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| 1 | A randomized controlled clinical trial on the treatment of Thymosin-a1 versus interferon-α in patients with hepatitis B显示文摘INTRODUCTIONChronic hepatitis B virus (HBV) infection is a serious problem because of its world wide distribution and possible adverse sequelae ,such as cirrhosis and hepatocellular carcinoma .The World Health Organization estimates that HBV has infected mord than 350 million people worldwide ,and up to 20% of them will become chromic carricrs and will be at significant risk for cirrhosis and HCC .The ultimate goal of the therapy for chronic hepatitis B is to prevent progression to cirrhosis and to prevent development of HCC. | Jing You Lin Zhuang Bao Zhang Tang Wei Bo Yang Su Ying Ding Wu Li Rong Xue Wu Hong Li Zhang Yan Mei Zhang Shao Ming Yan Lu Zhang ~1Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China ~2Departrnent of Hepatology,Kunming Third Municipal People’s Hospital,Kunming 650041,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 48 |
| 2 | BMPs functionally replace KLf4, and support efficient reprogramming of mouse fibroblasts by Oct4 alone显示文摘由定义因素的导致的 pluripotent 干细胞的产生成为了一个有用模型调查 reprogramming 和房间命运决心的机制。然而,基于因素的 reprogramming 的精确机制仍然保持不清楚。这里,我们证明 Klf4 主要在 reprogramming 的起始的阶段行动开始 mesenchymal-to-epithelial 转变并且能是机能上地由骨头代替了形态基因的蛋白质(BMP ) 。BMP 增加了老鼠的 Oct4/Sox2-mediated reprogramming 的效率胚胎的成纤维细胞(MEF ) 到 ~1% 。BMP 也支持了 MEF 和尾巴的单个因素的基于 Oct4 的 reprogramming 胫骨的成纤维细胞。我们的研究在 reprogramming 澄清 Klf4 的贡献并且在区分的房间作为 pluripotency 的单个 setter 建立 Oct4。 | Jiekai Chen Jing Liu Jiaqi Yang You Chen Jing Chen Su Ni Hong Song Lingwen Zeng Ke Ding Duanqing Pei | 2011 | Cell Research2011，21，1： | 26 |
| 3 | Preliminary results of Thymosin-a1 versus interferon-α treatment in patients with HBeAg negative and serum HBV DNA positive chronic hepatitis B显示文摘INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer . | Lin Zhuang Jing You Bao Zhang Tang Su Ying Ding Kui Hua Yan Dan Peng Yan Mei Zhang Lu Zhang ~1Department of Hepatology,Kunming Third Municipal Peoples Hospital,Kunming 650041,Yunnan Province,China ~2Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 22 |
| 4 | Global Attractors for a Nonclassical Diffusion Equation显示文摘我们在 H_0~1 证明全球引起注意的人的存在(为一个非古典的散开方程的Ω) 。非线性 f 的二种类型被考虑:一个人是批评代表,并且其它是任意的顺序的多项式生长。 | Chun You SUN Su Yun WANG Cheng Kui ZHONG | 2007 | Acta Mathematica Sinica,English Series2007，23，7： | 20 |
| 5 | Mycoplasma infections and different human carcinomas显示文摘AIM To explore relationships between human carcinomas and mycoplasma infection.METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffinembedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis. In other gastric diseases, the mycoplasma infection ratio was 28% (18/49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia. The difference is significant with gastric cancer (X2=12.06, P<0.05). In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/58), but it was 20.9% (10/49) in adenomarous polyp (X2=13.46, P<0.005).Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P< 0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/53), 52.6% (31/ 59), 39.7%(25/63) and 41% (38/91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two. The mechanism involved in oncogenesis by mycoplasma remains unknown. | Su Huang Ji You Li Jan Wu Lin Meng Cheng Chao Shou Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100034. ChinaSu Huang, received B. A from Jiangxi Medical College of China in 1994. Now she is a graduate student pursuing a Ph. D degree at the Peking University School of Oncology. | 2001 | World Journal of Gastroenterology2001，7，2： | 18 |
| 6 | Association between fifteen risk factors and progressing ischemic stroke in the Han population of northeast China显示文摘与进行的 ischemic 联系的死亡和残疾摸的背景比一般 ischemic 击高得多。这研究被进行决定为进行的 ischemic 的因素在有在 24 个小时以内的 ischemic 击的 2511 个病人的一个总数承认了到神经病学的部门的东北 China.Methods 的汉人口摸的风险,哈尔滨医药大学的首先隶属于的医院被学习,从 2007 年 11 月到 2009 年 5 月。所有病人被分类进根据斯堪的纳维亚的神经病学的击规模的分数进行或非进行的组。十五个通常认为的风险因素被评估。为进行的 ischemic 击的风险因素的影响与简单逻辑分析,多重逻辑分析,和逐步的逻辑回归模型被分析。所有统计分析被 SAS 9.1 .Results 完全执行 359 (14.3%) 病人们为进行的 ischemic 满足了标准击。逻辑分析显示出那年龄,家庭中风历史,吸烟历史,录取上的高血压,在在到医院的录取以后的血压的落下,录取上的高浆液葡萄糖,并且发烧与在有这些因素的 ischemic 中风的东北 China.Conclusion 人的汉人口的进行的 ischemic 击有关是更可能的发展进行 ischemic 击。 | YANG Shan-shan TENG Da YOU Ding-yun SU Zhi-qiang LI Fang ZHAO Ji-yang | 2010 | Chinese Medical Journal2010，，11： | 11 |
