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| 1 | China's lakes at present:Number,area and spatial distribution显示文摘Based on 11004 satellite images from CBERS CCD and Landsat TM/ETM,changes in the spatial characteristics of all lakes in China were determined following pre-established interpretation rules.This dataset was supported by 6843 digital raster images(1:100000 and 1:50000),a countrywide digital vector dataset(1:250000),and historical literature.Comparative data were corrected for seasonal variations using precipitation data.There are presently 2693 natural lakes in China with an area greater than 1.0 km2,excluding reservoirs.These lakes are distributed in 28 provinces,autonomous regions and municipalities and have a total area of 81414.6 km2,accounting for-0.9% of China's total land area.In the past 30 years,the number of newly formed and newly discovered lakes with an area greater than 1.0 km2 is 60 and 131,respectively.Conversely,243 lakes have disappeared in this time period. | MA RongHua YANG GuiShan DUAN HongTao JIANG JiaHu WANG SuMin FENG XueZhi LI AiNong KONG FanXiang XUE Bin WU JingLu LI ShiJie | 2011 | Science China Earth Sciences2011，54，2： | 79 |
| 2 | A 16000-year pollen record of Qinghai Lake and its paleoclimate and paleoenvironment显示文摘The paleoclimate and paleoenvironment of Qinghai Lake indicated by a 16000-year pollen record are as follows. It was very cold and dry before 15200 years. During the Late Glacial, the climate varied from colder and semiarid to cool and semi-humid and fluctuated frequently but with little amplitude. Three cold events in the periods of 13400-13000, 11600-12000, and 11000-10400 aBP respectively correspond to the Oldest Dryas, Older Dryas and Younger Dryas events, whereas the two warm periods between them, 12000-13000 and 11600-11000 aBP, respectively correspond to Boiling and Allerod periods. The temperature increased abruptly after the Younger Dryas event, and then the climate gradually turned to be warm and wet from warm and semiarid. In the Holocene, the largest amplitude of cold event that occurred at ca. 8200 aBP is quite prominent. The Holocene climatic optimum culminated at 6700 aBP. After 2100 aBP, the climate tended to be cold and dry, keeping on up to now. Palaeoclimatic evolution and events of | LIU Xingqi SHEN Ji WANG Sumin YANG Xiangdong TONG Guobang ZHANG Enlou | 2002 | Chinese Science Bulletin2002，47，22： | 33 |
| 3 | Characteristics of an early Holocene climate and environment from lake sediments in Ebinur region, NW China显示文摘The characteristics of climatic environment in the early Holocene epoch were studied through analyzing environmental proxies from the sediments in the Ebinur Lake--a closed one in the arid region. The pollen assemblage and other geochemical indices showed that, the temperature was somewhat low in the period (8.0-11.5 cal kaBP) as a whole, but in the early period (11.5-10.6 cal kaBP) the temperature was higher, in company with more precipitation. In the conversion period from the early Holocene epoch to the middle Holocene epoch (8.9-8.0 cal kaBP) the climate fluctuated remarkably. Particularly the three layers of peat sediment revealed the strong instability of climate in the early Holocene epoch in the Ebinur region. All information on the development of peat and the experimental data of pollen and stable isotopes implied that, the climatic condition at 8.2, 8.6 and 10.5 cal kaBP was characterized by noticeable cold and humidness, and could be regarded as three cold and humid events in the early Holocene epoch. | WU Jinglu SHEN Ji WANG Sumin JIN Zhangdong YANG Xiangdong | 2005 | Science China Earth Sciences2005，48，2： | 10 |
