的作用。myb34 myb51 myb122 三元组异种缺乏 IG,显示这三个 MYB 因素为在 standardgrowth conditions.Key 词下面的 IG 生产是不可缺少的: | Henning Frerigmann Tamara Gigolashvili | 2014 | Molecular Plant2014，7，5： | 29 |
| 5 | Role of Helicobacter pylori infection in gastric carcinogenesis:Current knowledge and future directions显示文摘Helicobacter pylori(H. pylori) plays a role in the patho-genesis of gastric cancer. The outcome of the infection depends on environmental factors and bacterial and host characteristics. Gastric carcinogenesis is a multistep process that is reversible in the early phase of mucosal damage, but the exact point of no return has not been identified. Therefore, two main therapeutic strategies could reduce gastric cancer incidence:(1) eradication of the already present infection; and(2) immunization(prior to or during the course of the infection). The success of a gastric cancer prevention strategy depends on timing because the prevention strategy must be introduced before the point of no return in gastric carcinogenesis. Although the exact point of no return has not been identified, infection should be eradicated before severe atrophy of the gastric mucosa develops. Eradication therapy rates remain suboptimal due to increasing H. pylori resistance to antibiotics and patient noncompliance. Vaccination against H. pylori would reduce the cost of eradication therapies and lower gastric cancer incidence. A vaccine against H. pylori is still a research challenge. An effective vaccine should have an adequate route of delivery, appropriate bacterial antigens and effective and safe adjuvants. Future research should focus on the development of rescue eradication therapy protocols until an efficacious vaccine against the bacterium becomes available. | Aleksandra Sokic-Milutinovic Tamara Alempijevic Tomica Milosavljevic | 2015 | World Journal of Gastroenterology2015，21，41： | 30 |
| 6 | Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets显示文摘Hepatocellular 癌(HCC ) 每年是为 500 000 死亡负责的世界范围的一个主要健康问题。很多个风险因素与也被联系疾病或它的前进的正式就职;这些与肝炎 B 或 C 病毒,白酒消费,非酒精的 steatohepatitis 和某些先天的混乱包括感染。在约 80% 盒子, HCC 与肝硬化或先进纤维变性并且与发炎和氧化应力被联系。在这评论,我们为 HCC 第一集中于不同风险因素并且总结由哪个各被认为贡献 HCC 的机制。在第二部分,我们看涉及癌症前进的分子的过程。HCC 开发作为 multistep 进程被认出通常在许多年发展。在几个变化在房间和那积累的这个时期上刺激诽谤转变,生长,和变形行为。在最近的年,不仅肿瘤房间本身而且肿瘤 microenviroment 在一个肿瘤的发展起一个主要作用,变得明显。与这 microenviroment 在发炎和肝硬化的角色之间有一个直接连接。在 vitro 并且在 vivo,它被看了那肿瘤形成,变形性质被连接到上皮间充质的转变(EMT ) ,由 facillitates,肿瘤房间是尝试移居到更赞成的 microenviroment 的一个过程。几个组由 microarray 在 HCC 和它的包围织物分析了基因表示,这导致了分子的分类进班的一个不同数字。这里,我们也发现为组织缺氧的一个角色导致了基因表示导致一临床上在 HCC 的更好攻击的基因表示。分子的分析也帮助识别重要细胞的小径和可能的治疗学的目标。这样为肝癌症显示出临床的申请的第一个分子是 multikinase 禁止者 sorafenib,其它当前在象 mTOR 禁止者 everolimus 一样的临床的研究的不同阶段。 | Tamara SEVERI Hannah van MALENSTEIN Chris VERSLYPE Jos F van PELT | 2010 | Acta Pharmacologica Sinica2010，31，11： | 23 |
| 7 | 西部农村地区家庭暴力发生情况及对妇女精神健康的影响显示文摘目的:了解西部农村针对妇女的家庭暴力发生情况及对妇女精神健康的影响。方法:使用夫妻冲突量表(the revised Conflict Tactics Scale,CTS2)及自编问卷对宁夏某县1 577名妇女进行调查。结果:24.6%的妇女报告过去1年遭受过精神暴力,轻度和重度精神暴力的发生率分别为23.9%和7.0%;5.5%的妇女过去1年遭受过躯体暴力,轻度和重度躯体暴力的发生率分别为4.4%和4.1%;1.1%的妇女报告过去1年曾受过性暴力。有2.2%的妇女报告在过去1年中曾因家庭暴力受到躯体伤害,轻度和重度躯体伤害的发生率分别为2.1%和1.0%。妇女过去任何时候曾经遭受家庭暴力的比例分别为精神暴力30%,躯体暴力16.3%,性暴力1.8%,躯体伤害6.4%。妇女精神健康分别用过去1个月精神症状出现的种类、过去1年是否有过自杀意念和过去1年心理精神健康状况的自我评价3个指标来描述,多元线性回归和Logistic回归显示,在同时考虑年龄、家庭收入、丈夫是否外出打工这3个因素时,家庭暴力持续显示为影响妇女精神健康的重要因素,遭受精神暴力或躯体暴力的妇女表述过去1个月内出现更多种类的精神症状;过去1年遭受过精神暴力的妇女,其过去1年出现自杀意念的风险是未遭受过精神暴力者的3.98倍,其自我评价过去1年心理精神健康状况差的风险是未遭受过精神暴力者的1.67倍;过去1年遭受过躯体暴力的妇女,其过去1年出现自杀意念的风险是未遭受过躯体暴力者的4.72倍,其自我评价过去1年心理精神健康状况差的风险是未遭受过躯体暴力者的4.57倍。研究还显示,老年妇女和家庭收入极低的妇女为精神健康的危险人群。结论:针对农村妇女的家庭暴力发生情况不容乐观,家庭暴力对妇女的身心健康造成极大威胁,今后应采取有效措施,降低类似农村地区家庭暴力的发生,保护妇女,提高其生活质量。 | 高燕秋 Tamara Jacka | 2012 | 北京大学学报(医学版)2012，44，3： | 16 |
