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| 1 | STRUCTURE DESIGN OF THE BEIJING SPECTROMETERⅢBEAM PIPE显示文摘The Beijing spectrometerⅢ(BESⅢ)beam pipe is in the center of the BESⅢ,which is the detector of the upgrade project of Beijing electron and positron collider(BEPCⅡ).Electrons and positrons collide in the BESⅢbeam pipe.According to the demands of the BEPCⅡ,a key program of Chinese Academy of Sciences,the BESⅢbeam pipe is designed based on the finite elements analysis.The BESⅢbeam pipe is installed in the inner cylinder of the BESⅢdrift chamber.As a vacuum tube,the BESⅢbeam pipe is designed as 1000 mm in length,63 mm in inner diameter and 114 mm in outer diameter,respectively.The BESⅢbeam pipe consists of a central beryllium pipe cooled by EDM-1,the oil No.1 for electric discharge machining,and two extended copper pipes cooled by deionized water(DW).The three parts are jointed by vacuum welding.Factors taken into account in the design are as follows.①The wall thickness of the central beryllium pipe should be designed as small as possible to reduce the multi-scattering and improve the particle momentum resolution.And the wall thickness of the extended copper pipe should be designed as large as possible to protect the detectors from the backgrounds.②The BESⅢbeam pipe must be sufficiently cooled to avoid the damage and prevents its influence to the BESⅢdrift chamber(DC)operation.The inner surface temperature of the DC inner cylinder must be maintained at 293±2 K.③The magnetic permeability of the materials used in the BESⅢbeam pipe must be less than 1.05 H/m to avoid large magnetic field distortions.④The static pressure of the vacuum chamber of the BESⅢbeam pipe must be less than 800μPa.The simulating results show that the designed structure oftbe BESⅢbeam pipe satisfies the requirements mentioned above.The structure design scheme is evaluated and adopted by the headquarters of BEPCⅡ. | ZHENG Lifang JI Quan WANG Li LI xunfeng XU Shaowang DONG Sujun ZHAO Libin LIU Jianping | 2008 | Chinese Journal of Mechanical Engineering2008，21，3： | 3 |
| 2 | Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism显示文摘 | Haoqiang Ying Alec C. Kimmelman Costas A. Lyssiotis Sujun Hua Gerald C. Chu Eliot Fletcher-Sananikone Jason W. Locasale Jaekyoung Son Hailei Zhang Jonathan L. Coloff Haiyan Yan Wei Wang Shujuan Chen Andrea Viale Hongwu Zheng Ji-hye Paik Carol Lim Alexande | 2012 | Cell2012，，3： | 1 |
| 3 | Direct-acting Antiviral-induced Transient Recovery of NK Cells in Early-stage Treatment of Chronic Hepatitis C Patients显示文摘Background and Aims:The rapid clearance of hepatitis C virus induced by direct-acting antivirals(DAAs)affects natural killer(NK)cells,but the reported results are not consistent,and the relative mechanism was unclear.This study focused on the dynamic changes of NK cells during and after DAA treatment and analyzed the reasons.Meth-ods:Peripheral blood from 35 chronic hepatitis C patients who were treated with DAAs were collected at baseline and weeks 1,2,4,12,and post-treatment week-12.The fre-quency,subset,and phenotype of NK cells were assayed by flow cytometry.Lactate dehydrogenase assays were used to evaluate the cytotoxicity of NK cells.Cytokine concentra-tions were measured with Luminex kits.Results:All pa-tients achieved a sustained viral response(SVR),and the NK cell frequencies were not changed significantly during DAA therapy.However,the cytotoxicity of NK cells recov-ered significantly early in week 1,and then continuously decreased below normal levels.The changes of genotypes including NKp30+,NKp46+,and NKG2A+NK cells were par-allel to NK function.The subset of CD56dim NK cells con-tinuously increased and did not return to normal even at 12 weeks after treatment.Interleukin(IL)-2,IL10,IL15,interferon-gamma,and tumor necrosis factor-alpha all in-creased after week 4,peaked at the end of therapy,and then exhibited varying degrees of reduction with time.Con-clusions:DAA treatment led to transient functional recov-ery of NK cells in the early stage of treatment,and then continuously decreased to below normal levels.Alterations of NK subsets,phenotypes,and the microenvironment may be involved in the changes. | Xiaohui Zhang Yingying Jiang Shaobin Li Dandan Bian Mei Liu Ming Kong Yu Chen Zhongping Duan Sujun Zheng | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 0 |
