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| 1 | 肛周Crohn病:评估动态增强MR成像作为疾病活动性指标显示文摘目的前瞻性研究动态增强MR成像评估肛周Crohn病活动性的临床价值。方法病人签署了知情同意书,机构审查委员会放弃了批准。33例肛周Crohn病病人进行盆腔MRI检查,其中男性17例[平均年龄(37.4±10.8)岁,范围18~54岁],女性16例[平均年龄(32.0±8.3)岁,范同16±43岁]。每例均行动态增强MRI检查,获得时间信号强度曲线。按预先设定的6种类型时间信号强度曲线对每一个像素进行分类。每次MRI检查均在病变范围最大、信号最高层面上沿窦道描画兴趣区,计算最大强化值、强化斜率和时间信号强度曲线类型。 | K. Horsthuis C. Lavini S. Bipat P.C. Stokkers J. Stoker. 龙淼淼(译) 季倩(校) | 2009 | 国际医学放射学杂志2009，32，4： | 10 |
| 2 | 应用MRI评估Crohn病的活动性:系统性综述显示文摘系统总结MRI对Crohn病活动性分级的准确性。在MEDLINE、EMBASE、CINAHL和Cochrane数据库检索有关MRI对Crohn病分级准确性的研究,以已有的标准做对照。2名观察者独立对所有相关的数据进行评分。将疾病分3期:缓和型病变、温和型病变、显著型病变。MRI分级的准确率都是通过随机效应的模式计算得出。从检索的253篇文章选择7项研究结果进行分析。140例病人(16例缓和型、29例温和型和95例显著型病人)被用来进行数据分析。 | K. Horsthuis S. Bipat P.C.F. Stokkers J. Stoker 郝彩仙(译) 刘筠(校) | 2009 | 国际医学放射学杂志2009，32，4： | 4 |
| 3 | ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease. | Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde | 2014 | World Journal of Gastroenterology2014，20，10： | 2 |
| 4 | Do Inflammatory Bowel Disease patients with anxiety and depressive symptoms receive the care they need?显示文摘 | F. Bennebroek Evertsz’ N.A.M. Thijssens P.C.F. Stokkers M.A. Grootenhuis C.L.H. Bockting P.T. Nieuwkerk M.A.G. Sprangers | 2011 | Journal of Crohn’s and Colitis2011，，1： | 2 |
| 5 | Adalimumab for Crohn’s disease: Long-term sustained benefit in a population-based cohort of 438 patients显示文摘 | Charlotte P. Peters Emma J. Eshuis Florien M. Toxopeüs Merel E. Hellemons Jeroen M. Jansen Geert R.A.M. D’Haens Paul Fockens Pieter C.F. Stokkers Hans A.R.E. Tuynman Adriaan A. van Bodegraven Cyriel Y. Ponsioen | 2014 | Journal of Crohn’s and Colitis2014，，： | 2 |
| 6 | Previous infliximab therapy and postoperative complications after proctocolectomy with ileum pouch anal anastomosis显示文摘 | Eshuis EJ Al Saady RL Stokkers PC | 2013 | J Crohns Colitis2013，7，2： | 1 |
| 7 | Developmental regulation of epidermal growth factor receptor kinase in rat intestine显示文摘 | Van M Stokkers PCF | 1994 | Gastroenterology1994，107，5： | 1 |
| 8 | HLA-DR and -DQ phenotypes in inflammatory bowel disease: a meta-analysis 显示文摘 | Stokkers P C F Reitsma P H Tytgat G N J | 1999 | Gut1999，45，3： | 1 |
| 9 | Long-term outcomes following laparoscopically assisted versus open ileocolic resection for Crohn's disease显示文摘 | Eshuis EJ Slors JF Stokkers PC | | 0，，04： | 1 |
| 10 | Inflammatory bowel disease and the genes for the natural resistance-associated macrophage protein-1 and the interferon-á receptor 1显示文摘 | P. C. F. Stokkers K. de Heer A. C. Leegwater P. H. Reitsma G. N. J. Tytgat S. J. H. van Deventer | 1999 | International Journal of Colorectal Disease1999，，1： | 1 |
| 11 | Long-term outcomes following laparoscopically assisted versus open ileocolic resec- tion for Crohn's disease显示文摘 | Eshuis E J Slors JF Stokkers PC | 2010 | Br J Surg2010，97，4： | 1 |
| 12 | Laparoscopic re- section with transcolonic specimen extraction for ileocaecal Crohn's disease显示文摘 | Eshuis E J Voermans RP Stokkers PC | 2010 | Br J Surg2010，97，4： | 1 |
| 13 | New cytokine therapeutics for inflammatory bowel disease显示文摘 | Stokkers PCF Hommes DW | 2004 | Cytokine2004，28，45： | 1 |
| 14 | Pilot study of probe-based confocal laser endomicroscopy during colonoscopic surveillance of patients with longstanding ulcerative colitis显示文摘 | F. van den Broek J. van Es S. van Eeden P. Stokkers C. Ponsioen J. Reitsma P. Fockens E. Dekker | 2011 | Endoscopy2011，，02： | 1 |
| 15 | Phase I, double-blind, randomized, placebo-controlled, dose-escalation study of NI-0401 ( a fully human anti-CD3 monoclonal antibody) in patients with moderate to severe active Crohn' s disease显示文摘 | van der Woude C J Stokkers P van Bodegraven AA | 2010 | Intlamm Bowel Dis2010，16，10： | 1 |
| 16 | Extensive platelet activation in preeclampsia comparedwith normal pregnancy : enhanced expression of cell adhesion of cell adhesion molecules 显示文摘 | KONIJNENBERG A STOKKERS EW VANDERPOST JAM | 2004 | Am J Obstet Gyneacol2004，176，： | 1 |
| 17 | Strong protective effect of DR3 against ulcerative colitis in the spanish population 显示文摘 | Stokkers PC Reitsma PH Tytgat GN | 2007 | Am J Gastroenterol2007，102，： | 1 |
| 18 | Five genetic markers in the interleukin 1 family in relation to inflammatory bowel disease显示文摘 | Stokkers P C van Aken B E Basoski N | 1998 | Gut1998，43，1： | 1 |
| 19 | Extensive platelet activation in preeclampsia compared with normal pregnancy : enhanced expression of cell adhesion molecules 显示文摘 | Konijnenberg A Stokkers EW van der Post JA | 1997 | Am J Obstet Gynecol1997，176，2： | 1 |
| 20 | Random biop- sies taken during colonoscopic surveillance of patients with long- standing ulcerative colitis : low yield and absence of clinical con- sequences显示文摘 | van den Broek FJ Stokkers PC Reitsma JB | 2014 | Am J Gastroenterol2014，109，5： | 1 |
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