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| 1 | Controversies in diagnosis and management of Kawasaki disease显示文摘Kawasaki disease(KD) is a common medium vessel systemic vasculitis that usually occurs in small children. It has a predilection for the coronary arteries, but other medium sized arteries can also be involved. The etiology of this disorder remains a mystery. Though typical presentation of KD is quite characteristic, it may also present as incomplete or atypical disease in which case the diagnosis can be very challenging. As both incomplete and atypical forms of KD can be associated with serious coronary artery complications, the pediatrician can ill afford to miss these diagnoses. The American Heart Association has enunciated consensus guidelines to facilitate the clinical diagnosis and treatment of this condition. However, there are still several issues that remain controversial. Intravenous immunoglobulin remains the cornerstone of management but several other treatment modalities, especially glucocorticoids, are increasingly finding favour. We review here some of the contemporary issues, and the controversies thereon, pertaining to management of KD. | Rakesh Kumar Pilania Dharmagat Bhattarai Surjit Singh | 2018 | World Journal of Clinical Pediatrics2018，7，1： | 16 |
| 2 | Platelets in Kawasaki disease:Is this only a numbers game or something beyond?显示文摘Kawasaki disease(KD)is a medium vessel vasculitis with predilection to cause coronary artery abnormalities.KD is now the most common cause of acquired heart disease in developed countries.Thrombocytosis is consistently found in patients with KD,usually in 2nd to 3rd week of illness.Thrombocytopenia has occasionally been reported in the acute phase of KD.An increase or decrease in platelet number in patients with KD was initially considered to be a benign phenomenon.However,recent literature on platelet biology in KD has suggested that platelets are not only increasing but are rather activated.This phenomenon has been found to increase the risk of thrombosis in these patients.Similarly a fall in platelet counts during acute stage of KD has also been found to be associated with increased severity of disease.In this review,we update on the current best understanding about pathogenic role of platelets in patients with KD. | Kanika Arora Sandesh Guleria Ankur Kumar Jindal Amit Rawat Surjit Singh | 2020 | Genes & Diseases2020，7，1： | 9 |
| 3 | 生物质热解渣应用于低温SCR脱硝催化剂的研究显示文摘对棉杆热解渣分别进行物理、化学及物理化学综合活化,并以它们为载体,分别负载锰铈的氧化物获得催化剂,探讨它们用于低温选择性催化还原的脱硝性能。同时对3种催化剂进行BET、NH3-TPD、H2-TPR和XRD表征研究。结果表明,经过物理化学综合法活化后所得催化剂的比表面积最大,可达到1 614 m2/g,且其微孔中孔分布最为丰富;NH3-TPD表征结果说明化学活化法所得催化剂对NH3吸附效果最佳,其次为物理化学综合活化法所得的催化剂;H2-TPR表征结果可知经化学活化法所得催化剂氧化还原性最好,其次为物理化学综合活化法所得的催化剂;脱硝试验结果可知物理化学综合活化法所得到的催化剂在低温条件下SCR活性最佳,并对结果进行了分析。 | 沈伯雄 孙喜 陈建宏 Surjit Singh 胡国丽 | 2013 | 环境科学与技术2013，36，5： | 5 |
| 4 | Sustainability Assessment and Ranking of Run of the River(RoR) Hydropower Projects Using Analytical Hierarchy Process(AHP):A Study from Western Himalayan Region of India显示文摘In the present scenario,tapping the unutilised hydropower potential is one of the highest priorities in developing countries of the world.Special emphasis is being imparted to run of the river(RoR)mode of power generation.However,the governments are now facing the dilemma whether to promote small hydropower projects(SHPs) or encourage large hydropower projects(LHPs).RoR large hydropower projects result into large scale cutting of mountains for constructing tunnels and access roads,generation of huge quantity of muck and large scale impact on flora and fauna due to diversion of rivers/streams.On the other hand,though SHPs are claimed to be greener and more sustainable by a section of researchers and energy planners but,they will be required to be set up in large number to generate equivalent amount of electricity.The aim of this study is to rank the most sustainable installed capacity range of RoR hydropower projects.To achieve this aim,the study proposes the use of quite popular multi-criteria decision making(MCDM)method of Operation Research named Analytical Hierarchy Process.A case study has been presented from Himachal Pradesh,a hydro rich state located in the western Himalayan region.As per sustainability assessment carried out in this study,hydropower projects in the capacity range 1 to 5 MW have been ranked to be the most sustainable. | Deepak KUMAR Surjit Singh KATOCH | 2015 | Journal of Mountain Science2015，12，5： | 2 |
| 5 | Pyrolysis of waste materials using TGA-MS and TGA-FTIR as complementary characterisation techniques显示文摘 | Surjit Singh Chunfei Wu Paul T. Williams | 2011 | Journal of Analytical and Applied Pyrolysis2011，，： | 1 |
| 6 | Current status and prospects of primary immunodeficiency diseases in Asia显示文摘Primary Immunodeficiency Diseases(PIDs)are increasingly being reported across the World.Several advances have been made in the diagnostic and therapeutic research related to PIDs.With increasing awareness,the field of PIDs has rapidly evolved in Asia as well.In this review,we summarize the progress that has been made in the field of PIDs in Asian countries;major limitations and challenges faced by the clinicians working in this field in Asia;difference in spectrum of PIDs in Asia from rest of the World;current state of diagnostic and treatment facilities available in various countries in Asia and the future prospects of these diseases in the continent. | Rakesh Kumar Pilania Himanshi Chaudhary Ankur Kumar Jindal Amit Rawat Surjit Singh | 2020 | Genes & Diseases2020，7，1： | 1 |