| 4 | Historical trophic evolutions and their ecological responses from shallow lakes in the middle and lower reaches of the Yangtze River: Case studies on Longgan Lake and Taibai Lake显示文摘The evolutions of diatom floras and the total phosphorous (TP) concentrations in the historical period were reconstructed for two lakes, Longgan and Taibai in the middle Yangtze River,based on high resolutional fossil diatom study from two sediment cores and an established regional diatom-TP transfer function. The TP concentration in Longgan Lake changed slightly in the range of 36-62 μg/L and kept its middle trophic level in the past 200 years. The changes of diatom assemblages reflect a macrophyte-dominated history of the lake. During the nineteenth century, the lake TP concentration increased comparatively, corresponding to the increase in abundance of benthic diatoms. The progressive increase of epiphytic diatoms since the onset of the twentieth century indicates the development of aquatic plants, coinciding with the twice drops of water TP level. The TP concentration in Taibai Lake kept a stable status about 50 μg/L before 1953 AD, while diatoms dominated by facultative planktonic Aulacoseira granulata shifted quickly to epiphytic diatom species, indicating a rapid expansion of aquatic vegetation. During 1953-1970 AD, the coverage of aquatic plants decreased greatly inferred by the low abundance of epiphytic diatoms as well as declined planktonic types, and the reconstructed TP concentration shows an obvious rising trend firstly, suggesting the beginning of the lake eutrophication. The lake was in the eutrophic condition after 1970, coinciding with the successive increase of planktonic diatoms. The comparison of the two lakes suggests the internal adjustment and purification function of aquatic plants for nutrients in water. The discrepancy of TP trends in the two lakes after 1960 reflects two different patterns of lake environmental response to human disturbance. Sediments in Taibai Lake clearly recorded the process of lake ecological transformation from the macrophyte-dominated stage to the algae-dominated stage. The limits of TP concentration (68-118 μg/L) in the transitional state can be considered as the critical value between the two stable ecosystems. Further work will be necessary to provide more evidence from the sediments in more eutrophic lakes for the primary inference. The reconstructive TP level and the inference of aquatic plants from fossil diatoms in different lakes, as well as their comparison provide a scientific basis for ecological restoration of eutrophic lakes in research regions. | YANG Xiangdong SHEN Ji DONG Xuhui LIU Enfeng WANG Sumin | 2006 | Science China Earth Sciences2006，49，z1： | 8 |
| 5 | Peptidome analysis of human intrauterine adhesion tissues and the identification of antifibrotic peptide显示文摘Intrauterine adhesion(IUA)is a common clinical endometrial disease,which can severely damage the fertility and quality of life in women.This study aims to find the differentially expressed endogenous peptides and their possible roles in IUA.Liquid chromatography-mass spectrometry was used to identify the peptidomic profiling of IUA tissues,and the differentially expressed peptides were screened out.Using real-time quantitative PCR,Western blotting,and immunocytochemistry staining,the function of six endogenous peptides was verified in vitro.It was found that peptide 6(T6)(peptide sequence:TFGGAPGFPLGSPLSSVFPR)could inhibit the expression of TGF-β1-induced cell fibrosis in human endometrial stromal cell line and primary human endometrial stromal cell at a concentration of 50μmol/L.This study provides new targets for further clarifying the formation and prevention of IUA. | Xiangdong Hua Yan Zhang Juan Xu Lu Xu Yaqian Shi Dazhen Yang Xiaoyan Gu Sumin Wang Xuemei Jia Feng Xu Jie Chen Xiaoyan Ying | 2022 | The Journal of Biomedical Research2022，36，4： | 3 |
| 6 | Comprehensive test stand for high-intensity cyclotron development显示文摘A comprehensive test stand for high-intensity cyclotron development,a 10 MeV 430 μA cyclotron,has been successfully constructed at China Institute of Atomic Energy (CIAE) for the experimental verification of the viability of a 100 MeV high-intensity cyclotron (CYCIAE-100) being constructed at CIAE.The verification includes the overall design technology,detail design and engineering technology for the crucial parts of the machine,e.g.main magnet and beam diagnostics.It will also pave the way for future enhancement of the beam intensity.The test stand consists of a H-ion source,axial injection system,central region,main magnet and coil,RF resonator,stripping extraction,and auxiliary systems,which include the RF power amplifier,high voltage and DC power supplies,electric apparatus,beam diagnostics,control,vacuum,water cooling,pneumatic system,and safety interlock.This paper presents the work regarding the design and sub-system development of the test sand,and the results of the beam commissioning of the machine. | ZHANG TianJue LI ZhenGuo CHU ChengJie XING JianSheng GUAN FengPing ZHONG JunQing JI Bin GE Tao YIN ZhiGuo HOU ShiGang PAN GaoFeng YAO HongJuan LU YinLong WANG ZhenHui WU LongCheng LIN Jun JIA XianLu WEI SuMin WEN LiPeng WANG Feng XIA Le CAI HongRu XIE HuaiDong CHEN RongFan ZHANG Yan ZHANG SuPing LIU GengShou ZOU Jian AN ShiZhong YANG JianJun BI YuanJie YANG Fang | 2011 | Chinese Science Bulletin2011，56，3： | 3 |
