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| 1 | Arctic Sea Ice and Eurasian Climate:A Review显示文摘The Arctic plays a fundamental role in the climate system and has shown significant climate change in recent decades,including the Arctic warming and decline of Arctic sea-ice extent and thickness. In contrast to the Arctic warming and reduction of Arctic sea ice, Europe, East Asia and North America have experienced anomalously cold conditions, with record snowfall during recent years. In this paper, we review current understanding of the sea-ice impacts on the Eurasian climate.Paleo, observational and modelling studies are covered to summarize several major themes, including: the variability of Arctic sea ice and its controls; the likely causes and apparent impacts of the Arctic sea-ice decline during the satellite era,as well as past and projected future impacts and trends; the links and feedback mechanisms between the Arctic sea ice and the Arctic Oscillation/North Atlantic Oscillation, the recent Eurasian cooling, winter atmospheric circulation, summer precipitation in East Asia, spring snowfall over Eurasia, East Asian winter monsoon, and midlatitude extreme weather; and the remote climate response(e.g., atmospheric circulation, air temperature) to changes in Arctic sea ice. We conclude with a brief summary and suggestions for future research. | GAO Yongqi SUN Jianqi LI Fei HE Shengping Stein SANDVEN YAN Qing ZHANG Zhongshi Katja LOHMANN Noel KEENLYSIDE Tore FUREVIK SUO Lingling | 2015 | Advances in Atmospheric Sciences2015，32，1： | 21 |
| 2 | Vision,application scenarios,and key technology trends for 6G mobile communications显示文摘With the global commercialization of the fifth-generation(5G)network,many countries,including China,USA,European countries,Japan,and Korea,have started exploring 6G mobile communication network,following the tradition of“planning the next while commercializing one generation”.Currently,studies on 6G networks are at the infancy stage.Research on the vision and requirements for 6G is still ongoing,and the industry is yet to clarify the key enabling technologies for 6G.However,6G will certainly build on the success of 5G.Therefore,developing high-quality 5G networks and seamlessly integrating 5G with verticals are the priorities before 2030,when 6G is projected to be commercialized.Also,global 5G standards will keep evolving to better support vertical applications.As a milestone,the Third-Generation Partnership Project(3GPP)published Release 16 in July 2020,which continuously enhanced the capabilities of mobile broadband service based on Release 15 and realized the support for low-delay and high-reliability applications,such as Internet of Vehicles and industrial Internet.Currently,3GPP is working on Releases 17 and 18,focusing on meeting the demands of medium-and high-data-rate machine communication with low-cost and high-precision positioning,which will be published in June 2022.Thus,6G networks will further expand the application fields and scope of the Internet of Things to accommodate those services and applications that are beyond the capabilities of 5G networks.Herein,we present our vision,application scenarios,and key technological trends for 6G networks.Furthermore,we propose several future research opportunities in 6G networks with regard to industrialization and standardization. | Zhiqin WANG Ying DU Kejun WEI Kaifeng HAN Xiaoyan XU Guiming WEI Wen TONG Peiying ZHU Jianglei MA Jun WANG Guangjian WANG Xueqiang YAN Jiying XIANG He HUANG Ruyue LI Xinhui WANG Yingmin WANG Shaohui SUN Shiqiang SUO Qiubin GAO Xin SU | 2022 | Science China(Information Sciences)2022，65，5： | 17 |
| 3 | Evaluation of malignancy using Ki-67,p53,EGFR and COX-2 expressions in gastrointestinal stromal tumors显示文摘AIM:To investigate the role of expressions of Ki-67, p53,epidermal growth factor receptor(EGFR)and cyclooxygenase-2(COX-2)in gastrointestinal stromal tumor(GIST)grading and prognosis. METHODS:Tumor tissue was collected retrospectively from 96 patients with GIST.Antibodies against Ki-67, p53,EGFR and COX-2 were used for immunohistochemical staining.Tumor grading was designated according to a consensus system and the staining was quantified in 3 categories for each antibody in the statistical analysis. RESULTS:The Ki-67 expression in GISTs was significantly