| 7 | An update on the genetics and pathogenesis of hereditary angioedema显示文摘Hereditary angioedema(HAE)is an uncommon genetic disorder characterized by recurrent episodes of edema involving subcutaneous tissue and submucosa.The pathogenesis of HAE reflects an intricate coordinated regulation of components of complement,kinin and hemostatic pathway.Till date,mutations in 4 different genes have been identified to cause HAE which includes serine protease inhibitor G1(SERPING1),factor XII(F12),plasminogen(PLG)and angiopoietin 1(ANGPT 1).These mutations lead to increased bradykinin 2 receptor mediated signalling via increased production of bradykinin except mutations in ANGPT1 gene that disturbs the cytoskeletal assembly of vascular endothelial cells.In this review we aim to summarize the recent advances in the pathogenesis and genetics of HAE.We also provide an overview of possible future prospects in the identification of new genetic defects in HAE. | Aaqib Zaffar Banday Anit Kaur Ankur Kumar Jindal Amit Rawat Surjit Singh | 2020 | Genes & Diseases2020，7，1： | 1 |
| 8 | Characteristics of biochars from crop residues: Potential for carbon sequestration and soil amendment显示文摘 | Jayne H. Windeatt Andrew B. Ross Paul T. Williams Piers M. Forster Mohamad A. Nahil Surjit Singh | 2014 | Journal of Environmental Management2014，，： | 1 |
| 9 | Novel application of cotton stalk as a waste derived catalyst in the low temperature SCR-deN Ox process显示文摘 | Singh Surjit Nahil Mohamad A Sun Xi | 2013 | Fuel2013，105，5： | 1 |
| 10 | Adipocytokine profile in children with Kawasaki disease at a mean follow-up period of 5.5 years: A study from North India显示文摘BACKGROUND Kawasaki disease(KD)is an acute self-limited vasculitis with a predilection for coronary arteries.Children with KD may have altered lipid metabolism and abnormal lipid profiles that may last for prolonged periods.However,there is a paucity of literature on the role of adipocytokines in KD.AIM To estimate the levels of adipocytokines(adiponectin,leptin and resistin)during the convalescent phase of KD.METHODS Twenty children,who had KD at least three years earlier,were enrolled in this study.In addition,20 healthy controls were also enrolled.Clinical and laboratory profiles of patients were obtained from hospital records.Serum adiponectin,leptin and resistin levels were estimated by enzyme-linked immunosorbent assay.RESULTS Mean age of the patients in the study group was 10.15±3 years and the male:female ratio was 1.5:1.Median serum resistin levels in patients with KD(27.77 ng/mL;[IQR:18.66,48.90])were decreased compared to controls(21.20 ng/mL;[IQR:14.80,27.00])(P=0.04).Median serum leptin levels in cases and controls were 1.83 ng/mL;(IQR:1.13,3.80),and 1.10 ng/mL;(IQR:0.41,2.88),respectively(P=0.09).Median serum adiponectin levels were similar in both cases(12.20μg/mL;[IQR:9.76,17.97])and controls(13.95μg/mL;[IQR:11.17,22.58]);(P=0.18).There was no significant difference in all 3 adipocytokines between children with(4/20)and without coronary artery abnormalities(16/20).CONCLUSION Serum resistin levels were significantly elevated in patients with KD during the convalescent phase compared to controls.Serum leptin levels appeared to be higher in patients with KD,although the difference was not statistically significant.Adiponectin levels were similar in both cases and controls.Raised resistin and leptin levels may partially explain lipid perturbations observed during the convalescent phase of KD. | Dibya Lochan Praharaj Amit Rawat Anju Gupta Kanika Arora Rakesh Kumar Pilania Sagar Bhattad Surjit Singh | 2022 | World Journal of Clinical Pediatrics2022，11，4： | 1 |
| 11 | Primary Immune Deficiencies e A rapidly emerging area of basic and clinical research显示文摘In this special issue of Genes&Diseases,Primary Immune Deficiencies(PIDs)are the main focus.This is an exciting and a rapidly emerging field of basic and clinical immunology wherein upwards of 400 clinical conditions,with approximately 350 defined mutations,are now recognized.Contrary to common perception,PIDs as a group are not uncommon.Epidemiologic studies show that population prevalence of PIDs is approximately 1:2000.Statistical extrapolations of this figure would suggest that in a large country like China or India,approximately 1 million individuals would be expected to have a PID.However,at present because of lack of awareness of these conditions amongst both the laity as well as medical professionals,majority of these patients remain undiagnosed and untreated in many developing countries.This is clearly unfortunate. | Surjit Singh Xiaodong Zhao Huijie Zhang | 2020 | Genes & Diseases2020，7，1： | 0 |
