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| 1 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 2 | Model of teacher stress 显示文摘 | Kyriacou C Sutcliffe JA | 1978 | Educ Studies1978，4，： | 1 |
| 3 | Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytoki- nesis显示文摘 | Neef R Preisinger C Sutcliffe J | 2003 | J Gell Biol2003，162，5： | 1 |
| 4 | Management of symptoms in children with autism spectrum disorders: a comprehensive review of pharmacologic and complementary-alternative medicine treatments显示文摘 | Huffman L C Sutcliffe T L Tanner I S | 2011 | ~ Dev Behav Pediatr2011，32，1： | 1 |
| 5 | Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinantsn显示文摘 | Roberts M C Sutcliffe J Courvalin P | 1999 | Antimicrob Agents Chemother1999，43，： | 1 |
| 6 | The measurement of seasonality within the tourist industry: an application to tourist arrivals in Spain 显示文摘 | SUTCLIFFE C M S SINCLAIR M T | 1980 | Appl Econs1980，12，4： | 1 |
| 7 | Interface interactions between porous titanium/tantalum coatings,produced by selective laser melting (SLM),on a cobalt-chromium alloy显示文摘 | FOX P POGSON S SUTCLIFFE C J | 2008 | Suface & Coating Technology2008，202，20： | 1 |
| 8 | Teacher Stress : Prevalence, Sources and Symptoms显示文摘 | Kyriacou C Sutcliffe J | 1978 | British Journal of Educational Psychology1978，48，： | 1 |
| 9 | Assisted reproductive therapies and imprinting disorders-a preliminary British survey显示文摘 | Peters C J Bowdin S | 2006 | Hum Reprod2006，21，4： | 1 |
| 10 | Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors 显示文摘 | Sutcliffe J S Delahanty R J Prasad H C | 2005 | Am J Hum Genet2005，77，2： | 1 |
| 11 | Green tea polyphenols react with 1,1-diphenyl-2-picrylhydrazyl free radicals in the bilayer of liposomes:Direct evidence from electron spin resonance studies显示文摘 | Chen C Tang H R Sutcliffe L H | 2000 | J Agric Food Chem2000，48，11： | 1 |
| 12 | Density analysis of direct metal re-melted 316L stainless steel cubic primitives显示文摘 | MORGAN R SUTCLIFFE C J O'NEILL W | 2004 | Journal of Materials Science2004，39，： | 1 |
| 13 | Problems encountered when using high frequency financial market data:suggested solutions显示文摘 | Gwilym O Sutcliffe C | 2001 | Journal of Financial Management and Analysis2001，14，1： | 1 |
| 14 | Interface interactions between porous titanium/tantalum coatings,produced by Selective Laser Melting(SLM),on a cobalt-chromium alloy显示文摘 | Fox P Pogson S Sutcliffe C | 2008 | Surface Coatings Tech2008，20，： | 1 |
| 15 | The Dual Listing of Stock Index Futures:Arbitrage,Spread Arbitrage,and Currency Risk显示文摘 | Board J Sutcliffe C | | 0，，02： | 1 |
| 16 | Density analysis of direct metal laser re-melted 316L stainless steel cubic primitives显示文摘 | MORGAN R H SUTCLIFFE C J O'NEILL W | 2004 | Journal of Materials Science2004，39，4： | 1 |
| 17 | Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants显示文摘 | Roberts M C Sutcliffe J Courvalin P | 1999 | Antimicrob Agents Chemother1999，43，12： | 1 |
| 18 | Density analysis of direct metal laser re-melted 316L stainless steel cubic primitives显示文摘 | Morgan R Sutcliffe C J O'Neill W | 2004 | Journal of Materials Science2004，39，： | 1 |
| 19 | High density net shape components by direct laser re-melting of single-phase powders显示文摘 | MORGAN R H PAPWORTH A J SUTCLIFFE C J | 2002 | Journal of Materials Science2002，37，15： | 1 |
| 20 | A contribution to the problem of development显示文摘 | SUTCLIFFE R C | 1947 | Qurt J Meteor Soc1947，317，： | 1 |
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