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| 1 | New fecal test for non-invasive Helicobacter pylori detection:A diagnostic accuracy study显示文摘AIM To assess the diagnostic accuracy of a new fecal test for detecting Helicobacter pylori(H. pylori), using ^(13)Curea breath test as the reference standard, and explore bacterial antibiotic resistance. METHODS We conducted a prospective two-center diagnostic test accuracy study. We enrolled consecutive people≥ 18 years without previous diagnosis of H. pylori infection, referred for dyspepsia between February and October 2017. At enrollment, all participants underwent 13 C-urea breath test. Participants aged over 50 years were scheduled to undergo upper endoscopy with histology. Participants collected stool samples 1-3 d after enrollment for a new fecal investigation(THD fecal test). The detection of bacterial 23 S rRNA subunit gene indicated H. pylori infection. We also used the index diagnostic test to examine mutations conferring resistance to clarithromycin and levofloxacin. Independent investigators analyzed index test and reference test standard results blinded to the other test findings. We estimated sensitivity, specificity, positive(PPV) and negative(NPV) predictive value, diagnostic accuracy, positive and negative likelihood ratio(LR), together with 95% confidence intervals(CI).RESULTS We enrolled 294 consecutive participants(age: Median 37.0 years, IQR: 29.0-46.0 years; men: 39.8%). Ninetyfive(32.3%) participants had a positive ^(13)C-urea breath test. Twenty-three(7.8%) participants underwent upper endoscopy with histology, with a full concordance between ^(13)C-urea breath test and histology in detecting H. pylori infection. Four(1.4%) out of the 294 participants withdrew from the study after the enrollment visit and did not undergo THD fecal testing. In the 290 participants who completed the study, the THD fecal test sensitivity was 90.2%(CI: 84.2%-96.3%), specificity 98.5%(CI:96.8%-100%), PPV 96.5%(CI: 92.6%-100%), NPV 95.6%(CI: 92.8%-98.4%), accuracy 95.9%(CI: 93.6%-98.2%), positive LR 59.5(CI: 19.3-183.4), negative LR 0.10(CI: 0.05-0.18). Out of 83 infected participants identified with the THD fecal test, 34(41.0%) had bacterial genotypic changes consistent with antibiotic-resistant H. pylori infection. Of these, 27(32.5%) had bacterial strains resistant to clarithromycin, 3(3.6%) to levofloxacin, and 4(4.8%) to both antibiotics. CONCLUSION The THD fecal test has high performance for the non-invasive diagnosis of H. pylori infection while additionally enabling the assessment of bacterial antibiotic resistances. | Andrea Iannone Floriana Giorgio Francesco Russo Giuseppe Riezzo Bruna Girardi Maria Pricci Suetonia C Palmer Michele Barone Mariabeatrice Principi Giovanni FM Strippoli Alfredo Di Leo Enzo Ierardi | 2018 | World Journal of Gastroenterology2018，24，27： | 5 |
| 2 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 3 | Effects of statins in patients with chronic kidney disease:metaanalysis and meta regression of randomised controlled trials显示文摘 | Strippoli GF Navaneethan SD Johnson DW et el | | 0，，： | 1 |
| 4 | Effect of statins in patients with chronic kidney dis- ease: meta-analysis and meta-regression of randomized controlled trails 显示文摘 | STRIPPOLI G F NAVANEETHAN S D JOHNSON D W | 2008 | BMJ2008，336，： | 1 |
| 5 | Wheeze and asthma prevalence and related health-service use in white and south Asian preschool children in the United Kingdom显示文摘 | Kuehni CE Strippoli MP Low N | 2007 | Clin Exp Allergy2007，37，： | 1 |
| 6 | An 'evidence-based' survey of therapeutic options for IgA nephropathy: Assessment and Criticism 显示文摘 | Strippoli GF Manno C Schena FP | 2003 | Am J Kidney Dis2003，41，6： | 1 |
| 7 | An ‘evidence-based'survey of therapeutic options for IgA nephropathy:assessment and criticism显示文摘 | Strippoli G Mano C Schena F | 2003 | Am J Kidney Dis2003，41，： | 1 |
| 8 | Role of blood pressure targets and specific antihypertensive agents used to prevent diabetic nephropathy and delay its progression 显示文摘 | Strippoli GF Craig MC Schena FP | 2006 | J Am Soc Nephrol2006，17，42： | 1 |
| 9 | Role of blood pressure targets and specific antihypertensive agents used to prevent diabetic nephropathy and delay its progression 显示文摘 | Strippoli GF Craig MC Schena FP | 2006 | J Am Soc Nephrol2006，17，4： | 1 |
| 10 | Immunosuppressive treatments for immunoglobulin A nephropathy:a meta-analysis of randomized controlled trials显示文摘 | Samuels JA Strippoli GF Craig JC | | 0，，04： | 1 |
| 11 | IgA nephropathy:a disease in search of a large-scale clinical trial to reliably inform practice显示文摘 | Strippoli GF Maione A Schena FP | | 0，，： | 1 |
| 12 | Snoring in preschool children:prevalence,severity and risk factors显示文摘 | Kuehni CE Strippoli MPF Chauliac ES | 2008 | Eur Respir J2008，31，2： | 1 |
| 13 | Haemoglobin andhaematocrit targets for the anaemia of chronic kidney disease 显示文摘 | Strippoli G F M Navaneethan S D Craig J C | 2006 | Cochrane Database Syst Rev2006，4，： | 1 |
| 14 | Nerve growth factor downregulates inflammatory response in human monocytes through TrkA显示文摘 | Prencipe G Minnone G Strippoli R | 2014 | J Immunol2014，192，7： | 1 |
| 15 | Effects of statins in patients with chronic kidney disease:metaanalysis and meta-regression of randomized controlled trials显示文摘 | Strippoli GF Navaneethan SD Johnson DW | 2008 | BMJ2008，336，： | 1 |
| 16 | Snoring in preschool children: prevalence, severity and risk factors 显示文摘 | Kuehni C E Strippoli M P Chauliac E S | 2008 | Eur Respir J2008，31，2： | 1 |
| 17 | Management of primary ciliary dyskinesia in European children: recommendations and clinical practice 显示文摘 | Strippoli MP Frischer T Barbato A | 2012 | Eur Respir J2012，39，6： | 1 |
| 18 | Cold single-strand conformation polymorphism analysis:optimization for detection of APC gene mutations in patients with familial Adenomatous polyposis显示文摘 | Strippoli P Sarchielli S Santucci R | 2001 | Int J Mol Med2001，8，5： | 1 |
| 19 | An ‘evidence-based'survey of therapeutic options for IgA nephropathy:assessment and criticism显示文摘 | Strippoli G Mano C Schena F | 2003 | Am J Kidney Dis2003，41，： | 1 |
| 20 | Predictors of bleeding complications in percutaneous ultrasound-guided renal biopsy显示文摘 | Manno C Strippoli GF Arnesano L | 2004 | Kidney Int2004，66，4： | 1 |
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