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| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | Primary pediatric mid-brain lymphoma:Report of a rare pediatric tumor in a rare location显示文摘Primary central nervous system lymphoma(PCNSL) is a rare disease in pediatric age group. A thirteen-yearold male child presented with complaints of headache for six months, vomiting and diplopia for three days. Magnetic resonance imaging of the brain showed a single lesion of 1.7 cm × 1.6 cm × 1.6 cm in the mid brain and tectum. He underwent a gross total resection of the tumor. The histopathological evaluation revealed B cell high grade non Hodgkin lymphoma. The patient was treated with High dose methotrexate and cranio spinal radiation. The patient was alive without disease 12 mo after completion of treatment. This case highlights importance of keeping PCNSL as differential in brain stem lesions of pediatric patients also. Radiation and chemotherapy remains the most important treatment for such patients. | Rony Benson Supriya Mallick Suvendu Purkait Vaishali Suri K P Haresh Subhash Gupta Dayanand Sharma Pramod Kumar Julka Goura Kishore Rath | 2016 | World Journal of Clinical Cases2016，4，12： | 2 |
| 3 | Tobacco Rattle Virus Vector: A Rapid and Transient Means of SilencingManduca sexta Genes by Plant Mediated RNA Interference显示文摘 | Pavan K Sagar Subhash P Ian T B | 2012 | PLoS ONE2012，7，31： | 1 |
| 4 | Evaluation of cyclic hot corrosion behavior of detonation gun sprayed Cr3C2-25% NiCr coatings on nickel-and iron-based superalloys 显示文摘 | Subhash K Jayaganthan R Satya P | 2009 | Surface & Coatings Technology2009，203，8： | 1 |
| 5 | Transition metal complexes of semicarbazones and thiosem icarbazones 显示文摘 | Subhash P George B K | 1985 | Coordination Chemistry Reviews1985，63，： | 1 |
| 6 | Laser-induced damage to spray pyrolysis deposited transparent conducting films显示文摘 | Radhakrishnan P Sathianandan K Subhash N | 1986 | J Appl Phys1986，59，3： | 1 |
| 7 | Heat transfer in a visco-elastic fluid past a stretching sheet with viscous dissipation and internal heat generation 显示文摘 | Veena P H Subhash Abel M Rajagopal K Pravin V K | 2006 | Zeitschrifl fi~r Angewandte Mathematik und Physik (ZAMP)2006，57，3： | 1 |
| 8 | Thidiazuron induced high fre- quency adventitious shoot formation and plant regeneration in Capsicum ann- uum L显示文摘 | Venkataiah P Christopher T Subhash K | 2003 | Plant Biotechnol2003，，5： | 1 |
| 9 | Genotype-explant and medium effects on ad- ventitious shoot bud formation and plant regeneration in Capsicwn annuum L 显示文摘 | Venkataiah P Subhash K | 2001 | Journal of Genetics and Breeding2001，55，2： | 1 |
| 10 | Preparation of 2-azaanthraquinones via aryne reaction显示文摘 | Subhash K P Edward B R | 1988 | Heterocycles1988，27，： | 1 |
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