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| 1 | Endoscopic papillary large balloon dilatation with sphincterotomy is safe and effective for biliary stone removal independent of timing and size of sphincterotomy显示文摘AIM To describe the efficacy and safety of endoscopic papillary large balloon dilatation(EPLBD) in the management of bile duct stones in a Western population. METHODS Data was collected from the endoscopic retrograde cholangiopancreatography(ERCP) and Radiology electronic database along with a review of case notes over a period of six years from 1 st August 2009 to 31 st July 2015 and incorporated into Microsoft excel. Statistical analyses were performed using Med Calc for Windows,version 12.5(Med Calc Software,Ostend,Belgium). Simple statistical applications were applied in order to determine whether significant differences exist in comparison groups. We initially used simple proportions to describe the study populations. Furthermore,we used chi-square test to compare proportions and categorical variables. Non-parametric Mann-Whitney U-test was applied in order to compare continuous variables. All comparisons were deemed to be statistically significant if P values were less than 0.05.RESULTS EPLBD was performed in 229 patients(46 females) with mean age of 68 ± 14.3 years. 115/229(50%) patients had failed duct clearance at previous ERCP referred from elsewhere with standard techniques. Duct clearance at the Index* ERCP(1 st ERCP at our centre) was 72.5%. Final duct clearance rate was 98%. EPLBD after fresh sphincterotomy was performed in 81(35.4%). Median balloon size was 13.5 mm(10-18). In addition to EPLBD,per-oral cholangioscopy(POC) and electrohydraulic lithotripsy(EHL) was performed in 35(15%) patients at index* ERCP. 63(27.5%) required repeat ERCP for stone clearance. 28(44.5%) required POC and EHL and 11(17.4%) had repeat EPLBD for complete duct clearance. Larger stone size(12.4 mm vs 17.4 mm,P < 0.000001),multiple stones(2,range(1-13) vs 3,range(1-12),P < 0.006) and dilated common bile duct(CBD)(12.4 mm vs 18.3 mm,P < 0.001) were significant predictors of failed duct clearance at index ERCP. 47 patients(20%) had ampullary or peri-ampullary diverticula. Procedure related adverse events included 2 cases of bleeding and pancreatitis(0.87%) each.CONCLUSION EPLBD is a safe and effective technique for CBDS removal. There is no difference in outcomes whether it is performed at the time of sphincterotomy or at a later procedure or whether there is a full or limited sphincterotomy. | Usman Iqbal Aujla Nimzing Ladep Laura Dwyer Stephen Hood Nicholas Stern Richard Sturgess | 2017 | World Journal of Gastroenterology2017，23，48： | 8 |
| 2 | Portal vein cannulation:An uncommon complication of endoscopic retrograde cholangiopancreatography显示文摘Portal vein cannulation is a rare complication of endo-scopic retrograde cholangiopancreatography(ERCP).It has been reported that it usually occurs after endo-scopic sphincterotomy,whereas in cases without prior sphincterotomy,the presence of portobiliary fistulas has been shown.Here,we present a case in which cannulation of the portal vein occurred despite careful wire-guided cannulation and the absence of sphinc-terotomy.Although fatal cases of cerebral and pulmo-nary air and/or bile embolism have been reported in patients with combined portal and hepatic vein trauma after ERCP and sphincterotomy,isolated portal vein cannulation,as in the current case,does not usu-ally result in mortality or serious morbidity.However,awareness of this rare complication is important so that no further intervention is performed. | Evangelos Kalaitzakis Nicholas Stern Richard Sturgess | 2011 | World Journal of Gastroenterology2011，17，46： | 2 |
| 3 | An immunochemiluminometric assay forthe measurement of free thyroxine显示文摘 | Sturgess ML, Weeks I, Woodhead JS | 1988 | J Biolum and1988，3329，： | 1 |
| 4 | Finite-element modelling of metal flow in three-dimensional forming显示文摘 | HARTLEY P P STURGESS C E N ROWE R W | 1985 | Int J Mach Tool Des Res1985，25，： | 1 |
| 5 | Improving the effectiveness of autoantibody tesring in the clinic 显示文摘 | Sturgess A Edmond J | 2002 | Autoimm Rev2002，1，5： | 1 |
| 6 | Lean blowout in a research combustor at simulated low pressures显示文摘 | Sturgess G J Heneghan S P Vangsness M D | 1996 | Journal of Engineer- ing for Gas Turbines and Power1996，118，4： | 1 |
| 7 | Endoscopic therapy in the management of malignant biliary obstruction 显示文摘 | Stern N Sturgess R | 2008 | Eur J Surg Oncol2008，34，3： | 1 |
| 8 | Evidence for a separatemechanism of toxicity for the Type I and the Type II pyrethroid insec-ticides显示文摘 | Breckenridge CB Holden L Sturgess N | | Neurotoxicology0，30，1： | 1 |
| 9 | Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NMDA-2B subunit 显示文摘 | Laube B Hirai H Sturgess M | 1997 | Neuron1997，18，： | 1 |
| 10 | Molecular determinants of agonist discrimination by NMDA receptor subunits:analysis of the glutamate binding site on the NR2B subunit显示文摘 | Laube B Hirai H Sturgess M | 1997 | Neuron1997，18，3： | 1 |
| 11 | Improving the effectiveness of autoantibody testing in the clinic显示文摘 | Sturgess A Edmond J | 2002 | Autoimmunity Reviews2002，1，5： | 1 |
| 12 | Finite-element modeling of deformation and spread in slab rolling显示文摘 | C Liu P Hartley C E N Sturgess | 1987 | International Journal of Mechanical Science1987，29，4： | 1 |
| 13 | Prediction of hospi- tal outcome in septic shock:a prospective comparison of tissue Doppler and cardiac blomarkers显示文摘 | Sturgess DJ Marwick TH Joyce C | 2010 | Crit Care2010，14，2： | 1 |
| 14 | Fracture prediction in plastic deformation process 显示文摘 | Clift S E Hartley P Sturgess C E N | 1990 | Int J Mech Sci1990，32，： | 1 |
| 15 | Molecular determinants of agonist discrimination by NMDA receptor subunits:analy- sis of the glutamatebinding site on the NR2B subunit显示文摘 | Laube B Hirai H Sturgess M | 1997 | Neuron1997，18，3： | 1 |
| 16 | Activation of T Cells from the Intestinal Lamina Propria of the Pig显示文摘 | Bailey Plunkett Clarke Sturgess Haverson Stokes | 2002 | Scandinavian Journal of Immunology2002，，2： | 1 |
| 17 | Emissions reduc- tion technologies for military gas turbine engines显示文摘 | Sturgess G J Zelin J Shouse D T | 2005 | Jour- nal of Propulsion and Power2005，21，2： | 1 |
| 18 | Anti-citrullinated peptide antibody: death of the rheumatoid factor显示文摘 | CHATFIELD SM WICKS IP STURGESS AD | 2009 | Med J Aust2009，190，12： | 1 |
| 19 | Forging Die Design and Flow Simulation:Their Integration in Intelligent Knowledge-based Systems显示文摘 | Hartley P Sturgess C E N | 1987 | Journal of Mechanical Working Technology1987，，15： | 1 |
| 20 | Fracture prediction in plastic deformation processes显示文摘 | CLIFT S E HARTLEY P STURGESS C E N | 1990 | International Journal of Mechanical Sciences1990，32，1： | 1 |
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