| 7 | Two adaptive detectors for range-spread targets in non-Gaussian clutter显示文摘This paper addresses adaptive detection of range-spread target in spherically invariant random vector clutter. Based on the nonadaptive detectors of NSDD-GLRT and SDD-GLRT, two adaptive detectors named ANSDD-GLRT and ASDD-GLRT are devised by replacing the unknown normalized clutter covariance matrix with the sample covariance matrix based on the secondary data. The formulas of detection probability and false alarm probability are deduced. Moreover, the constant false alarm rate properties of both adaptive detectors are assessed and the inffuence of mismatched steering vector on detection probability is analyzed. The experimental results show that the adaptive detectors have an acceptable loss with respect to the nonadaptive counterparts. Furthermore, the ANSDD-GLRT converges much faster than the ASDD-GLRT, however, the latter rejects the misaligned signals more effectively. Both detectors perform well for the uniformly-distributedenergy target, but degenerate for the fluctuating targets. In addition, the correlation between target scatterers results in an additional gain for low signal-to-clutter power ratio. | HE You JIAN Tao SU Feng PING DianFa | 2011 | Science China(Information Sciences)2011，54，2： | 10 |
| 8 | Toothpick impaction with sigmoid colon pseudodiverticulum formation successfully treated with colonoscopy显示文摘Foreign bodies in the colon are encountered with increasing frequency, but only sporadic reports concerning their management have appeared in the literature. While most ingested foreign bodies usually pass through the gastrointestinal tract uneventfully, sharp foreign bodies such as toothpicks infrequently cause intestinal perforation and may even result in death. We report our experience with a patient with a sigmoid colon pseudodiverticulum formation, a complication of accidental ingestion of a toothpick that was diagnosed and successfully managed colonoscopically. | Youn Son Chung Yong Woo Chung Sun You Moon Su Mi Yoon Min-Jeong Kim Kyoung Oh Kim Cheol Hee Park Taeho Hahn Kyo-Sang Yoo Sang Hoon Park Jong Hyeok Kim Choong Kee Park | 2008 | World Journal of Gastroenterology2008，14，6： | 10 |
| 9 | MicroTom Metabolic Network: Rewiring Tomato Metabolic Regulatory Network throughout the Growth Cycle显示文摘Tomato(Solanum lycopersicum)is a major horticultural crop worldwide and has emerged as a preeminent model for metabolic research.Although many research efforts have focused on the analysis of metabolite differences between varieties and species,the dynamics of metabolic changes during the tomato growth cycle and the regulatory networks that underlie these changes are poorly understood.In this study,we integrated high-resolution spatio-temporal metabolome and transcriptome data to systematically explore the metabolic landscape across 20 major tomato tissues and growth stages.In the resulting MicroTom Metabolic Network,the 540 detected metabolites and their co-expressed genes could be divided into 10 distinct clusters based on their biological functions.Using this dataset,we constructed a global map of the major metabolic changes that occur throughout the tomato growth cycle and dissected the underlying regulatory network.In addition to verifying previously well-established regulatory networks for important metabolites,we identified novel transcription factors that regulate the biosynthesis of important secondary metabolites such as steroidal glycoalkaloids and flavonoids.Our findings provide insights into spatiotemporal changes in tomato metabolism and generate a valuable resource for the study of metabolic regulatory processes in model plants. | Yan Li Yang Chen Lu Zhou Shengjie You Heng Deng Ya Chen Saleh Alseekh Yong Yuan Rao Fu Zixin Zhang Dan Su Alisdair R.Fernie Mondher Bouzayen Tao Ma Mingchun Liu Yang Zhang | 2020 | Molecular Plant2020，13，8： | 10 |