| 8 | Endoscopic management of esophageal stenosis in children:New and traditional treatments显示文摘Post-esophageal atresia anastomotic strictures and postcorrosive esophagitis are the most frequent types of cicatricial esophageal stricture. Congenital esophageal stenosis has been reported to be a rare but typical disease in children; other pediatric conditions are peptic, eosinophilic esophagitis and dystrophic recessive epidermolysis bullosa strictures. The conservative treatment of esophageal stenosis and strictures(ES) rather than surgery is a well-known strategy for children. Before planning esophageal dilation, the esophageal morphology should be assessed in detail for its length, aspect, number and level, and different conservative strategies should be chosen accordingly. Endoscopic dilators and techniques that involve different adjuvant treatment strategies have been reported and depend on the stricture's etiology, the availability of different tools and the operator's experience and preferences. Balloon and semirigid dilators are the most frequently used tools. No high-quality studies have reported on the differences in the efficacies and rates of complications associated with these two types of dilators. There is no consensus in the literature regarding the frequency of dilations or the diameter that should be achieved. The use of adjuvant treatments has been reported in cases of recalcitrant stenosis or strictures with evidence of dysphagic symptoms. Corticosteroids(either systemically or locally injected), the local application of mitomycin C, diathermy and laser ES sectioning have been reported. Some authors have suggested that stenting can reduce both the number of dilations and the treatment length. In many cases, this strategy is effective when either metallic or plastic stents are utilized. Treatment complications, such esophageal perforations, can be conservatively managed, considering surgery only in cases with severe pleural cavity involvement. In cases of stricture relapse,even if such relapses occur following the execution of well-conducted conservative strategies, surgical stricture resection and anastomosis or esophageal substitution are the only remaining options. | Luigi Dall rsquo Oglio Tamara Caldaro Francesca Foschia Simona Faraci Giovanni Federici di Abriola Francesca Rea Erminia Romeo Filippo Torroni Giulia Angelino Paola De Angelis | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，4： | 16 |
| 9 | Laparoscopic vs open approach to resection of hepatocellular carcinoma in patients with known cirrhosis:Systematic review and meta-analysis显示文摘AIM: To review the currently available literature comparing laparoscopic to open resection of hepatocellular carcinoma(HCC) in patients with known liver cirrhosis.METHODS: A literature search of MEDLINE, EMBASE, and Cochrane databases was conducted. The search terms used included(laparoscopic OR laparoscopy) AND(hepatic or liver) AND(surgery or resection) AND 'hepatocellular carcinoma' AND(cirrhosis or cirrhotic). Furthermore, to widen the search, we also used the 'related articles' section. Studies reporting a comparison of outcomes and methods of open vs laparoscopic hepatic resection for HCC in patients with liver cirrhosis were included. Meta-analysis of results was performed using a random effects model to compute relative risk(RR) and for dichotomous variablesand standard mean differences(SMD) for continuous variables.RESULTS: A total of 420 patients from 4 cohort studies were included in final analysis. Patients undergoing laparoscopic procedures had statistically less blood loss compared to the open cohort, SMD of-1.01(95%CI:-1.23-0.79), P < 