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您的检索式：作者名="Syed Hissar"
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| 1 | Combination of pegylated interferon and lamivudine for patients with chronic hepatitis B who have failed treatment显示文摘BACKGROUND: Treatment of chronic hepatitis B (CHB) alone with interferon or lamivudine alone or in combination is effective in only a small proportion of patients. Treatment of patients in whom antiviral therapy fails is challenging. This study was made to determine the efficacy of combined pegylated interferon alpha (peg-IFN) and lamivudine in patients with CHB who had failed to respond to antiviral treatment. METHODS: Twenty patients with CHB proven by liver biopsy, with ALT levels >1.5×ULN,HBV DNA levels>141 500 copies/ml, and previous treatment failure with an adequate regimen were treated with a combination of peg-IFN 1.5μg/kg and lamivudine 100 mg/day for 52 weeks and followed up for a further 24 weeks. Biochemical response was defined as normalization of ALT and DNA response as HBV DNA<141 500 copies/ml. Secondary efficacy measures included HBsAg loss, HBeAg loss and appearance of anti-HBe (in cases of HBeAg-positive patients). RESULTS: Twenty patients were treated, of whom 16 were HBeAg positive. At 52 weeks, normal ALT was seen in 10 (50%) (8 of 16 HBeAg+ and 2 of 4 HBeAg), HBV DNA response in 5 (25%) (5 of 16 in HBeAg+ and none in HBeAg-), and HBeAg loss with appearance of anti-HBe in 5 (31.3%) of the 16 HBeAg positive patients. At 76 weeks, 8 (80%) of the 10 patients with normal ALT at 52 weeks relapsed, with normal ALT only in 2 (10%) (1 of 16 HBeAg+ and 1 of 4 HBeAg-), and all 5 patients who had a DNA response at 52 weeks relapsed at 76 weeks and had no DNA response. HBeAg loss with appearance of anti-HBe was seen in 1 (6.3%) of 16 HBeAg-positive patients. None of the patients lost HBsAg. CONCLUSIONS: The combination of peg-IFN and lamivudine for 52 weeks is not effective for treatment of CHB patients with a failed treatment. New treatment strategies need to be developed. | Shiv K.Sarin Manoj Kumar Syed Hissar Barjesh C.Sharma | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，3： | 3 |
| 2 | Impaired monocyte‐macrophage functions and defective toll‐like receptor signaling in hepatitis E virus‐infected pregnant women with acute liver failure显示文摘 | Rashi Sehgal Sharda Patra Paul David Ashish Vyas Arshi Khanam Syed Hissar Ekta Gupta Guresh Kumar Shyam Kottilil Rakhi Maiwall Shiv Kumar Sarin Nirupama Trehanpati | 2015 | Hepatology2015，，6： | 1 |
| 3 | Virologic and Histologic Features of Chronic Hepatitis B Virus-Infected Asymptomatic Patients With Persistently Normal ALT显示文摘 | Manoj Kumar Shiv K. Sarin Syed Hissar Chandana Pande Puja Sakhuja Barjesh Chander Sharma Ranjit Chauhan Sujoy Bose | 2008 | Gastroenterology2008，，5： | 1 |
| 4 | Virologic and Histologic Features of Chronic Hepatitis B Virus-Infected Asymptomatic Patients With Persistently Normal ALT显示文摘 | Manoj Kumar Shiv K. Sarin Syed Hissar Chandana Pande Puja Sakhuja Barjesh Chander Sharma Ranjit Chauhan Sujoy Bose | 2008 | Gastroenterology2008，，5： | 1 |
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