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| 1 | Liposome based drug delivery as a potential treatment option for Alzheimer’s disease显示文摘Alzheimer’s disease is a neurodegenerative condition leading to atrophy of the brain and robbing nearly 5.8 million individuals in the United States age 65 and older of their cognitive functions.Alzheimer’s disease is associated with dementia and a progressive decline in memory,thinking,and social skills,eventually leading to a point that the individual can no longer perform daily activities independently.Currently available drugs on the market temporarily alleviate the symptoms,however,they are not successful in slowing down the progression of Alzheimer’s disease.Treatment and cures have been constricted due to the difficulty of drug delivery to the blood-brain barrier.Several studies have led to identification of vesicles to transport the necessary drugs through the blood-brain barrier that would typically not achieve the targeted area through systemic delivered medications.Recently,liposomes have emerged as a viable drug delivery agent to transport drugs that are not able to cross the blood-brain barrier.Liposomes are being used as a component of nanoparticle drug delivery;due to their biocompatible nature;and possessing the capability to carry both lipophilic and hydrophilic therapeutic agents across the blood brain barrier into the brain cells.Studies indicate the importance of liposomal based drug delivery in treatment of neurodegenerative disorders.The idea is to encapsulate the drugs inside the properly engineered liposome to generate a response of treatment.Liposomes are engineered to target specific diseased moieties and also several surface modifications of liposomes are under research to create a clinical path to the management of Alzheimer’s disease.This review deals with Alzheimer’s disease and emphasize on challenges associated with drug delivery to the brain,and how liposomal drug delivery can play an important role as a drug delivery method for the treatment of Alzheimer’s disease.This review also sheds some light on variation of liposomes.Additionally,it emphasizes on the liposomal formulations which are currently researched or used for treatment of Alzheimer’s disease and also discusses the future prospect of liposomal based drug delivery in Alzheimer’s disease. | Carely Hernandez Surabhi Shukla | 2022 | Neural Regeneration Research2022，17，6： | 3 |
| 2 | Plasma cathepsin L:A prognostic marker for pancreatic cancer显示文摘AIM:To assess the prognostic significance of cathepsin L,a cysteine protease that degrades the peri-tumoral tissue,in patients with pancreatic cancer.METHODS:Plasma samples from 127 pancreatic cancer patients were analyzed for cathepsin L levels by ELISA.Out of these patients,25 underwent surgeryand their paraffin-embedded tissue was analyzed for cathepsin L expression by immunohistochemistry.Survival of patients and clinicopathological parameters was correlated with cathepsin L expression in plasma and tissue using appropriate statistical analysis.RESULTS:The mean(±SD)cathepsin L in plasma samples of pancreatic cancer patients was 5.98±2.5ng/m L that was significantly higher compared to the levels in healthy controls(3.83±0.45)or chronic pancreatitis patients(3.97±1.06).Using ROC curve,a cut-off level of 5.0 ng/m L was decided for survival analysis.Elevated plasma levels of cathepsin L were found to be associated with poor prognosis(P=0.01)in multivariate analysis.The plasma levels of the protease decreased after surgery.Though no significant correlation was seen between plasma and tissue expression of this protease,a trend did emerge that high cathepsin L expression in tissue correlated with its high levels in plasma.CONCLUSION:Cathepsin L levels in plasma of pancreatic cancer patients may be used as a potential prognostic marker for the disease. | Nidhi Singh Prasenjit Das Surabhi Gupta Vikas Sachdev Siddhartha Srivasatava Siddhartha Datta Gupta Ravindra Mohan Pandey Peush Sahni Shyam S Chauhan Anoop Saraya | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 3 | Prognostic Significance of Extracellular Matrix Degrading Enzymes—Cathepsin L and Matrix Metalloproteases-2 [MMP-2] in Human Pancreatic Cancer显示文摘 | Nidhi Singh Prasenjit Das Siddhartha Datta Gupta Peush Sahni R. M. Pandey Surabhi Gupta Shyam S. Chauhan Anoop Saraya | 2013 | Cancer Investigation2013，，7： | 2 |