0.001, with a reduced risk of transfusion, RR = 0.19(95%CI: 0.09-0.38), P < 0.001. A wider clearance at tumour resection margins was achieved following a laparoscopic approach, SMD of 0.34(95%CI: 0.08-0.60), P = 0.011. No significant difference was noted between laparoscopic and open resection operative times, SMD of-0.15(95%CI: 0.35-0.05), P = 0.142. The overall RR of suffering from postoperative morbidity is 0.25 in favour of the open surgery cohort(95%CI: 0.17-0.37), P < 0.001. Patients under-going laparoscopic surgery had significantly shorter length of stays in hospital compared to the open cohort, SMD of-0.53(95%CI:-0.73 to-0.32), P < 0.001.CONCLUSION: This review suggests that laparoscopic resection of hepatocellular carcinoma in patients with cirrhosis is safe and may provide improved patient outcomes when compared to the open technique. | Ahmed Twaij Philip H Pucher Mikael H Sodergren Tamara Gall Ara Darzi Long R Jiao | 2014 | World Journal of Gastroenterology2014，20，25： | 16 |
| 10 | Drug-induced liver injury: Do we know everything?显示文摘Interest in drug-induced liver injury(DILI) has dramatically increased over the past decade, and it has become a hot topic for clinicians, academics, pharmaceutical companies and regulatory bodies. By investigating the current state of the art, the latest scientific findings, controversies, and guidelines, this review will attempt to answer the question: Do we know everything? Since the first descriptions of hepatotoxicity over 70 years ago, more than 1000 drugs have been identified to date, however, much of our knowledge of diagnostic and pathophysiologic principles remains unchanged. Clinically ranging from asymptomatic transaminitis and acute or chronic hepatitis, to acute liver failure, DILI remains a leading causes of emergent liver transplant. The consumption of unregulated herbal and dietary supplements has introduced new challenges in epidemiological assessment and clinician management. As such, numerous registries have been created, including the United States Drug-Induced Liver Injury Network, to further our understanding of all aspects of DILI. The launch of Liver Tox and other online hepatotoxicity resources has increased our awareness of DILI. In 2013, the first guidelines for the diagnosis and management of DILI, were offered by the Practice Parameters Committee of the American College of Gastroenterology, and along with the identification of risk factors and predictors of injury, novel mechanisms of injury, refined causality assessment tools, and targeted treatment options have come to define the current state of the art, however, gaps in our knowledge still undoubtedly remain. | Tamara Alempijevic Simon Zec Tomica Milosavljevic | 2017 | World Journal of Hepatology2017，9，10： | 13 |
| 11 | Does playing a sports active video game improve object control skills of children with autism spectrum disorder?显示文摘Background: Active video games(AVGs) encourage whole body movements to interact or control the gaming system, allowing the opportunity for skill development. Children with autism spectrum disorder(ASD) show decreased fundamental movement skills in comparison with their typically developing(TD) peers and might benefit from this approach. This pilot study investigates whether playing sports AVGs can increase the actual and perceived object control(OC) skills of 11 children with ASD aged 6–10 years in comparison to 19 TD children of a similar age.Feasibility was a secondary aim.Methods: Actual(Test of Gross Motor Development) and perceived OC skills(Pictorial Scale of Perceived Movement Skill Competence for Young Children) were assessed before and after the intervention(6 × 45 min).Results: Actual skill scores were not improved in either group. The ASD group improved in perceived skill. All children completed the required dose and parents reported the intervention was feasible.Conclusion: The use of AVGs as a play-based intervention may not provide enough opportunity for children to perform the correct movement patterns to influence skill. However, play of such games may influence perceptions of skill ability in children with ASD, which could improve motivation to participate in physical activities. | Jacqueline Edwards Sarah Jeffrey Tamara May Nicole J.Rinehart Lisa M.Barnett | 2017 | Journal of Sport and Health Science2017，6，1： | 12 |
| 12 | Epac and PKA: a tale of two intracellular cAMP receptors显示文摘调停营地的发信号小径在生理、病理学的条件下面调整大量的重要生物过程,包括糖尿病,心失败和癌症。在真核细胞的房间,营地的效果被二无所不在地表示的细胞内部的营地受体,经典蛋白质 kinase A (PKA )/cAMP-dependent 蛋白质 kinase 和营地(Epac ) 直接激活的最近发现的交换蛋白质调停 /cAMP-regulated guanine 核苷酸交换因素。象 PKA 一样, Epac 包含一个进化联盟者为察觉到细胞内部的秒送信人营地层次控制多样的生物函数充当一个分子的开关的保存营地绑定领域。营地受动器的二个家庭的存在为以一种空间、时间的方式表明小径的营地的更精确、综合的控制提供机制。象他们丰富,分发和本地化, Epac 和 PKA 可以独立地扮演, synergistically 收敛或在调整特定的细胞的功能反对对方的亲戚一样取决于特定的细胞的环境。 | Xiaodong Cheng Zhenyu Ji Tamara Tsalkova Fang Mei | 2008 | Acta Biochimica et Biophysica Sinica2008，40，7： | 10 |
| 13 | Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization显示文摘临床的试用和动物实验的增加的数字显示出细菌为过敏症预防正在答应工具的那 probiotic。这里,我们在过敏促进感受性上分析了三选择乳杆菌紧张的 immunomodulatory 性质和他们的混合的影响赌 1 用一只 gnotobiotic 老鼠建模的 v。我们显示出那乳杆菌(L.) rhamnosus LOCK0900, L。rhamnosus LOCK0908 和 L。casei LOCK0919 经由像使用费的受体被认出 2 (TLR2 ) 并且核苷酸绑定 oligomerization 包含域的蛋白质 2 (NOD2 ) 受体并且刺激骨头在种类依赖者和紧张依赖者礼貌生产 cytokines 的导出髓的树枝状的房间。殖民无菌(GF ) 有所有三紧张(Lmix ) 的混合物的鼠标由加强 enterocytes 的顶端的 junctional 建筑群并且恢复延续到终端网的微细丝的结构改进了肠的障碍。与 Lmix 开拓殖民地于并且敏化 1 变应原到赌注 v 的老鼠显著地象一个增加的转变生长因素(TGF ) 一样在 sera 和肠的 lavages 显示出变应原特定的 IgE, IgG1 和 IgG2a 和提高的全部的 IgA 水平的底层 -β与敏化的 GF 老鼠相比铺平。从开拓殖民地于 Lmix 的老鼠的 Splenocytes 和 mesenteric 淋巴节点房间显示出 TGF-β 的重要 upregulation;在以后在有赌注 v 的 vitro 刺激 1。我们的结果证明 Lmix 殖民改进了内脏对赌注 v 的上皮的障碍和减少的过敏促进感受性 1。而且,这些调查结果被传播和能分泌的 IgA 和规章的 cytokine TGF-β 的增加的生产伴随;。因此,三乳杆菌紧张的这混合物在人在增加的内脏渗透和过敏症的发作的预防为使用显示出潜力。 | Hana Kozakova Martin Schwarzer Ludmila Tuckova Dagmar Srutkova Elzbieta Czarnowska Ilona Rosiak Tomas Hudcovic Irma Schabussova Petra Hermanova Zuzana Zakostelska Tamara Aleksandrzak-Piekarczyk Anna Koryszewska-Baginska Helena Tlaskalova-Hogenova Bozena Cukrowska | 2016 | Cellular & Molecular Immunology2016，13，2： | 10 |
| 14 | Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis显示文摘Osteoarthritis(OA),long considered a primary disorder of articular cartilage,is commonly associated with subchondral bone sclerosis.However,the cellular mechanisms responsible for changes to subchondral bone in OA,and the extent to which these changes are drivers of or a secondary reaction to cartilage degeneration,remain unclear.In knee joints from human patients with end-stage OA,we found evidence of profound defects in osteocyte function.Suppression of osteocyte perilacunar/canalicular remodeling(PLR)was most severe in the medial compartment of OA subchondral bone,with lower protease expression,diminished canalicular networks,and disorganized and hypermineralized extracellular matrix.As a step toward evaluating the causality of PLR suppression in OA,we ablated the PLR enzyme MMP13 in osteocytes while leaving chondrocytic MMP13 intact,using Cre recombinase driven by the 9.6-kb DMP1 promoter.Not only did osteocytic MMP13 deficiency suppress PLR in cortical and subchondral bone,but it also compromised cartilage.Even in the absence of injury,osteocytic MMP13 deficiency was sufficient to reduce cartilage proteoglycan content,change chondrocyte production of collagen