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| 1 | Thymoquinone inhibits the migration of mouse neuroblastoma(Neuro-2a) cells by down-regulating MMP-2 and MMP-9显示文摘Thymoquinone(TQ), an active component derived from the medial plant Nigella sativa, has been used for medical purposes for more than 2 000 years. Recent studies have reported that TQ blocked angiogenesis in animal model and reduced migration, adhesion, and invasion of glioblastoma cells. We have recently shown that TQ could exhibit a potent cytotoxic effect and induce apoptosis in mouse neuroblastoma(Neuro-2a) cells. In the present study, TQ treatment markedly decreased the adhesion and migration of Neuro-2a cells. TQ down-regulated MMP-2 and MMP-9 protein expression and m RNA levels and their activities. Furthermore, TQ significantly down-regulated the protein expression of transcription factor NF-κB(p65) but not significantly altered the expression of N-Myc. Taken together, our data indicated that TQ's inhibitory effect on the migration of Neuro-2a cells was mediated through the suppression of MMP-2 and MMP-9 expression, suggesting that TQ treatment can be a promising therapeutic strategy for human malignant neuroblastoma. | Arumugam Paramasivam Subramanian Raghunandhakumar Jayaseelan Vijayashree Priyadharsini Gopalswamy Jayaraman | 2016 | Chinese Journal of Natural Medicines2016，14，12： | 6 |
| 2 | Implications of m6A modification in autoimmune disorders显示文摘N6-Methyladenosine(m6A)is the most common and abundant modification of RNA molecules,including mRNAs,microRNAs(miRNAs),and long noncoding RNAs(lncRNAs).1 The m6A modification is catalyzed and dynamically regulated by recently discovered enzymes termed“writers”(methyltransferases including METTL3,METTL14,and WTAP),“erasers”(demethylases including FTO and ALKBH5)and“readers”(m6A-binding proteins including YTHDC1,YTHDC2,YTHDF1,YTHDF2,and YTHDF3).These modifications were recently shown to be involved in the regulation of different biological processes. | Arumugam Paramasivam Jayaseelan Vijayashree Priyadharsini Subramanian Raghunandhakumar | 2020 | Cellular & Molecular Immunology2020，17，5： | 2 |
| 3 | Antimagic Labeling of Generalized Pyramid Graphs显示文摘An antimagic labeling of a graph withq edges is a bijection from the set of edges to the set of positive integers{1,2,...,q}such that all vertex weights are pairwise distinct,where the vertex weight of a vertex is the sum of the labels of all edges incident with that vertex.A graph is antimagic if it has an antimagic labeling.In this paper,we provide antimagic labelings for a family of generalized pyramid graphs. | Subramanian ARUMUGAM Mirka MILLER Oudone PHANALASY Joe RYAN | 2014 | Acta Mathematica Sinica,English Series2014，30，2： | 2 |
| 4 | Synergistic interactions of Ferulic acid with Ascorbic acid: Its cardioprotective role during isoproterenol induced myocardial infarction in rats显示文摘 | Surinder Kumar Yogeeta Arunachalam Gnanapragasam Subramanian Senthil Kumar Rajakannu Subhashini Arumugam Sathivel Thiruvengadum Devaki | 2006 | Molecular and Cellular Biochemistry (-)2006，，1： | 1 |
| 5 | A st-udy of rivastigmine liposomes for delivery into the brain through intranasal route显示文摘 | Arumugam K Subramanian GS Mallayasamy SR | 2008 | Acta Pharm2008，58，3： | 1 |
| 6 | In vitro and comparative study on the extracellular enzyme activity of molds isolated from keratomycosis and soil显示文摘AIM:To isolate and identify the molds involved in mycotic keratitis; to isolate corresponding species from soil samples; to compare the extracellular enzyme activity indices of the molds isolated from keratitis cases and the corresponding soil isolates.METHODS:The specimens were collected from the target patients attending the microbiology laboratory of tertiary eye hospital in Coimbatore, Tamilnadu state,India. The isolates were subjected for identification based on the growth on solid media, direct microscopy and lacto phenol cotton blue wet mount preparation.Extracellular enzymes such as lipase, deoxyribonuclease(DNase), α-amylase, protease, cellulase and pectinase produced by the fungal isolates were screened on solid media supplemented with the corresponding substrates.Based on growth and zone diameter, the enzyme activity indices were calculated and were compared with that of the soil fungal isolates.RESULTS:A total of 108 clinical samples were collected from a tertiary eye care hospital and out of which 60 fungal isolates were obtained. Among these,Fusarium spp.(n =30), non sporulating molds(n =9),Aspergillus flavus(n =6), Bipolaris spp.(n =6),Exserohilum spp.(n =4), Curvularia spp.(n =3),Alternaria spp.(n =1) and Exophiala spp.(n =1) were identified and designated as FS1-30, NSM1-9, AF1-6,BS1-6, ES1-4, CS1-3, AS1 and EX1, respectively. For comparative analysis, soil samples were also collected from which, one isolate of each Fusarium spp.,Aspergillus flavus, Bipolaris spp., Exserohilum spp., and Curvularia spp., respectively were selected. Highest lipase activity was seen in corneal isolate NSM2(EAI= 2.14).The DNase activity was higher in NSM9(EAI =1.88). In case of protease, Fusarium spp.(FS9) had prominent enzyme activity index of 1.38; α-amylase activity was also superior in corneal isolate FS13 with EAI of 1.63 when compared to other isolates. The enzyme activity index for cellulase was also noted to be higher in corneal isolates i.e. NSM7 with EAI of 1.98 when compared to other corneal and soil isolates. The pectinase activity index was also prominent for corneal isolate NSM5 versus the soil isolates, SAF1, SFS1, SES1, SBS1 and SCS 1 as 1.76 versus 1.47, 1.38, 1.16, 1.11 and 1.14,respectively.CONCLUSION:Themostcommon isolate was Fusarium spp. followed by Aspergillus, Curvularia, Exserohilum,Bipolaris, Exophiala and Alternaria species. Enzyme activity indices(EAI) of the enzymes analysed varied with the clinical and soil isolates with respect to protease and cellulase(P =0.01). Of all the strains compared it was noted that mean EAI was greater in many clinical fusarial isolates followed by non sporulating molds. | Arumugam Mythili Yendranbam Randhir Babu Singh Ravindran Priya Anamangadan Shafeeq Hassan Palanisamy Manikandan Kanesan Panneerselvam Venkatapathy Narendran Coimbatore Subramanian Shobana | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 1 |
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