associated with the size of the tumors,mitotic rate and the risk of malignancy(x2=15.51,P=0.02; x2=22.27,P<0.001;x2=20.05;P<0.001).The p53 expression was also significantly correlated with mitotic rate and the risk of malignancy(x2=9.92,P= 0.04;x2=9.97;P=0.04).Over-expression of Ki-67 was strongly correlated with poor survival(x2=10.44, P=0.006),but no correlation was found between the expression of p53,EGFR or COX-2 and survival. Multivariate analysis further demonstrated that Ki-67 expression(relative risk=15.78,95%CI:4.25-59.37) could be used as an independent prognostic value for GIST patients.Adjuvant imatinib therapy could improve clinical outcomes in the patients with high risk and intermediate risk of recurrence after complete tumor resections(median survival time:52 mo vs 37 mo, x2=7.618,P=0.006). CONCLUSION:Our results indicated that the expression of Ki-67 could be used as an independent prognostic factor for GIST patients. | Jing Jiang Mei-Shan Jin Jian Suo Yin-Ping Wang Liang He Xue-Yuan Cao | 2012 | World Journal of Gastroenterology2012，18，20： | 13 |
| 4 | Cerebral mechanism of puncturing at He-Mu point combination for functional dyspepsia: study protocol for a randomized controlled parallel trial显示文摘Acupuncture is widely used to treat functional dyspepsia with satisfactory outcomes. Combination of the He and Mu acupoints is commonly used and has a synergistic effect on functional dyspepsia; however, its underlying mechanisms remain unclear. Therefore, a randomized controlled parallel clinical trial is currently underway at Chengdu University of Traditional Chinese Medicine, China. This trial is designed to explore the efficacy of and central responses to the He-Mu point combination in patients with functional dyspepsia using functional magnetic resonance imaging. A total of 105 patients with functional dyspepsia will be allocated into 3 groups: the low-He point group(puncturing at Zusanli(ST36)), Mu point group(puncturing at Zhongwan(CV12)), and He-Mu point combination group(puncturing at ST36 and CV12). Every participant will receive 20 sessions of manual acupuncture for 4 weeks. The needles will be inserted perpendicularly to a depth of 1 to 2 cun. The angle of rotation and twisting will range from 90 to 180 degrees, while lifting and thrusting will range from 0.3 to 0.5 cm. The various manipulations will be performed 60 to 90 times per minute. The needles will remain in place for 30 minutes, during which manipulation will be applied every 10 minutes. Magnetic resonance imaging will be performed before and after 20 sessions of acupuncture. The primary outcome is symptom improvement according to the Chinese version of the Nepean Dyspepsia Index. Secondary outcomes include the Leeds dyspepsia questionnaire, Self-Rating Anxiety Scale, Self-Rating Depression Scale, Beck Anxiety Inventory, Beck Depression Inventory, and visual analogue scale scores before and after 10 and 20 sessions of acupuncture. Needle sensation and adverse events will be used to assess the therapeutic effects. This study will promote more widespread awareness of the benefits of acupoint combination in the clinical setting and provide a further explanation of the neuromechanism by which acupuncture at the He-Mu point combination for functional dyspepsia. Registration: Chinese Clinical Trial Registry, Chi CTR-IOR-15006402. | Shuai Yin Yuan Chen Du Lei Rui-rui Sun Ting-ting Ma Pei-min Feng Zhao-xuan He Xue-ling Suo Pei-hong Ma Yu-zhu Qu Ke Qiu Miao-miao Jing Qi-yong Gong Fan-rong Liang Jiao Chen Fang Zeng | 2017 | Neural Regeneration Research2017，12，5： | 9 |
| 5 | Radiofrequency ablation technique eradicating palpebral margin neoplasm显示文摘·AIM:To report the study on radiofrequency ablation technique for eradication of palpebral margin neoplasm and its clinical effects.·METHODS:One hundred and six cases with the palpebral margin neoplasm were performed surgical removal with radiofrequency ablation technique.The 1-2 months postoperative follow-up was investigated and the lost cases were excluded from statistics.The continuing follow-up lasted about 6-16months.·RESULTS:One hundred cases underwent one treatment and 6 cases underwent two treatments.Six cases were missed.All the cases followed up healed well without pigmentation or scar left,nor eyelash loss or palpebral margin deformation.No case was recurrent.·CONCLUSION:Radiofrequency ablation has significant efficiency in eradicating the palpebral margin neoplasm.· | Tian-Yu Jiang, Hong-Yu Xiao | 2011 | International Journal of Ophthalmology(English edition)2011，4，2： | 7 |
