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| 1 | Human enamel thickness and ENAM polymorphism显示文摘The tooth enamel development gene, enamelin(ENAM), showed evidence of positive selection during a genome-wide scan of human and primate DNA for signs of adaptive evolution. The current study examined the hypothesis that a single-nucleotide polymorphism(SNP) C14625T(rs7671281) in the ENAM gene identified in the genome-wide scan is associated with a change in enamel phenotype. African Americans were selected as the target population, as they have been reported to have a target SNP frequency of approximately 50%, whereas non-Africans are predicted to have a 96% SNP frequency. Digital radiographs and DNA samples from 244 teeth in 133 subjects were analysed, and enamel thickness was assessed in relation to SNP status,controlling for age, sex, tooth number and crown length. Crown length was found to increase with molar number, and females were found to have thicker enamel. Teeth with larger crowns also had thicker enamel, and older subjects had thinner enamel.Linear regression and generalized estimating equations were used to investigate the relationship between enamel thickness of the mandibular molars and ENAM SNP status; enamel in subjects with the derived allele was significantly thinner(P = 0.040)when the results were controlled for sex, age, tooth number and crown length. The derived allele demonstrated a recessive effect on the phenotype. The data indicate that thinner dental enamel is associated with the derived ENAM genotype. This is the first direct evidence of a dental gene implicated in human adaptive evolution as having a phenotypic effect on an oral structure. | Diane M Daubert Joanna L Kelley Yuriy G Udod Carolina Habor Chris G Kleist Ilona K Furman Igor N Tikonov Willie J Swanson Frank A Roberts | 2016 | International Journal of Oral Science2016，8，2： | 2 |
| 2 | Aplysamine-1 and related analogs as histamine H3 receptor antagonists显示文摘 | SWANSON D M WILSON S J BOGGS J D | 2006 | Bioorg Med Chem Lett2006，16，4： | 1 |
| 3 | Infantile hemangiomas: an emerging health issue linked to an increased rate of low birth weight infants 显示文摘 | DROLET B A SWANSON E A FRIEDEN I J | 2008 | J Pediatr2008，153，5： | 1 |
| 4 | Comparison of a higher order theory for sandwich beams with finite element and elasticity analyses 显示文摘 | Swanson S R Kim J | 2000 | Journal of Sandwich Structure Material2000，2，1： | 1 |
| 5 | Monoclonal anticodies for immunoassay of avermeetins 显示文摘 | Schmidt D J Clarkson C E Swanson T A | 1990 | J Agriec Food Chem1990，38，： | 1 |
| 6 | Stage specific guidelines for surveillance after radical nephrectomy for local renal cell carcinoma 显示文摘 | LEVY D A SLATON J W SWANSON D A | 1998 | J Urol1998，159，4： | 1 |
| 7 | Low plasma D - dimer concentration predicts the absence of traumatic brain injury in children显示文摘 | SWANSON C A BURNS J C PETERSON B M | 2010 | J Trauma2010，65，5： | 1 |
| 8 | Characterization of the interlaminar fracture toughness of a laminated carbon/epoxy composite显示文摘 | Mathews M J Swanson S R | 2007 | Compos Sci Technol2007，67，： | 1 |
| 9 | Characterization of phycocyanin produced by cpcE and cpcF mutants and identification of an intergenic suppressor of the defect in bilin attachment显示文摘 | Swanson R V Zhou J Leary J A | 1992 | J Biol Chem1992，267，16： | 1 |
| 10 | Microbialinactivation of foods by pulsed electric fields显示文摘 | Castro A J Barbosa-Canovas G V Swanson B G | 1993 | J Food Proc Preserv1993，17，1： | 1 |
| 11 | Combined magnetic resonance imaging and spectroscopic imaging approach to molecular imaging of prostate cancer显示文摘 | Kurhanewicz J Swanson MG Nelson SJ | 2002 | J Magn Reson Imaging2002，16，： | 1 |
| 12 | Ecology of coarse woody debris in temperate ecosystems 显示文摘 | Harmon ME Franklin J F Swanson F J | 1986 | Advances in Ecology Research1986，15，： | 1 |
| 13 | Application of air-mercury and oil-air capillary pressure data in the study of pore structure and fluid distribution显示文摘 | Pickell J J Swanson B F Hickman W B | 1966 | SPE Journal1966，6，1： | 1 |
| 14 | Effect of high hydrostatic pressure on spores of Geoba- cillus stearothermophilus suspended in soymilk显示文摘 | Estrada-Gir6n Y Guerrero-Beltran J A Swanson B G | 2007 | J Food Process Pres2007，31，5： | 1 |
| 15 | Video-assisted thoracic surgery (VATS) resection for lung cancer显示文摘 | Scott J Swanson Hasan F Batirel | 2002 | Surgical Clinics of North America2002，，3： | 1 |
| 16 | Etiologic subtypes of attention-deficit/hyperactivity disorder:brain imaging,molecular genetic and environmental factors and the dopamine hypothesis显示文摘 | Swanson J M Kinsbourne M Nigg J | 2007 | Neuropsychol Rev2007，17，1： | 1 |
| 17 | Reliability of the Fugl-Mey- er assessment for testing motor-performance in patients following stroke 显示文摘 | Sanford J Moreland J Swanson LR | 1993 | Phys Ther1993，73，7： | 1 |
| 18 | Mechanisms of taurine antihypoxic and antioxidant action显示文摘 | Mankovskaya IN Serebrovskaya TV Swanson R J | 2000 | High Alt Med Biol2000，1，： | 1 |
| 19 | Dopamine D4 receptor gene polymorphisms is associated with attention deficit hyperactivity disorder显示文摘 | Swanson J Wigal SB | 1996 | Mol Psychiatry1996，1，： | 1 |
| 20 | T4 lymphopenia in patients with active pulmonary tuberculosis显示文摘 | Potts RC Kardjito T | 1985 | Clin Exp Immunol(Clinical & Experimental Immunology)1985，60，1： | 1 |
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