3篇
您的检索式：作者名="T.HUTCHINSON"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The COVID-19 pandemic and physical activity显示文摘The SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health,economy,and lifestyle.Although the virus usually first invades and infects the lung and respiratory track tissue,in extreme cases,almost all major organs in the body are now known to be negatively impacted often leading to severe systemic failure in some people.Unfortunately,there is currently no effective treatment for this disease.Pre-existing pathological conditions or comorbidities such as age are a major reason for premature death and increased morbidity and mortality.The immobilization due to hospitalization and bed rest and the physical inactivity due to sustained quarantine and social distancing can downregulate the ability of organs systems to resist to viral infection and increase the risk of damage to the immune,respiratory,cardiovascular,musculoskeletal systems and the brain.The cellular mechanisms and danger of this“second wave”effect of COVID-19 to the human body,along with the effects of aging,proper nutrition,and regular physical activity,are reviewed in this article. | Jeffrey A.Woods Noah T.Hutchinson Scott K.Powers William O.Roberts Mari Carmen Gomez-Cabrera Zsolt Radak Istvan Berkes Anita Boros Istvan Boldogh Christiaan Leeuwenburgh Helio Jose Coelho-Júnior Emanuele Marzetti Ying Cheng Jiankang Liu J.Larry Durstine Junzhi Sun Li Li Ji | 2020 | Sports Medicine and Health Science2020，2，2： | 2 |
| 2 | Peroxiredoxin: a central player in immune modulation显示文摘 | M. W.ROBINSON A. T.HUTCHINSON J. P.DALTON S.DONNELLY | 2010 | Parasite Immunology2010，，5： | 1 |
| 3 | Behavioral strategies to prevent and mitigate COVID-19 infection显示文摘The single stranded RNA virus SARS-CoV-2 has caused a massive addition to the already leading global cause of mortality,viral respiratory tract infections.Characterized by and associated with early and deleteriously enhanced production of pro-inflammatory cytokines by respiratory epithelial cells,severe COVID-19 illness has the potential to inflict acute respiratory distress syndrome and even death.Due to the fast spreading nature of COVID-19 and the current lack of a vaccine or specific pharmaceutical treatments,understanding of viral pathogenesis,behavioral prophylaxis,and mitigation tactics are of great public health concern.This review article outlines the immune response to viral pathogens,and due to the novelty of COVID-19 and the large body of evidence suggesting the respiratory and immune benefits from regular moderate intensity exercise,provides observational and mechanistic evidence from research on other viral infections that suggests strategically planned exercise regimens may help reduce susceptibility to infection,while also mitigating severe immune responses to infection commonly associated with poor COVID-19 prognosis.We propose that regular moderate intensity exercise should be considered as part of a combinatorial approach including widespread hygiene initiatives,properly planned and well-executed social distancing policies,and use of efficacious facial coverings like N95 respirators.Studies discerning COVID-19 pathogenesis mechanisms,transfer dynamics,and individual responses to pharmaceutical and adjunct treatments are needed to reduce viral transmission and bring an end to the COVID-19 pandemic. | Noah T.Hutchinson Andrew Steelman Jeffrey A.Woods | 2020 | Sports Medicine and Health Science2020，2，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员