| 6 | In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells显示文摘Circulating tumor cells(CTCs)is an established biomarker of cancer metastasis.The circulation dynamics of CTCs are important for understanding the mechanisms underlying tumor cell dissemination.Although studies have revealed that the circadian rhythm may disrupt the growth of tumors,it is generally unclear whether the circadian rhythm controls the release of CTCs.In clinical examinations,the current in vitro methods for detecting CTCs in blood samples are based on a fundamental assumption that CTC counts in the peripheral blood do not change significantly over time,which is being challenged by recent studies.Since it is not practical to draw blood from patients repeatedly,a feasible strategy to investigate the circadian rhythm of CTCs is to monitor them by in vivo detection methods.Fluoresce nee in vivo flow cytometry(IVFC)is a powerful optical technique that is able to detect fluoresce nt circulating cells directly in living animals in a noninvasive manner over a long period of time.In this study,we applied fluorescence IVFC to monitor CTCs noninvasively in an orthotopic mouse model of human prostate cancer.We observed that CTCs exhibited stochastic bursts over cancer progression.The probability of the bursting activity was higher at early stages than at late stages.We longitudinally monitored CTCs over a 24-h period,and our results revealed striking daily oscillations in CTC counts that peaked at the onset of the night(active phase for rodents),suggesting that the release of CTCs might be regulated by the circadian rhythm. | Xi Zhu Yuanzhen Suo Yuting Fu Fuli Zhang Nan Ding Kai Pang Chengying Xie Xiaofu Weng Meilu Tian Hao He Xunbin Wei | 2021 | Light(Science & Applications)2021，10，6： | 6 |
| 7 | Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing显示文摘Targeting immune checkpoints such as programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for treating melanoma,gastric cancer(GC)and bladder cancer with clinical benefit.Nevertheless,many patients failed to respond to anti-PD-1/PD-L1 treatment,so it is necessary to seek an alternative strategy for traditional PD-1/PD-L1 targeting immunotherapy.Here with the data from The Cancer Genome Atlas(TCGA)and our in-house tissue library,PD-L1 expression was found to be positively correlated with the expression of ubiquitin-specific processing protease 7(USP7)in GC.Furthermore,USP7 directly interacted with PD-L1 in order to stabilize it,Gastric cancer;Immunosuppression;Cancer biologywhile abrogation of USP7 attenuated PD-L1/PD-1 interaction and sensitized cancer cells to T cell killing in vitro and in vivo.Besides,USP7 inhibitor suppressed GC cells proliferation by stabilizing P53 in vitro and in vivo.Collectively,our findings indicate that in addition to inhibiting cancer cells proliferation,USP7 inhibitor can also downregulate PD-L1 expression to enhance anti-tumor immune response simultaneously.Hence,these data posit USP7 inhibitor as an anti-proliferation agent as well as a novel therapeutic agent in PD-L1/PD-1 blockade strategy that can promote the immune response of the tumor. | Zhiru Wang Wenting Kang Ouwen Li Fengyu Qi Junwei Wang Yinghua You Pengxing He Zhenhe Suo Yichao Zheng Hong-Min Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 5 |
| 8 | Differentiation renders susceptibility to excitotoxicity in HT22 neurons显示文摘HT22 is an immortalized mouse hippocampal neuronal cell line that does not express cholinergic and glutamate receptors like mature hippocampal neurons in vivo.This in part prevents its use as a model for mature hippocampal neurons in memory-related studies.We now report that HT22 cells were appropriately induced to differentiate and possess properties similar to those of mature hippocampal neurons in vivo,such as becoming more glutamate-receptive and excitatory.Results showed that sensitivity of HT22 cells to glutamate-induced toxicity changed dramatically when comparing undifferentiated with differentiated cells,with the half-effective concentration for differentiated cells reducing