| 10 | CFAR assessment of covariance matrix estimators for non-Gaussian clutter显示文摘In the non-Gaussian clutter modeled as independent and identically distributed spherically invariant random vectors, three estimators of sample covariance matrix (SCM), normalized sample covariance matrix (NSCM) and the corresponding recursive estimator (NSCM-RE) are analyzed. Based on the uniform theorem, three corresponding adaptive normalized matched filters (ANMF) are evaluated from the standpoint of constant false alarm rate (CFAR) property. The theoretical results demonstrate that the SCM-ANMF is only CFAR to the normalized clutter covariance matrix (NCCM); the NSCM-ANMF is only CFAR to the clutter power level; and the NSCM-RE-ANMF with finite number of iterations is still not CFAR to the NCCM. To ensure CFAR property of ANMF, an adaptive estimator (AE) is devised. Moreover, with AE as the initialization matrix for the iterations, the AE-RE is proposed. With finite number of iterations, the corresponding AE-REANMF guarantees CFAR property to both of the NCCM and the clutter power level. Finally, the performance assessment conducted by Monte Carlo simulation confirms the effectiveness of the proposed detectors. | HE You, JIAN Tao, SU Feng, QU ChangWen & PING DianFa Research Institute of Information Fusion, Naval Aeronautical and Astronautical University, Yantai 264001, China | 2010 | Science China(Information Sciences)2010，53，11： | 8 |
| 11 | Screening of Serum Biomarkers for Distinguishing between Latent and Active Tuberculosis Using Proteome Microarray显示文摘Objective To identify potential serum biomarkers for distinguishing between latent tuberculosis infection(LTBI) and active tuberculosis(TB). Methods A proteome microarray containing 4,262 antigens was used for screening serum biomarkers of 40 serum samples from patients with LTBI and active TB at the systems level. The interaction network and functional classification of differentially expressed antigens were analyzed using STRING 10.0 and the TB database, respectively. Enzyme-linked immunosorbent assays(ELISA) were used to validate candidate antigens further using 279 samples. The diagnostic performances of candidate antigens were evaluated by receiver operating characteristic curve(ROC) analysis. Both antigen combination and logistic regression analysis were used to improve diagnostic ability. Results Microarray results showed that levels of 152 Mycobacterium tuberculosis(Mtb)-antigenspecific IgG were significantly higher in active TB patients than in LTBI patients(P < 0.05), and these differentially expressed antigens showed stronger associations with each other and were involved in various biological processes. Eleven candidate antigens were further validated using ELISA and showed consistent results in microarray analysis. ROC analysis showed that antigens Rv2031 c, Rv1408, and Rv2421 c had higher areas under the curve(AUCs) of 0.8520, 0.8152, and 0.7970, respectively. In addition, both antigen combination and logistic regression analysis improved the diagnostic ability. Conclusion Several antigens have the potential to serve as serum biomarkers for discrimination between LTBI and active TB. | CAO Shu Hui CHEN Yan Qing SUN Yong LIU Yang ZHENG Su Hua ZHANG Zhi Guo LI Chuan You | 2018 | Biomedical and Environmental Sciences2018，31，7： | 8 |
| 12 | Chitinase-3 like-protein-1 function and its role in diseases显示文摘Non-enzymatic chitinase-3 like-protein-1(CHI3L1)belongs to glycoside hydrolase family 18.It binds to chitin,heparin,and hyaluronic acid,and is regulated by extracellular matrix changes,cytokines,growth factors,drugs,and stress.CHI3L1 is synthesized and secreted by a multitude of cells including macrophages,neutrophils,synoviocytes,chondrocytes,fibroblast-like cells,smooth muscle cells,and tumor cells.It plays a major role in tissue injury,inflammation,tissue repair,and remodeling responses.CHI3L1 has been strongly associated with diseases including asthma,arthritis,sepsis,diabetes,liver fibrosis,and coronary artery disease.Moreover,following its initial identification in the culture supernatant of the MG63 osteosarcoma cell line,CHI3L1 has been shown to be overexpressed in a wealth of both human cancers and animal tumor models.To date,interleukin-13 receptor subunit alpha-2,transmembrane protein 219,galectin-3,chemo-attractant receptor-homologous 2,and CD44 have been identified as CHI3L1 receptors.CHI3L1 signaling plays a critical role in cancer cell growth,proliferation,invasion,metastasis,angiogenesis,activation of tumor-associated macrophages,and Th2 polarization of CD4+T cells.Interestingly,CHI3L1-based targeted therapy has been increasingly applied to the treatment of tumors including glioma and colon cancer as well as rheumatoid arthritis.This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis,then posits investigational strategies for targeted therapies. | Ting Zhao Zhongping Su Yingchang Li Xiaoren Zhang Qiang You | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 8 |