| 12 | Emerging role of computed tomography coronary angiography in evaluation of children with Kawasaki disease显示文摘Coronary artery abnormalities are the most important complications in children with Kawasaki disease(KD).Two-dimensional transthoracic echocardiography currently is the standard of care for initial evaluation and follow-up of children with KD.However,it has inherent limitations with regard to evaluation of mid and distal coronary arteries and,left circumflex artery and the poor acoustic window in older children often makes evaluation difficult in this age group.Catheter angiography(CA)is invasive,has high radiation exposure and fails to demonstrate abnormalities beyond lumen.The limitations of echocardiography and CA necessitate the use of an imaging modality that overcomes these problems.In recent years advances in computed tomography technology have enabled explicit evaluation of coronary arteries along their entire course including major branches with optimal and acceptable radiation exposure in children.Computed tomography coronary angiography(CTCA)can be performed during acute as well as convalescent phases of KD.It is likely that CTCA may soon be considered the reference standard imaging modality for evaluation of coronary arteries in children with KD. | Manphool Singhal Rakesh Kumar Pilania Pankaj Gupta Nameirakpam Johnson Surjit Singh | 2023 | World Journal of Clinical Pediatrics2023，12，3： | 0 |
| 13 | Radiation dose analysis of computed tomography coronary angiography in Children with Kawasaki disease显示文摘BACKGROUND There is evolving role of computed tomography coronary angiography(CTCA)in non-invasive evaluation of coronary artery abnormalities in children with Kawasaki disease(KD).Despite this,there is lack of data on radiation dose in this group of children undergoing CTCA.AIM To audit the radiation dose of CTCA in children with KD.METHODS Study(December 2013-February 2018)was performed on dual source CT scanner using adaptive prospective electrocardiography-triggering.The dose length product(DLP in milligray-centimeters-mGy.cm)was recorded.Effective radiation dose(millisieverts-mSv)was calculated by applying appropriate age adjusted conversion factors as per recommendations of International Commission on Radiological Protection.Radiation dose was compared across the groups(0-1,1-5,5-10,and>10 years).RESULTS Eighty-five children(71 boys,14 girls)with KD underwent CTCA.The median age was 5 years(range,2 mo-11 years).Median DLP and effective dose was 21 mGy.cm,interquartile ranges(IQR)=15(13,28)and 0.83 mSv,IQR=0.33(0.68,1.01)respectively.Mean DLP increased significantly across the age groups.Mean effective dose in infants(0.63 mSv)was significantly lower than the other age groups(1-5 years 0.85 mSv,5-10 years 1.04 mSv,and>10 years 1.38 mSv)(P<0.05).There was no significant difference in the effective dose between the other groups of children.All the CTCA studies were of diagnostic quality.No child required a repeat examination.CONCLUSION CTCA is feasible with submillisievert radiation dose in most children with KD.Thus,CTCA has the potential to be an important adjunctive imaging modality in children with KD. | Mahesh Chandra Bhatt Manphool Singhal Rakesh Kumar Pilania Subhash Chand Bansal Niranjan Khandelwal Pankaj Gupta Surjit Singh | 2023 | World Journal of Clinical Pediatrics2023，12，4： | 0 |
| 14 | An analysis of tourist’s perceptions toward tourism development:Study of cold desert destination,India显示文摘Tourism impacts on society are complex and mixed.However,they are vital to diverse societies,clusters,and individuals dependent upon their morals,attitudes,and resources existing for tourism development.Increasing tourism also brings many problems.Hence,tourist experience is fundamental for destination image and devel-opment.This research examines tourist perceptions and attitudes toward tourism impacts in Chitkul,Kalpa,and Nako in Kinnaur.Random sampling has been used to measure tourist responses on a range of indicators related to tourism development.Likert scale responses were analyzed using factor analysis,ANOVA,Mann-Whitney U-test,Kolmogorov test,and descriptive statistics.The results confirmed that tourists do not perceive any type of pollu-tion or societal barriers.They observed that natural magnetism and the socio-cultural milieu of the destination is what attracts tourists.However,tourists are not satisfied with‘networking services’,‘organization efforts’,‘sup-plementary conveniences’,and‘carriage concerns’at selected destinations in Kinnaur.Moreover,Chitkul emerged as the top tourist destination in Kinnaur.Since the destination would emerge as a hub of tourist activities shortly considering the congestion and exploitation of nearby tourist destinations at Kulu-Manali-Rohtang in Beas Valley.Hence,the assessment of tourist perceptions can be used as an indicator of tourism destination competitiveness and can assist in developing appropriate tourism policies and infrastructure upgrades. | Ravinder Jangra S.P.Kaushik Surjit Singh Saini | 2021 | Geography and Sustainability2021，2，1： | 0 |
| 15 | 倒格子空间中的克罗尼格-潘奈模型显示文摘 | Surjit Singh 俞志毅 | 1984 | 大学物理1984，0，12： | 0 |
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