|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Weight loss interventions in living donor liver transplantation as a tool in expanding the donor pool: A systematic review and metaanalysis显示文摘BACKGROUND With increasing rates of liver transplantation and a stagnant donor pool,the annual wait list removals have remained high.Living donor liver transplantation(LDLT)is an established modality in expanding the donor pool and is the primary method of liver donation in large parts of the world.Marginal living donors,including those with hepatic steatosis,have been used to expand the donor pool.However,due to negative effects of steatosis on graft and recipient outcomes,current practice excludes overweight or obese donors with more than 10%macro vesicular steatosis.This has limited a potentially important source to help expand the donor pool.Weight loss is known to improve or resolve steatosis and rapid weight loss with short-term interventions have been used to convert marginal donors to low-risk donors in a small series of studies.There is,however,a lack of a consensus driven standardized approach to such interventions.AIM To assess the available data on using weight loss interventions in potential living liver donors with steatotic livers and investigated the feasibility,efficacy,and safety of using such donors on the donor,graft and recipient outcomes.The principal objective was to assess if using such treated donor livers,could help expand the donor pool.METHODS We performed a comprehensive literature review and meta-analysis on studies examining the role of short-term weight loss interventions in potential living liver donors with hepatic steatosis with the aim of increasing liver donation rates and improving donor,graft,and recipient outcomes.RESULTS A total of 6 studies with 102 potential donors were included.Most subjects were males(71).All studies showed a significant reduction in body mass index postintervention with a mean difference of-2.08(-3.06,1.10,I2=78%).A significant reduction or resolution of hepatic steatosis was seen in 93 of the 102(91.2%).Comparison of pre-and post-intervention liver biopsies showed a significant reduction in steatosis with a mean difference of-21.22(-27.02,-15.43,I2=56%).The liver donation rates post-intervention was 88.5(74.5,95.3,I2=42%).All donors who did not undergo LDLT had either recipient reasons or had fibrosis/steatohepatitis on post intervention biopsies.Post-operative biliary complications in the intervention group were not significantly different compared to controls with an odds ratio of 0.96[(0.14,6.69),I2=0].The overall post-operative donor,graft,and recipient outcomes in treated donors were not significantly different compared to donors with no steatosis.CONCLUSION Use of appropriate short term weight loss interventions in living liver donors is an effective tool in turning marginal donors to low-risk donors and therefore in expanding the donor pool.It is feasible and safe,with comparable donor,graft,and recipient outcomes,to non-obese donors.Larger future prospective studies are needed. | Sushrut Trakroo Nakul Bhardwaj Rajat Garg Jamak Modaresi Esfeh | 2021 | World Journal of Gastroenterology2021，27，24： | 2 |
| 2 | Mortality after Hospitalization with Mild,Moderate,and Severe Hyponatremia显示文摘 | SUSHRUT S DAVID B GARY C | 2009 | Am J Med2009，122，： | 1 |
| 3 | Diagnosis, Epidemiology and Outcomes of Acute Kidney Injury显示文摘 | Sushrut S Waikar Kathleen D | 2008 | Clin J Am Soc Nephrol2008，，3： | 1 |
| 4 | Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans显示文摘 | Vishal S Vaidya Sushrut S Waikar Michael A Ferguson | 2008 | Clin Transl Sci2008，1，3： | 1 |
| 5 | Controversies in the management of intra-articular ftaetures of distal humerus in aduhs显示文摘 | Suhir B Sushrut B | 2011 | Indian J Orthop2011，17，3： | 1 |
| 6 | Covert infrared image encoding through imprinted plasmonic cavities显示文摘Functional surfaces that can control light across the electromagnetic spectrum are highly desirable.Plasmonic nanostructures can assume this role by exhibiting dimension-tunable resonances that span multiple electromagnetic regimes.However,changing these structural parameters often impacts the higher-order resonances and spectral features in lower-wavelength domains.In this study,we discuss a cavity-coupled plasmonic system with resonances that are tunable across the 3–5 or 8–14μm infrared bands while retaining near-invariant spectral properties in the visible domain.This result is accomplished by regime-dependent resonance mechanisms and their dependence on independent structural parameters.Through the identification and constraint of key parameters,we demonstrate multispectral data encoding,where images,viewable in the infrared spectral domain,appear as uniform areas of color in the visible domain—effectively hiding the information.Fabricated by large area nanoimprint lithography and compatible with flexible surfaces,the proposed system can produce multifunctional coatings for thermal management,camouflage,and anti-counterfeiting. | Daniel Franklin Sushrut Modak Abraham Vázquez-Guardado Alireza Safaei Debashis Chanda | 2018 | Light(Science & Applications)2018，7，1： | 1 |
| 7 | KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for Acute Kidney Injury显示文摘 | Paul M. Palevsky Kathleen D. Liu Patrick D. Brophy Lakhmir S. Chawla Chirag R. Parikh Charuhas V. Thakar Ashita J. Tolwani Sushrut S. Waikar Steven D. Weisbord | 2013 | American Journal of Kidney Diseases2013，，5： | 1 |
| 8 | Serum blood urea Nitrogen as an independent marker of subsequent mortality among patients with acute coronary syndromes and normal to mildly reduced glomerular Filtration Rates显示文摘 | Ajay J K David M L Sushruts W | 2005 | J Am College of Cardiology2005，45，11： | 1 |
| 9 | Outcome of critically ill patients with acute kidney injury using the Acute Kidney Injury Network criteria显示文摘 | Tal Mandelbaum Daniel J. Scott Joon Lee Roger G. Mark Atul Malhotra Sushrut S. Waikar Michael D. Howell Daniel Talmor | 2011 | Critical Care Medicine2011，，12： | 1 |
| 10 | Declining Mortality in Patients with Acute Renal Failure,1988 to 2002显示文摘 | Waikar Sushrut Curhan Gary Wald Ron | 2006 | J Am Soc Nephrol2006，17，： | 1 |
| 11 | Controversies in the management of intra-artic- ular fractures of distal humerus in adults 显示文摘 | Sudhir B Sushrut B | 2011 | Indian J Orthop2011，3，： | 1 |
| 12 | Mastitis detection: current trends and future perspectives显示文摘 | Caroline Viguier Sushrut Arora Niamh Gilmartin Katherine Welbeck Richard O’Kennedy | 2009 | Trends in Biotechnology2009，，8： | 1 |
| 13 | Mortality after Hospitalization with Mild, Moderate, and Severe Hyponatremia显示文摘 | Sushrut S. Waikar David B. Mount Gary C. Curhan | 2009 | The American Journal of Medicine2009，，9： | 1 |
| 14 | Controversies in the management of intra-articular fractures of distal humerus in adults显示文摘 | Sudhir B Sushrut B | 2011 | Indian J Orthop2011，45，3： | 1 |
| 15 | Penetrating soft palate injury by lollypop candy stick显示文摘Incidents of soft palate injury or laceration caused by unintended movement when holding a sharp object in the mouth in the pediatric population are usually rarely reported.Here we report a case of soft palate laceration in a child due to a lollypop stick tip. | Shalendra Singh Sushrut Avinash Kulkarni Nitesh Agrawal Abhishek Mishra | 2023 | Journal of Acute Disease2023，12，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员