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| 1 | Rescue associating liver partition and portal vein ligation for staged hepatectomy after portal embolization: Our experience and literature review显示文摘AIM To report a single-center experience in rescue associating liver partition and portal vein ligation for staged hepatectomy(ALPPS), after failure of previous portal embolization. We also performed a literature review.METHODS Between January 2014 and December 2015, every patient who underwent a rescue ALPPS procedure in Toulouse Rangueil University Hospital, France, was included. Every patient included had a project of major hepatectomy and a previous portal vein embolization(PVE) with insufficient future liver remnant to body weight ratio after the procedure. The ALPPS procedure was performed in two steps(ALPPS-1 and ALPPS-2), separated by an interval phase. ALPPS-2 was done within 7 to 9 d after ALPPS-1. To estimate the FLR, a computed tomography scan examination was performed 3 to 6 wk after the PVE procedure and 6 to 8 d after ALPPS-1. A transcystic stent was placed during ALPPS-1 and remained opened duringthe interval phase, in order to avoid biliary complications. Postoperative liver failure was defined using the 50-50 criteria. Postoperative complications were assessed according to the Dindo-Clavien Classification.RESULTS From January 2014 to December 2015, 7 patients underwent a rescue ALPPS procedure. Median FLR before PVE, ALPPS-1 and ALPPS-2 were respectively 263 cc(221-380), 450 cc(372-506), and 660 cc(575-776). Median FLR/BWR before PVE, ALPPS-1 and ALPPS-2 were respectively 0.4%(0.3-0.5), 0.6%(0.5-0.8), and 1%(0.8-1.2). Median volume growth of FLR was 69%(18-92) after PVE, and 45%(36-82) after ALPPS-1. The combination of PVE and ALPPS induced a growth of median initial FLR of +408 cc(254-513), leading to an increase of +149%(68-199). After ALPPS-2, 4 patients had stage Ⅰ-Ⅱ complications. Three patients had more severe complications(one stage Ⅲ, one stage Ⅳ and one death due to bowel perforation). Two patients suffered from postoperative liver failure according to the 50/50 criteria. None of our patients developed any biliary complication during the ALPPS procedure.CONCLUSION Rescue ALPPS may be an alternative after unsuccessful PVE and could allow previously unresectable patients to reach surgery. Biliary drainage seems to reduce biliary complications. | Charlotte Maulat Antoine Philis Bérénice Charriere Fatima-Zohra Mokrane Rosine Guimbaud Philippe Otal Bertrand Suc Fabrice Muscari | 2017 | World Journal of Clinical Oncology2017，8，4： | 7 |
| 2 | Contribution of alpha-fetoprotein in liver transplantation for hepatocellular carcinoma显示文摘Alpha-fetoprotein(AFP) is the main tumor biomarker available for the management of hepatocellular carcinoma(HCC). Although it is neither a good screening test nor an accurate diagnostic tool for HCC, it seems to be a possible prognostic marker. However, its contribution in liver transplantation for HCC has not been fully determined, although its use to predict recurrence after liver transplantation has been underlined by international societies. In an era of organ shortages, it could also have a key role in the selection of patients eligible for liver transplantation. Yet unanswered questions remain. First, the cut-off value of serum AFP above which liver transplantation should not be performed is still a subject of debate. We show that a concentration of 1000 ng/m L could be an exclusion criterion, whereas values of < 15 ng/m L indicate patients with an excellent prognosis whatever the size and number of tumors. Monitoring the dynamics of AFP could also prove useful. However, evidence is lacking regarding the values that should be used. Today, the real input of AFP seems to be its integration into new criteria to select patients eligible for a liver transplantation. These recent tools have associated AFP values with morphological criteria, thus refining pre-existing criteria, such as Milan, University of California, San Francisco, or 'up-to-seven'. We provide a review of the different criteria submitted within the past years. Finally, AFP can be used to monitor recurrence after transplantation, although there is little evidence to support this claim. Future challenges will be to draft new international guidelines to implement the use of AFP as a selection tool, and to determine a clear cut-off value above which liver transplantation should not be performed. | Bérénice Charrière Charlotte Maulat Bertrand Suc Fabrice Muscari | 2016 | World Journal of Hepatology2016，8，21： | 3 |