| 13 | Juvenile hominoid cranium from the terminal Miocene of Yunnan,China显示文摘Fossil apes are known from several late Miocene localities in Yunnan Province,southwestern China,principally from Shihuiba(Lufeng)and the Yuanmou Basin,and represent three species of Lufengpithecus.They mostly comprise large samples of isolated teeth,but there are also several partial or complete adult crania from Shihuiba and a single juvenile cranium from Yuanmou.Here we describe a new,relatively complete and largely undistorted juvenile cranium from the terminal Miocene locality of Shuitangba,also in Yunnan.It is only the second ape juvenile cranium recovered from the Miocene of Eurasia and it is provisionally assigned to the species present at Shihuiba,Lufengpithecus lufengensis.Lufengpithecus has most often been linked to the extant orangutan,Pongo pygmaeus,but recent studies of the crania from Shihuiba and Yuanmou have demonstrated that this is unlikely.The new cranium reinforces the view that Lufengpithecus represents a distinct,late surviving lineage of large apes in the late Miocene of East Asia that does not appear to be closely affiliated with any extant ape lineage.It substantially increases knowledge of cranial morphology in Lufengpithecus and demonstrates that species of this genus represent a morphologically diverse radiation of apes,which is consistent with the dynamic tectonic and biotic milieu of southwestern China in the late Miocene. | JI XuePing JABLONSKI Nina G SU Denise F DENG ChengLong FLYNN Lawrence J YOU YouShan KELLEY Jay | 2013 | Chinese Science Bulletin2013，58，31： | 8 |
| 14 | Isolation of cabbage exosome-like nanovesicles and investigation of their biological activities in human cells显示文摘There are extensive studies on the applications of extracellular vesicles(EVs)produced in cell culture for therapeutic drug development.However,large quantities of EVs are needed for in vivo applications,which requires high production costs and time.Thus,the development of new EV sources is essential to facilitate their use.Accordingly,plant-derived exosome-like nanovesicles are an emerging alternative for culture-derived EVs.Until now,however,few studies have explored their biological functions and uses.Therefore,it is necessary to elucidate biological activities of plant-derived exosome-like nanovesicles and harness vesicles for biomedical applications.Herein,cabbage and red cabbage were used as nanovesicle sources owing to their easy cultivation.First,an efficient method for nanovesicle isolation from cabbage(Cabex)and red cabbage(Rabex)was developed.Furthermore,isolated nanovesicles were characterized,and their biological functions were assessed.Both Cabex and Rabex promoted mammalian cell proliferation and,interestingly,suppressed inflammation in immune cells and apoptosis in human keratinocytes and fibroblasts.Finally,therapeutic drugs were encapsulated in Cabex or Rabex and successfully delivered to human cells,demonstrating the potential of these vesicles as alternative drug delivery vehicles.Overall,the current results provide strong evidence for the wide application of Cabex and Rabex as novel therapeutic biomaterials. | Jae Young You Su Jin Kang Won Jong Rhee | 2021 | Bioactive Materials2021，6，12： | 7 |