| 7 | Holocene moisture evolution in arid central Asia and its out-of-phase relationship with Asian monsoon history显示文摘 | Fahu Chen Zicheng Yu Meilin Yang Emi Ito Sumin Wang David B. Madsen Xiaozhong Huang Yan Zhao Tomonori Sato H. John B. Birks Ian Boomer Jianhui Chen Chengbang An Bernd Wünnemann | 2007 | Quaternary Science Reviews2007，，3： | 2 |
| 8 | Holocene moisture evolution in arid central Asia and its out-of-phase relationship with Asian monsoon history显示文摘 | Fahu Chen Zicheng Yu Meilin Yang Emi Ito Sumin Wang David B. Madsen Xiaozhong Huang Yan Zhao Tomonori Sato H. John B. Birks Ian Boomer Jianhui Chen Chengbang An Bernd Wünnemann | 2007 | Quaternary Science Reviews2007，，3： | 2 |
| 9 | The present situation and the prospect of medical cyclotrons in China显示文摘The paper introduces the increasing applications of cyclotrons in the field of health care and some major work carried out abroad. Its emphasis is placed on the introduction to the application status and the development process of medical cyclotrons in China. The paper has assessed possible developing trends of medical cyclotrons based on the current application demand and the technological development status. | ZHANG TianJue FAN MingWu WEI SuMin CHEN ShengZu YANG Fang | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 2 |
| 10 | Autonomous driving in the uncertain traffic--a deep reinforcement learning approach显示文摘representation capability of deep learning(DL) and the optimal decision making and control capability of reinforcement learning(RL), is a good approach to address this problem. Traffic environment is built up by combining intelligent driver model(IDM) and lane-change model as behavioral model for vehicles. To increase the stochastic of the established traffic environment, tricks such as defining a speed distribution with cutoff for traffic cars and using various politeness factors to represent distinguished lane-change style, are taken. For training an artificial agent to achieve successful strategies that lead to the greatest long-term rewards and sophisticated maneuver, deep deterministic policy gradient(DDPG) algorithm is deployed for learning. Reward function is designed to get a trade-off between the vehicle speed, stability and driving safety. Results show that the proposed approach can achieve good autonomous maneuvering in a scenario of complex traffic behavior through interaction with the environment. | Yang Shun Wu Jian Zhang Sumin Han Wei | 2018 | The Journal of China Universities of Posts and Telecommunications2018，25，6： | 2 |
| 11 | Study on the nutrient evolution and its controlling factors of Longgan Lake for the last 200 years显示文摘Based on the total phosphorous (TP) concentration in sediment core, the TP concentration in lake water quantitatively reconstructed from fossil diatoms and diatom-TP transfer function in the Longgan Lake during the last 200 years, the temperature and precipitation data from meteorological observation for the last 50 years, the temperatures and precipitation sequences of climate simulation for the last 200 years, as well as the amount of the agricultural phosphate fertilizer in Longgan area for nearly 50 years, the characteristic and the law of the nutrient status evolution were analyzed, and the influence of the climatic factor, the anthropologic factor and the aquatic biology factor on the nutrient status evolution and its mechanism were discussed for the Longgan Lake during the last 200 years. The results showed that, in the nearly 200 years, the TP concentration in the sediment core of the Longgan Lake gradually increased, its range of variation was situated between 330-580 mg/kg, the mean value was 388 mg/kg, a nearly 30-year vibration adjustment period existed at 1950 around. The TP concentration in lake water changed in a different