II,aggrecan,and MMP13,and increase the incidence of cartilage lesions,consistent with early OA.Thus,in humans and mice,defects in PLR coincide with cartilage defects.Osteocyte-derived MMP13 emerges as a critical regulator of cartilage homeostasis,likely via its effects on PLR.Together,these findings implicate osteocytes in bone-cartilage crosstalk in the joint and suggest a causal role for suppressed perilacunar/canalicular remodeling in osteoarthritis. | Courtney MMazur Jonathon JWoo Cristal SYee Aaron JFields Claire Acevedo Karsyn NBailey Serra Kaya Tristan WFowler Jeffrey CLotz Alexis Dang Alfred CKuo Thomas PVail Tamara Alliston | 2019 | Bone Research2019，7，4： | 10 |
| 15 | The breast tumor microenvironment alters the phenotype and function of natural killer cells显示文摘生来的杀手(NK ) 房间是有识别并且消除转变房间的能力的天生的有免疫力的房间。在肿瘤以内,然而,许多研究把 NK 房间描述了为非功能。联系肿瘤的 NK 房间的发展阶段并且这怎么可以联系到功能,没被探索。我们从 polyoma 中间 T 抗原(pyMT ) 检验了 NK 房间的发展状态转基因的老鼠(MMTV-pMT ) 胸肿瘤。在 pyMT 肿瘤, NK 房间是不成熟的是由他们 DX5 和他们的 CD27 低 CD11b 低 显型。这些不成熟的 NK 房间也增加了 NKG2A 的表示并且表示了 NKp46, perforin,和 granzyme B 的底层。相反,从一样的老鼠孤立的脾的 NK 房间维持了他们的成熟和他们激活标记的表示。描出肿瘤微型环境是否直接改变 NK 房间,我们采纳地转移了标记的 NK 房间并且在怒气和肿瘤跟随了他们的激活地位。到达了肿瘤的 NK 房间与到达了怒气的那些相比在三天转移以内有 NKp46 的半表示。以修改肿瘤微型环境并且估计 intratumoral NK 房间的粘性,我们与 IL-12 和 anti-TGF-β 治疗了 pyMT 肿瘤;。在一星期处理以后,联系肿瘤的 NK 房间的成熟被增加;因此,显示这些房间拥有能力成熟并且变得激活。NK 房间怎么被肿瘤微型环境修改的更好的理解将帮助开发策略的 A 瞄准了对肿瘤支持有免疫力的回答。 | Tamara Krnetal Amy Gillgrass Marianne Chew Ali A. Ashkar | 2016 | Cellular & Molecular Immunology2016，13，5： | 7 |
| 16 | Paediatric cholestatic liver disease:Diagnosis,assessment of disease progression and mechanisms of fibrogenesis显示文摘Cholestatic liver disease causes significant morbidity and mortality in children.The diagnosis and management of these diseases can be complicated by an inability to detect early stages of fibrosis and a lack of adequate interventional therapy.There is no single gold standard test that accurately reflects the presence of liver disease,or that can be used to monitor fibrosis progression,particularly in conditions such as cystic fibrosis.This has lead to controversy over how suspected liver disease in children is detected and diagnosed.This review discusses the challenges in using commonly available methods to diagnose hepatic fibrosis and monitor disease progression in children with cholestatic liver disease.In addition,the review examines the mechanisms hypothesised to be involved in the development of hepatic fibrogenesis in paediatric cholestatic liver injury which may ultimately aid in identifying new modalities to assist in both disease detection and therapeutic intervention. | Tamara N Pereira Meagan J Walsh Peter J Lewindon Grant A Ramm | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 7 |
| 17 | Expression of Acyl-lipid 12-desaturase Gene in Prokaryotic and Eukaryotic Cells and Its Effect on Cold Stress Tolerance of Potato显示文摘We report the expression profile of acyl-lipid 12-desaturase (desA) gene from Synechocystis sp. PCC6803 and its effect on cell membrane lipid composition and cold tolerance in prokaryotic (Escherichia coli) and eukaryotic (Solanum tuberosum) cells. For this purpose, a hybrid of desA and reporter gene encoding thermostable lichenase (licBM3) was constructed and used to transform these cells. The expression of this hybrid gene was measured using qualitative (Petri dish test, electrophoregram and zymogram) and quantitative methods (spectrometry and gas liquid chromatography assays). The maximum level of linoleic acid in the bacterial cells containing hybrid gene was 1.9% of total fatty acids. Cold stress tolerance assays using plant damage index and growth parameters showed that cold tolerance was