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| 1 | Pancreatic stellate cell: Pandora's box for pancreatic disease biology显示文摘Pancreatic stellate cells(PSCs) were identified in the early 1980 s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiological condition, but are essential for maintaining the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Upon PSC activation, these perinuclear lipid droplets disappear from the cytosol, attain a myofibroblast like phenotype and expresses the activation marker, alpha smooth muscle actin. PSCs maintain their activated phenotype via an autocrine loop involving different cytokines and contribute to progressive fibrosis in chronic pancreatitis(CP) and pancreatic ductal adenocarcinoma(PDAC). Several pathways(e.g., JAK-STAT, Smad, Wnt signaling, Hedgehog etc.), transcription factors and mi RNAs have been implicated in the inflammatory and profibrogenic function of PSCs. The role of PSCs goes much beyond fibrosis/desmoplasia in PDAC. It is now shown that PSCs are involved in significant crosstalk between the pancreatic cancer cells and the cancer stroma. These interactions result in tumour progression, metastasis, tumour hypoxia, immune evasion and drug resistance. This is the rationale for therapeutic preclinical and clinical trials that have targeted PSCs and the cancer stroma. | Ratnakar R Bynigeri Aparna Jakkampudi Ramaiah Jangala Chivukula Subramanyam Mitnala Sasikala G Venkat Rao D Nageshwar Reddy Rupjyoti Talukdar | 2017 | World Journal of Gastroenterology2017，23，3： | 25 |
| 2 | A K-band tunable microstrip bandpass filter using a thin-film conductor/ferroelectric/dielectric multilayer configuration 显示文摘 | Subramanyam G Van Keuls F Miranda F A | 1998 | Microwave and Guided Wave Letters IEEE1998，8，2： | 1 |
| 3 | Estimation of transient overvoltage in gas insulated busduct from 220 kV GIS显示文摘 | KONDALU M REDDY G S SUBRAMANYAM P S | 2011 | International Journal of Computer Applications2011，20，8： | 1 |
| 4 | Selenium levels in dilated cardiomyopathy 显示文摘 | Vijaya J Subramanyam G Sukhaveni V | 2000 | Indian Med Assoc2000，98，4： | 1 |
| 5 | Phage lysin to control the overgrowth of normal flora in processed sputum samples for the rapid and sensitive detection of Mycobacterium tuberculosis by luciferase reporter phage assay显示文摘 | Subramanyam B Sivaramakrishnan G Dusthackeer A | 2013 | BMC Infect Dis2013，28，13： | 1 |
| 6 | Process Parameter Dependent Property Studies on CdO Films Prepared by DC Reactive Magnetron Sputtering显示文摘 | Subramanyam T K Mohan R G Uthanna S | 2001 | Materials Chemistry and Physics2001，69，13： | 1 |
| 7 | A Si MMIC compatible ferroelectric varactor shunt switch for microwave applications 显示文摘 | SUBRAMANYAM G AHAMED F BIGGERS R | 2008 | IEEE Microwave and Wireless Component Letters2008，15，11： | 1 |
| 8 | Muscarinic stimulation of gallbladder epithelium Ⅰ:electrophysiology and signaling mechanisms 显示文摘 | Altenberg G A Subramanyam M Bergmann J S | 1993 | Am J Physiol1993，265，： | 1 |
| 9 | Unruptured sinus of Valsalva aneurysms manifesting as complete heart block显示文摘 | Rajashekar D Subramanyam G Panchamukheswar R | 2003 | Asian Cardiovasc Thorac Ann2003，13，3： | 1 |
| 10 | Establish- ment of somatic embryogenesis and podophyllotoxin production in liquid shake cultures of Podophyllum hexandrum Royle 显示文摘 | Rajesh M Sivanandhan G Subramanyam K | 2014 | Ind Crop Prod2014，60，： | 1 |
| 11 | Thermal isomerizati on of isodicyclopentadiene and its cycloaddition reactions 显示文摘 | Subramanyam R Bartlett P D Mohrasias G Y | 1982 | J Qrg Chem1982，47，： | 1 |
| 12 | Behavior of battered piles un-der lateral loads显示文摘 | Prakash S Subramanyam G | 1965 | Journal of the Indian National Societyof SoilMechanics and Foundation Engineering1965，4，2： | 1 |
| 13 | 查看详情显示文摘 | Venkataiah G Krishna D C Vithal M Rao S S Bhat S V Prasad V Subramanyam S V Venugopal Reddy P | | 0，，： | 1 |
| 14 | Selenium levels in dilated cardiomyopathy显示文摘 | VIJAYA J SUBRAMANYAM G SUKHAVEN I | 2000 | Indian Med Assoc2000，98，4： | 1 |
| 15 | Effect of chromium on atherosclerosis in experimental rabbits 显示文摘 | SUBRAMANYAM G VIJAYA I PERAMMA D | 1995 | Atherosclerosis1995，115，1： | 1 |
| 16 | Highly Efficient Quantum-dot Light-emitting Diodes with DNA-CTMA as a Combined Hole-transporting and Electron-blocking Layer 显示文摘 | SUN Q J SUBRAMANYAM G DAI L M | 2009 | ACS Nano2009，3，3： | 1 |
| 17 | 显示文摘 | Subramanyam G | 2000 | IEEE Transactions on Microwave Theory and Techniques2000，48，： | 1 |
| 18 | Acute coronary syndrome in an intensive care unit of a tertiary care centre:the spectrum and coronary risk factors显示文摘 | Gautam M P Sogunuru G Subramanyam G | 2013 | JNMA J Nepal Med Assoc2013，52，190： | 1 |
| 19 | Dyslipidemia in preeclampsia-risk factor for future maternal cardiovascular diseases显示文摘 | Pushparaj JL Subramanyam G | | 0，，4： | 1 |
| 20 | The role of cadmium in induction of atherosclerosis in rabbits显示文摘 | Subramanyam G Bhaskar M Govindappa S | 1992 | Ind Heart J1992，44，3： | 1 |
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