way. Before 1950, it had a slow increasing tendency in fluctuated background, to 1950 around it reached up to the mean value (52.18 μg/L), and vibrated and adjusted around the mean value, then it fast declined, its change range was situated between 37.75-62.33 μg/L. The analyses indicated that, in the centennial time scale, the climate change was the main controlling factor, while in the decadal time scale in the recent 50 years, human activities were the leading factors for the nutrient status evolution of the Longgan Lake. 60% of the variability of the TP concentration in the sediments and 57% of that in lake water were due to human activities. The differentiation between phosphorus concentration in the sediment and in the lake water reflected the response processes and the adjustment abilities of the lake aquatic ecosystems to the lake nutrient level, implying the maintenance and the destruction of the balances between the algae and the aquatic plants, as well as the corresponding accumulating characteristics of the phosphorus. | LIU Jian YANG Xiangdong WANG Sumin | 2006 | Science China Earth Sciences2006，49，z1： | 2 |
| 12 | Lacustrine environment responses to human activities in the past 300 years in Longgan Lake catchment, southeast China显示文摘 | Yang Xiangdong Wang Sumin Shen Ji | 2002 | Science in China (Series D)2002，45，8： | 1 |
| 13 | Potential regulation of small RNAs on bacterial function activities in pig farm wastewater treatment plants显示文摘Small RNAs(sRNAs)are key players in the regulation of bacterial gene expression.However,the distribution and regulatory functions of sRNA in pig farm wastewater treatment plants(WWTPs)remains unknown.In this study,the wastewaters in anoxic and oxic tanks of the WWTPs were collected.The profiles of the community structure,mRNA expression,and sRNA expression of bacteria in pig farm wastewater were investigated using transcriptome sequencing and qPCR.This study demonstrated that there was a higher abundance of sRNA in the pig farm WWTPs and 52 sRNAs were detected.The sRNAs were mainly present in Proteobacteria and Firmicutes,including the potential human pathogenic bacteria(HPB)(Escherichia,Shigella,Bordetella and Morganella),crop pathogen(Pectobacterium)and denitrifying bacteria(Zobellella).And the sRNAs were involved in the bacterial functional activities such as translation,transcription,drug resistance,membrane transport and amino acid metabolism.In addition,most sRNAs had a higher abundance in anoxic tanks which contained a higher abundance of the genes associated with infectious diseases and drug resistance than that in oxic tanks.The results presented here show that in pig farm WWTPs,sRNA played an important role in bacterial function activities,especially the infectious diseases,drug resistance and denitrification,which can provide a new point of penetration for improving the pig farm WWTPs. | Yiwen Yang Sicheng Xing Sumin Li Yajing Niu Cheng Li Tuoxin Huang Xindi Liao | 2020 | Journal of Environmental Sciences2020，32，5： | 1 |
| 14 | On-line two dimensional liquid chromatography/mass spectrometry for the analysis of triacylglycerides in peanut oil and mouse tissue显示文摘 | Qin Yang Xianzhe Shi Qun Gu Sumin Zhao Yuanhong Shan Guowang Xu | 2012 | Journal of Chromatography B2012，，： | 1 |
| 15 | Cloning and biological comparison of Restin, novel member of Mage superfamily显示文摘 | Zhongliang Zhao Fan Lu Feng Zhu Hui Yang Yubo Chai Sumin Chen | 2002 | Science in China Series C: Life Sciences2002，，4： | 1 |
| 16 | Purification and determination of stachyose in Chinese artichoke ( Stachys Sieboldii Miq.) by high-performance liquid chromatography with evaporative light scattering detection显示文摘 | Junfa Yin Gengliang Yang Sumin Wang Yi Chen | 2006 | Talanta2006，，1： | 1 |