enhanced in primary transgenic lines because of increased unsaturated fatty acid concentration in their lipids. The greatest content of 18:2 and 18:3 fatty acids in primary transgenic plants was observed for lines 2 (73%) and 3 (41%). Finally, our results showed that desaturase could enhance tolerance to cold stress in potato, and desaturase and lichenase retain their functionality in the structure of the hybrid protein where the enzymatic activity of target gene product was higher than in the case of reporter lichenase gene absence in the construction. | Reza Maali Amiri Natalia O. Yur'eva Khristina R. Shimshilashvili Irina V. Goldenkova-Pavlova Vasiliy P. Pchelkin Elmira I. Kuznitsova Vladimir D. Tsydendambaev Tamara I. Trunova Dmitry A. Los Gholamreza Salehi Jouzani Alexander M. Nosov | 2010 | Journal of Integrative Plant Biology2010，52，3： | 6 |
| 18 | A tale of worldwide success:Behind the scenes of Carex(Cyperaceae)biogeography and diversification显示文摘The megadiverse genus Carex(c.2000 species,Cyperaceae)has a nearly cosmopolitan distribution,displaying an inverted latitudinal richness gradient with higher species diversity in cold-temperate areas of the Northern Hemisphere.Despite great expansion in our knowledge of the phylogenetic history of the genus and many molecular studies focusing on the biogeography of particular groups during the last few decades,a global analysis of Carex biogeography and diversification is still lacking.For this purpose,we built the hitherto most comprehensive Carex-dated phylogeny based on three markers(ETS-ITS-matK),using a previous phylogenomic Hyb-Seq framework,and a sampling of two-thirds of its species and all recognized sections.Ancestral area reconstaiction,biogeographic stochastic mapping,and diversification rate analyses were conducted to elucidate macroevolutionary biogeographic and diversification patterns.Our results reveal that Carex originated in the late Eocene in E Asia,where it probably remained until the synchronous diversification of its main subgeneric lineages during the late Oligocene.E Asia is supported as the cradle of Carex diversification,as well as a< | Santiago Martin-Bravo Pedro Jimenez-Mejias Tamara Villaverde Marcial Escudero Marlene Hahn Daniel Spalink Eric H.Roalson Andrew L.Hipp the Global Carex Group Carmen Benitez-Benitez Leo P.Bruederle Elisabeth Fitzek Bruce A.Ford Kerry A.Ford Mira Gamer Sebastian Gebauer Matthias H.Hoffmann Xiao-Feng Jin Isabel Larridon Etienne Ldveilld-Bourret Yi-Fei Lu Modesto Luceno Enrique Maguilla Jose Ignacio Marquez-Corro Monica Miguez Robert Naczi Anton A.Reznicek Julian R.Starr | 2019 | Journal of Systematics and Evolution2019，57，6： | 6 |
| 19 | Steal syndrome secondary to coronary artery fistulae associated with giant aneurysm显示文摘Giant coronary artery aneurysms and coronary artery fistulae are uncommon pathologies. We present the case of an elderly woman who was referred to cardiology for investigation of possible ischaemic heart disease prior to orthopaedic surgery. The patient had developed chest pain in the setting of a septic total knee replacement associated with changes on electrocardiography. Coronary angiography revealed multiple coronary arteriovenous fistulae associated with giant coronary artery aneurysm causing steal syndrome in the setting of haemodynamic stress. | Anastasia Vlachadis Castles Tamara Mogilevski Muhammad Asrar ul Haq | 2014 | World Journal of Cardiology2014，6，3： | 6 |
| 20 | New insights into the regulation of cholesterol eft from the sperm membrane显示文摘 | Tamara Leahy Bart M Gadella | 2015 | Asian Journal of Andrology2015，17，4： | 5 |
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