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| 1 | Routine defunctioning stoma after chemoradiation and total mesorectal excision:A single-surgeon experience显示文摘AIM:To investigate the 10-year results of treating low rectal cancer by a single surgeon in one institution.METHODS:From Oct 1998 to Feb 2009,we prospectively followed a total of 62 patients with cT2-4 low rectal cancer with lower tumor margins measuring at 3 to 6 cm above the anal verge.All patients received neoadjuvant chemoradiation(CRT) for 6 wk.Among them,85% of the patients received 225 mg/m2/d 5-fluorouracil using a portable infusion pump.The whole pelvis received a total dose of 45 Gy of irradiation in 25 fractions over 5 wk.The interval from CRT completion to surgical intervention was planned to be approximately 6-8 wk.Total mesorectal excision(TME) and routine defunctioning stoma construction were performed by one surgeon.The distal resection margin,circumferential resection margin,tumor regression grade(TRG) and other parameters were recorded.We used TRG to evaluate the tumor response after neoadjuvant CRT.We evaluated anal function outcomes using the Memorial Sloan-Kettering Cancer Center anal function scores after closure of the defunctioning stoma.RESULTS:The median distance from the lower margin of rectal cancer to the anal verge was 5 cm:6 cm in 9 patients,5 cm in 32 patients,4 cm in 10 patients,and 3 cm in 11 patients.Before receiving neoadjuvant CRT,45 patients(72.6%) had a cT3-4 tumor,and 21(33.9%) patients had a cN1-2 lymph node status.After CRT,30 patients(48.4%) had a greater than 50% clinical reduction in tumor size.The final pathology reports revealed that 33 patients(53.2%) had a ypT3-4 tumor and 12(19.4%) patients had ypN1-2 lymph node involvement.All patients completed the entire course of neoadjuvant CRT.Most patients developed only Grade 1-2 toxicities during CRT.Thirteen patients(21%) achieved a pathologic complete response.Few post-operative complications occurred.Nearly 90% of the defunctioning stomas were closed within 6 mo.The local recurrence rate was 3.2%.Pathologic lymph node involvement was the only prognostic factor predicting disease recurrence(36.5% vs 76.5%,P = 0.006).Nearly 90% of patients recovered sphincter function within 2 year after closure of the defunctioning stoma.CONCLUSION:Neoadjuvant CRT followed by TME,combined with routine defunctioning stoma construction and high-volume surgeon experience,can provide excellent surgical quality and good local disease control. | Shao-Chieh Lin Po-Chuan Chen Chung-Ta Lee Hong-Ming Tsai Peng-Chan Lin Helen HW Chen Yuan-Hwa Wu Bo-Wen Lin Wen-Pin Su Jenq-Chang Lee | 2013 | World Journal of Gastroenterology2013，19，11： | 3 |
| 2 | Transsubmental tongue-base suspension in treating patients with severe obstructive sleep apnoea after failed uvulopalatopharyngoplasty: Our Experience 显示文摘 | Huang TW Su HW Wang CT | 2014 | Clin O tolaryngol2014，39，2： | 1 |
| 3 | Hippocampus and serum metabolo- mic studies to explore the regulation of Chaihu - Shu - Gan - San on metabolic network disturbances of rats exposed to chronic variable stress 显示文摘 | Su ZH Jia HM Zhang HW | 2014 | Mol Biosyst2014，10，3： | 1 |
| 4 | Gene expression profile of CD4+ T cells reveals an interferon signaling suppression associated with progression of experimental Schistosoma japonicum infection显示文摘 | Ji MJ Su C Wu HW | 2003 | Cell Immunol2003，224，1： | 1 |
| 5 | Epidemiology of myeloproliferative neoplasms in the United States显示文摘 | Mehta J Wang HW Iqbal SU | 2014 | Leukemia Lymphoma2014，55，3： | 1 |
| 6 | Pelvic retroperitoneal leiomyoma显示文摘 | Lin HW Su WC Tsai MS | 2010 | Am J Surg2010，199，4： | 1 |
| 7 | Hippocampus and serum metabolomic studies to explore the regulation of Chaihu-Shu-Gan- San on metabolic network disturbances of rats exposed to chronic variable stress显示文摘 | Su ZH Jia HM Zhang HW | 2014 | Mol Biosyst2014，10，3： | 1 |
| 8 | Polycystic ovary syn- drome or hyperprolactinaemia:a study of mild hyper- prolactinaemia 显示文摘 | Su HW Chen CM Chou SY | 2011 | 6ynecol Endocrinol2011，27，1： | 1 |
| 9 | Assessment of HBV persistent infection in an adult population in Taiwan 显示文摘 | Peng HW Su TS Han SH | 1988 | J Med Virol1988，24，4： | 1 |
| 10 | Diversity of single small sub-cortical Infarctions according to Infarct location and parent arterydisease : analysis of Indicators for small vessel disease and athero-sclerosis显示文摘 | Nah HW Kang DW Kwon SU ei al | | Stroke0，41，12： | 1 |
| 11 | Hypopituitarism: a sequela of severe hypoxic encephalopatby 显示文摘 | Su DH Liao KM Chen HW | 2006 | J Formos Med Assoc2006，105，： | 1 |
| 12 | Rapid control of manic symptoms during combination of electroconvulsive therapy and lithi-um显示文摘 | Li TC Chiu HW Su PY | 2011 | J Neuropsychiatry Clin Neurosci2011，23，1： | 1 |
| 13 | Optimal length of mus- cle contraction显示文摘 | Chang YW Su FC Wu HW | 1999 | Clinical Biomechanics1999，14，8： | 1 |
| 14 | Radiation dose in the thyroid and the thyroid cancer risk attributable to CT scans for pediatric patients in one general hospital of China显示文摘 | Su YP Niu HW Chen JB | 2014 | Int J Environ Res Public Health2014，11，3： | 1 |
| 15 | Titanium dioxide nanoparticles in- duce emphysema-like lung injury in mice 显示文摘 | Chen HW Su SF Chien CT | 2006 | FASEB J2006，20，13： | 1 |
| 16 | Left ventricular Tei index : comparison between flow and tissue Doppler analyses 显示文摘 | Voon WC Su HM Yen HW | 2005 | Echocardiography2005，22，9： | 1 |
| 17 | Design of steel trian gular plate energy absorbers for seismic resistant construction显示文摘 | Tsai K C Chen HW Hong CP Su Y F | 1993 | Earthquake Spectra1993，19，3： | 1 |
| 18 | Effect of laser in situ keratomileusis on retinal nerve fiber layer thickness measurements by scanning laser polarimetry显示文摘 | Kook MS Lee SU Tchah HW Sung KR Park RH Kim KR | 2002 | J Cataract Refract Surg2002，28，： | 1 |
| 19 | Inhibitory effects of schisandrin A and schisandrin B on CYP3A activity 显示文摘 | Li WL Xin HW Su MW | 2010 | Methods Find Exp Clin Pharmacol2010，32，3： | 1 |
| 20 | Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt sig- naling pathways 显示文摘 | Lu KH Yang HW Su CW | 2013 | Food Chem Toxicol2013，52，： | 1 |
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