| 15 | Risk of gestational diabetes recurrence and the development of type 2 diabetes among women with a history of gestational diabetes and risk factors: a study among 18 clinical centers in China显示文摘Background:Gestational diabetes mellitus(GDM)brings health issues for both mothers and offspring,and GDM prevention is as important as GDM management.It was shown that a history of GDM was significantly associated with a higher maternal risk for GDM recurrence.The incidence of GDM recurrence was unclear because of the incidence of second-child was low before 2016 in China.We aim to investigate the prevalence of GDM recurrence and its associated high-risk factors which may be useful for the prediction of GDM recurrence in China.Methods:A retrospective study was conducted which enrolled participants who underwent regular prenatal examination and delivered twice in the same hospital of 18 research centers.All participants were enrolled from January 2018 to October 2018,where they delivered the second baby during this period.A total of 6204 women were enrolled in this study,and 1002 women with a history of GDM were analyzed further.All participants enrolled in the study had an oral glucose tolerance test(OGTT)result at 24 to 28 weeks and were diagnosed as GDM in the first pregnancy according to the OGTT value(when any one of the following values is met or exceeded to the 75-g OGTT:0 h[fasting],≥5.10 mmol/L;1 h,≥10.00 mmol/L;and 2 h,≥8.50 mmol/L).The prevalence of GDM recurrence and development of type 2 diabetes mellitus were calculated,and its related risk factors were analyzed.Results:In 6204 participants,there are 1002 women(1002/6204,16.15%)with a history of GDM and 5202 women(5202/6204,83.85%)without a history of GDM.There are significant differences in age(32.43±4.03 years vs.33.00±3.34 years vs.32.19±3.37 years,P<0.001),pregnancy interval(4.06±1.44 years vs.3.52±1.43 years vs.3.38±1.35 years,P=0.004),prepregnancy body mass index(BMI)(27.40±4.62 kg/m^(2)vs.23.50±3.52 kg/m^(2)vs.22.55±3.47 kg/m^(2),P<0.001),history of delivered macrosomia(22.7%vs.11.0%vs.6.2%,P<0.001)among the development of diabetes mellitus(DM),recurrence of GDM,and normal women.Moreover,it seems so important in the degree of abnormal glucose metabolism in the first pregnancy to the recurrence of GDM and the development of DM.There are significant differences in OGTT levels of the first pregnancy such as area under the curve of OGTT value(18.31±1.90 mmol/L vs.16.27±1.93 mmol/L vs.15.55±1.92 mmol/L,P<0.001),OGTT fasting value(5.43±0.48 mmol/L vs.5.16±0.49 mmol/L vs.5.02±0.47 mmol/L,P<0.001),OGTT 1-hour value(10.93±1.34 mmol/L vs.9.69±1.53 mmol/L vs.9.15±1.58 mmol/L,P<0.001),OGTT 2-hour value(9.30±1.66 mmol/L vs.8.01±1.32 mmol/L vs.7.79±1.38 mmol/L,P<0.001),incidence of impaired fasting glucose(IFG)(fasting plasma glucose≥5.6 mmol/L)(31.3%vs.14.6%vs.8.8%,P<0.001),and incidence of two or more abnormal OGTT values(68.8%vs.39.7%vs.23.9%,P<0.001)among the three groups.Using multivariate analysis,the factors,such as age(1.07[1.02-1.12],P=0.006),prepregnancy BMI(1.07[1.02,1.12],P=0.003),and area under the curve of OGTT in the first pregnancy(1.14[1.02,1.26],P=0.02),have an effect on maternal GDM recurrence;the factors,such as age(1.28[1.01-1.61],P=0.04),pre-pregnancy BMI(1.26[1.04,1.53],P=0.02),and area under the curve of OGTT in the first pregnancy(1.65[1.04,2.62],P=0.03),have an effect on maternal DM developed further.Conclusions:The history of GDM was significantly associated with a higher maternal risk for GDM recurrence during follow-up after the first pregnancy.The associated risk factors for GDM recurrence or development of DM include age,high pre-pregnancy BMI,history of delivered macrosomia,the OGTT level in the first pregnancy,such as the high area under the curve of OGTT,IFG,and two or more abnormal OGTT values.To prevent GDM recurrence,women with a history of GDM should do the preconception counseling before preparing next pregnancy. | Yumei Wei Juan Juan Rina Su Geng Song Xu Chen Ruiqin Shan Ying Li Shihong Cui Shangrong Fan Ling Feng Zishan You Haixia Meng Yan Cai Cuilin Zhang Huixia Yang | 2022 | Chinese Medical Journal2022，，6： | 7 |
