|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Mechanisms of pulmonary edema clearance显示文摘 | Mutlu G M Sznajder J I | 2005 | Am J Physiol Lung Cell Mol Physiol2005，289，5： | 1 |
| 3 | Diabetes and periodontal dis- eases显示文摘 | Sznajder R Carraro JJ Rugna S | 2000 | J Periodontol2000，71，4： | 1 |
| 4 | Epidermal growth factor increases lung liquid clearance in rat lungs 显示文摘 | SZNAJDER J I RIDGE K M YEATES D B | 1998 | J Appl Physiol1998，85，3： | 1 |
| 5 | Mechanisms of pulmonary edema clearance显示文摘 | Mutlu GM Sznajder JI | 2005 | Am J Physiol Lung Cell Mol Physiol2005，289，5： | 1 |
| 6 | New highly efficient aziridine -functionalized tridentate sulfinyl catalysts for enantioselective diethylzinc addition to earbonyl compounds 显示文摘 | Lesniak S Rachwalski M Sznajder E | 2009 | Tetrahedron : Asymmetry2009，20，20： | 1 |
| 7 | A corpus-based evaluation of metaphors in a business English textbook English for Specific Purposes显示文摘 | Hanna Skorczynska Sznajder | 2010 | 29(1):30-422010，29，1： | 1 |
| 8 | Regulation of Na, K-ATPase during acute lung injury 显示文摘 | Lecuona E Trejo H E Sznajder J I | 2007 | J Bioenerg Biomembr2007，39，56： | 1 |
| 9 | Effects of hypoxia on the alveolar epithelium显示文摘 | Jain M Sznajder J I | 2005 | Proc Am Thorac Soc2005，2，3： | 1 |
| 10 | Central vein catheterization:failure and complication rates by three percutaneous approaches显示文摘 | Sznajder JI Zveibil FR Bitterman H | | 0，，02： | 1 |
| 11 | Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human fetal testis and ovary显示文摘 | Robinson LL Sznajder NA Riley SC | 2001 | Mol Hum Reprod2001，7，7： | 1 |
| 12 | Some P-properties for linear transformations on Euclidean Jordan algebras 显示文摘 | Gowda M S Sznajder R Tao J | 2004 | Linear Algebra and its Applications2004，393，： | 1 |
| 13 | Estimation of direct cost and resource allocation in intensive care: correlation with Omega system显示文摘 | Sznajder M Leleu G Buonamico G | 1998 | Intensive Care Med1998，24，11： | 1 |
| 14 | Mechanisms of pulmonary edema clearance during acute hypoxemic respiratory failure: role of the Na, K - ATPase 显示文摘 | Dada IA Sznajder JI | 2003 | Crit Care Med2003，6，2： | 1 |
| 15 | A corpus-based evaluation of metaphors in a business English textbook 显示文摘 | Sznajder H S | 2010 | English for Specific Purposes2010，29，1： | 1 |
| 16 | Stretch the lung and programmed cell death显示文摘 | Chandel NS Sznajder JI | 2000 | Am J Physiol2000，279，4： | 1 |
| 17 | Weak Univalence and Conneetedness of Inverse Images of Continuous Functions显示文摘 | Gowda M S Sznajder R | 1999 | Math of Operation Research1999，24，： | 1 |
| 18 | Diabetes and periodontal diseases显示文摘 | Sznajder R Carraro JJ Rugna S | 2000 | J Periodontol2000，71，4： | 1 |
| 19 | Beta(2)-agonists for treatment of pulmonary edema: Ready for clinical studies显示文摘 | Mutlu GM Sznajder JI | 2004 | Crit Care Med2004，32，7： | 1 |
| 20 | Epidermal growth factor increases lung liquid clearance in rat lungs显示文摘 | Sznajder J I Ridge K M Yeates D B | 1998 | J Appl Physiol1998，85，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员