approximately two orders of magnitude.Moreover,glutamate-induced toxicity in differentiated cells,but not undifferentiated cells,was inhibited by the N-methyl-Daspartate receptor antagonists MK-801 and memantine.Evidently,differentiated HT22 cells expressed N-methyl-D-aspartate receptors,while undifferentiated cells did not.Our experimental findings indicated that differentiation is important for immortalized cell lines to render post-mitotic neuronal properties,and that differentiated HT22 neurons represent a better model of hippocampal neurons than undifferentiated cells. | Minchao He Jun Liu haowu Cheng Yigang Xing William Z Suo | 2013 | Neural Regeneration Research2013，8，14： | 3 |
| 9 | Reaction characteristic of PTFE/Al/Cu/Pb composites and application in shaped charge liner显示文摘In this paper, the reaction characteristic and its application in shaped charge warhead of a novel reactive material, which introduced copper(Cu) and plumbum(Pb) into traditional polytetrafluoroethylene/aluminum(PTFE/Al), are studied. The thermal analysis and chemical reaction behavior of the PTFE/Al/Cu/Pb mixture are investigated by Differential Scanning Calorimetry(DSC),Thermo-gravimetry(TG), and Xray Diffraction(XRD) techniques. Then, the shaped charge liners with PTFE/Al/Cu/Pb reactive materials are fabricated, and the X-ray experiments show that they could form reactive jets with excellent performance under the detonation effects of the shaped charge. Based on that, the penetration experiments of shaped charge with PTFE/Al/Cu/Pb reactive liner against steel plates are carried out, and the results demonstrate that the PTFE/Al/Cu/Pb reactive jets could produce a deeper penetration depth compared to the traditional PTFE/Al reactive jets. Meanwhile, the PTFE/Al/Cu/Pb reactive jets also show significant inner-blast effects, leading to dramatically cracking or fragmentation behavior of the penetrated steel plates. This new PTFE/Al/Cu/Pb reactive liner shaped charge presents enhanced penetration behavior for steel targets that incorporates the penetration capability of a high-density and ductility jet, and the chemical energy release of PTFE-matrix reactive materials. | Huan-Guo Guo Yuan-feng Zheng Suo He Qing-Bo Yu Chao Ge Hai-fu Wang | 2022 | Defence Technology(防务技术)2022，18，9： | 3 |
| 10 | Reply to Comment on “In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells”显示文摘Dear Editor,We thank Niedre et al.for their correspondence regarding our recent paper1.They proposed a point that the temporal distribution of circulating tumor cells(CTCs)monitored by diffuse in vivo flow cytometry in a multiple myeloma mouse model in their previous work2 might be different from our results.Niedre et al.claimed that CTC detection statistics deviated from Poisson but did not found circadian variations in CTC numbers in a multiple myeloma mouse model.They also cite another literature by Juratli.et al.3,in which the authors reported that CTC numbers did not always correlate with tumor size during cancer progression.However,by establishing an orthotopic mouse model of prostate cancer and utilizing the technology in vivo flow cytometry(IVFC),we found CTCs exhibited bursting activity and daily oscillation in an orthotopic model of prostate cancer. | Xi Zhu Yuanzhen Suo Yuting Fu Fuli Zhang Nan Ding Kai Pang Chengying Xie Xiaofu Weng Meilu Tian Hao He Xunbin Wei | 2021 | Light(Science & Applications)2021，10，10： | 2 |
| 11 | Stratifin promotes renal dysfunction in ischemic and nephrotoxic AKI mouse models via enhancing RIPK3-mediated necroptosis显示文摘Stratifin(SFN)is a member of the 14-3-3 family of highly conserved soluble acidic proteins,which regulates a variety of cellular activities such as cell cycle,cell growth and development,cell survival and death,and gene transcription.Acute kidney injury(AKI)is prevalent disorder characterized by inflammatory response,oxidative stress,and programmed cell death in renal tubular epithelial cells,but there is still a lack of effective therapeutic target for AKI.In this study,we investigated the role of SFN in AKI and the underlying mechanisms.We established ischemic and nephrotoxic AKI mouse models caused by ischemia–reperfusion(I/R)and cisplatin,respectively.We conducted proteomic and immunohistochemical analyses and found that SFN expression levels were significantly