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| 1 | Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma显示文摘AIM:To investigate cell cycle proteins in chronic hepatitis C virus infection in order to analyze their role in the process of hepatocyte transformation and to characterize their prognostic properties. METHODS:Subjects of the current study included 50 cases of chronic hepatitis C(CHC) without cirrhosis,30 cases of CHC with liver cirrhosis(LC) ,and 30 cases of hepatitis C-related hepatocellular carcinoma(HCC) admitted to the Department of Hepato-Gastroenterology,Theodor Bilharz Research Institute(TBRI) ,Giza,Egypt.Fifteen wedge liver biopsies,taken during laparoscopic cholecystectomy,were also included as normal controls.Laboratory investigations including urine and stool analysis,liver function tests and prothrombin concentration;serologic markers for viral hepatitis and ultrasonography were done for all cases of the study together with immunohistochemical analysis using primary antibodies against Cyclin D1,Cyclin E,p21,p27 and Rb/p105 proteins. RESULTS:Normal wedge liver biopsies didn't express Cyclin E or Rb/p105 immunostaining but show positive staining for Cyclin D1,p21 and p27.Cyclin D1 expressed nuclear staining that was sequentially increased from CHC to LC(P<0.01) to HCC(P<0.001) cases;meanwhile,Cyclin E revealed nuclear positivity only in the case of HCCs patients that was directly correlated to Rb/p105 immuno-reactivity.The expression of p21 and p27 was significantly increased in CHC and LC cases compared to normal controls and HCCs with no significant difference between well-and poorlydifferentiated tumors.p21 showed only a nuclear pattern of staining,while,p27 presented with either cytoplasmic and/or nuclear reactivity in all studied cases.Correlation analysis revealed a direct relation between Cyclin D1 and p21 in CHC cases(P<0.001) ,between Cyclin D1 and Cyclin E in HCCs(P<0.01);however,an inverserelationship was detected between Cyclin D1 and p21 or p27(P<0.001) and between p21 and Rb/p105(P<0.05) in HCCs. CONCLUSION:Upregulation of Cyclin D1 in CHC plays a vital role in the development and differentiation of HCC;while,Cyclin E may be a useful marker for monitoring tumor behavior.p21 and p27 can be used as predictive markers for HCC.Furthermore,higher expression of Rb/p105 as well as inverse relation with p21 and histologic grades suggests its important role in hepatic carcinogenesis. | Azza E El Bassiouny Mona M Nosseir Mona K Zoheiry Noha A Ameen Ahmed M Abdel-Hadi Ibrahim M Ibrahim Suher Zada Abdel-Hakeem Saad El-Deen Nora E El-Bassiouni | 2010 | World Journal of Hepatology2010，2，1： | 3 |
| 2 | Simple renal cyst prevalence in in- ternal medicine department and concomitant diseases 显示文摘 | Suher M Koc E Bayrak G | 2006 | Ren Faii2006，28，2： | 1 |
| 3 | Relation of thyroid disfunction, thy-roid autoantibodies, and renal function显示文摘 | Suher M Koc E Ata N | 2005 | Ren Fail2005，27，6： | 1 |
| 4 | Relation of thyroid disfunction, thyroid autoantibodies and renal function显示文摘 | Suher M Koc E Ata N | 2005 | Ren Fail2005，27，6： | 1 |
| 5 | Relation of thyroid dysfunction thyroid autoantibodies and renal function显示文摘 | Suher M Koc E | | 0，，06： | 1 |
| 6 | Relation of thyroid disfunction,thyroid autoantibodies,and renal function显示文摘 | Suher M Koc E Ata N | 2005 | Ren Fail2005，27，： | 1 |
| 7 | The relationship between the level of glutathione,impairment of glucose metabolism and complications of diabetes mellitus显示文摘 | Hakki Kalkan I Suher M | 2013 | Pak J Med Sci2013，29，4： | 1 |
| 8 | Ralation of thyroid disfunction, thyroid autoantibodies and renal function显示文摘 | Suher M Koc E Ata N | 2005 | Ren Fail2005，27，6： | 1 |
| 9 | Relation of thyroid disfunction, thyroid autoantibodies, and renal function显示文摘 | SUHER M KOC E ATA N | 2005 | Ren Fail2005，27，6： | 1 |
| 10 | Immunoglobulins of the snake Psammophis sibilans-studies using a monoclonal antibody 显示文摘 | Rashika ER Moustafa M Suher Z | 1991 | Immunobiol1991，184，： | 1 |
| 11 | Relation of thyroid disfunction, thyroid autoantibodies and renal function显示文摘 | Suher M Koc E Ata N | 2005 | Ren Fail2005，27，6： | 1 |
| 12 | The relationship between the level of glutathione,impairment of glucose metabolism and complications of diabetes mellitus显示文摘 | HakkiKalkan I Suher M | 2013 | Pak J Med Sci2013，29，4： | 1 |
| 13 | Relation of thyroid disfunetion, thy- roid autoantibodies, and renal function 显示文摘 | Suher M Koc E Ata N et aI | 2005 | Ren l~''ail2005，27，6： | 1 |
| 14 | Relation of thyroid disfunction,thy- mid autoantibodies, and renal function 显示文摘 | Suher M Koc E Ata N | 2005 | Ren Fail2005，27，6： | 1 |
| 15 | Relation of thyroid disfunction, thyroid autoantibodies, and renal function显示文摘 | Suher M Koc E Ata N | 2005 | Ren Fail2005，27，： | 1 |
| 16 | Relation of thyroid disfunction,thyroid autoantibodies,and renal function显示文摘 | SUHER M KOC E ATA N | 2005 | Ren Fail2005，27，6： | 1 |
| 17 | Relation of thyroid disfunction,thyroid autoantibodies,and renal function显示文摘 | Suher M Koc E Ata N | 2005 | Ren Fail2005，27，6： | 1 |
| 18 | Relation of thyroid disfunc- tion, thyroid autoantibodies, and renal function 显示文摘 | Suher M Koc E Ata N | 2005 | Ren Fail2005，27，6： | 1 |
| 19 | Relation of thyroid disfunction, thyroid autoantibodies, and renal function显示文摘 | Suher M Koc E Ata N | 2005 | Ren Fail2005，27，6： | 1 |
| 20 | Relation of thyroid disfunction, thyroid autoantibodies, and renal function 显示文摘 | Suher M Koc E Ata N | 2005 | Renal Failure2005，27，6： | 1 |
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