| 16 | High resolution radar target adaptive detector and performance assessment显示文摘The high resolution radar target detection is addressed in the non-Gaussian clutter. An adaptive detector is derived for range-spread target based on a novel covariance matrix estimator. It is proved that the new detector is constant false alarm rate (CFAR) to both of the clutter covariance matrix structure and power level theoretically for match cases. The simulation results show that the new detector is almost CFAR for mismatch cases, and it outperforms the existing adaptive detector based on the sample covariance matrix. It also shows that the detection performance improves, as the number of pulses, the number of secondary data or the clutter spike increases. In addition, the derived detector is robust to different subsets, estimated clutter group sizes and correlations of clutter. Importantly, the number of iterations for practical application is just one. | Tao Jian You He Feng Su Changwen Qu Dianfa Ping | 2011 | Journal of Systems Engineering and Electronics2011，22，2： | 7 |
| 17 | Effect of metoprolol on myocardial apoptosis after coronary microembolization in rats显示文摘BACKGROUND:Coronary microembolization(CME) is a serious complication following percutaneous coronary intervention(PCI) in patients with acute coronary syndromes.The use of metoprolol before PCI can significantly protect ischemic myocardium from myocardial damage,but the function of metoprolol in the treatment of CME is not entirely clear.This study was to explore the effect and significance of metoprolol on myocardial apoptosis and caspase-3 activation after CME in rats.METHODS:Thirty rats were randomly divided into three groups including sham-operation(control group),CME plus saline(CME group),CME plus metoprolol(metoprolol group),10 rats for each group.The CME group was induced by injecting 3 000 polyethylene microspheres(42 urn)into the left ventricle during a 10-second occlusion of the ascending aorta;the control group was injected with physiological saline instead of microembolization ball;the metoprolol or saline group was given three intravenous bolus injections before CME.Echocardiography,TUNEL staining,and Western blotting were used to evaluate cardiac function,proportion of apoptotic cells and activation of caspase-3 respectively at 6 hours after operation.RESULTS:Echocardiography parameters displayed that the metoprolol group improved cardiac function significantly compared with the CME group(PO.05).The myocardial apoptotic rate of the CME group as well as the contents of activated caspase-3 increased significantly(P<0.05),both of which were ameliorated significantly by metoprolol treatment(P<0.05).CONCLUSIONS:This study demonstrates that metoprolol can protect the myocardium during CME in rats by inhibiting apoptosis and improving cardiac function.These results suggest that the inhibition of apoptosis can be a potential therapeutic strategy for the treatment of CME. | Qiang Su Lang Li Yang-chun Liu You Zhou Wei-ming Wen | 2013 | World Journal of Emergency Medicine2013，4，2： | 7 |
| 18 | Review on evolution and evaluation of asphalt pavement structures and materials显示文摘The purpose of this study was to summarize the wide-range literatures on asphalt pavements, explore the evolution of road pavements, analyze typical asphalt pavement structures, highlight current trends in research and industry, and to recommend future areas of research and development. In this research, road pavement evolution was explored from the earliest roads to the modern pavements. A new method was recommended to categorize asphalt pavement materials into the three large families which may be further sub-divided according to their mechanical parameters. A unified asphalt pavement classification(UAPC) method was proposed and the worldwide asphalt pavements could be divided into six types through the new method. Based o n the UAPC method, 1087 asphalt pavement structures were classified and analyzed to explore the asphalt thickness variation. In order to evaluate asphalt pavement performance, the Chinese design specification was employed for analyzing lives of 29 high-volume pavements and 28 low-volume pavements. Through this research, it was found that:(1) in the past 100 years, asphalt pavement materials and structures had been becoming more and more strong;(2) asphalt layer thicknesses were various from 5 to 60 cm and the overall pavement thicknesses were various from 28 to 160 cm;(3) the long-life pavements in the other countries may become'shorter-life' pavements according to the prediction based on the Chinese specification. | Yu Liu Peifeng Su Miaomiao Li Zhanping You Mohan Zhao | 2020 | Journal of Traffic and Transportation Engineering(English Edition)2020，7，5： | 6 |