increased in AKI patients,cisplatin-or I/R-induced AKI mice.In cisplatin-or hypoxia/reoxygenation(H/R)-treated human proximal tubule epithelial cells(HK2),we showed that knockdown of SFN significantly reduced the expression of kidney injury marker Kim-1,attenuated programmed cell death and inflammatory response.Knockdown of SFN also significantly alleviated the decline of renal function and histological damage in cisplatin-caused AKI mice in vivo.We further revealed that SFN bound to RIPK3,a key signaling modulator in necroptosis,to induce necroptosis and the subsequent inflammation in cisplatin-or H/R-treated HK2 cells.Overexpression of SFN increased Kim-1 protein levels in cisplatin-treated MTEC cells,which was suppressed by RIPK3 knockout.Taken together,our results demonstrate that SFN that enhances cisplatin-or I/R-caused programmed cell death and inflammation via interacting with RIPK3 may serve as a promising therapeutic target for AKI treatment. | Fang Wang Jia-nan Wang Xiao-yan He Xiao-guo Suo Chao Li Wei-jian Ni Yu-ting Cai Yuan He Xin-yun Fang Yu-hang Dong Tian Xing Ya-ru Yang Feng Zhang Xiang Zhong Hong-mei Zang Ming-ming Liu Jun Li Xiao-ming Meng Juan Jin | 2022 | Acta Pharmacologica Sinica2022，43，2： | 2 |
| 12 | Extraction of coal-tar pitch using NMP/ILs mixed solvents显示文摘Coal-tar pitch(CP)is a promising carbon raw material for producing needle coke,carbon fiber etc.During processing,the H/C ratio,ash content,and quinoline insoluble(QI)in the CP are the key factors that influence the material preparation.In this study,NMP was selected to extract CP first;then[BMIM]Cl/NMP mixed solvent was used;and finally a series of ionic liquids(ILs)mixtures with NMP were developed for the extraction of CP to obtain the refined pitch.The extracts were analyzed via elemental analysis,TGA,FT-IR,and 13C-NMR.Results indicate that different NMP/IL mass ratios or different kinds of ILs have impact on the extraction yield.The relationship of the hydrogen to carbon(H/C)ratio changed with different solvents and QI extracts were obtained.Results showed that the H/C ratios changed little between NMP extracts and could be adjusted by changing the NMP/ILs mass ratio or using different ILs.The extracts are suitable for preparation mesophase pitch because of no ash content,low QI,and appropriate H/C ratios.As a result,NMP can be used to refine pitch.In addition,[BMIM]Cl is good mixed with NMP for CP extraction,because it can obtain a relatively high yield under the same extraction conditions. | HUANG Jin Cheng LI Chun Shan BAI Lu NIE Yi WANG Er Qiang HE Yu Jian ZHANG Suo Jiang | 2014 | Science China Chemistry2014，57，12： | 2 |
| 13 | Analysis of energy efficiency of air in atomizing pseudoplastic liquid using a specially designed prefilming airblast atomizer 显示文摘 | He W Z Jiang Z H Suo Q L | 2003 | Ind Eng Chem Res2003，42，13： | 1 |
| 14 | Development of a monoclonal antibody- based ELISA for detection of sulfamethazine and N4-acetyl sulfamethazine in chicken breast muscle tissue显示文摘 | He J H Shen J Z Suo X | 2005 | J Food Science2005，70，： | 1 |
| 15 | A multiplex real-time polymerase chain reaction for simultaneous detection of Salmonella spp, Escherichia coli O157, and Listeria monocytogenes in meat products显示文摘 | SUO B HE Y TU SI | 2010 | Foodborne Pathog Dis2010，7，6： | 1 |
| 16 | Fault Diagnosis of Rotating Machinery Based on Im- proved Wavelet Package Transform and SVMs Ensemble 显示文摘 | HU Qiao HE Zheng - jia ZHANG Zhou - suo | 2007 | Mechanical Systems and Signal Processing2007，，2： | 1 |
| 17 | Micronization of the natural pigment-bixin by the SEDS process through prefilming atomization显示文摘 | Suo Q L He W Z | 2005 | Powder Technology2005，，154： | 1 |
| 18 | Micronization of the natural pigment-bixin by the SEDS process through prefilming atomization显示文摘 | Quan Ling Suo Wen Zhi He Yah Chun Huang | 2005 | Power technology2005，154，： | 1 |
| 19 | Supercritical antisolvent micronization of naturat carotene by the SEDS process through prefilming atomization显示文摘 | He WZ Suo QL Hong HL | | 0，，06： | 1 |
| 20 | Development of a monoclonal antibody-based ELISA for detection of sulfamethazine and N4- acctyl sulfamethazinc in chicken breast muscle tissue显示文摘 | HE Jihong SHEN Jianzhong SUO Xun | 2005 | Journal of Food Science2005，70，1： | 1 |
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