| 4 | Performance of Hepatitis Delta Virus(HDV)RNA Testing for the Diagnosis of Active HDV Infection:Systematic Review and Meta-analysis显示文摘Background and Aims:Hepatitis delta virus(HDV)is a defective virus and causes severe liver disease.Several HDV RNA assays have been developed,however the diagnostic efficacy remains unclear.This systematic review and metaanalysis aims to evaluate the diagnostic accuracy of HDV RNA assays to aid in the diagnosis of active hepatitis D.Methods:The PubMed,Embase,and Cochrane Library databases were systematically searched from the beginning to June 31,2022.Information on the characteristics of the literature and data on sensitivity,specificity,and area under curve(AUC)of the receiver operating characteristic(ROC)were extracted.Stata 14.0 was used for meta-analysis of the combined sensitivity,specificity,positive likelihood ratio,and negative likelihood ratio.Results:A total of 10 studies were included in the meta-analysis.The summary sensitivity,specificity,positive likelihood ratio,negative likelihood ratio,and diagnostic odds ratio of HDV RNA assays for HDV diagnosis were 0.92(95%CI:0.87-0.95),0.90(95%CI:0.86-0.93),7.74(95%CI:5.31-11.29),0.10(95%CI:0.06-0.18)and 99.90(95%CI:47.08-211.99),respectively.The AUC of the pooled ROC curve was 0.95(95%CI:0.92-0.96).Conclusions:The results show that HDV RNA assays had high diagnostic performance.However,that is limited by the number and quality of studies.Standard protocols for the development of assays by manufacturers and larger studies on the use of the assays are needed. | Sisi Chen Xiangying Zhang Ling Xu Yuan Tian Zihao Fan Yaling Cao Zhenzhen Pan Yao Gao Sujun Zheng Zhongping Duan Mei Liu Feng Ren | 2023 | Journal of Clinical and Translational Hepatology2023，11，6： | 0 |
| 5 | UGT1A1-related Bilirubin Encephalopathy/Kernicterus in Adults显示文摘Background and Aims:Bilirubin encephalopathy/kernicterus is very rare in adults.This study is aimed to investigate the clinical manifestations and genetic features of two patients with UGT1A1-related kernicterus.Methods:Sanger sequencing analysis was performed to identify UGT1A1 gene mutations in the patients and their families.Bioinformatics analysis was used to predict the potential functional effects of novel missense mutations.Clinical manifestations and biochemical parameters were collected and analyzed.Results:Two patients with Crigler-Najjar syndrome type II(CNS2)developed kernicterus in adulthood.Sanger sequencing identified a compound heterozygous mutation in the UGT1A1 gene in patient 1,which was inherited from his mother(G71R)and his father(c.-3279T>G;S191F).Patient 2 carried three heterozygous mutations,namely G71R,R209W and M391K;among which,the M391K mutation has not been reported before.Multiple prediction software showed that the M391K mutation was pathogenic.Symptoms were relieved in the two patients after phenobarbital and artificial liver support treatment.Patient 1 also underwent liver transplantation.Conclusions:Adults with CNS2 are at risk for kernicterus.Phenobarbital treatment is beneficial for maintaining bilirubin levels and preventing kernicterus. | Jie Bai Lu Li Hui Liu Shuang Liu Li Bai Wenyan Song Yu Chen Sujun Zheng Zhongping Duan | 2021 | Journal of Clinical and Translational Hepatology2021，9，2： | 0 |
| 6 | An analytic model for transient heat conduction in bi-layered structures with flexible serpentine heaters显示文摘Uniform heating of complex surfaces,especially non-developable surfaces,is a crucial problem that traditional rigid heaters cannot solve.Inspired by flexible electronic devices,a novel design for the stretchable heating film is proposed with the flexible serpentine wire embedded in the soft polymer film,which can be attached to non-developable surfaces conformally.It provides a new way for the stretchable heaters to realize uniform heating of complex surfaces.However,the thermal field of flexible serpentine heaters(FSHs)depends on the configurations of the embedded serpentine heating wire,which requires accurate theoretical prediction of real-time temperature distribution.Therefore,the analytical model for the transient heat conduction in FSHs is solved by the separation of variables method and validated by the finite element analysis(FEA)in this paper.Based on this model,the effects of the geometric parameters,such as the radius and the length of the serpentine heaters,on the thermal uniformity are systematically investigated.This study can help to design and fabricate flexible heaters with uniform heating in the future. | Zhao ZHAO Yuhang LI Sujun DONG Yi CUI Zheng DAI | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，9： | 0 |
| 7 | A HRG novel mutation associated with idiopathic portal hypertension: Case report and literature review显示文摘Idiopathic portal hypertension(IPH)is defined as the presence of portal hypertension in the absence of a common cause.IPH can have several etiologies,one of which is a genetic disorder.Some genetic mutations,such as KCNN3 and DGUOK,were shown to be related to IPH pathogenesis.This is the first case report of a 22-year-old man who was diagnosed with IPH with a novel heterozygous mutation in the histidine-rich glycoprotein gene(c.545G>C,p.R182T).Using bioinformatics analysis and the protein quantification method,we showed that this novel mutation has a pathogenetic role in IPH.Our study broadens the mutation spectrum of the histidine-rich glycoprotein gene and provides new ideas for IPH etiology. | Shan Tang Li Bai Wei Zhang Wenyan Song Hui Liu Lei Li Chen Liang Zhongping Duan Sujun Zheng | 2022 | iLIVER2022，1，2： | 0 |
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