| 19 | Safety of endoscopic ultrasound-guided ethanol ablation for pancreatic cystic lesions: A single-center experience of 214 patients显示文摘Background:Endoscopic ultrasound-guided ethanol ablation(EUS-EA)for pancreatic cystic lesions(PCLs)has been used in recent years as a feasible treatment modality for low malignant probability PCLs or patients considered high-risk for surgery.The present study aimed to confirm the safety of EUS-EA and to find predictive factors for adverse event(AE).Methods:A retrospective review was performed from the prospectively maintained database of patients who underwent EUS-EA for PCLs from June 2006 to April 2018 at Seoul National University Hospital.The primary outcomes of the study were the rates of AEs and severe AEs by EUS-EA.The secondary outcome was the predictive factors of AEs including acute pancreatitis and abdominal pain.Results:A total of 214 patients were evaluated and the diagnoses of PCLs according to cystic fluid analysis and clinical features were as follows:serous cystic neoplasm(32.2%),mucinous cystic neoplasm(26.6%),branch duct type intraductal papillary mucinous neoplasm(BD-IPMN)(29.4%),and pseudocyst(11.7%).Three patients(1.4%)experienced severe AEs.Overall,AEs occurred in 71(33.2%)patients.BD-IPMN(OR:2.87;95%CI:1.05–7.84;P=0.040),multilocular cysts(OR:3.59;95%CI:1.09–11.85;P=0.036),suspected ethanol leakage during procedure(OR:10.68;95%CI:1.98–57.53;P=0.006),and sticky cystic fluid(OR:3.83;95%CI:1.20–12.24;P=0.024)were predictive factors for post-procedural acute pancreatitis.PCLs of uncinate process(OR:2.99;95%CI:1.22–7.35;P=0.017)and PCLs with exophytic portion(OR:3.70;95%CI:1.96–7.01;P<0.001)were predictive factors for post-procedural abdominal pain.Conclusions:EUS-EA is a safe procedure with a very low rate of severe AEs.It seems possible to predict the AEs according to the features of the procedure and PCLs. | Jin Ho Choi Sang Hyub Lee Young Hoon Choi Min Su You Bang-Sup Shin Woo Hyun Paik Ji Kon Ryu Yong-Tae Kim | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，6： | 6 |
| 20 | Identifying changes in the wheat kernel proteome under heat stress using iTRAQ显示文摘Wheat(Triticum aestivum L.) is one of the three major global food crops. Hightemperature stress can affect its yield and quality. Studies of the effect of hightemperature stress on wheat kernel development are important because they can reveal the stability of wheat quality and lead to the genetic improvement of wheat quality traits. In this study, the isobaric tags for relative and absolute quantitation(iTRAQ)method was adopted to analyze changes in the protein expression profile of wheat cultivars under high temperature stress. The protein content of wheat grain increased under heat stress, while the SDS-sedimentation value and starch content decreased.Grain filling was deficient under high temperature stress, which reduced thousandkernel weight but did not affect wheat kernel length. The 207 differentially expressed proteins identified in Gaocheng 8901 under heat stress were associated with energy metabolism, growth and development, and stress response. Gene Ontology enrichment analysis showed that the annotated proteins that were differentially expressed in Gaocheng 8901 under heat stress were involved mainly in stimulus response, abiotic stress response, stress response, and plasma membrane. A set of 78 differentially expressed proteins were assigned to 83 KEGG signaling/metabolic pathways. KEGG pathway enrichment analysis showed that this set of proteins was significantly enriched in members of 51 pathways, and the proteins participated mainly in protein synthesis in the endoplasmic reticulum, starch and sucrose metabolism, and reaction on ribosomes. Five differentially expressed proteins were involved in protein–protein interaction networks that may greatly influence the yield and quality of wheat grain. In wheat, high-temperature stress leads to a variety of effects on protein expression and may ultimately cause changes in yield and quality. | Yufeng Zhang Hongyao Lou Dandan Guo Ruiqi Zhang Meng Su Zhenghong Hou Haiying Zhou Rongqi Liang Chaojie Xie Mingshan You Baoyun Li | 2018 | The Crop Journal2018，6，6： | 5 |
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