| 3 | A controlled randomized multicenter trial of pancreatogastrostomy or pancreatojejunostomy after pancreatoduodenectomy 显示文摘 | Duffas JP Suc B Msika S | 2005 | Am J Surg2005，189，6： | 1 |
| 4 | Octreotide in the prevention of intra-abdominal complications following elective pancreatic resection : a prospective, multicenter randomized controlled trial 显示文摘 | Suc B Msika S Piceinini M | 2004 | Arch Surg2004，139，3： | 1 |
| 5 | Orthotopic Liver Transplantation with Vena Cava Preservation in Cirrhotic Patients:is Systematic Temporary Portacaval Anastomosis a Justified Procedure?显示文摘 | MUSCARI F SUC B AGUIRRE J | 2005 | Transplant Proc2005，37，2： | 1 |
| 6 | A controlled randomized multicentertrail of pancreatogastrostomy or pancreatojejunosto- my after pancreatoduodenectomy 显示文摘 | DUFAS J P SUC B MSIKA S | 2005 | Am J Surg2005，189，6： | 1 |
| 7 | Temporary fibrin glue occlusion of the main pancreatic duct in the prevention of intra-abdominal complication after pancreatic resection: Prospective randomial trial显示文摘 | Suc B Msika S Fingrhut A | 2003 | Ann Surg2003，237，1： | 1 |
| 8 | Risk factors for mortality and intra-abdominal complications after pancreatoduodenectomy : multivariate analysis in 300 patients显示文摘 | Muscari F Suc B Kirzin S | 2006 | Surgery2006，139，： | 1 |
| 9 | Temporary fibrin glue occlusion of the main pancreatic duct in the prevention of intra - abdominal complication after pancreatic resection: prospective randomial trial 显示文摘 | Suc B Msika S Fingerhut A | 2003 | Ann Surg2003，237，1： | 1 |
| 10 | A controlled randomized multicenter trial of pancreatogastrostomy or pancreatojejunostomy after pancreatoduodenectomy 显示文摘 | Duffas JP Suc B Msika S | 2005 | Am J Surg2005，189，6： | 1 |
| 11 | Risk factors for mortality and intra-abdominal complications after pancreatoduodenectomy: multivariate analysis in 300 patients 显示文摘 | Muscari F Suc B Kirzin S | 2006 | Surgery2006，139，5： | 1 |
| 12 | A controlled randomized multicenter trial of pancreatogastrostomy or pancreatojejunostomy after pancreatoduodenectomy显示文摘 | Duffas JP Suc B Msika S | | 0，，06： | 1 |
| 13 | Blood Salvage autotransfusion during transplantation for hepatocarcinoma does it increasethe risk of neoplastic recurrence显示文摘 | Muscari F Suc B Vigouroux D | 2005 | Transp 1 Int2005，18，11： | 1 |
| 14 | A controlled randomized multicenter trial of pancreatogastrostomy or pancreatojejunostomy after pancreatoduodenectomy 显示文摘 | Duffas JP Suc B Msika S | 2005 | Am J Surg2005，189，6： | 1 |
| 15 | A controlled randomized muhicenter trial of pancreatogastrostomy or panereatojejunostomy after panereato- dudeneetomy显示文摘 | Duffas JP Suc B Msika S et d | 2005 | Am J Surg2005，189，6： | 1 |
| 16 | Octreotide in the prevention of intra-abdominal complications following elective pancreatic resection: a prospective, muhicenter randomized controlled trial显示文摘 | Suc B Msika S Piccinini M | 2004 | Arch Surg2004，139，3： | 1 |
| 17 | Risk factors for mortality and intra-abdominal complications after pancreatoduodenectomy multivariate analysis in 300 patients 显示文摘 | Muscari F Suc B Kirzin S | 2006 | Surgery2006，139，5： | 1 |
| 18 | Risk factors for mortality and intra-abdominal complications after pancreatoduodenectomy : multivariate analysis in 300 patients显示文摘 | Muscari F Suc B Kirzin S | 2006 | Surgery2006，139，5： | 1 |
| 19 | Risk factors for mortality and intraabdominal complications after pancreatoduodenectomy:multivariate analysis in 300 patients显示文摘 | Muscari F Suc B Kirzin S | 2006 | Surgery2006，139，5： | 1 |
| 20 | A controlled randomized multicenter trial of pancreatogastrostomy or pancreatojeiunos to my after pancreaticoduodenectomy 显示文摘 | Duffas JP Suc B Msika S | 2005 | Am J Surg2005，189，6： | 1 |
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