| 4 | Fabrication of Graphitic Carbon Nitride-Based Film:An Emerged Highly Efficient Catalyst for Direct C-H Arylation under Solar Light显示文摘Main observation and conclusion Photoredox C-H bond formation can proceed in aerobic environment under solar light and has therefore become attractive.Nowa-days,different types of expensive novel metal complexes and nanomaterials have been urbanized as photocatalysts for direct C-H bond formation in between derivatives of heteroarenes(HAs)and aryl diazonium salts.These photocatalysts,however,still suffer from poor stability,high cost,and decay.Herein,a graphitic carbon nitride-based fluorescein isothiocyanate(g-C_(3)N_(4)-FITC)film pho-tocatalyst has been reported,which shows ecellent light harvesting ability,and band gap suitability to catalyze the metal free direct C-H arylation of HAs under solar light at ambient temperature.Moreover,the g-C_(3)N_(4)-FITC film photocatalyst can be reused four times without significant loss of activity,confirming the excellent photocatalytic stability.The current strategy to constructa g-C_(3)N_(4)-FITC film photocatalyst for direct C-H arylation opens a new path towards replacing metal-based catalysts in fine chemical Sy nthesis. | Surabhi Chaubey Rajesh K.Yadav Tae Wu Kim Tara Chand Yadav Abhishek Kumar D.K.Dwivedi B.K.Pandey Atul P.Singh | 2021 | Chinese Journal of Chemistry2021，39，3： | 2 |
| 5 | Is liver transplantation a risk factor for cardiovascular disease? a meta‐analysis of observational studies显示文摘 | Surabhi Madhwal Ashish Atreja Mazen Albeldawdi Rocio Lopez Anthony Post Marco A. Costa | 2012 | Liver Transpl2012，，10： | 2 |
| 6 | A clinical and rsdiologic review of uncommon ty pes and causes of pancreatitis显示文摘 | Shanbhogue AK Fasih N Surabhi VR | | 0，，： | 1 |
| 7 | Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells显示文摘 | Verma UN Surabhi RM Schmaltieg A | 2003 | Clin Cancer Res2003，9，4： | 1 |
| 8 | Benign renal neoplasms in adults: cross-sectional imaging findings 显示文摘 | Prasad SR Surabhi VR Menias CO | 2008 | AJR2008，190，1： | 1 |
| 9 | RNA interference directed against viral and cellular targets inhibits human immu-nodeficiency Virus Type 1 replication 显示文摘 | SURABHI R M GAYNOR R B | 2002 | J Virol2002，76，12： | 1 |
| 10 | Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells显示文摘 | Verma UN Surabhi RM Schmaltieg A | 2003 | Clin Cancer Res2003，9，： | 1 |
| 11 | Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells 显示文摘 | VERMA UN SURABHI RM SCHMALTIEG A | 2003 | Clin Cancer Res2003，9，4： | 1 |
| 12 | Small interfering RNAs directed against β-catenin inhibit the in vitro and in vivo growth of colon cancer cells 显示文摘 | Verma UN Surabhi RM Schmaltieg A | 2003 | Clin Cancer Res2003，9，4： | 1 |
| 13 | TAK1 is critical for I kappa B kinase-mediated activation of the NF-kappaB pathway显示文摘 | Surabhi R M Park K J | 2003 | J Mol Biol2003，326，1： | 1 |
| 14 | Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells 显示文摘 | Verma U N Surabhi R M Scbmaltieg A | 2003 | Clin Cancer Res2003，9，4： | 1 |
| 15 | Successful large-volume cerebrospinal fluid aspiration for an accidental overdose of intrathecal cytarabine显示文摘 | Gerges M Muhanad A Surabhi A | 2013 | Med Oncol2013，30，5： | 1 |
| 16 | RNA interference directed against viral and cellular targets inhibits human immunodeficiency virus typel replication 显示文摘 | Surabhi RM Gaynor RB | 2002 | J Viro12002，76，12： | 1 |
| 17 | TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway 显示文摘 | Takaesu G Surabhi R M Park K J | 2003 | J Mol Biol2003，326，1： | 1 |
| 18 | Salt stress - in- duced alterations in the root proteome of barley genotypes with con- trasting response towards salinity显示文摘 | Witzel K Surabhi G K Jyothsnakumari G | 2009 | Journal of Experimental Bota- ny2009，60，12： | 1 |
| 19 | Gallbladder Lesions Identified on Ultrasound. Lessons from the Last 10?Years显示文摘 | Ioannis T. Konstantinidis Surabhi Bajpai Avinash R. Kambadakone Kenneth K. Tanabe David L. Berger Hui Zheng Dushyant V. Sahani Gregory Y. Lauwers Carlos Fernandez-del Castillo Andrew L. Warshaw Cristina R. Ferrone | 2012 | Journal of Gastrointestinal Surgery2012，，3： | 1 |
| 20 | RNA interference directed against viral and cellular targets inhibits human immunodeficiency virus type 1replication显示文摘 | Surabhi R M Gaynor R B | 2002 | J Virol2002，76，12： | 1 |
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