| 17 | Visible light assisted enzyme-photocatalytic cascade degradation of organophosphorus pesticides显示文摘The worldwide application of organophosphorus pesticides(OPs)has promoted agricultural development,but their gradual accumulation in soil and water can seriously affect the central nervous system of humans and other mammals.Organophosphorus hydrolase(OPH)is an effective enzyme that can catalyze the degradation of the residual OPs.However,the degradation products such as p-nitrophenol(p-NP)is still toxic.Thus,it is of great significance to develop a multi-functional support that can be simultaneously used for the immobilization of OPH and the further degradation of p-NP.Herein,a visible light assisted enzyme-photocatalytic integrated catalyst was constructed by immobilizing OPH on hollow structured Au-TiO_(2)(named OPH@H-Au-TiO_(2))for the degradation of OPs.The obtained OPH@H-Au-TiO_(2)can degrade methyl parathion to p-NP by OPH and then degrade p-NP to hydroquinone with low toxicity by using H-Au-TiO_(2)under visible light.OPH molecules were immobilized on HAu-TiO_(2)through adsorption method to prepare OPH@H-Au-TiO_(2).After 2.5 h of reaction,methyl parathion is completely degraded,and about 82.64%of the generated p-NP is further degraded into hydroquinone.After reused for 4 times,the OPH@H-Au-TiO_(2)retains more than 80%of the initial degradation activity.This research presents a new insight in designing and constructing multi-functional biocatalyst,which greatly expands the application scenarios and industrial value of enzyme catalysis. | Ying Zhang Xue Cao Yufeng Yang Sumin Guan Xiaotian Wang Heyu Li Xiaobing Zheng Liya Zhou Yanjun Jiang Jing Gao | 2023 | Green Chemical Engineering2023，4，1： | 1 |
| 18 | Legacy of Hongxi Su:Pioneer of Chinese Cardiosurgery显示文摘Prof.Hongxi Su(苏鸿熙)was born in Tongshan,Jiangsu Province,in January of 1915(Fig.1).He is the pioneer of Chinese cardiosurgery and one of the most renowned Chinese cardiothoracic surgeons,performing the first successful intracardiac surgery under extracorporeal circulation,as well as applying artificial blood vessels in aortic-carotid artery bypass surgery,shaping the cardiosurgery landscape of China. | Sumin Yang Haoyu Hu Xin Zheng Shizhong Wang Li Yuan | 2022 | Protein & Cell2022，13，8： | 0 |
| 19 | Smart nanoparticles for cancer therapy显示文摘Smart nanoparticles,which can respond to biological cues or be guided by them,are emerging as a promising drug delivery platform for precise cancer treatment.The field of oncology,nanotechnology,and biomedicine has witnessed rapid progress,leading to innovative developments in smart nanoparticles for safer and more effective cancer therapy.In this review,we will highlight recent advancements in smart nanoparticles,including polymeric nanoparticles,dendrimers,micelles,liposomes,protein nanoparticles,cell membrane nanoparticles,mesoporous silica nanoparticles,gold nanoparticles,iron oxide nanoparticles,quantum dots,carbon nanotubes,black phosphorus,MOF nanoparticles,and others.We will focus on their classification,structures,synthesis,and intelligent features.These smart nanoparticles possess the ability to respond to various external and internal stimuli,such as enzymes,pH,temperature,optics,and magnetism,making them intelligent systems.Additionally,this review will explore the latest studies on tumor targeting by functionalizing the surfaces of smart nanoparticles with tumor-specific ligands like antibodies,peptides,transferrin,and folic acid.We will also summarize different types of drug delivery options,including small molecules,peptides,proteins,nucleic acids,and even living cells,for their potential use in cancer therapy.While the potential of smart nanoparticles is promising,we will also acknowledge the challenges and clinical prospects associated with their use.Finally,we will propose a blueprint that involves the use of artificial intelligence-powered nanoparticles in cancer treatment applications.By harnessing the potential of smart nanoparticles,this review aims to usher in a new era of precise and personalized cancer therapy,providing patients with individualized treatment options. | Leming Sun Hongmei Liu Yanqi Ye Yang Lei Rehmat Islam Sumin Tan Rongsheng Tong Yang-Bao Miao Lulu Cai | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 20 | CYCIAE-100 Cyclotron Beamdump Beam Line Control System显示文摘The CYCIAE-100 cyclotron Beamdump beam line will realize the acceptance and debugging of the beam strength of 200μA at the end of2017,and the beam collector will be stabilized at the Beamdump beam collector to the beam intensity 204.65μA.The control system of the CYCIAE-100cyclotron Beamdump beam | LU Xiaotong CAO Lei WEI Sumin WEN Lipeng SONG Guofang WANG Feng WANG Yang | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
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